M. Sharon Stack Department of Chemistry & Biochemistry, Harper Cancer Research Institute University of Notre Dame Biography Publications Institution JoVE Articles M. Sharon Stack has not added a biography. If you are M. Sharon Stack and would like to personalize this page please email our Author Liaison for assistance. Publications Aggressive Breast Cancer in Western Kenya Has Early Onset, High Proliferation, and Immune Cell Infiltration BMC Cancer. 2016 | Pubmed ID: 26964534 Integrin-linked Kinase Activity Modulates the Pro-metastatic Behavior of Ovarian Cancer Cells Oncotarget. Mar, 2016 | Pubmed ID: 26959113 Protease-activated Receptor-2 (PAR-2)-mediated Nf-κB Activation Suppresses Inflammation-associated Tumor Suppressor MicroRNAs in Oral Squamous Cell Carcinoma The Journal of Biological Chemistry. Mar, 2016 | Pubmed ID: 26839311 Obesity Contributes to Ovarian Cancer Metastatic Success Through Increased Lipogenesis, Enhanced Vascularity, and Decreased Infiltration of M1 Macrophages Cancer Research. Dec, 2015 | Pubmed ID: 26573796 Integrated, DC Voltage-driven Nucleic Acid Diagnostic Platform for Real Sample Analysis: Detection of Oral Cancer Talanta. Dec, 2015 | Pubmed ID: 26459441 Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma The Journal of Biological Chemistry. Sep, 2015 | Pubmed ID: 26175151 Decrease of MiR-146a is Associated with the Aggressiveness of Human Oral Squamous Cell Carcinoma Archives of Oral Biology. Sep, 2015 | Pubmed ID: 26159827 Identification of a Human Papillomavirus-associated Oncogenic MiRNA Panel in Human Oropharyngeal Squamous Cell Carcinoma Validated by Bioinformatics Analysis of the Cancer Genome Atlas The American Journal of Pathology. Mar, 2015 | Pubmed ID: 25572154 Correlation of X-ray Computed Tomography with Quantitative Nuclear Magnetic Resonance Methods for Pre-clinical Measurement of Adipose and Lean Tissues in Living Mice Sensors (Basel, Switzerland). 2014 | Pubmed ID: 25299952 Membrane-type I Matrix Metalloproteinase-dependent Ectodomain Shedding of Mucin16/ CA-125 on Ovarian Cancer Cells Modulates Adhesion and Invasion of Peritoneal Mesothelium Biological Chemistry. Oct, 2014 | Pubmed ID: 25205731 An Ion-exchange Nanomembrane Sensor for Detection of Nucleic Acids Using a Surface Charge Inversion Phenomenon Biosensors & Bioelectronics. Oct, 2014 | Pubmed ID: 24787123 Inhibitors of NF-kappaB Reverse Cellular Invasion and Target Gene Upregulation in an Experimental Model of Aggressive Oral Squamous Cell Carcinoma Oral Oncology. May, 2014 | Pubmed ID: 24582884 Detecting MicroRNA in Human Cancer Tissues with Fluorescence in Situ Hybridization Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 24026683 Matrix Rigidity Activates Wnt Signaling Through Down-regulation of Dickkopf-1 Protein The Journal of Biological Chemistry. Jan, 2013 | Pubmed ID: 23152495 Fluorescence In Situ Hybridization for MicroRNA Detection in Archived Oral Cancer Tissues Journal of Oncology. 2012 | Pubmed ID: 22654907 Lysophosphatidic Acid Disrupts Junctional Integrity and Epithelial Cohesion in Ovarian Cancer Cells Journal of Oncology. 