Leonard Zon Department of Hematology and Oncology Children’s Hospital Boston Biography Publications Institution JoVE Articles Leonard Zon has not added a biography. If you are Leonard Zon and would like to personalize this page please email our Author Liaison for assistance. Publications Screening for Melanoma Resistance Genes in Vivo Pigment Cell & Melanoma Research. Mar, 2015 | Pubmed ID: 25818368 A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish Developmental Cell. Mar, 2015 | Pubmed ID: 25752963 Angiopoietin-like Proteins Stimulate HSPC Development Through Interaction with Notch Receptor Signaling ELife. 2015 | Pubmed ID: 25714926 Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche Cell. Jan, 2015 | Pubmed ID: 25594182 Notch1 Acts Via Foxc2 to Promote Definitive Hematopoiesis Via Effects on Hemogenic Endothelium Blood. Feb, 2015 | Pubmed ID: 25587036 A Zebrafish Model of Myelodysplastic Syndrome Produced Through Tet2 Genomic Editing Molecular and Cellular Biology. Mar, 2015 | Pubmed ID: 25512612 A Comparison of Non-integrating Reprogramming Methods Nature Biotechnology. Jan, 2015 | Pubmed ID: 25437882 Selective MicroRNA Uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4) Nucleic Acids Research. Oct, 2014 | Pubmed ID: 25223788 Getting More for Your Marrow: Boosting Hematopoietic Stem Cell Numbers with PGE2 Experimental Cell Research. Dec, 2014 | Pubmed ID: 25094063 Intrinsic Expression of a Multiexon Type 3 Deiodinase Gene Controls Zebrafish Embryo Size Endocrinology. Oct, 2014 | Pubmed ID: 25004091 From Fish Tank to Bedside in Cancer Therapy: an Interview with Leonard Zon Disease Models & Mechanisms. Jul, 2014 | Pubmed ID: 24973742 Dissection of Vertebrate Hematopoiesis Using Zebrafish Thrombopoietin Blood. Jul, 2014 | Pubmed ID: 24869937 Whole-exome Sequencing and Functional Studies Identify RPS29 As a Novel Gene Mutated in Multicase Diamond-Blackfan Anemia Families Blood. Jul, 2014 | Pubmed ID: 24829207 Neural Crest Development and Craniofacial Morphogenesis is Coordinated by Nitric Oxide and Histone Acetylation Chemistry & Biology. Apr, 2014 | Pubmed ID: 24684905 Mutations in QARS, Encoding Glutaminyl-tRNA Synthetase, Cause Progressive Microcephaly, Cerebral-cerebellar Atrophy, and Intractable Seizures American Journal of Human Genetics. Apr, 2014 | Pubmed ID: 24656866 Unexpectedly Uneven: Posttransplant Skeletal Distribution of Hematopoietic Stem Cell Clones The Journal of Experimental Medicine. Mar, 2014 | Pubmed ID: 24616474 Translational Research: the Path for Bringing Discovery to Patients Cell Stem Cell. Feb, 2014 | Pubmed ID: 24506882 Tissue Specific Roles for the Ribosome Biogenesis Factor Wdr43 in Zebrafish Development PLoS Genetics. Jan, 2014 | Pubmed ID: 24497835 A Non-canonical Function of Telomerase RNA in the Regulation of Developmental Myelopoiesis in Zebrafish Nature Communications. 2014 | Pubmed ID: 24496182 Novel Cardiovascular Gene Functions Revealed Via Systematic Phenotype Prediction in Zebrafish Development (Cambridge, England). Jan, 2014 | Pubmed ID: 24346703 A Cdx4-Sall4 Regulatory Module Controls the Transition from Mesoderm Formation to Embryonic Hematopoiesis Stem Cell Reports. 2013 | Pubmed ID: 24286030 Of Fish and Men: Using Zebrafish to Fight Human Diseases Trends in Cell Biology. Dec, 2013 | Pubmed ID: 24275383 A Network of Epigenetic Regulators Guides Developmental Haematopoiesis in Vivo Nature Cell Biology. Dec, 2013 | Pubmed ID: 24240475 A Zebrafish Embryo Culture System Defines Factors That Promote Vertebrate Myogenesis Across Species Cell. Nov, 2013 | Pubmed ID: 24209627 Zebraflash Transgenic Lines for in Vivo Bioluminescence Imaging of Stem Cells and Regeneration in Adult Zebrafish Development (Cambridge, England). Dec, 2013 | Pubmed ID: 24198277 The Genetic Heterogeneity and Mutational Burden of Engineered Melanomas in Zebrafish Models Genome Biology. Oct, 2013 | Pubmed ID: 24148783 The Zebrafish Granulocyte Colony Stimulating Factors (Gcsfs): Two Paralogous Cytokines and Their Roles in Hematopoietic Development and Maintenance Blood. Oct, 2013 | Pubmed ID: 24128862 Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells Via Respecification of Lineage-restricted Precursors Cell Stem Cell. Oct, 2013 | Pubmed ID: 24094326 