Kim A. Caldwell Department of Biological Sciences University of Alabama Biography Publications Institution JoVE Articles Kim A. Caldwell has not added a biography. If you are Kim A. Caldwell and would like to personalize this page please email our Author Liaison for assistance. Publications Functional Analysis of VPS41-Mediated Neuroprotection in Caenorhabditis Elegans and Mammalian Models of Parkinson's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2012 | Pubmed ID: 22323726 Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity Through Distinct Mechanisms The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22147697 Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast Science (New York, N.Y.). Dec, 2011 | Pubmed ID: 22033521 Modeling Dopamine Neuron Degeneration in Caenorhabditis Elegans Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21913098 Inhibitors of LRRK2 Kinase Attenuate Neurodegeneration and Parkinson-like Phenotypes in Caenorhabditis Elegans and Drosophila Parkinson's Disease Models Human Molecular Genetics. Oct, 2011 | Pubmed ID: 21768216 TorsinA Participates in Endoplasmic Reticulum-associated Degradation Nature Communications. 2011 | Pubmed ID: 21750546 Structural Features and Chaperone Activity of the NudC Protein Family Journal of Molecular Biology. Jun, 2011 | Pubmed ID: 21530541 Caenorhabditis Elegans As a Model System for Identifying Effectors of α-synuclein Misfolding and Dopaminergic Cell Death Associated with Parkinson's Disease Methods (San Diego, Calif.). Mar, 2011 | Pubmed ID: 21195766 The Early-onset Torsion Dystonia-associated Protein, TorsinA, is a Homeostatic Regulator of Endoplasmic Reticulum Stress Response Human Molecular Genetics. Sep, 2010 | Pubmed ID: 20584926 Low-dose Bafilomycin Attenuates Neuronal Cell Death Associated with Autophagy-lysosome Pathway Dysfunction Journal of Neurochemistry. Aug, 2010 | Pubmed ID: 20534000 Chemical Enhancement of TorsinA Function in Cell and Animal Models of Torsion Dystonia Disease Models & Mechanisms. May-Jun, 2010 | Pubmed ID: 20223934 The Early-onset Torsion Dystonia-associated Protein, TorsinA, Displays Molecular Chaperone Activity in Vitro Cell Stress & Chaperones. Sep, 2010 | Pubmed ID: 20169475 C. Elegans As a Model Organism to Investigate Molecular Pathways Involved with Parkinson's Disease Developmental Dynamics : an Official Publication of the American Association of Anatomists. May, 2010 | Pubmed ID: 20108318 Compounds from an Unbiased Chemical Screen Reverse Both ER-to-Golgi Trafficking Defects and Mitochondrial Dysfunction in Parkinson's Disease Models Disease Models & Mechanisms. Mar-Apr, 2010 | Pubmed ID: 20038714 VPS41, a Protein Involved in Lysosomal Trafficking, is Protective in Caenorhabditis Elegans and Mammalian Cellular Models of Parkinson's Disease Neurobiology of Disease. Feb, 2010 | Pubmed ID: 19850127 Investigating Bacterial Sources of Toxicity As an Environmental Contributor to Dopaminergic Neurodegeneration PloS One. 2009 | Pubmed ID: 19806188 Pharmacogenetic Analysis Reveals a Post-developmental Role for Rac GTPases in Caenorhabditis Elegans GABAergic Neurotransmission Genetics. Dec, 2009 | Pubmed ID: 19797046 Rapid Selection of Cyclic Peptides That Reduce Alpha-synuclein Toxicity in Yeast and Animal Models Nature Chemical Biology. Sep, 2009 | Pubmed ID: 19597508 Alpha-synuclein is Part of a Diverse and Highly Conserved Interaction Network That Includes PARK9 and Manganese Toxicity Nature Genetics. Mar, 2009 | Pubmed ID: 19182805 The Microtubule-associated Protein, NUD-1, Exhibits Chaperone Activity in Vitro Cell Stress & Chaperones. Jan, 2009 | Pubmed ID: 18626791 Traversing a Wormhole to Combat Parkinson's Disease Disease Models & Mechanisms. Jul-Aug, 2008 | Pubmed ID: 19048050 Lysosomal Enzyme Cathepsin D Protects Against Alpha-synuclein Aggregation and Toxicity Molecular Brain. 