2012 | Pubmed ID: 22593767 Virology and Molecular Pathogenesis of HPV (human Papillomavirus)-associated Oropharyngeal Squamous Cell Carcinoma The Biochemical Journal. Apr, 2012 | Pubmed ID: 22452816 The Cell Surface Glycoprotein CUB Domain-containing Protein 1 (CDCP1) Contributes to Epidermal Growth Factor Receptor-mediated Cell Migration The Journal of Biological Chemistry. Mar, 2012 | Pubmed ID: 22315226 Nonsteroidal Antiinflammatory Drugs and Progestins Synergistically Enhance Cell Death in Ovarian Epithelial Cells American Journal of Obstetrics and Gynecology. Mar, 2012 | Pubmed ID: 22206747 Diverse Mechanisms for Activation of Wnt Signalling in the Ovarian Tumour Microenvironment The Biochemical Journal. Jul, 2011 | Pubmed ID: 21668411 Urinary-type Plasminogen Activator Receptor (uPAR) Modulates Oral Cancer Cell Behavior with Alteration in P130cas Molecular and Cellular Biochemistry. Nov, 2011 | Pubmed ID: 21630091 Integrin Regulation of Beta-catenin Signaling in Ovarian Carcinoma The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21518759 Kallikrein-5 Promotes Cleavage of Desmoglein-1 and Loss of Cell-cell Cohesion in Oral Squamous Cell Carcinoma The Journal of Biological Chemistry. Mar, 2011 | Pubmed ID: 21163944 Bisphosphonate Effects on the Behaviour of Oral Epithelial Cells and Oral Fibroblasts Archives of Oral Biology. May, 2011 | Pubmed ID: 21146154 Molecules of Cell Adhesion and Extracellular Matrix Proteolysis in Oral Squamous Cell Carcinoma Histology and Histopathology. Jul, 2010 | Pubmed ID: 20503180 Microenvironmental Regulation of Chemokine (C-X-C-motif) Receptor 4 in Ovarian Carcinoma Molecular Cancer Research : MCR. May, 2010 | Pubmed ID: 20460402 Masticatory Loading, Function, and Plasticity: a Microanatomical Analysis of Mammalian Circumorbital Soft-tissue Structures Anatomical Record (Hoboken, N.J. : 2007). Apr, 2010 | Pubmed ID: 20235321 Urinary-type Plasminogen Activator Receptor/alpha 3 Beta 1 Integrin Signaling, Altered Gene Expression, and Oral Tumor Progression Molecular Cancer Research : MCR. Feb, 2010 | Pubmed ID: 20145038 Targeting the EGF Receptor for Ovarian Cancer Therapy Journal of Oncology. 2010 | Pubmed ID: 20066160 Microenvironmental Regulation of Ovarian Cancer Metastasis Cancer Treatment and Research. 2009 | Pubmed ID: 19763443 Activated Epidermal Growth Factor Receptor in Ovarian Cancer Cancer Treatment and Research. 2009 | Pubmed ID: 19763438 Ovarian Cancer Cell Detachment and Multicellular Aggregate Formation Are Regulated by Membrane Type 1 Matrix Metalloproteinase: a Potential Role in I.p. Metastatic Dissemination Cancer Research. Sep, 2009 | Pubmed ID: 19706774 Epidermal Growth Factor Receptor-mediated Membrane Type 1 Matrix Metalloproteinase Endocytosis Regulates the Transition Between Invasive Versus Expansive Growth of Ovarian Carcinoma Cells in Three-dimensional Collagen Molecular Cancer Research : MCR. Jun, 2009 | Pubmed ID: 19509114 Modulation of the Membrane Type 1 Matrix Metalloproteinase Cytoplasmic Tail Enhances Tumor Cell Invasion and Proliferation in Three-dimensional Collagen Matrices The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19458085 Downregulation of Connective Tissue Growth Factor by Three-dimensional Matrix Enhances Ovarian Carcinoma Cell Invasion International Journal of Cancer. Journal International Du Cancer. Aug, 2009 | Pubmed ID: 19382180 EGF-receptor Regulation of Matrix Metalloproteinases in Epithelial Ovarian Carcinoma Future Oncology (London, England). Apr, 2009 | Pubmed ID: 19374540 Multiple Kallikrein (KLK 5, 7, 8, and 10) Expression in Squamous Cell Carcinoma of the Oral Cavity Histology and Histopathology. Feb, 2009 | Pubmed ID: 19085836 Expression of Membrane Type 1 Matrix Metalloproteinase (MMP-14) in Epithelial Ovarian Cancer: High Level Expression in Clear Cell Carcinoma Gynecologic Oncology. Feb, 2009 | Pubmed ID: 