Prostaglandin-modulated Umbilical Cord Blood Hematopoietic Stem Cell Transplantation Blood. Oct, 2013 | Pubmed ID: 23996087 Zebrafish Cancer: the State of the Art and the Path Forward Nature Reviews. Cancer. Sep, 2013 | Pubmed ID: 23969693 Assaying Hematopoiesis Using Zebrafish Blood Cells, Molecules & Diseases. Dec, 2013 | Pubmed ID: 23916372 Zebrafish Rhabdomyosarcoma Reflects the Developmental Stage of Oncogene Expression During Myogenesis Development (Cambridge, England). Jul, 2013 | Pubmed ID: 23821038 Site-directed Zebrafish Transgenesis into Single Landing Sites with the PhiC31 Integrase System Developmental Dynamics : an Official Publication of the American Association of Anatomists. Aug, 2013 | Pubmed ID: 23723152 Hematopoiesis Development (Cambridge, England). Jun, 2013 | Pubmed ID: 23715539 The Histone Methyltransferase SUV39H1 Suppresses Embryonal Rhabdomyosarcoma Formation in Zebrafish PloS One. 2013 | Pubmed ID: 23705022 A Novel Chemical Screening Strategy in Zebrafish Identifies Common Pathways in Embryogenesis and Rhabdomyosarcoma Development Development (Cambridge, England). Jun, 2013 | Pubmed ID: 23615277 The Zebrafish Reference Genome Sequence and Its Relationship to the Human Genome Nature. Apr, 2013 | Pubmed ID: 23594743 A Model for Primary Melanoma of the CNS Implicates NRAS Cancer Discovery. Apr, 2013 | Pubmed ID: 23580282 Ageing: Stem Cells on a Stress-busting Diet Nature. Feb, 2013 | Pubmed ID: 23389448 Signaling Axis Involving Hedgehog, Notch, and Scl Promotes the Embryonic Endothelial-to-hematopoietic Transition Proceedings of the National Academy of Sciences of the United States of America. Jan, 2013 | Pubmed ID: 23236128 Phospholipase C Gamma-1 is Required for Granulocyte Maturation in Zebrafish Developmental Biology. Feb, 2013 | Pubmed ID: 23220656 TiF1-gamma Plays an Essential Role in Murine Hematopoiesis and Regulates Transcriptional Elongation of Erythroid Genes Developmental Biology. Jan, 2013 | Pubmed ID: 23159334 Teleost Growth Factor Independence (gfi) Genes Differentially Regulate Successive Waves of Hematopoiesis Developmental Biology. Jan, 2013 | Pubmed ID: 22960038 Small Molecule Screening in Zebrafish: Swimming in Potential Drug Therapies Wiley Interdisciplinary Reviews. Developmental Biology. May-Jun, 2012 | Pubmed ID: 23801494 The Transcriptional Landscape of Hematopoietic Stem Cell Ontogeny Cell Stem Cell. Nov, 2012 | Pubmed ID: 23122293 CHMP1A Encodes an Essential Regulator of BMI1-INK4A in Cerebellar Development Nature Genetics. Nov, 2012 | Pubmed ID: 23023333 In Situ Hybridization Assay-based Small Molecule Screening in Zebrafish Current Protocols in Chemical Biology. Jun, 2012 | Pubmed ID: 23001521 Loss of 5-hydroxymethylcytosine is an Epigenetic Hallmark of Melanoma Cell. Sep, 2012 | Pubmed ID: 22980977 A Splice Site Mutation in Laminin-α2 Results in a Severe Muscular Dystrophy and Growth Abnormalities in Zebrafish PloS One. 2012 | Pubmed ID: 22952766 Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of P53 PLoS Genetics. 2012 | Pubmed ID: 22952453 Formation of a PKCζ/β-catenin Complex in Endothelial Cells Promotes Angiopoietin-1-induced Collective Directional Migration and Angiogenic Sprouting Blood. Oct, 2012 | Pubmed ID: 22936663 Cancer and Inflammation: an Aspirin a Day Keeps the Cancer at Bay Current Biology : CB. Jul, 2012 | Pubmed ID: 22789999 Histocompatibility and Hematopoietic Transplantation in the Zebrafish Advances in Hematology. 2012 | Pubmed ID: 22778744 Hooked! Modeling Human Disease in Zebrafish The Journal of Clinical Investigation. Jul, 2012 | Pubmed ID: 22751109 A Great Match Cell Stem Cell. Jun, 2012 | Pubmed ID: 22704496 Zebrafish Globin Switching Occurs in Two Developmental Stages and is Controlled by the LCR Developmental Biology. Jun, 2012 | Pubmed ID: 22537494 Nanog-like Regulates Endoderm Formation Through the Mxtx2-Nodal Pathway Developmental Cell. Mar, 2012 | Pubmed ID: 22421047 Direct Recruitment of Polycomb Repressive Complex 1 to Chromatin by Core Binding Transcription Factors Molecular Cell. Feb, 2012 | Pubmed ID: 22325351 Stem Cells: The Right Neighbour Nature. Jan, 2012 | Pubmed ID: 22281591 Linking Hematopoietic Regeneration to Developmental Signaling Pathways: A Story of BMP and Wnt Cell Cycle (Georgetown, Tex.). Feb, 2012 | Pubmed ID: 22262185 Extensive Genetic Diversity and Substructuring Among Zebrafish Strains Revealed Through Copy Number Variant Analysis Proceedings of the National Academy of Sciences of the United States of America. Jan, 2012 | Pubmed ID: 22203992 An Optical Platform for Cell Tracking in Adult Zebrafish Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Feb, 2012 | Pubmed ID: 22162445 Hematopoietic Defects in Rps29 Mutant Zebrafish Depend Upon P53 Activation Experimental Hematology. Mar, 2012 | Pubmed ID: 22120640 Hematopoietic Stem Cells, Hematopoiesis and Disease: Lessons from the Zebrafish Model Genome Medicine. Dec, 2011 | Pubmed ID: 22206610 The Zebrafish. Preface Methods in Cell Biology. 2011 | Pubmed ID: 22043535 Lineage Regulators Direct BMP and Wnt Pathways to Cell-specific Programs During Differentiation and Regeneration Cell. Oct, 2011 | Pubmed ID: 22036566 Chemical Screening in Zebrafish for Novel Biological and Therapeutic Discovery Methods in Cell Biology. 2011 | Pubmed ID: 21951544 Transplantation in Zebrafish Methods in Cell Biology. 2011 | Pubmed ID: 21951540 The NOTCH Pathway Contributes to Cell Fate Decision in Myelopoiesis Haematologica. Dec, 2011 | Pubmed ID: 21933862 Chromatin Immunoprecipitation in Adult Zebrafish Red Cells Methods in Cell Biology. 2011 | Pubmed ID: 21924172 The Zon Laboratory Guide to Positional Cloning in Zebrafish Methods in Cell Biology. 2011 | Pubmed ID: 21924169 Advanced Zebrafish Transgenesis with Tol2 and Application for Cre/lox Recombination Experiments Methods in Cell Biology. 2011 | Pubmed ID: 21924163 Genetic Suppressor Screens in Haploids Methods in Cell Biology. 2011 | Pubmed ID: 21924160 A New System for the Rapid Collection of Large Numbers of Developmentally Staged Zebrafish Embryos PloS One. 2011 | Pubmed ID: 21738776 Zebrafish As a Model for Normal and Malignant Hematopoiesis Disease Models & Mechanisms. Jul, 2011 | Pubmed ID: 21708900 Stromal Cell-derived Factor-1 and Hematopoietic Cell Homing in an Adult Zebrafish Model of Hematopoietic Cell Transplantation Blood. Jul, 2011 | Pubmed ID: 21622651 Stem Cell Migration: a Zebrafish Model Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21618090 Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-term Safety in Preclinical Nonhuman Primate Transplant Models Cell Stem Cell. Apr, 2011 | Pubmed ID: 21474107 Modeling Diamond Blackfan Anemia in the Zebrafish Seminars in Hematology. Apr, 2011 | Pubmed ID: 21435504 DHODH Modulates Transcriptional Elongation in the Neural Crest and Melanoma Nature. Mar, 2011 | Pubmed ID: 21430780 The Histone Methyltransferase SETDB1 is Recurrently Amplified in Melanoma and Accelerates Its Onset Nature. Mar, 2011 | Pubmed ID: 21430779 Clonal Analysis of Hematopoietic Progenitor Cells in the Zebrafish Blood. Aug, 2011 | Pubmed ID: 21415264 Characterization of Immune-matched Hematopoietic Transplantation in Zebrafish Blood. Apr, 2011 | Pubmed ID: 21346254 Isolation and Transcriptome Analysis of Adult Zebrafish Cells Enriched for Skeletal Muscle Progenitors Muscle & Nerve. May, 2011 | Pubmed ID: 21337346 Cpsf1 is Required for Definitive HSC Survival in Zebrafish Blood. Apr, 2011 | Pubmed ID: 21330472 The ERGonomics of Hematopoietic Stem Cell Self-renewal Genes & Development. Feb, 2011 | Pubmed ID: 21325129 The Zebrafish Dag1 Mutant: a Novel Genetic Model for Dystroglycanopathies Human Molecular Genetics. May, 2011 | Pubmed ID: 21296866 Ubiquitous Transgene Expression and Cre-based Recombination Driven by the Ubiquitin Promoter in Zebrafish Development (Cambridge, England). Jan, 2011 | Pubmed ID: 21138979 Stem Cells: The Blood Balance Nature. Dec, 2010 | Pubmed ID: 21124447 The Zebrafish: Cellular and Developmental Biology, Part A. Preface Methods in Cell Biology. 2010 | Pubmed ID: 21111211 T-lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation Cancer Cell. Oct, 2010 | Pubmed ID: 20951945 PGE2-regulated Wnt Signaling and N-acetylcysteine Are Synergistically Hepatoprotective in Zebrafish Acetaminophen Injury Proceedings of the National Academy of Sciences of the United States of America. Oct, 2010 | Pubmed ID: 20855591 Hematopoietic Development in the Zebrafish The International Journal of Developmental Biology. 