Leo Timmers Department of Experimental Cardiology University Medical Center Utrecht Biography Publications Institution JoVE Articles Leo Timmers has not added a biography. If you are Leo Timmers and would like to personalize this page please email our Author Liaison for assistance. Publications No Benefit of Additional Treatment with Exenatide in Patients with an Acute Myocardial Infarction International Journal of Cardiology. Oct, 2016 | Pubmed ID: 27394978 Coronary Aneurysm Without Malapposition After Bioresorbable Vascular Scaffold Implantation EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. May, 2016 | Pubmed ID: 27173862 Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure: An Observational Study in a Dyspnoea Cohort PloS One. 2016 | Pubmed ID: 26820481 Suspected Acute Coronary Syndrome in the Emergency Room: Limited Added Value of Heart Type Fatty Acid Binding Protein Point of Care or ELISA Tests: The FAME-ER (Fatty Acid Binding Protein in Myocardial Infarction Evaluation in the Emergency Room) Study European Heart Journal. Acute Cardiovascular Care. Aug, 2016 | Pubmed ID: 25906779 Ethnic Differences in Clinical Outcome of Patients Presenting to the Emergency Department with Chest Pain European Heart Journal. Acute Cardiovascular Care. Dec, 2015 | Pubmed ID: 26714971 The Diagnostic and Prognostic Potential of Plasma Extracellular Vesicles for Cardiovascular Disease Expert Review of Molecular Diagnostics. 2015 | Pubmed ID: 26535492 BLT1 Antagonist LSN2792613 Reduces Infarct Size in a Mouse Model of Myocardial Ischaemia-reperfusion Injury Cardiovascular Research. Dec, 2015 | Pubmed ID: 26449403 Very Late Bioresorbable Vascular Scaffold Thrombosis Following Discontinuation of Antiplatelet Therapy European Heart Journal. Feb, 2015 | Pubmed ID: 25336226 Fast Assessment and Management of Chest Pain Without ST-elevation in the Pre-hospital Gateway: Rationale and Design European Heart Journal. Acute Cardiovascular Care. Apr, 2015 | Pubmed ID: 25202026 Leucocyte Expression of Complement C5a Receptors Exacerbates Infarct Size After Myocardial Reperfusion Injury Cardiovascular Research. Sep, 2014 | Pubmed ID: 24935433 Systemic Toll-like Receptor and Interleukin-18 Pathway Activation in Patients with Acute ST Elevation Myocardial Infarction Journal of Molecular and Cellular Cardiology. Feb, 2014 | Pubmed ID: 24389343 Serum Extracellular Vesicle Protein Levels Are Associated with Acute Coronary Syndrome European Heart Journal. Acute Cardiovascular Care. Mar, 2013 | Pubmed ID: 24062934 Optical Coherence Tomography Imaging of Acute Stent Thrombosis After Stentys Stent Implantation Journal of the American College of Cardiology. Apr, 2013 | Pubmed ID: 23500257 Microvesicle Protein Levels Are Associated with Increased Risk for Future Vascular Events and Mortality in Patients with Clinically Manifest Vascular Disease International Journal of Cardiology. Oct, 2013 | Pubmed ID: 23484740 Taking Risk Prediction to the Next Level. Advances in Biomarker Research for Atherosclerosis Current Pharmaceutical Design. 2013 | Pubmed ID: 23438953 Mesenchymal Stem Cell-derived Exosomes Increase ATP Levels, Decrease Oxidative Stress and Activate PI3K/Akt Pathway to Enhance Myocardial Viability and Prevent Adverse Remodeling After Myocardial Ischemia/reperfusion Injury Stem Cell Research. May, 2013 | Pubmed ID: 23399448 Lack of Haptoglobin Results in Unbalanced VEGFα/angiopoietin-1 Expression, Intramural Hemorrhage and Impaired Wound Healing After Myocardial Infarction Journal of Molecular and Cellular Cardiology. Mar, 2013 | Pubmed ID: 23274064 Effect of Additional Treatment with EXenatide in Patients with an Acute Myocardial Infarction: the EXAMI Study International Journal of Cardiology. Jul, 2013 | Pubmed ID: 23084550 Treatment with OPN-305, a Humanized Anti-Toll-Like Receptor-2 Antibody, Reduces Myocardial Ischemia/reperfusion Injury in Pigs Circulation. Cardiovascular Interventions. Apr, 2012 | Pubmed ID: 22354933 The Innate Immune Response in Reperfused Myocardium Cardiovascular Research. May, 2012 | Pubmed ID: 22266751 Effect of Additional Treatment with EXenatide in Patients with an Acute Myocardial Infarction (EXAMI): Study Protocol for a Randomized Controlled Trial Trials. 