Leonard K. Kaczmarek Department of Pharmacology Yale School of Medicine Biography Publications Institution JoVE Articles Leonard K. Kaczmarek has not added a biography. If you are Leonard K. Kaczmarek and would like to personalize this page please email our Author Liaison for assistance. Publications Clinical Whole-genome Sequencing in Severe Early-onset Epilepsy Reveals New Genes and Improves Molecular Diagnosis Human Molecular Genetics. Jan, 2014 | Pubmed ID: 24463883 The Contribution of TWIK-1 Channels to Astrocyte K(+) Current is Limited by Retention in Intracellular Compartments Frontiers in Cellular Neuroscience. 2013 | Pubmed ID: 24368895 Slack, Slick and Sodium-Activated Potassium Channels ISRN Neuroscience. Apr, 2013 | Pubmed ID: 24319675 Expression of Kv1.3 Potassium Channels Regulates Density of Cortical Interneurons Developmental Neurobiology. Nov, 2013 | Pubmed ID: 23821603 A Sodium-activated Potassium Channel Supports High-frequency Firing and Reduces Energetic Costs During Rapid Modulations of Action Potential Amplitude Journal of Neurophysiology. Apr, 2013 | Pubmed ID: 23324315 An Evolutionarily Conserved Mode of Modulation of Shaw-like K⺠Channels FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2013 | Pubmed ID: 23233530 Regulation of Neuronal Excitability by Interaction of Fragile X Mental Retardation Protein with Slack Potassium Channels The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2012 | Pubmed ID: 23115170 De Novo Gain-of-function KCNT1 Channel Mutations Cause Malignant Migrating Partial Seizures of Infancy Nature Genetics. Nov, 2012 | Pubmed ID: 23086397 Gradients and Modulation of K(+) Channels Optimize Temporal Accuracy in Networks of Auditory Neurons PLoS Computational Biology. 2012 | Pubmed ID: 22438799 Bcl-xL Regulates Mitochondrial Energetics by Stabilizing the Inner Membrane Potential The Journal of Cell Biology. Oct, 2011 | Pubmed ID: 21987637 Potassium Channel Modulation and Auditory Processing Hearing Research. Sep, 2011 | Pubmed ID: 21414395 Fragile X Mental Retardation Protein is Required for Rapid Experience-dependent Regulation of the Potassium Channel Kv3.1b The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2010 | Pubmed ID: 20685971 A Less Flexible BK Channel Opens More Easily Neuron. Jun, 2010 | Pubmed ID: 20620867 Localization of Kv1.3 Channels in Presynaptic Terminals of Brainstem Auditory Neurons The Journal of Comparative Neurology. Aug, 2010 | Pubmed ID: 20575068 Fragile X Mental Retardation Protein Controls Gating of the Sodium-activated Potassium Channel Slack Nature Neuroscience. Jul, 2010 | Pubmed ID: 20512134 Controlling Auditory Excitability: the Benefits of a Cultured Environment The Journal of Physiology. May, 2010 | Pubmed ID: 20436041 The Slack Sodium-activated Potassium Channel Provides a Major Outward Current in Olfactory Neurons of Kv1.3-/- Super-smeller Mice Journal of Neurophysiology. Jun, 2010 | Pubmed ID: 20393063 Kv1.3 is the Exclusive Voltage-gated K+ Channel of Platelets and Megakaryocytes: Roles in Membrane Potential, Ca2+ Signalling and Platelet Count The Journal of Physiology. May, 2010 | Pubmed ID: 20308249 Use of Optical Biosensors to Detect Modulation of Slack Potassium Channels by G Protein-coupled Receptors Journal of Receptor and Signal Transduction Research. 