2010 | Pubmed ID: 20711990 Zebrafish Models of P53 Functions Cold Spring Harbor Perspectives in Biology. Aug, 2010 | Pubmed ID: 20679337 Fishing at the Cellular Level Nature Methods. Aug, 2010 | Pubmed ID: 20676080 Blood Flow: Metalloproteases Cut Loose in Primitive Erythrocytes Current Biology : CB. Jul, 2010 | Pubmed ID: 20619808 TIF1gamma Controls Erythroid Cell Fate by Regulating Transcription Elongation Cell. Jul, 2010 | Pubmed ID: 20603019 Cdx4 is Dispensable for Murine Adult Hematopoietic Stem Cells but Promotes MLL-AF9-mediated Leukemogenesis Haematologica. Oct, 2010 | Pubmed ID: 20494928 Newly Emerging Roles for Prostaglandin E2 Regulation of Hematopoiesis and Hematopoietic Stem Cell Engraftment Current Opinion in Hematology. Jul, 2010 | Pubmed ID: 20473159 A Chemical Genetic Screen in Zebrafish for Pathways Interacting with Cdx4 in Primitive Hematopoiesis Zebrafish. Mar, 2010 | Pubmed ID: 20415644 The New Age of Chemical Screening in Zebrafish Zebrafish. Mar, 2010 | Pubmed ID: 20415642 Interaction of Retinoic Acid and Scl Controls Primitive Blood Development Blood. Jul, 2010 | Pubmed ID: 20410509 The Wnt/beta-catenin Pathway is Required for the Development of Leukemia Stem Cells in AML Science (New York, N.Y.). Mar, 2010 | Pubmed ID: 20339075 Small Molecule Screen in Zebrafish and HSC Expansion Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20336531 Resolving the Controversy About N-cadherin and Hematopoietic Stem Cells Cell Stem Cell. Mar, 2010 | Pubmed ID: 20207222 Swimming into the Future of Drug Discovery: in Vivo Chemical Screens in Zebrafish ACS Chemical Biology. Feb, 2010 | Pubmed ID: 20166761 High-throughput Cell Transplantation Establishes That Tumor-initiating Cells Are Abundant in Zebrafish T-cell Acute Lymphoblastic Leukemia Blood. Apr, 2010 | Pubmed ID: 20056790 Melanocytes in Development and Cancer Journal of Cellular Physiology. Jan, 2010 | Pubmed ID: 19795394 Lessons from the Niche for Generation and Expansion of Hematopoietic Stem Cells Drug Discovery Today. Therapeutic Strategies. 2009 | Pubmed ID: 21212834 Zebrafish Tumor Assays: the State of Transplantation Zebrafish. Dec, 2009 | Pubmed ID: 20047467 Oncogenic NRAS Cooperates with P53 Loss to Generate Melanoma in Zebrafish Zebrafish. Dec, 2009 | Pubmed ID: 19954345 Chemical Genetic Screening in the Zebrafish Embryo Nature Protocols. 2009 | Pubmed ID: 19745824 Defining Cancer Stem Cells by Xenotransplantation in Zebrafish Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19582417 Zebrafish Blood Stem Cells Journal of Cellular Biochemistry. Sep, 2009 | Pubmed ID: 19565566 Hematopoietic Stem Cell Development is Dependent on Blood Flow Cell. May, 2009 | Pubmed ID: 19450519 Zebrafish Kidney Stromal Cell Lines Support Multilineage Hematopoiesis Blood. Jul, 2009 | Pubmed ID: 19433857 Topoisomerase II Alpha is Required for Embryonic Development and Liver Regeneration in Zebrafish Molecular and Cellular Biology. Jul, 2009 | Pubmed ID: 19380487 A Genetic Screen in Zebrafish Defines a Hierarchical Network of Pathways Required for Hematopoietic Stem Cell Emergence Blood. Jun, 2009 | Pubmed ID: 19332767 Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration Cell. Mar, 2009 | Pubmed ID: 19303855 Abnormal Nuclear Pore Formation Triggers Apoptosis in the Intestinal Epithelium of Elys-deficient Zebrafish Gastroenterology. Mar, 2009 | Pubmed ID: 19073184 Transferrin-a Modulates Hepcidin Expression in Zebrafish Embryos Blood. Mar, 2009 | Pubmed ID: 19047682 Construction and Application of a Zebrafish Array Comparative Genomic Hybridization Platform Genes, Chromosomes & Cancer. Feb, 2009 | Pubmed ID: 18973135 Potential of Zebrafish for Anticancer Drug Screening Expert Opinion on Drug Discovery. Dec, 2008 | Pubmed ID: 23506108 The Effect of a Depth Gradient on the Mating Behavior, Oviposition Site Preference, and Embryo Production in the Zebrafish, Danio Rerio Zebrafish. Dec, 2008 | Pubmed ID: 19133832 Melanoma Biology and the Promise of Zebrafish Zebrafish. Dec, 2008 | Pubmed ID: 19133823 A Non-canonical Function of Zebrafish Telomerase Reverse Transcriptase is Required for Developmental Hematopoiesis PloS One. 2008 | Pubmed ID: 18846223 Intestinal Differentiation in Zebrafish Requires Cdx1b, a Functional Equivalent of Mammalian Cdx2 