2011 | Pubmed ID: 22067476 Human Mesenchymal Stem Cell-conditioned Medium Improves Cardiac Function Following Myocardial Infarction Stem Cell Research. May, 2011 | Pubmed ID: 21419744 Assessment of Collateral Artery Function and Growth in a Pig Model of Stepwise Coronary Occlusion American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2011 | Pubmed ID: 20952668 Arteriogenesis Requires Toll-like Receptor 2 and 4 Expression in Bone-marrow Derived Cells Journal of Molecular and Cellular Cardiology. Jan, 2011 | Pubmed ID: 20708624 Exosome Secreted by MSC Reduces Myocardial Ischemia/reperfusion Injury Stem Cell Research. May, 2010 | Pubmed ID: 20138817 Myocardial Ischemia/reperfusion Injury is Mediated by Leukocytic Toll-like Receptor-2 and Reduced by Systemic Administration of a Novel Anti-toll-like Receptor-2 Antibody Circulation. Jan, 2010 | Pubmed ID: 20026776 Exenatide Reduces Infarct Size and Improves Cardiac Function in a Porcine Model of Ischemia and Reperfusion Injury Journal of the American College of Cardiology. Feb, 2009 | Pubmed ID: 19195607 Targeted Deletion of Nuclear Factor KappaB P50 Enhances Cardiac Remodeling and Dysfunction Following Myocardial Infarction Circulation Research. Mar, 2009 | Pubmed ID: 19168865 The Nuclear Factor-kappa B P50 Subunit is Involved in Flow-induced Outward Arterial Remodeling Atherosclerosis. Feb, 2009 | Pubmed ID: 18617174 Bridging Innate Immunity and Myocardial Ischemia/reperfusion Injury: the Search for Therapeutic Targets Current Pharmaceutical Design. 2008 | Pubmed ID: 18473868 Toll-like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction Circulation Research. Feb, 2008 | Pubmed ID: 18007026 Reduction of Myocardial Infarct Size by Human Mesenchymal Stem Cell Conditioned Medium Stem Cell Research. Nov, 2007 | Pubmed ID: 19383393 Microsomal Prostaglandin E2 Synthase: a Safer Target Than Cyclooxygenases? Molecular Interventions. Aug, 2007 | Pubmed ID: 17827439 Growth Factor Therapy in Atherosclerotic Disease-friend or Foe Current Pharmaceutical Design. 2007 | Pubmed ID: 17584109 Cyclooxygenase-2 Inhibition Increases Mortality, Enhances Left Ventricular Remodeling, and Impairs Systolic Function After Myocardial Infarction in the Pig Circulation. Jan, 2007 | Pubmed ID: 17210840 Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction Guilielmus H.J.M. Ellenbroek1, Gerardus P.J. van Hout1,2, Leo Timmers1,2, Pieter A. Doevendans2,4, Gerard Pasterkamp1,3, Imo E. Hoefer1,3 1Department of Experimental Cardiology, University Medical Center Utrecht, 2Department of Cardiology, University Medical Center Utrecht, 3Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, 4Interuniversity Cardiology Institutes of the Netherlands (ICIN) JoVE 54021 Medicine
Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction Guilielmus H.J.M. Ellenbroek1, Gerardus P.J. van Hout1,2, Leo Timmers1,2, Pieter A. Doevendans2,4, Gerard Pasterkamp1,3, Imo E. Hoefer1,3 1Department of Experimental Cardiology, University Medical Center Utrecht, 2Department of Cardiology, University Medical Center Utrecht, 3Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, 4Interuniversity Cardiology Institutes of the Netherlands (ICIN) JoVE 54021 Medicine