Kristoffer Valerie Department of Radiation Oncology Virginia Commonwealth University Biography Publications Institution JoVE Articles Kristoffer Valerie has not added a biography. If you are Kristoffer Valerie and would like to personalize this page please email our Author Liaison for assistance. Publications Dynamic Inhibition of ATM Kinase Provides a Strategy for Glioblastoma Multiforme Radiosensitization and Growth Control Cell Cycle (Georgetown, Tex.). Mar, 2012 | Pubmed ID: 22370485 BRCA1-directed, Enhanced and Aberrant Homologous Recombination: Mechanism and Potential Treatment Strategies Cell Cycle (Georgetown, Tex.). Feb, 2012 | Pubmed ID: 22306997 Nanomaterial-mediated CNS Delivery of Diagnostic and Therapeutic Agents Advanced Drug Delivery Reviews. May, 2012 | Pubmed ID: 22178615 MRE11 and ATM AKTivate Pro-survival Signaling Cell Cycle (Georgetown, Tex.). Oct, 2011 | Pubmed ID: 21946569 DNA Double-strand Break - Induced Pro-survival Signaling Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. Oct, 2011 | Pubmed ID: 21726915 Mutations in the BRCT Binding Site of BRCA1 Result in Hyper-recombination Aging. May, 2011 | Pubmed ID: 21666281 ATM-dependent ERK Signaling Via AKT in Response to DNA Double-strand Breaks Cell Cycle (Georgetown, Tex.). Feb, 2011 | Pubmed ID: 21263216 ATM-independent, High-fidelity Nonhomologous End Joining Predominates in Human Embryonic Stem Cells Aging. Sep, 2010 | Pubmed ID: 20844317 Dynamic Dependence on ATR and ATM for Double-strand Break Repair in Human Embryonic Stem Cells and Neural Descendants PloS One. 2010 | Pubmed ID: 20368801 Improved ATM Kinase Inhibitor KU-60019 Radiosensitizes Glioma Cells, Compromises Insulin, AKT and ERK Prosurvival Signaling, and Inhibits Migration and Invasion Molecular Cancer Therapeutics. Oct, 2009 | Pubmed ID: 19808981 Tyrosyl-DNA Phosphodiesterase and the Repair of 3'-phosphoglycolate-terminated DNA Double-strand Breaks DNA Repair. Aug, 2009 | Pubmed ID: 19505854 Requirement for XLF/Cernunnos in Alignment-based Gap Filling by DNA Polymerases Lambda and Mu for Nonhomologous End Joining in Human Whole-cell Extracts Nucleic Acids Research. Jul, 2009 | Pubmed ID: 19420065 Nuclear Factor I Isoforms Regulate Gene Expression During the Differentiation of Human Neural Progenitors to Astrocytes Stem Cells (Dayton, Ohio). May, 2009 | Pubmed ID: 19418463 Pro-survival AKT and ERK Signaling from EGFR and Mutant EGFRvIII Enhances DNA Double-strand Break Repair in Human Glioma Cells Cancer Biology & Therapy. Apr, 2009 | Pubmed ID: 19252415 In Vitro Complementation of Tdp1 Deficiency Indicates a Stabilized Enzyme-DNA Adduct from Tyrosyl but Not Glycolate Lesions As a Consequence of the SCAN1 Mutation DNA Repair. May, 2009 | Pubmed ID: 19211312 Cloning and Characterization of SARI (suppressor of AP-1, Regulated by IFN) Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19074269 Coordinate 5' and 3' Endonucleolytic Trimming of Terminally Blocked Blunt DNA Double-strand Break Ends by Artemis Nuclease and DNA-dependent Protein Kinase Nucleic Acids Research. Jun, 2008 | Pubmed ID: 18440975 Novel Mode for Neutrophil Protease Cathepsin G-mediated Signaling: Membrane Shedding of Epidermal Growth Factor is Required for Cardiomyocyte Anoikis Circulation Research. Jan, 2008 | Pubmed ID: 17975113 Progression Elevated Gene-3 Promoter (PEG-Prom) Confers Cancer Cell Selectivity to Human Polynucleotide Phosphorylase (hPNPase(old-35))-mediated Growth Suppression Journal of Cellular Physiology. May, 2008 | Pubmed ID: 17960560 Phosphorylation in the Serine/threonine 2609-2647 Cluster Promotes but is Not Essential for DNA-dependent Protein Kinase-mediated Nonhomologous End Joining in Human Whole-cell Extracts Nucleic Acids Research. 