Gastroenterology. Nov, 2008 | Pubmed ID: 18804112 Eya4 Regulation of Na+/K+-ATPase is Required for Sensory System Development in Zebrafish Development (Cambridge, England). Oct, 2008 | Pubmed ID: 18799547 Melanocytes in Development, Regeneration, and Cancer Cell Stem Cell. Sep, 2008 | Pubmed ID: 18786412 Zebrafish Mutants with Disrupted Early T-cell and Thymus Development Identified in Early Pressure Screen Developmental Dynamics : an Official Publication of the American Association of Anatomists. Sep, 2008 | Pubmed ID: 18729230 APC Mutant Zebrafish Uncover a Changing Temporal Requirement for Wnt Signaling in Liver Development Developmental Biology. Aug, 2008 | Pubmed ID: 18585699 Montalcino, A Zebrafish Model for Variegate Porphyria Experimental Hematology. Sep, 2008 | Pubmed ID: 18550261 Self-renewal and Differentiation at Cell Stem Cell Cell Stem Cell. Jun, 2008 | Pubmed ID: 18522838 Zebrafish VEGF Receptors: a Guideline to Nomenclature PLoS Genetics. May, 2008 | Pubmed ID: 18516225 Intrinsic and Extrinsic Control of Haematopoietic Stem-cell Self-renewal Nature. May, 2008 | Pubmed ID: 18480811 Transparent Adult Zebrafish As a Tool for in Vivo Transplantation Analysis Cell Stem Cell. Feb, 2008 | Pubmed ID: 18371439 BMP and Wnt Specify Hematopoietic Fate by Activation of the Cdx-Hox Pathway Cell Stem Cell. Jan, 2008 | Pubmed ID: 18371423 Minimum Information Specification for in Situ Hybridization and Immunohistochemistry Experiments (MISFISHIE) Nature Biotechnology. Mar, 2008 | Pubmed ID: 18327244 SnapShot: Hematopoiesis Cell. Feb, 2008 | Pubmed ID: 18295585 Hematopoiesis: an Evolving Paradigm for Stem Cell Biology Cell. Feb, 2008 | Pubmed ID: 18295580 Combinatorial Regulation of Novel Erythroid Gene Expression in Zebrafish Experimental Hematology. Apr, 2008 | Pubmed ID: 18243489 Generation and Characterization of Transgenic Zebrafish Lines Using Different Ubiquitous Promoters Transgenic Research. Apr, 2008 | Pubmed ID: 17968670 Teratoma Formation Assays with Human Embryonic Stem Cells: a Rationale for One Type of Human-animal Chimera Cell Stem Cell. Sep, 2007 | Pubmed ID: 18371359 Cell Stem Cell Cell Stem Cell. Jun, 2007 | Pubmed ID: 18371324 Prostaglandin E2: Making More of Your Marrow Cell Cycle (Georgetown, Tex.). Dec, 2007 | Pubmed ID: 18075310 APC and Colon Cancer: Two Hits for One Nature Medicine. Nov, 2007 | Pubmed ID: 17987022 Duplicate VegfA Genes and Orthologues of the KDR Receptor Tyrosine Kinase Family Mediate Vascular Development in the Zebrafish Blood. Nov, 2007 | Pubmed ID: 17698971 The Zebrafish Runzel Muscular Dystrophy is Linked to the Titin Gene Developmental Biology. Sep, 2007 | Pubmed ID: 17678642 Definition of the Zebrafish Genome Using Flow Cytometry and Cytogenetic Mapping BMC Genomics. 2007 | Pubmed ID: 17597531 Prostaglandin E2 Regulates Vertebrate Haematopoietic Stem Cell Homeostasis Nature. Jun, 2007 | Pubmed ID: 17581586 Functional Conservation of Erythropoietin Signaling in Zebrafish Blood. Oct, 2007 | Pubmed ID: 17579187 The Zebra Fish Cassiopeia Mutant Reveals That SIL is Required for Mitotic Spindle Organization Molecular and Cellular Biology. Aug, 2007 | Pubmed ID: 17576815 Ultrasound Biomicroscopy Permits in Vivo Characterization of Zebrafish Liver Tumors Nature Methods. Jul, 2007 | Pubmed ID: 17572681 New Waves of Discovery: Modeling Cancer in Zebrafish Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2007 | Pubmed ID: 17557959 Heat Shock-inducible Cre/Lox Approaches to Induce Diverse Types of Tumors and Hyperplasia in Transgenic Zebrafish Proceedings of the National Academy of Sciences of the United States of America. May, 2007 | Pubmed ID: 17517602 Effects of RAS on the Genesis of Embryonal Rhabdomyosarcoma Genes & Development. Jun, 2007 | Pubmed ID: 17510286 Network of Coregulated Spliceosome Components Revealed by Zebrafish Mutant in Recycling Factor P110 Proceedings of the National Academy of Sciences of the United States of America. Apr, 2007 | Pubmed ID: 17416673 Zebrafish Orthologs of Human Muscular Dystrophy Genes BMC Genomics. 