Martin Biel Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Department of Pharmacy Ludwig-Maximilians-Universität München Biography Publications Institution JoVE Articles Martin Biel has not added a biography. If you are Martin Biel and would like to personalize this page please email our Author Liaison for assistance. Publications CAMP-dependent Regulation of HCN4 Controls the Tonic Entrainment Process in Sinoatrial Node Pacemaker Cells Nature Communications. 11, 2020 | Pubmed ID: 33144559 A Gene Therapy for Inherited Blindness Using DCas9-VPR-mediated Transcriptional Activation Science Advances. Aug, 2020 | Pubmed ID: 32875106 Antisense Oligonucleotide- and CRISPR-Cas9-Mediated Rescue of MRNA Splicing for a Deep Intronic CLRN1 Mutation Molecular Therapy. Nucleic Acids. Sep, 2020 | Pubmed ID: 32841912 TPC1 Deficiency or Blockade Augments Systemic Anaphylaxis and Mast Cell Activity Proceedings of the National Academy of Sciences of the United States of America. 07, 2020 | Pubmed ID: 32661165 Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial JAMA Ophthalmology. 06, 2020 | Pubmed ID: 32352493 Neuropathic and CAMP-induced Pain Behavior is Ameliorated in Mice Lacking CNGB1 Neuropharmacology. 07, 2020 | Pubmed ID: 32272140 Enigmatic Rhodopsin Mutation Creates an Exceptionally Strong Splice Acceptor Site Human Molecular Genetics. 01, 2020 | Pubmed ID: 31816042 Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes Journal of Pharmaceutical Sciences. 01, 2020 | Pubmed ID: 31639391 Advancing Gene Therapy for PDE6A Retinitis Pigmentosa Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 31884596 HCN3 Ion Channels: Roles in Sensory Neuronal Excitability and Pain The Journal of Physiology. 09, 2019 | Pubmed ID: 31290157 Abolishing CAMP Sensitivity in HCN2 Pacemaker Channels Induces Generalized Seizures JCI Insight. 05, 2019 | Pubmed ID: 31045576 The Protein Interaction Networks of Mucolipins and Two-pore Channels Biochimica Et Biophysica Acta. Molecular Cell Research. 07, 2019 | Pubmed ID: 30395881 Optimized Subretinal Injection Technique for Gene Therapy Approaches Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30324458 In Vitro Evaluation of AAV Vectors for Retinal Gene Therapy Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30324456 Accessory Heterozygous Mutations in Cone Photoreceptor CNGA3 Exacerbate CNG Channel-associated Retinopathy The Journal of Clinical Investigation. 12, 2018 | Pubmed ID: 30418171 Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of RAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial Human Gene Therapy. Clinical Development. 09, 2018 | Pubmed ID: 30187779 Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients Investigative Ophthalmology & Visual Science. 04, 2018 | Pubmed ID: 29677353 Hif1a Inactivation Rescues Photoreceptor Degeneration Induced by a Chronic Hypoxia-like Stress Cell Death and Differentiation. 12, 2018 | Pubmed ID: 29666476 Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy International Journal of Molecular Sciences. Mar, 2018 | Pubmed ID: 29518895 Endolysosomal Cation Channels and Cancer-A Link with Great Potential Pharmaceuticals (Basel, Switzerland). Jan, 2018 | Pubmed ID: 29303993 Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa Frontiers in Immunology. 2017 | Pubmed ID: 29354133 Gene Therapy Successfully Delays Degeneration in a Mouse Model of -Linked Retinitis Pigmentosa (RP43) Human Gene Therapy. Dec, 2017 | Pubmed ID: 29212391 Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Toward Treating Human -Retinitis Pigmentosa Human Gene Therapy. Dec, 2017 | Pubmed ID: 29212382 Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates Investigative Ophthalmology & Visual Science. 11, 2017 | Pubmed ID: 29117317 Abstracts from the 8th International Conference on CGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017 BMC Pharmacology & Toxicology. Oct, 2017 | Pubmed ID: 29035170 AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2017 | Pubmed ID: 28970046 TPC2 Polymorphisms Associated with a Hair Pigmentation Phenotype in Humans Result in Gain of Channel Function by Independent Mechanisms Proceedings of the National Academy of Sciences of the United States of America. 