2007 | Pubmed ID: 17526517 Molecular Cancer Therapeutics. Mar, 2007 | Pubmed ID: 17363476 Extracellular Signal-related Kinase Positively Regulates Ataxia Telangiectasia Mutated, Homologous Recombination Repair, and the DNA Damage Response Cancer Research. Feb, 2007 | Pubmed ID: 17283137 Human Chorionic Gonadotropin Modulates Prostate Cancer Cell Survival After Irradiation or HMG CoA Reductase Inhibitor Treatment Molecular Pharmacology. Jan, 2007 | Pubmed ID: 17050804 N-glycosylation of MDA-7/IL-24 is Dispensable for Tumor Cell-specific Apoptosis and "bystander" Antitumor Activity Cancer Research. Dec, 2006 | Pubmed ID: 17178884 BiP/GRP78 is an Intracellular Target for MDA-7/IL-24 Induction of Cancer-specific Apoptosis Cancer Research. Aug, 2006 | Pubmed ID: 16912197 Effect of Hepatitis C Virus Core Protein on the Molecular Profiling of Human B Lymphocytes Molecular Medicine (Cambridge, Mass.). Jan-Mar, 2006 | Pubmed ID: 16838065 ErbB Receptor Tyrosine Kinase Network Inhibition Radiosensitizes Carcinoma Cells International Journal of Radiation Oncology, Biology, Physics. Jul, 2006 | Pubmed ID: 16751066 Molecular Target-based Therapy of Pancreatic Cancer Cancer Research. Feb, 2006 | Pubmed ID: 16489047 Activation of the Nuclear Factor KappaB Pathway by Astrocyte Elevated Gene-1: Implications for Tumor Progression and Metastasis Cancer Research. Feb, 2006 | Pubmed ID: 16452207 Compensatory ErbB3/c-Src Signaling Enhances Carcinoma Cell Survival to Ionizing Radiation Breast Cancer Research and Treatment. Jan, 2006 | Pubmed ID: 16267617 Mda-9/Syntenin: a Positive Regulator of Melanoma Metastasis Cancer Research. Dec, 2005 | Pubmed ID: 16322237 Radiosensitization of MDA-MB-231 Breast Tumor Cells by Adenovirus-mediated Overexpression of a Fragment of the XRCC4 Protein Molecular Cancer Therapeutics. Oct, 2005 | Pubmed ID: 16227403 Targeted Virus Replication Plus Immunotherapy Eradicates Primary and Distant Pancreatic Tumors in Nude Mice Cancer Research. Oct, 2005 | Pubmed ID: 16204080 Defining the Domains of Human Polynucleotide Phosphorylase (hPNPaseOLD-35) Mediating Cellular Senescence Molecular and Cellular Biology. Aug, 2005 | Pubmed ID: 16055741 Requirement of Tyr-992 and Tyr-1173 in Phosphorylation of the Epidermal Growth Factor Receptor by Ionizing Radiation and Modulation by SHP2 The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15708852 Deficiency in 3'-phosphoglycolate Processing in Human Cells with a Hereditary Mutation in Tyrosyl-DNA Phosphodiesterase (TDP1) Nucleic Acids Research. 2005 | Pubmed ID: 15647511 Targeting Gene Expression Selectively in Cancer Cells by Using the Progression-elevated Gene-3 Promoter Proceedings of the National Academy of Sciences of the United States of America. Jan, 2005 | Pubmed ID: 15647352 Inhibition of the Type III Epidermal Growth Factor Receptor Variant Mutant Receptor by Dominant-negative EGFR-CD533 Enhances Malignant Glioma Cell Radiosensitivity Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2004 | Pubmed ID: 15475464 Radiation-induced Activation of a Common Variant of EGFR Confers Enhanced Radioresistance Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. Sep, 2004 | Pubmed ID: 15450724 Melanoma Differentiation Associated Gene-7/interleukin-24 Promotes Tumor Cell-specific Apoptosis Through Both Secretory and Nonsecretory Pathways Cancer Research. May, 2004 | Pubmed ID: 15126330 Double Strand Break Repair by Homologous Recombination is Regulated by Cell Cycle-independent Signaling Via ATM in Human Glioma Cells The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14744854 Expression Analysis and Genomic Characterization of Human Melanoma Differentiation Associated Gene-5, Mda-5: a Novel Type I Interferon-responsive Apoptosis-inducing Gene Oncogene. Mar, 2004 | Pubmed ID: 14676839 Activation of the Stress-activated JNK and P38 MAP Kinases in Human Cells by Photofrin-mediated Photodynamic Therapy Journal of Photochemistry and Photobiology. B, Biology. Oct, 2003 | Pubmed ID: 14705642 Curcumin Inhibits Ultraviolet Light Induced Human Immunodeficiency Virus Gene Expression Molecular and Cellular Biochemistry. Dec, 2003 | Pubmed ID: 14674708 Triggering of Apoptosis is Not Sufficient to Induce Human Immunodeficiency Virus Gene Expression IUBMB Life. Jul, 2003 | Pubmed ID: 14584593 Regulation and Mechanisms of Mammalian Double-strand Break Repair Oncogene. Sep, 2003 | Pubmed ID: 12947387 EGFRvIII-mediated Radioresistance Through a Strong Cytoprotective Response Oncogene. Aug, 2003 | Pubmed ID: 12944901 MDA-7 (interleukin-24) Inhibits the Proliferation of Renal Carcinoma Cells and Interacts with Free Radicals to Promote Cell Death and Loss of Reproductive Capacity Molecular Cancer Therapeutics. Jul, 2003 | Pubmed ID: 12883035 Involvement of Crm1 in Hepatitis B Virus X Protein-induced Aberrant Centriole Replication and Abnormal Mitotic Spindles Molecular and Cellular Biology. Aug, 2003 | Pubmed ID: 12861014 Adenovirus Expressing P53 Methods in Molecular Biology (Clifton, N.J.). 