2009 | Pubmed ID: 19640220 The N-terminal Domain of Slack Determines the Formation and Trafficking of Slick/Slack Heteromeric Sodium-activated Potassium Channels The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2009 | Pubmed ID: 19403831 Na+-mediated Coupling Between AMPA Receptors and KNa Channels Shapes Synaptic Transmission Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19095801 Amino-termini Isoforms of the Slack K+ Channel, Regulated by Alternative Promoters, Differentially Modulate Rhythmic Firing and Adaptation The Journal of Physiology. Nov, 2008 | Pubmed ID: 18787033 Protein Kinase C Modulates Inactivation of Kv3.3 Channels The Journal of Biological Chemistry. Aug, 2008 | Pubmed ID: 18539595 PKC-induced Intracellular Trafficking of Ca(V)2 Precedes Its Rapid Recruitment to the Plasma Membrane The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2008 | Pubmed ID: 18322103 Repetitive Firing Triggers Clustering of Kv2.1 Potassium Channels in Aplysia Neurons The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18276591 Bcl-xL Inhibitor ABT-737 Reveals a Dual Role for Bcl-xL in Synaptic Transmission Journal of Neurophysiology. Mar, 2008 | Pubmed ID: 18160428 Comparative Effects of Sodium Pyrithione Evoked Intracellular Calcium Elevation in Rodent and Primate Ventral Horn Motor Neurons Biochemical and Biophysical Research Communications. Feb, 2008 | Pubmed ID: 18053804 Sodium-dependent Potassium Channels of a Slack-like Subtype Contribute to the Slow Afterhyperpolarization in Lamprey Spinal Neurons The Journal of Physiology. Nov, 2007 | Pubmed ID: 17884929 Slack and Slick K(Na) Channels Regulate the Accuracy of Timing of Auditory Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2007 | Pubmed ID: 17344399 Functional Analysis of a Novel Potassium Channel (KCNA1) Mutation in Hereditary Myokymia Neurogenetics. Apr, 2007 | Pubmed ID: 17136396 Non-conducting Functions of Voltage-gated Ion Channels Nature Reviews. Neuroscience. Oct, 2006 | Pubmed ID: 16988652 A Store-operated Ca(2+) Influx Pathway in the Bag Cell Neurons of Aplysia Journal of Neurophysiology. Nov, 2006 | Pubmed ID: 16885525 Pharmacological Activation and Inhibition of Slack (Slo2.2) Channels Neuropharmacology. Sep, 2006 | Pubmed ID: 16876206 Opposite Regulation of Slick and Slack K+ Channels by Neuromodulators The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2006 | Pubmed ID: 16687497 Modulation of Kv3.1b Potassium Channel Phosphorylation in Auditory Neurons by Conventional and Novel Protein Kinase C Isozymes The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16595659 Policing the Ball: a New Potassium Channel Subunit Determines Inactivation Rate Neuron. Mar, 2006 | Pubmed ID: 16504937 Retraction Science (New York, N.Y.). Dec, 2005 | Pubmed ID: 16373558 Acoustic Environment Determines Phosphorylation State of the Kv3.1 Potassium Channel in Auditory Neurons Nature Neuroscience. Oct, 2005 | Pubmed ID: 16136041 Association/dissociation of a Channel-kinase Complex Underlies State-dependent Modulation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2005 | Pubmed ID: 16135761 Actions of BAX on Mitochondrial Channel Activity and on Synaptic Transmission Antioxidants & Redox Signaling. Sep-Oct, 2005 | Pubmed ID: 16115013 Regulation of the Timing of MNTB Neurons by Short-term and Long-term Modulation of Potassium Channels Hearing Research. Aug, 2005 | Pubmed ID: 16081004 For K+ Channels, Na+ is the New Ca2+ Trends in Neurosciences. Aug, 2005 | Pubmed ID: 15979166 Localization of the Na+-activated K+ Channel Slick in the Rat Central Nervous System The Journal of Comparative Neurology. Mar, 2005 | Pubmed ID: 15717307 Requirement of Voltage-gated Calcium Channel Beta4 Subunit for T Lymphocyte Functions Science (New York, N.Y.). Jan, 2005 | Pubmed ID: 15637280 Exposure to Hypoxia Rapidly Induces Mitochondrial Channel Activity Within a Living Synapse The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15561723 Aminoglycosides Block the Kv3.1 Potassium Channel and Reduce the Ability of Inferior Colliculus Neurons to Fire at High Frequencies Journal of Neurobiology. Mar, 2005 | Pubmed ID: 15547932 The Appearance of a Protein Kinase A-regulated Splice Isoform of Slo is Associated with