18976802 Using "Mighty Mouse" to Understand Masticatory Plasticity: Myostatin-deficient Mice and Musculoskeletal Function Integrative and Comparative Biology. Sep, 2008 | Pubmed ID: 21669797 SV40 Early Genes Induce Neoplastic Properties in Serous Borderline Ovarian Tumor Cells Gynecologic Oncology. Oct, 2008 | Pubmed ID: 18678400 Matrix Metalloproteinase 9 is a Mediator of Epidermal Growth Factor-dependent E-cadherin Loss in Ovarian Carcinoma Cells Cancer Research. Jun, 2008 | Pubmed ID: 18559505 Polypyrimidine Tract-binding Protein (PTB) Differentially Affects Malignancy in a Cell Line-dependent Manner The Journal of Biological Chemistry. Jul, 2008 | Pubmed ID: 18499661 Phenotypic Plasticity of Neoplastic Ovarian Epithelium: Unique Cadherin Profiles in Tumor Progression Clinical & Experimental Metastasis. 2008 | Pubmed ID: 18398687 Motility-related Actinin Alpha-4 is Associated with Advanced and Metastatic Ovarian Carcinoma Laboratory Investigation; a Journal of Technical Methods and Pathology. Jun, 2008 | Pubmed ID: 18362906 Wilms Tumor Gene Protein 1 is Associated with Ovarian Cancer Metastasis and Modulates Cell Invasion Cancer. Apr, 2008 | Pubmed ID: 18260155 Synthesis and Anticancer Activities of 6-amino Amonafide Derivatives Anti-cancer Drugs. Jan, 2008 | Pubmed ID: 18043127 Membrane Type 1-matrix Metalloproteinase: Substrate Diversity in Pericellular Proteolysis Seminars in Cell & Developmental Biology. Feb, 2008 | Pubmed ID: 17702616 Urinary-type Plasminogen Activator (uPA) and Its Receptor (uPAR) in Squamous Cell Carcinoma of the Oral Cavity The Biochemical Journal. Oct, 2007 | Pubmed ID: 17880283 Activation-coupled Membrane-type 1 Matrix Metalloproteinase Membrane Trafficking The Biochemical Journal. Oct, 2007 | Pubmed ID: 17650075 Multi-step Pericellular Proteolysis Controls the Transition from Individual to Collective Cancer Cell Invasion Nature Cell Biology. Aug, 2007 | Pubmed ID: 17618273 Engagement of Collagen-binding Integrins Promotes Matrix Metalloproteinase-9-dependent E-cadherin Ectodomain Shedding in Ovarian Carcinoma Cells Cancer Research. Mar, 2007 | Pubmed ID: 17332331 Lysophosphatidic Acid Down-regulates Stress Fibers and Up-regulates Pro-matrix Metalloproteinase-2 Activation in Ovarian Cancer Cells Molecular Cancer Research : MCR. Feb, 2007 | Pubmed ID: 17314270 Pushing the Limit: Masticatory Stress and Adaptive Plasticity in Mammalian Craniomandibular Joints The Journal of Experimental Biology. Feb, 2007 | Pubmed ID: 17267649 Microenvironmental Regulation of Membrane Type 1 Matrix Metalloproteinase Activity in Ovarian Carcinoma Cells Via Collagen-induced EGR1 Expression The Journal of Biological Chemistry. Feb, 2007 | Pubmed ID: 17158885 Mesenchymal Transformation in Epithelial Ovarian Tumor Cells Expressing Epidermal Growth Factor Receptor Variant III Molecular Carcinogenesis. Nov, 2006 | Pubmed ID: 16788982 Functional Relevance of Urinary-type Plasminogen Activator Receptor-alpha3beta1 Integrin Association in Proteinase Regulatory Pathways The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16510444 Down-regulation of Integrin Alpha2 Surface Expression by Mutant Epidermal Growth Factor Receptor (EGFRvIII) Induces Aberrant Cell Spreading and Focal Adhesion Formation Cancer Research. Oct, 2005 | Pubmed ID: 16230389 Cyclooxygenase-2 Functions As a Downstream Mediator of Lysophosphatidic Acid to Promote Aggressive Behavior in Ovarian Carcinoma Cells Cancer Research. Mar, 2005 | Pubmed ID: 15781636 Proinvasive