Marie-José Goumans Department of Molecular Cell Biology Leiden University Medical Center Biography Publications Institution JoVE Articles Marie-José Goumans has not added a biography. If you are Marie-José Goumans and would like to personalize this page please email our Author Liaison for assistance. Publications Structural and Cellular Mechanisms of Peptidyl-prolyl Isomerase Pin1-mediated Enhancement of Tissue Factor Gene Expression, Protein Half-life, and Pro-coagulant Activity Haematologica. Mar, 2018 | Pubmed ID: 29545340 Endothelial Dysfunction in Pulmonary Arterial Hypertension: Loss of Cilia Length Regulation Upon Cytokine Stimulation Pulmonary Circulation. Apr-Jun, 2018 | Pubmed ID: 29480152 The Morphological and Molecular Mechanisms of Epithelial/endothelial-to-mesenchymal Transition and Its Involvement in Atherosclerosis Vascular Pharmacology. Feb, 2018 | Pubmed ID: 29471141 Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension Circulation. Feb, 2018 | Pubmed ID: 29167228 The Epicardium As a Source of Multipotent Adult Cardiac Progenitor Cells: Their Origin, Role and Fate Pharmacological Research. 01, 2018 | Pubmed ID: 28751220 Leukocyte-Associated Immunoglobulin-like Receptor-1 is Regulated in Human Myocardial Infarction but Its Absence Does Not Affect Infarct Size in Mice Scientific Reports. Dec, 2017 | Pubmed ID: 29269840 Inhibiting DPP4 in a Mouse Model of HHT1 Results in a Shift Towards Regenerative Macrophages and Reduces Fibrosis After Myocardial Infarction PloS One. 2017 | Pubmed ID: 29253907 Thoracic Aortic Aneurysm Development in Patients with Bicuspid Aortic Valve: What Is the Role of Endothelial Cells? Frontiers in Physiology. 2017 | Pubmed ID: 29249976 Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms Frontiers in Physiology. 2017 | Pubmed ID: 29075204 Preeclampsia and Coronary Plaque Erosion: Manifestations of Endothelial Dysfunction Resulting in Cardiovascular Events in Women European Journal of Pharmacology. Dec, 2017 | Pubmed ID: 28899695 Glycosylated Cell Surface Markers for the Isolation of Human Cardiac Progenitors Stem Cells and Development. Nov, 2017 | Pubmed ID: 28891400 Bone Morphogenetic Protein 9 Protects Against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation Frontiers in Physiology. 2017 | Pubmed ID: 28751863 TGFβ1-induced SMAD2/3 and SMAD1/5 Phosphorylation Are Both ALK5-kinase-dependent in Primary Chondrocytes and Mediated by TAK1 Kinase Activity Arthritis Research & Therapy. May, 2017 | Pubmed ID: 28569204 TGFβ Pathway Deregulation and Abnormal Phospho-SMAD2/3 Staining in Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch Type Brain Pathology (Zurich, Switzerland). May, 2017 | Pubmed ID: 28557134 Higher Functionality of Extracellular Vesicles Isolated Using Size-exclusion Chromatography Compared to Ultracentrifugation Nanomedicine : Nanotechnology, Biology, and Medicine. Mar, 2017 | Pubmed ID: 28365418 Bone Morphogenetic Proteins in Vascular Homeostasis and Disease Cold Spring Harbor Perspectives in Biology. Mar, 2017 | Pubmed ID: 28348038 TGF-β Signaling in Control of Cardiovascular Function Cold Spring Harbor Perspectives in Biology. Mar, 2017 | Pubmed ID: 28348036 BMP-9 Interferes with Liver Regeneration and Promotes Liver Fibrosis Gut. May, 2017 | Pubmed ID: 28336518 Mimicking Cardiac Fibrosis in a Dish: Fibroblast Density Rather Than Collagen Density Weakens Cardiomyocyte Function Journal of Cardiovascular Translational Research. Apr, 2017 | Pubmed ID: 28281243 Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair Circulation. May, 2017 | Pubmed ID: 28167635 Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells Versus Cardiac Fibroblasts ACS Chemical Biology. 01, 2017 | Pubmed ID: 28103692 The Microvasculature: The Next Battlefield Where Transforming Growth Factor-β and Endoglin Draw Their Double-Edged Swords? Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2017 | Pubmed ID: 28062457 Part and Parcel of the Cardiac Autonomic Nerve System: Unravelling Its Cellular Building Blocks During Development Journal of Cardiovascular Development and Disease. Sep, 2016 | Pubmed ID: 29367572 Long-term Self-renewing Human Epicardial Cells Generated from Pluripotent Stem Cells Under Defined Xeno-free Conditions Nature Biomedical Engineering. 2016 | Pubmed ID: 28462012 Human Fetal and Adult Epicardial-derived Cells: a Novel Model to Study Their Activation Stem Cell Research & Therapy. 11, 2016 | Pubmed ID: 27899163 Cardiomyocyte Progenitor Cell Mechanoresponse Unrevealed: Strain Avoidance and Mechanosome Development Integrative Biology : Quantitative Biosciences from Nano to Macro. 09, 2016 | Pubmed ID: 27722606 Comparative Transcriptomic Analysis Identifies Genes Differentially Expressed in Human Epicardial Progenitors and HiPSC-derived Cardiac Progenitors Physiological Genomics. Nov, 2016 | Pubmed ID: 27591124 Response by Van Der Bruggen Et Al to Letter Regarding Article, "Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle" Circulation. Aug, 2016 | Pubmed ID: 27572883 Exosomes from Cardiomyocyte Progenitor Cells and Mesenchymal Stem Cells Stimulate Angiogenesis Via EMMPRIN Advanced Healthcare Materials. Aug, 2016 | Pubmed ID: 27570124 Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle Circulation. May, 2016 | Pubmed ID: 26984938 Cardiac Stem Cell Treatment in Myocardial Infarction: A Systematic Review and Meta-Analysis of Preclinical Studies Circulation Research. Apr, 2016 | Pubmed ID: 26888636 Measuring the Primary Cilium Length: Improved Method for Unbiased High-throughput Analysis Cilia. 2016 | Pubmed ID: 26870322 Age-Dependent Changes in Geometry, Tissue Composition and Mechanical Properties of Fetal to Adult Cryopreserved Human Heart Valves PloS One. 2016 | Pubmed ID: 26867221 The Roadmap of WT1 Protein Expression in the Human Fetal Heart Journal of Molecular and Cellular Cardiology. Jan, 2016 | Pubmed ID: 26686990 Regulatory RNAs Controlling Vascular (dys)function by Affecting TGF-ß Family Signalling EXCLI Journal. 2015 | Pubmed ID: 26862319 Xenotransplantation of Human Cardiomyocyte Progenitor Cells Does Not Improve Cardiac Function in a Porcine Model of Chronic Ischemic Heart Failure. Results from a Randomized, Blinded, Placebo Controlled Trial PloS One. 2015 | Pubmed ID: 26678993 The Epicardium As Modulator of the Cardiac Autonomic Response During Early Development Journal of Molecular and Cellular Cardiology. Dec, 2015 | Pubmed ID: 26527381 Environmental Influences on Endothelial to Mesenchymal Transition in Developing Implanted Cardiovascular Tissue-Engineered Grafts Tissue Engineering. Part B, Reviews. Oct, 2015 | Pubmed ID: 26414174 Regional Differences in WT-1 and Tcf21 Expression During Ventricular Development: Implications for Myocardial Compaction PloS One. 2015 | Pubmed ID: 26390289 Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2015 | Pubmed ID: 26373572 Behavior of CMPCs in Unidirectional Constrained and Stress-free 3D Hydrogels Journal of Molecular and Cellular Cardiology. Aug, 2015 | Pubmed ID: 26278995 Histopathology of Aortic Complications in Bicuspid Aortic Valve Versus Marfan Syndrome: Relevance for Therapy? Heart and Vessels. Jul, 2015 | Pubmed ID: 26129868 Mononuclear Cells and Vascular Repair in HHT Frontiers in Genetics. 2015 | Pubmed ID: 25852751 Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections Journal of the American College of Cardiology. Apr, 2015 | Pubmed ID: 25835445 Functional Maturation of Human Pluripotent Stem Cell Derived Cardiomyocytes in Vitro--correlation Between Contraction Force and Electrophysiology Biomaterials. May, 2015 | Pubmed ID: 25771005 Cardiac Endothelial Cells Express Wilms' Tumor-1: Wt1 Expression in the Developing, Adult and Infarcted Heart Journal of Molecular and Cellular Cardiology. Apr, 2015 | Pubmed ID: 25681586 SLUG is Expressed in Endothelial Cells Lacking