2008 | Pubmed ID: 19021916 Acetaminophen Attenuates Dopamine Neuron Degeneration in Animal Models of Parkinson's Disease Neuroscience Letters. Jul, 2008 | Pubmed ID: 18514411 Hypothesis-based RNAi Screening Identifies Neuroprotective Genes in a Parkinson's Disease Model Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18182484 The Parkinson's Disease Protein Alpha-synuclein Disrupts Cellular Rab Homeostasis Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18162536 Ubiquitin Conjugating Enzymes Participate in Polyglutamine Protein Aggregation BMC Cell Biology. 2007 | Pubmed ID: 17663792 Genetic Interactions Among Cortical Malformation Genes That Influence Susceptibility to Convulsions in C. Elegans Brain Research. Nov, 2006 | Pubmed ID: 16996038 Deletion of the Ubiquitin Ligase CHIP Leads to the Accumulation, but Not the Aggregation, of Both Endogenous Phospho- and Caspase-3-cleaved Tau Species The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2006 | Pubmed ID: 16807328 Alpha-synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models Science (New York, N.Y.). Jul, 2006 | Pubmed ID: 16794039 Torsin-mediated Protection from Cellular Stress in the Dopaminergic Neurons of Caenorhabditis Elegans The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2005 | Pubmed ID: 15829632 Epileptic-like Convulsions Associated with LIS-1 in the Cytoskeletal Control of Neurotransmitter Signaling in Caenorhabditis Elegans Human Molecular Genetics. Sep, 2004 | Pubmed ID: 15254012 Using Caenorhabditis Elegans to Probe Toxicity of 1-alkyl-3-methylimidazolium Chloride Based Ionic Liquids Chemical Communications (Cambridge, England). Mar, 2004 | Pubmed ID: 15010772 An Animal Model to Discern Torsin Function: Suppression of Protein Aggregation in C. Elegans Advances in Neurology. 2004 | Pubmed ID: 14509658 Role for NudC, a Dynein-associated Nuclear Movement Protein, in Mitosis and Cytokinesis Journal of Cell Science. May, 2003 | Pubmed ID: 12679384 Suppression of Polyglutamine-induced Protein Aggregation in Caenorhabditis Elegans by Torsin Proteins Human Molecular Genetics. Feb, 2003 | Pubmed ID: 12554684 Mikroenjeksiyon Kararlı Transgenik C. elegans Üretimi Laura A. Berkowitz1, Adam L. Knight1, Guy A. Caldwell1, Kim A. Caldwell1 1Department of Biological Sciences, University of Alabama JoVE 833 Biology Potansiyel Parkinson Hastalığı Genler Doğrulama için C. elegans Dopamin Nöron Dejenerasyonu Testi Uygulama Laura A. Berkowitz1, Shusei Hamamichi1, Adam L. Knight1, Adam J. Harrington1, Guy A. Caldwell1, Kim A. Caldwell1 1Department of Biological Sciences, University of Alabama JoVE 835 Biology
Mikroenjeksiyon Kararlı Transgenik C. elegans Üretimi Laura A. Berkowitz1, Adam L. Knight1, Guy A. Caldwell1, Kim A. Caldwell1 1Department of Biological Sciences, University of Alabama JoVE 833 Biology
Potansiyel Parkinson Hastalığı Genler Doğrulama için C. elegans Dopamin Nöron Dejenerasyonu Testi Uygulama Laura A. Berkowitz1, Shusei Hamamichi1, Adam L. Knight1, Adam J. Harrington1, Guy A. Caldwell1, Kim A. Caldwell1 1Department of Biological Sciences, University of Alabama JoVE 835 Biology