2007 | Pubmed ID: 17374169 Notch and MAML Signaling Drives Scl-dependent Interneuron Diversity in the Spinal Cord Neuron. Mar, 2007 | Pubmed ID: 17359917 Gene Duplication of the Zebrafish Kit Ligand and Partitioning of Melanocyte Development Functions to Kit Ligand A PLoS Genetics. Jan, 2007 | Pubmed ID: 17257055 A Mutation in Separase Causes Genome Instability and Increased Susceptibility to Epithelial Cancer Genes & Development. Jan, 2007 | Pubmed ID: 17210788 Derivation of Adult Stem Cells During Embryogenesis Harvey Lectures. -2007, 2006 | Pubmed ID: 20166566 Homing Sweet Homing: Odyssey of Hematopoietic Stem Cells Immunity. Dec, 2006 | Pubmed ID: 17174927 A Chemical Genetic Screen for Cell Cycle Inhibitors in Zebrafish Embryos Chemical Biology & Drug Design. Oct, 2006 | Pubmed ID: 17105485 Cdx4 Dysregulates Hox Gene Expression and Generates Acute Myeloid Leukemia Alone and in Cooperation with Meis1a in a Murine Model Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17068127 A Novel Endothelial-specific Heat Shock Protein HspA12B is Required in Both Zebrafish Development and Endothelial Functions in Vitro Journal of Cell Science. Oct, 2006 | Pubmed ID: 16968741 AlphaA-crystallin Expression Prevents Gamma-crystallin Insolubility and Cataract Formation in the Zebrafish Cloche Mutant Lens Development (Cambridge, England). Jul, 2006 | Pubmed ID: 16728471 BMP Signaling Restricts Hemato-vascular Development from Lateral Mesoderm During Somitogenesis Development (Cambridge, England). Jun, 2006 | Pubmed ID: 16672337 Mitoferrin is Essential for Erythroid Iron Assimilation Nature. Mar, 2006 | Pubmed ID: 16511496 The Caudal-related Homeobox Genes Cdx1a and Cdx4 Act Redundantly to Regulate Hox Gene Expression and the Formation of Putative Hematopoietic Stem Cells During Zebrafish Embryogenesis Developmental Biology. Apr, 2006 | Pubmed ID: 16457800 Piloting the Zebrafish Genome Browser Developmental Dynamics : an Official Publication of the American Association of Anatomists. Mar, 2006 | Pubmed ID: 16372332 Genetic Analysis of Cavefish Reveals Molecular Convergence in the Evolution of Albinism Nature Genetics. Jan, 2006 | Pubmed ID: 16341223 A Critical Role for Calponin 2 in Vascular Development The Journal of Biological Chemistry. Mar, 2006 | Pubmed ID: 16317011 Zebrafish to Humans: Evolution of the Alpha3-chain of Type IV Collagen and Emergence of the Autoimmune Epitopes Associated with Goodpasture Syndrome Blood. Mar, 2006 | Pubmed ID: 16254142 Taking Human Cancer Genes to the Fish: a Transgenic Model of Melanoma in Zebrafish Zebrafish. 2005 | Pubmed ID: 18248215 Small Molecules That Delay S Phase Suppress a Zebrafish Bmyb Mutant Nature Chemical Biology. Dec, 2005 | Pubmed ID: 16372403 Use of the Zebrafish System to Study Primitive and Definitive Hematopoiesis Annual Review of Genetics. 2005 | Pubmed ID: 16285869 Zebrafish KLF4 is Essential for Anterior Mesendoderm/pre-polster Differentiation and Hatching Developmental Dynamics : an Official Publication of the American Association of Anatomists. Dec, 2005 | Pubmed ID: 16222715 Hematopoietic Stem Cell Fate is Established by the Notch-Runx Pathway Genes & Development. Oct, 2005 | Pubmed ID: 16166372 A Zebrafish Bmyb Mutation Causes Genome Instability and Increased Cancer Susceptibility Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005 | Pubmed ID: 16150706 Transcriptional Regulation of Hematopoietic Stem Cell Development in Zebrafish Experimental Hematology. Sep, 2005 | Pubmed ID: 16140148 Deficiency of Glutaredoxin 5 Reveals Fe-S Clusters Are Required for Vertebrate Haem Synthesis Nature. Aug, 2005 | Pubmed ID: 16110529 Analysis of Thrombocyte Development in CD41-GFP Transgenic Zebrafish Blood. Dec, 2005 | Pubmed ID: 16099879 The Iron Exporter Ferroportin/Slc40a1 is Essential for Iron Homeostasis Cell Metabolism. Mar, 2005 | Pubmed ID: 16054062 Zebrafish Slc4a2/ae2 Anion Exchanger: CDNA Cloning, Mapping, Functional Characterization, and Localization American Journal of Physiology. Renal Physiology. Oct, 2005 | Pubmed ID: 15914778 Ferroportin1 is Required for Normal Iron Cycling in Zebrafish The Journal of Clinical Investigation. Jun, 2005 | Pubmed ID: 15902304 Regulation of the Lmo2 Promoter During Hematopoietic and Vascular Development in Zebrafish Developmental Biology. May, 2005 | Pubmed ID: 15893977 The Complex Cartography of Stem Cell Commitment Cell. Apr, 2005 | Pubmed ID: 15851023 Mutant-specific Gene Programs in the Zebrafish Blood. Jul, 2005 | Pubmed ID: 15827125 The Zebrafish: a New Model of T-cell and Thymic Development Nature Reviews. Immunology. Apr, 2005 | Pubmed ID: 15803150 Mutation in the Transcriptional Coactivator EYA4 Causes Dilated Cardiomyopathy and Sensorineural Hearing Loss Nature Genetics. Apr, 2005 | Pubmed ID: 15735644 BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with P53 in the Genesis of Melanoma Current Biology : CB. Feb, 2005 | Pubmed ID: 15694309 In Vivo Drug Discovery in the Zebrafish Nature Reviews. Drug Discovery. Jan, 2005 | Pubmed ID: 15688071 Tp53 Mutant Zebrafish Develop Malignant Peripheral Nerve Sheath Tumors Proceedings of the National Academy of Sciences of the United States of America. Jan, 2005 | Pubmed ID: 15630097 Loss of Gata1 but Not Gata2 Converts Erythropoiesis to Myelopoiesis in Zebrafish Embryos Developmental Cell. Jan, 2005 | Pubmed ID: 15621534 Zebrafish Scl Functions Independently in Hematopoietic and Endothelial Development Developmental Biology. Jan, 2005 | Pubmed ID: 15617691 Analysis of Hematopoietic Development in the Zebrafish Methods in Molecular Medicine. 2005 | Pubmed ID: 15492396 The Zon Laboratory Guide to Positional Cloning in Zebrafish Methods in Cell Biology. 2004 | Pubmed ID: 15602919 Use of the DsRed Fluorescent Reporter in Zebrafish Methods in Cell Biology. 2004 | Pubmed ID: 15602868 The Chianti Zebrafish Mutant Provides a Model for Erythroid-specific Disruption of Transferrin Receptor 1 Development (Cambridge, England). Dec, 2004 | Pubmed ID: 15563524 An Mll-dependent Hox Program Drives Hematopoietic Progenitor Expansion Current Biology : CB. Nov, 2004 | Pubmed ID: 15556871 The Clinical Potential of Stem Cells Current Opinion in Cell Biology. Dec, 2004 | Pubmed ID: 15530786 Hematopoietic Gene Expression Profile in Zebrafish Kidney Marrow Proceedings of the National Academy of Sciences of the United States of America. Nov, 2004 | Pubmed ID: 15520368 The 'definitive' (and 'primitive') Guide to Zebrafish Hematopoiesis Oncogene. Sep, 2004 | Pubmed ID: 15378083 The Zebrafish Moonshine Gene Encodes Transcriptional Intermediary Factor 1gamma, an Essential Regulator of Hematopoiesis PLoS Biology. Aug, 2004 | Pubmed ID: 15314655 Two Distinct Teleost Hepatocyte Nuclear Factor 1 Genes, Hnf1alpha/tcf1 and Hnf1beta/tcf2, Abundantly Expressed in Liver, Pancreas, Gut and Kidney of Zebrafish Gene. Aug, 2004 | Pubmed ID: 15302404 Taking the Stem Cell Debate to the Public PLoS Biology. Jun, 2004 | Pubmed ID: 15208732 Expression and Mapping of Duplicate Neuropilin-1 and Neuropilin-2 Genes in Developing Zebrafish Gene Expression Patterns : GEP. Jul, 2004 | Pubmed ID: 15183302 Effects of Lethal Irradiation in Zebrafish and Rescue by Hematopoietic Cell Transplantation Blood. Sep, 2004 | Pubmed ID: 15142873 In Vivo Tracking of T Cell Development, Ablation, and Engraftment in Transgenic Zebrafish Proceedings of the National Academy of Sciences of the United States of America. May, 2004 | Pubmed ID: 15123839 The Use of Zebrafish to Understand Immunity Immunity. Apr, 2004 | Pubmed ID: 15084267 The Pu.1 Promoter Drives Myeloid Gene Expression in Zebrafish Blood. Sep, 2004 | Pubmed ID: 14996705 Allan J. Erslev, M.d.: Truly a Great Dane (1919-2003) Stem Cells (Dayton, Ohio). 2004 | Pubmed ID: 14688399 The Zebrafish As a Model Organism to Study Development of the Immune System Advances in Immunology. 2003 | Pubmed ID: 14711058 Transplantation and in Vivo Imaging of Multilineage Engraftment in Zebrafish Bloodless Mutants Nature Immunology. Dec, 2003 | Pubmed ID: 14608381 Modeling Human Hematopoietic and Cardiovascular Diseases in Zebrafish Developmental Dynamics : an Official Publication of the American Association of Anatomists. Nov, 2003 | Pubmed ID: 14579393 Cdx4 Mutants Fail to Specify Blood Progenitors and Can Be Rescued by Multiple Hox Genes Nature. Sep, 2003 | Pubmed ID: 13679919 The Zebrafish Van Gogh Mutation Disrupts Tbx1, Which is Involved in the DiGeorge Deletion Syndrome in Humans Development (Cambridge, England). Oct, 2003 | Pubmed ID: 12952905 Inhibition of Zebrafish Epidermal Growth Factor Receptor Activity Results in Cardiovascular Defects Mechanisms of Development. Jul, 2003 | Pubmed ID: 12915231 The Zebrafish Spi1 Promoter Drives Myeloid-specific Expression in Stable