10, 2017 | Pubmed ID: 28923947 Protein Kinase A Regulates Inflammatory Pain Sensitization by Modulating HCN2 Channel Activity in Nociceptive Sensory Neurons Pain. Oct, 2017 | Pubmed ID: 28767511 Small Molecules for Early Endosome-Specific Patch Clamping Cell Chemical Biology. Jul, 2017 | Pubmed ID: 28732201 Patch-clamp Technique to Characterize Ion Channels in Enlarged Individual Endolysosomes Nature Protocols. Aug, 2017 | Pubmed ID: 28726848 Photopharmacological Control of Bipolar Cells Restores Visual Function in Blind Mice The Journal of Clinical Investigation. Jun, 2017 | Pubmed ID: 28581442 Peripherin-2 and Rom-1 Have Opposing Effects on Rod Outer Segment Targeting of Retinitis Pigmentosa-linked Peripherin-2 Mutants Scientific Reports. 05, 2017 | Pubmed ID: 28539581 Endoplasmic Reticulum (ER) Ca-channel Activity Contributes to ER Stress and Cone Death in Cyclic Nucleotide-gated Channel Deficiency The Journal of Biological Chemistry. 07, 2017 | Pubmed ID: 28495882 From Mucolipidosis Type IV to Ebola: TRPML and Two-pore Channels at the Crossroads of Endo-lysosomal Trafficking and Disease Cell Calcium. 11, 2017 | Pubmed ID: 28457591 Recombinant Tandem of Pore-domains in a Weakly Inward Rectifying K Channel 2 (TWIK2) Forms Active Lysosomal Channels Scientific Reports. 04, 2017 | Pubmed ID: 28381826 Mosaic Synaptopathy and Functional Defects in Cav1.4 Heterozygous Mice and Human Carriers of CSNB2 Human Molecular Genetics. Jan, 2017 | Pubmed ID: 28365780 Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion After Cone Precursor Transplantation Molecular Therapy : the Journal of the American Society of Gene Therapy. 03, 2017 | Pubmed ID: 28143742 Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells Cancer Research. 03, 2017 | Pubmed ID: 28108508 Gene Therapy for Achromatopsia The Journal of Gene Medicine. Mar, 2017 | Pubmed ID: 28095637 Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response Investigative Ophthalmology & Visual Science. 05, 2016 | Pubmed ID: 27152964 Peripherin-2 Differentially Interacts with Cone Opsins in Outer Segments of Cone Photoreceptors Human Molecular Genetics. Mar, 2016 | Pubmed ID: 27033727 HCN1 Channels Enhance Rod System Responsivity in the Retina Under Conditions of Light Exposure PloS One. 2016 | Pubmed ID: 26807953 In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in MRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors PLoS Genetics. Jan, 2016 | Pubmed ID: 26796962 Loss of HCN1 Enhances Disease Progression in Mouse Models of CNG Channel-linked Retinitis Pigmentosa and Achromatopsia Human Molecular Genetics. Mar, 2016 | Pubmed ID: 26740549 Comprehensive Multilevel in Vivo and in Vitro Analysis of Heart Rate Fluctuations in Mice by ECG Telemetry and Electrophysiology Nature Protocols. Jan, 2016 | Pubmed ID: 26658468 Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated Via Its C-Terminal PDZ Binding Motif PloS One. 2015 | Pubmed ID: 26352593 Retinitis Pigmentosa: Impact of Different Pde6a Point Mutations on the Disease Phenotype Human Molecular Genetics. Oct, 2015 | Pubmed ID: 26188004 CGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice The Journal of Biological Chemistry. Aug, 2015 | Pubmed ID: 26124274 Electroretinographic Assessment of Rod- and Cone-mediated Bipolar Cell Pathways Using Flicker Stimuli in Mice Scientific Reports. Jun, 2015 | Pubmed ID: 26029863 Expression of Ca²⁺-permeable Two-pore Channels Rescues NAADP Signalling in TPC-deficient Cells The EMBO Journal. Jul, 2015 | Pubmed ID: 25872774 Vitreal Delivery of AAV Vectored Cnga3 Restores Cone Function in CNGA3-/-/Nrl-/- Mice, an All-cone Model of CNGA3 Achromatopsia Human Molecular Genetics. Jul, 2015 | Pubmed ID: 25855802 TET3 is Recruited by REST for Context-specific Hydroxymethylation and Induction of Gene Expression Cell Reports. Apr, 2015 | Pubmed ID: 25843715 Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments Anesthesiology. May, 2015 | Pubmed ID: 25782754 Ebola Virus. Two-pore Channels Control Ebola Virus Host Cell Entry and Are Drug Targets for Disease Treatment Science (New York, N.Y.). Feb, 2015 | Pubmed ID: 25722412 Retinal Gene Delivery by Adeno-associated Virus (AAV) Vectors: Strategies and Applications European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Sep, 