Primary Cilia to Promote Cellular Calcification Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2015 | Pubmed ID: 25633317 Inhibition of TGFβ Type I Receptor Activity Facilitates Liver Regeneration Upon Acute CCl4 Intoxication in Mice Archives of Toxicology. Jan, 2015 | Pubmed ID: 25566828 Bicuspid Aortic Valve: Phosphorylation of C-Kit and Downstream Targets Are Prognostic for Future Aortopathy European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. Nov, 2014 | Pubmed ID: 25161185 The MicroRNA-15 Family Inhibits the TGFβ-pathway in the Heart Cardiovascular Research. Oct, 2014 | Pubmed ID: 25103110 A Straightforward Guide to the Basic Science Behind Cardiovascular Cell-based Therapies Heart (British Cardiac Society). Aug, 2014 | Pubmed ID: 24993501 A Multistep Procedure to Prepare Pre-vascularized Cardiac Tissue Constructs Using Adult Stem Sells, Dynamic Cell Cultures, and Porous Scaffolds Frontiers in Physiology. 2014 | Pubmed ID: 24917827 Nuclear Receptor NR4A1 Promotes Breast Cancer Invasion and Metastasis by Activating TGF-β Signalling Nature Communications. 2014 | Pubmed ID: 24584437 Ascending Aorta Dilation in Association with Bicuspid Aortic Valve: a Maturation Defect of the Aortic Wall The Journal of Thoracic and Cardiovascular Surgery. Oct, 2014 | Pubmed ID: 24560417 ENDOGLIN is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-induced Angiogenesis PloS One. 2014 | Pubmed ID: 24489709 Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides Molecular Therapy. Nucleic Acids. 2014 | Pubmed ID: 24448195 Extraembryonic Endoderm Cells As a Model of Endoderm Development Development, Growth & Differentiation. Apr, 2013 | Pubmed ID: 23414197 Deficiency for Endoglin in Tumor Vasculature Weakens the Endothelial Barrier to Metastatic Dissemination The Journal of Experimental Medicine. Mar, 2013 | Pubmed ID: 23401487 Bone Marrow Alterations and Lower Endothelial Progenitor Cell Numbers in Critical Limb Ischemia Patients PloS One. 2013 | Pubmed ID: 23383236 Cardiac Regeneration: Stem Cells and Beyond Current Medicinal Chemistry. 2012 | Pubmed ID: 22963568 TGFβ and BMP Signaling in Cardiac Cushion Formation: Lessons from Mice and Chicken Differentiation; Research in Biological Diversity. Jul, 2012 | Pubmed ID: 22656450 The Arterial and Cardiac Epicardium in Development, Disease and Repair Differentiation; Research in Biological Diversity. Jul, 2012 | Pubmed ID: 22652098 Isolation and Differentiation of Human Cardiomyocyte Progenitor Cells into Cardiomyocytes Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22610569 Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22493445 Gap Junctional Coupling with Cardiomyocytes is Necessary but Not Sufficient for Cardiomyogenic Differentiation of Cocultured Human Mesenchymal Stem Cells Stem Cells (Dayton, Ohio). Jun, 2012 | Pubmed ID: 22438316 Shear Induced Collateral Artery Growth Modulated by Endoglin but Not by ALK1 Journal of Cellular and Molecular Medicine. Oct, 2012 | Pubmed ID: 22436015 TGF-β Signaling in Endothelial-to-mesenchymal Transition: the Role of Shear Stress and Primary Cilia Science Signaling. Feb, 2012 | Pubmed ID: 22355187 Cardiomyogenic Differentiation-independent Improvement of Cardiac Function by Human Cardiomyocyte Progenitor Cell Injection in Ischaemic Mouse Hearts Journal of Cellular and Molecular Medicine. Jul, 2012 | Pubmed ID: 22003890 Age-dependent Alteration of TGF-β Signalling in Osteoarthritis Cell and Tissue Research. Jan, 2012 | Pubmed ID: 21638205 Human Embryonic and Fetal Mesenchymal Stem Cells Differentiate Toward Three Different Cardiac Lineages in Contrast to Their Adult Counterparts PloS One. 2011 | Pubmed ID: 21931658 Controlling Angiogenesis by Two Unique TGF-β Type I Receptor Signaling Pathways Histology and Histopathology. Sep, 2011 | Pubmed ID: 21751154 Shedding New Light on the Mechanism Underlying Stem Cell Therapy for the Heart Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2011 | Pubmed ID: 21720378 TGF-β Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy Current Pharmaceutical Biotechnology. May, 2011 | Pubmed ID: 21619534 Tgfβ/Alk5 Signaling is Required for Shear Stress Induced Klf2 Expression in Embryonic Endothelial Cells Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jul, 2011 | Pubmed ID: 21604321 In Vitro Epithelial-to-mesenchymal Transformation in Human Adult Epicardial Cells is Regulated by TGFβ-signaling and WT1 Basic Research in Cardiology. Sep, 2011 | Pubmed ID: 21516490 Lack of Primary Cilia Primes Shear-induced Endothelial-to-mesenchymal Transition Circulation Research. Apr, 2011 | Pubmed ID: 21393577 Low Oxygen Tension Positively Influences Cardiomyocyte Progenitor Cell Function Journal of Cellular and Molecular Medicine. Dec, 2011 | Pubmed ID: 21306557 Epithelial-to-mesenchymal Transformation Alters Electrical Conductivity of Human Epicardial Cells Journal of Cellular and Molecular Medicine. Dec, 2011 | Pubmed ID: 21251220 Modulation of TGF-β/BMP-6 Expression and Increased Levels of Circulating Smooth Muscle Progenitor Cells in a Type I Diabetes Mouse Model Cardiovascular Diabetology. 2010 | Pubmed ID: 20858224 Cardiac Malformations in Pdgfralpha Mutant Embryos Are Associated with Increased Expression of WT1 and Nkx2.5 in the Second Heart Field Developmental Dynamics : an Official Publication of the American Association of Anatomists. Aug, 2010 | Pubmed ID: 20658695 Signaling by Members of the TGF-beta Family in Vascular Morphogenesis and Disease Trends in Cell Biology. Sep, 2010 | Pubmed ID: 20656490 Foetal and Adult Cardiomyocyte Progenitor Cells Have Different Developmental Potential Journal of Cellular and Molecular Medicine. Apr, 2010 | Pubmed ID: 20219011 Genetic and Pharmacological Targeting of Activin Receptor-like Kinase 1 Impairs Tumor Growth and Angiogenesis The Journal of Experimental Medicine. Jan, 2010 | Pubmed ID: 20065063 ALK2 R206H Mutation Linked to Fibrodysplasia Ossificans Progressiva Confers Constitutive Activity to the BMP Type I Receptor and Sensitizes Mesenchymal Cells to BMP-induced Osteoblast Differentiation and Bone Formation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2010 | Pubmed ID: 19929436 A New Direction for Cardiac Regeneration Therapy: Application of Synergistically Acting Epicardium-derived Cells and Cardiomyocyte Progenitor Cells Circulation. Heart Failure. Nov, 2009 | Pubmed ID: 19919990 VEGF and Inhibitors of TGFbeta Type-I Receptor Kinase Synergistically Promote Blood-vessel Formation by Inducing Alpha5-integrin Expression Journal of Cell Science. Sep, 2009 | Pubmed ID: 19706683 A New in Vitro Model for Stem Cell Differentiation and Interaction Stem Cell Research. Mar, 2009 | Pubmed ID: 19383416 TGF-beta Signaling in Vascular Biology and Dysfunction Cell Research. Jan, 2009 | Pubmed ID: 19114994 Transforming Growth Factor Beta-induced Endothelial-to-mesenchymal Transition: a Switch to Cardiac Fibrosis? Trends in Cardiovascular Medicine. Nov, 2008 | Pubmed ID: 19345316 Endoglin in Angiogenesis and Vascular Diseases Angiogenesis. 2008 | Pubmed ID: 18283546 Smad7 and Protein Phosphatase 1alpha Are Critical Determinants in the Duration of TGF-beta/ALK1 Signaling in Endothelial Cells BMC Cell Biology. 2006 | Pubmed ID: 16571110 Изоляции и культуры клеток первичного эпикардиальной, производный от сердца человека взрослых и плода образцов Esther Dronkers1, Asja T. Moerkamp1, Tessa van Herwaarden1, Marie-José Goumans1, Anke M. Smits1 1Department of Molecular Cell Biology, Leiden University Medical Center JoVE 57370 Developmental Biology
Изоляции и культуры клеток первичного эпикардиальной, производный от сердца человека взрослых и плода образцов Esther Dronkers1, Asja T. Moerkamp1, Tessa van Herwaarden1, Marie-José Goumans1, Anke M. Smits1 1Department of Molecular Cell Biology, Leiden University Medical Center JoVE 57370 Developmental Biology