Properties of Ovarian Cancer Ascites-derived Membrane Vesicles Cancer Research. Oct, 2004 | Pubmed ID: 15466198 Differential Regulation of Membrane Type 1-matrix Metalloproteinase Activity by ERK 1/2- and P38 MAPK-modulated Tissue Inhibitor of Metalloproteinases 2 Expression Controls Transforming Growth Factor-beta1-induced Pericellular Collagenolysis The Journal of Biological Chemistry. Sep, 2004 | Pubmed ID: 15247230 Epidermal Growth Factor Receptor Inhibition Promotes Desmosome Assembly and Strengthens Intercellular Adhesion in Squamous Cell Carcinoma Cells The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15205458 Calcium-induced Matrix Metalloproteinase 9 Gene Expression is Differentially Regulated by ERK1/2 and P38 MAPK in Oral Keratinocytes and Oral Squamous Cell Carcinoma The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15180997 Membrane Protease Proteomics: Isotope-coded Affinity Tag MS Identification of Undescribed MT1-matrix Metalloproteinase Substrates Proceedings of the National Academy of Sciences of the United States of America. May, 2004 | Pubmed ID: 15118097 Proteases, Extracellular Matrix, and Cancer: a Workshop of the Path B Study Section The American Journal of Pathology. Apr, 2004 | Pubmed ID: 15039201 Glycosylation Broadens the Substrate Profile of Membrane Type 1 Matrix Metalloproteinase The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14670950 Selective Hydrolysis of Triple-helical Substrates by Matrix Metalloproteinase-2 and -9 The Journal of Biological Chemistry. May, 2003 | Pubmed ID: 12642591 Loss of Adhesion-regulated Proteinase Production is Correlated with Invasive Activity in Oral Squamous Cell Carcinoma Cancer. Dec, 2002 | Pubmed ID: 12467066 Calcium Regulation of Matrix Metalloproteinase-mediated Migration in Oral Squamous Cell Carcinoma Cells The Journal of Biological Chemistry. Nov, 2002 | Pubmed ID: 12194986 Collagen Binding Properties of the Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Hemopexin C Domain. The Ectodomain of the 44-kDa Autocatalytic Product of MT1-MMP Inhibits Cell Invasion by Disrupting Native Type I Collagen Cleavage The Journal of Biological Chemistry. Oct, 2002 | Pubmed ID: 12145314 Proteinase Suppression by E-cadherin-mediated Cell-cell Attachment in Premalignant Oral Keratinocytes The Journal of Biological Chemistry. Oct, 2002 | Pubmed ID: 12138162 Analysis of Matrix Degradation Methods in Cell Biology. 2002 | Pubmed ID: 12070993 The Mechanism of Action of Angiostatin: Can You Teach an Old Dog New Tricks? Thrombosis and Haemostasis. Mar, 2002 | Pubmed ID: 11916069 Tumor Production of Angiostatin is Enhanced After Exposure to TNF-alpha International Journal of Cancer. Feb, 2002 | Pubmed ID: 11802200 Ovarian Cancer-associated Proteinases Cancer Treatment and Research. 2002 | Pubmed ID: 11775460 Critical Role of Lysophospholipids in the Pathophysiology, Diagnosis, and Management of Ovarian Cancer Cancer Treatment and Research. 2002 | Pubmed ID: 11775454 Quantitation of Intra-peritoneal Ovarian Cancer Metastasis Kyle A. Lewellen*1, Matthew N. Metzinger*1, Yueying Liu1, M. Sharon Stack1 1Department of Chemistry & Biochemistry, Harper Cancer Research Institute, University of Notre Dame JoVE 53316 Medicine
Quantitation of Intra-peritoneal Ovarian Cancer Metastasis Kyle A. Lewellen*1, Matthew N. Metzinger*1, Yueying Liu1, M. Sharon Stack1 1Department of Chemistry & Biochemistry, Harper Cancer Research Institute, University of Notre Dame JoVE 53316 Medicine