2003 | Pubmed ID: 12824521 Dominant-negative CAMP-responsive Element-binding Protein Inhibits Proliferating Cell Nuclear Antigen and DNA Repair, Leading to Increased Cellular Radiosensitivity The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12734192 Down-regulation of Myc As a Potential Target for Growth Arrest Induced by Human Polynucleotide Phosphorylase (hPNPaseold-35) in Human Melanoma Cells The Journal of Biological Chemistry. Jul, 2003 | Pubmed ID: 12721301 Bile Acid Regulation of C/EBPbeta, CREB, and C-Jun Function, Via the Extracellular Signal-regulated Kinase and C-Jun NH2-terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes Molecular and Cellular Biology. May, 2003 | Pubmed ID: 12697808 Melanoma Differentiation Associated Gene-7, Mda-7/IL-24, Selectively Induces Growth Suppression, Apoptosis and Radiosensitization in Malignant Gliomas in a P53-independent Manner Oncogene. Feb, 2003 | Pubmed ID: 12606943 BLM Helicase-dependent Transport of P53 to Sites of Stalled DNA Replication Forks Modulates Homologous Recombination The EMBO Journal. Mar, 2003 | Pubmed ID: 12606585 Stress and Radiation-induced Activation of Multiple Intracellular Signaling Pathways Radiation Research. Mar, 2003 | Pubmed ID: 12600231 Mood-enhancing Antidepressant St. John's Wort Inhibits the Activation of Human Immunodeficiency Virus Gene Expression by Ultraviolet Light IUBMB Life. Dec, 2002 | Pubmed ID: 12665247 Identification and Cloning of Human Polynucleotide Phosphorylase, HPNPase Old-35, in the Context of Terminal Differentiation and Cellular Senescence Proceedings of the National Academy of Sciences of the United States of America. Dec, 2002 | Pubmed ID: 12473748 SAGE Transcript Profiles of Normal Primary Human Hepatocytes Expressing Oncogenic Hepatitis B Virus X Protein FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2002 | Pubmed ID: 12207007 Epidermal Growth Factor Receptor Dependence of Radiation-induced Transcription Factor Activation in Human Breast Carcinoma Cells Molecular Biology of the Cell. Jul, 2002 | Pubmed ID: 12134064 Mda-7 (IL-24) Mediates Selective Apoptosis in Human Melanoma Cells by Inducing the Coordinated Overexpression of the GADD Family of Genes by Means of P38 MAPK Proceedings of the National Academy of Sciences of the United States of America. Jul, 2002 | Pubmed ID: 12114539 UVB-mediated Activation of P38 Mitogen-activated Protein Kinase Enhances Resistance of Normal Human Keratinocytes to Apoptosis by Stabilizing Cytoplasmic P53 The Biochemical Journal. Jul, 2002 | Pubmed ID: 12071847 Ionizing Radiation Activates Erb-B Receptor Dependent Akt and P70 S6 Kinase Signaling in Carcinoma Cells Oncogene. Jun, 2002 | Pubmed ID: 12037685 Radiosensitization of Human Glioma Cells in Vitro and in Vivo with Acyclovir and Mutant HSV-TK75 Expressed from Adenovirus International Journal of Radiation Oncology, Biology, Physics. Mar, 2002 | Pubmed ID: 11849808 Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins Jason M. Beckta1,2, Scott C. Henderson3, Kristoffer Valerie1,2,4 1Department of Radiation Oncology, Virginia Commonwealth University, 2Department of Biochemistry & Molecular Biology, Virginia Commonwealth University, 3Department of Anatomy & Neurobiology, Virginia Commonwealth University, 4Massey Cancer Center, Virginia Commonwealth University JoVE 4251 Biology
Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins Jason M. Beckta1,2, Scott C. Henderson3, Kristoffer Valerie1,2,4 1Department of Radiation Oncology, Virginia Commonwealth University, 2Department of Biochemistry & Molecular Biology, Virginia Commonwealth University, 3Department of Anatomy & Neurobiology, Virginia Commonwealth University, 4Massey Cancer Center, Virginia Commonwealth University JoVE 4251 Biology