2015 | Pubmed ID: 25615882 High Susceptibility to Fatty Liver Disease in Two-pore Channel 2-deficient Mice Nature Communications. Aug, 2014 | Pubmed ID: 25144390 A Small Molecule Restores Function to TRPML1 Mutant Isoforms Responsible for Mucolipidosis Type IV Nature Communications. Aug, 2014 | Pubmed ID: 25119295 Peripherin-2 Couples Rhodopsin to the CNG Channel in Outer Segments of Rod Photoreceptors Human Molecular Genetics. Nov, 2014 | Pubmed ID: 24963162 Gene Therapy Restores Vision and Delays Degeneration in the CNGB1(-/-) Mouse Model of Retinitis Pigmentosa Advances in Experimental Medicine and Biology. 2014 | Pubmed ID: 24664765 Mosaic Synaptopathy and Functional Defects in Cav1.4 Heterozygous Mice and Human Carriers of CSNB2 Human Molecular Genetics. Mar, 2014 | Pubmed ID: 24163243 CGMP Accumulation Causes Photoreceptor Degeneration in CNG Channel Deficiency: Evidence of CGMP Cytotoxicity Independently of Enhanced CNG Channel Function The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2013 | Pubmed ID: 24027293 Gene Replacement Therapy for Retinal CNG Channelopathies Molecular Genetics and Genomics : MGG. Oct, 2013 | Pubmed ID: 23861024 Loss of Cone Cyclic Nucleotide-gated Channel Leads to Alterations in Light Response Modulating System and Cellular Stress Response Pathways: a Gene Expression Profiling Study Human Molecular Genetics. Oct, 2013 | Pubmed ID: 23740940 Up-regulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channel 3 (HCN3) by Specific Interaction with K+ Channel Tetramerization Domain-containing Protein 3 (KCTD3) The Journal of Biological Chemistry. Mar, 2013 | Pubmed ID: 23382386 Characterization of Neurite Outgrowth and Ectopic Synaptogenesis in Response to Photoreceptor Dysfunction Cellular and Molecular Life Sciences : CMLS. May, 2013 | Pubmed ID: 23269435 Isotope-based Analysis of Modified TRNA Nucleosides Correlates Modification Density with Translational Efficiency Angewandte Chemie (International Ed. in English). Oct, 2012 | Pubmed ID: 23037940 Complex Regulation of Voltage-dependent Activation and Inactivation Properties of Retinal Voltage-gated Cav1.4 L-type Ca2+ Channels by Ca2+-binding Protein 4 (CaBP4) The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22936811 Gene Therapy Restores Vision and Delays Degeneration in the CNGB1(-/-) Mouse Model of Retinitis Pigmentosa Human Molecular Genetics. Oct, 2012 | Pubmed ID: 22802073 Regulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Activity by CCMP The Journal of Biological Chemistry. Aug, 2012 | Pubmed ID: 22715094 Role of TRPML and Two-pore Channels in Endolysosomal Cation Homeostasis The Journal of Pharmacology and Experimental Therapeutics. Aug, 2012 | Pubmed ID: 22518024 CNGA3 Deficiency Affects Cone Synaptic Terminal Structure and Function and Leads to Secondary Rod Dysfunction and Degeneration Investigative Ophthalmology & Visual Science. Mar, 2012 | Pubmed ID: 22247469 Gene Therapy Restores Missing Cone-mediated Vision in the CNGA3-/- Mouse Model of Achromatopsia Advances in Experimental Medicine and Biology. 2012 | Pubmed ID: 22183332 The Role of HCN Channels in Ventricular Repolarization Trends in Cardiovascular Medicine. Nov, 2011 | Pubmed ID: 22902068 Exploring HCN Channels As Novel Drug Targets Nature Reviews. Drug Discovery. Nov, 2011 | Pubmed ID: 22094868 HCN3 Contributes to the Ventricular Action Potential Waveform in the Murine Heart Circulation Research. Oct, 2011 | Pubmed ID: 21903939 The CGMP-dependent Protein Kinase II Is an Inhibitory Modulator of the Hyperpolarization-activated HCN2 Channel PloS One. Feb, 2011 | Pubmed ID: 21347269 The Glutamic Acid-rich Protein is a Gating Inhibitor of Cyclic Nucleotide-gated Channels The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2011 | Pubmed ID: 21209198 Planar Patch Clamp Approach to Characterize Ionic Currents from Intact Lysosomes Science Signaling. Dec, 2010 | Pubmed ID: 21139138 Un Sous-système Olfactif Qui Détecte Le Disulfure De Carbone Et Intervient Dans L'apprentissage Social Liées à L'alimentation Current Biology : CB. Aug, 2010 | Pubmed ID: 20637621 Restoration of Cone Vision in the CNGA3-/- Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 20628362 Grueneberg Les Neurones