Transgenic Fish Blood. Nov, 2003 | Pubmed ID: 12869502 Cancer Genetics and Drug Discovery in the Zebrafish Nature Reviews. Cancer. Jul, 2003 | Pubmed ID: 12835673 Cell-specific Mitotic Defect and Dyserythropoiesis Associated with Erythroid Band 3 Deficiency Nature Genetics. May, 2003 | Pubmed ID: 12669066 Characterization of Embryonic Globin Genes of the Zebrafish Developmental Biology. Mar, 2003 | Pubmed ID: 12618133 Myc-induced T Cell Leukemia in Transgenic Zebrafish Science (New York, N.Y.). Feb, 2003 | Pubmed ID: 12574629 Biomedicine. Love, Honor, and Protect (your Liver) Science (New York, N.Y.). Feb, 2003 | Pubmed ID: 12574609 Ontogeny of Hematopoiesis: Examining the Emergence of Hematopoietic Cells in the Vertebrate Embryo Current Topics in Developmental Biology. 2003 | Pubmed ID: 12510667 Use of Zebrafish Models for the Analysis of Human Disease Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [et Al.]. Nov, 2002 | Pubmed ID: 18428328 Isolation and Characterization of Runxa and Runxb, Zebrafish Members of the Runt Family of Transcriptional Regulators Experimental Hematology. Dec, 2002 | Pubmed ID: 12482499 Portrait of a Stem Cell Developmental Cell. Nov, 2002 | Pubmed ID: 12431368 SUMO-1 Protease-1 Regulates Gene Transcription Through PML Molecular Cell. Oct, 2002 | Pubmed ID: 12419228 SUMO-1 Modification Represses Sp3 Transcriptional Activation and Modulates Its Subnuclear Localization Molecular Cell. Oct, 2002 | Pubmed ID: 12419227 The Zebrafish Mutant Gene Chardonnay (cdy) Encodes Divalent Metal Transporter 1 (DMT1) Blood. Dec, 2002 | Pubmed ID: 12393445 Isolation and Characterization of Zebrafish NFE2 Physiological Genomics. Oct, 2002 | Pubmed ID: 12388799 Characterization of Zebrafish Merlot/chablis As Non-mammalian Vertebrate Models for Severe Congenital Anemia Due to Protein 4.1 Deficiency Development (Cambridge, England). Sep, 2002 | Pubmed ID: 12183387 Attack of the Fish Clones Nature Biotechnology. Aug, 2002 | Pubmed ID: 12148002 Neuropilin-1 is Required for Vascular Development and is a Mediator of VEGF-dependent Angiogenesis in Zebrafish Proceedings of the National Academy of Sciences of the United States of America. Aug, 2002 | Pubmed ID: 12142468 Zebrafish As a Cancer Model System Cancer Cell. Apr, 2002 | Pubmed ID: 12086858 Zebrafish SPI-1 (PU.1) Marks a Site of Myeloid Development Independent of Primitive Erythropoiesis: Implications for Axial Patterning Developmental Biology. Jun, 2002 | Pubmed ID: 12051816 Evolutionary Conservation of Zebrafish Linkage Group 14 with Frequently Deleted Regions of Human Chromosome 5 in Myeloid Malignancies Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002 | Pubmed ID: 11983906 Walking the Walk: Migration and Other Common Themes in Blood and Vascular Development Cell. Mar, 2002 | Pubmed ID: 11955426 Hematopoiesis and Stem Cells: Plasticity Versus Developmental Heterogeneity Nature Immunology. Apr, 2002 | Pubmed ID: 11919568 Non-cell Autonomous Requirement for the Bloodless Gene in Primitive Hematopoiesis of Zebrafish Development (Cambridge, England). Feb, 2002 | Pubmed ID: 11830566 Organogenesis--heart and Blood Formation from the Zebrafish Point of View Science (New York, N.Y.). Jan, 2002 | Pubmed ID: 11799232 Retro-orbital de injeção no Zebrafish Adulto Emily K. Pugach1,2, Pulin Li1,2, Richard White1,2,3, Leonard Zon1,2 1Department of Hematology and Oncology, Children’s Hospital Boston, 2Harvard Stem Cell Institute, Harvard Medical School, 3Department of Medical Oncology, Dana Farber Cancer Institute JoVE 1645 Biology Transplante de Medula Renal inteiro em Zebrafish Adulto Jocelyn LeBlanc1, Teresa Venezia Bowman1, Leonard Zon1 1Children's Hospital, Harvard Stem Cell Institute, Harvard Medical School JoVE 159 Biology
Retro-orbital de injeção no Zebrafish Adulto Emily K. Pugach1,2, Pulin Li1,2, Richard White1,2,3, Leonard Zon1,2 1Department of Hematology and Oncology, Children’s Hospital Boston, 2Harvard Stem Cell Institute, Harvard Medical School, 3Department of Medical Oncology, Dana Farber Cancer Institute JoVE 1645 Biology
Transplante de Medula Renal inteiro em Zebrafish Adulto Jocelyn LeBlanc1, Teresa Venezia Bowman1, Leonard Zon1 1Children's Hospital, Harvard Stem Cell Institute, Harvard Medical School JoVE 159 Biology