the Maturation of Neurons That Control Reproductive Behavior The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15375169 Proapoptotic N-truncated BCL-xL Protein Activates Endogenous Mitochondrial Channels in Living Synaptic Terminals Proceedings of the National Academy of Sciences of the United States of America. Sep, 2004 | Pubmed ID: 15342906 Activation of a Calcium Entry Pathway by Sodium Pyrithione in the Bag Cell Neurons of Aplysia Journal of Neurobiology. Sep, 2004 | Pubmed ID: 15307146 Loss of Kv3.1 Tonotopicity and Alterations in CAMP Response Element-binding Protein Signaling in Central Auditory Neurons of Hearing Impaired Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2004 | Pubmed ID: 14985434 The Voltage-gated Potassium Channel Kv1.3 Regulates Peripheral Insulin Sensitivity Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 14981264 Slick (Slo2.1), a Rapidly-gating Sodium-activated Potassium Channel Inhibited by ATP The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2003 | Pubmed ID: 14684870 Functional Specialization of Male and Female Vocal Motoneurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2003 | Pubmed ID: 14684859 How to Make a Relationship Last: Release Sites with Different Levels of Commitment Neuron. Sep, 2003 | Pubmed ID: 14527428 Modulation of Synaptic Transmission by the BCL-2 Family Protein BCL-xL The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2003 | Pubmed ID: 12968005 Compensatory Anion Currents in Kv1.3 Channel-deficient Thymocytes The Journal of Biological Chemistry. Oct, 2003 | Pubmed ID: 12878608 Modulation of Mitochondrial Function by Endogenous Zn2+ Pools Proceedings of the National Academy of Sciences of the United States of America. May, 2003 | Pubmed ID: 12724524 BAK Alters Neuronal Excitability and Can Switch from Anti- to Pro-death Function During Postnatal Development Developmental Cell. Apr, 2003 | Pubmed ID: 12689595 Modulation of the Kv3.1b Potassium Channel Isoform Adjusts the Fidelity of the Firing Pattern of Auditory Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2003 | Pubmed ID: 12598601 Act Locally: New Ways of Regulating Voltage-gated Ion Channels Molecular Interventions. Jul, 2002 | Pubmed ID: 14993392 Prolonged Activation of Ca2+-activated K+ Current Contributes to the Long-lasting Refractory Period of Aplysia Bag Cell Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2002 | Pubmed ID: 12451114 Localization of the Slack Potassium Channel in the Rat Central Nervous System The Journal of Comparative Neurology. Dec, 2002 | Pubmed ID: 12442315 HSV-1 Helper Virus 5dl1.2 Suppresses Sodium Currents in Amplicon-transduced Neurons Journal of Neurophysiology. Apr, 2002 | Pubmed ID: 11929932 Endogenous Parathyroid Hormone-related Protein Functions As a Neuroprotective Agent Brain Research. Mar, 2002 | Pubmed ID: 11879796 Protein Kinase Modulation of a Neuronal Cation Channel Requires Protein-protein Interactions Mediated by an Src Homology 3 Domain The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2002 | Pubmed ID: 11756482 Gebruik van Label-free Optische biosensoren om Modulatie van kaliumkanalen Detect door G-proteïne gekoppelde receptoren Matthew R. Fleming1, Steven M. Shamah3, Leonard K. Kaczmarek1,2 1Department of Pharmacology, Yale School of Medicine, 2Department of Cellular and Molecular Physiology, Yale School of Medicine, 3X-BODY Biosciences JoVE 51307 Bioengineering
Gebruik van Label-free Optische biosensoren om Modulatie van kaliumkanalen Detect door G-proteïne gekoppelde receptoren Matthew R. Fleming1, Steven M. Shamah3, Leonard K. Kaczmarek1,2 1Department of Pharmacology, Yale School of Medicine, 2Department of Cellular and Molecular Physiology, Yale School of Medicine, 3X-BODY Biosciences JoVE 51307 Bioengineering