Ganglionnaires Sont Des Capteurs Froids Finement Réglés The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2010 | Pubmed ID: 20519530 Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca2+ Currents in Isolated Lysosomes The Journal of Biological Chemistry. Jul, 2010 | Pubmed ID: 20495006 Calmodulin is a Functional Regulator of Cav1.4 L-type Ca2+ Channels The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19717559 Hyperpolarization-activated Cation Channels: from Genes to Function Physiological Reviews. Jul, 2009 | Pubmed ID: 19584315 The Two-pore Channel TPCN2 Mediates NAADP-dependent Ca(2+)-release from Lysosomal Stores Pflugers Archiv : European Journal of Physiology. Sep, 2009 | Pubmed ID: 19557428 Cyclic Nucleotide-gated Channels Handbook of Experimental Pharmacology. 2009 | Pubmed ID: 19089328 Cyclic Nucleotide-regulated Cation Channels The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19054768 Function and Dysfunction of CNG Channels: Insights from Channelopathies and Mouse Models Molecular Neurobiology. Jun, 2007 | Pubmed ID: 17917115 Contribution De La Récepteurs Guanylyl Cyclase GC-D De La Fonction Chimiosensorielle Dans L'épithélium Olfactif Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17724338 Switching off Calcium-dependent Inactivation in L-type Calcium Channels by an Autoinhibitory Domain Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17028172 Perte De CNGB1 Protéines Entraîne Une Dysfonction Olfactive Et Sous-ciliaire Piégeage Cyclique Manche Nucleotide-gated The Journal of Biological Chemistry. Nov, 2006 | Pubmed ID: 16980309 The Enhancement of HCN Channel Instantaneous Current Facilitated by Slow Deactivation is Regulated by Intracellular Chloride Concentration Pflugers Archiv : European Journal of Physiology. Sep, 2006 | Pubmed ID: 16715293 A Novel Mechanism of Modulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channels by Src Kinase The Journal of Biological Chemistry. Oct, 2005 | Pubmed ID: 16079136 The Murine HCN3 Gene Encodes a Hyperpolarization-activated Cation Channel with Slow Kinetics and Unique Response to Cyclic Nucleotides The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15923185 Impaired Opsin Targeting and Cone Photoreceptor Migration in the Retina of Mice Lacking the Cyclic Nucleotide-gated Channel CNGA3 Investigative Ophthalmology & Visual Science. Apr, 2005 | Pubmed ID: 15790924 An Arginine Residue in the Pore Region is a Key Determinant of Chloride Dependence in Cardiac Pacemaker Channels The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15644313 Impaired Channel Targeting and Retinal Degeneration in Mice Lacking the Cyclic Nucleotide-gated Channel Subunit CNGB1 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2005 | Pubmed ID: 15634774 Role of Subunit Heteromerization and N-linked Glycosylation in the Formation of Functional Hyperpolarization-activated Cyclic Nucleotide-gated Channels The Journal of Biological Chemistry. Oct, 2003 | Pubmed ID: 12928435 Molecular Cloning and Functional Characterization of a New Modulatory Cyclic Nucleotide-gated Channel Subunit from Mouse Retina The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2000 | Pubmed ID: 10662822 Implantation d’ECG télémétrique et de transmetteurs de pression artérielle combinés pour déterminer la sensibilité spontanée aux baroréflexes chez des souris conscientes René D. Rötzer1, Verena F. Brox1, Konstantin Hennis1, Stefan B. Thalhammer1, Martin Biel1,2, Christian Wahl-Schott3, Stefanie Fenske1,2 1Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians-Universität München, 2German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 3Hannover Medical School, Institute for Neurophysiology JoVE 62101 Medicine
Implantation d’ECG télémétrique et de transmetteurs de pression artérielle combinés pour déterminer la sensibilité spontanée aux baroréflexes chez des souris conscientes René D. Rötzer1, Verena F. Brox1, Konstantin Hennis1, Stefan B. Thalhammer1, Martin Biel1,2, Christian Wahl-Schott3, Stefanie Fenske1,2 1Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians-Universität München, 2German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 3Hannover Medical School, Institute for Neurophysiology JoVE 62101 Medicine
