Mary C. Farach-Carson Department of BioSciences Rice University Biography Publications Institution JoVE Articles Mary C. Farach-Carson has not added a biography. If you are Mary C. Farach-Carson and would like to personalize this page please email our Author Liaison for assistance. Publications Building a Functional Salivary Gland for Cell-Based Therapy: More Than Secretory Epithelial Acini Tissue Engineering. Part A. Sep, 2020 | Pubmed ID: 32829674 SULF1 Suppresses Wnt3A-driven Growth of Bone Metastatic Prostate Cancer in Perlecan-modified 3D Cancer-stroma-macrophage Triculture Models PloS One. 2020 | Pubmed ID: 32413029 Flipping the Molecular Switch: Influence of Perlecan and Its Modifiers in the Tumor Microenvironment Advances in Experimental Medicine and Biology. 2020 | Pubmed ID: 32266656 Cabozantinib Reverses Renal Cell Carcinoma-mediated Osteoblast Inhibition in Three-dimensional Coculture and Reduces Bone Osteolysis Molecular Cancer Therapeutics. 06, 2020 | Pubmed ID: 32220969 Dynamic Assembly of Human Salivary Stem/Progenitor Microstructures Requires Coordinated αβ Integrin-Mediated Motility Frontiers in Cell and Developmental Biology. 2019 | Pubmed ID: 31750298 Perlecan Domain I Gradients Establish Stable Biomimetic Heparin Binding Growth Factor Gradients for Cell Migration in Hydrogels Acta Biomaterialia. 10, 2019 | Pubmed ID: 31351252 Modular Proteoglycan Perlecan/: Mutations, Phenotypes, and Functions Genes. Nov, 2018 | Pubmed ID: 30453502 Perlecan/HSPG2: Signaling Role of Domain IV in Chondrocyte Clustering with Implications for Schwartz-Jampel Syndrome Journal of Cellular Biochemistry. Sep, 2018 | Pubmed ID: 30203597 Reassembly of Functional Human Stem/Progenitor Cells in 3D Culture Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29959699 Matrilysin/MMP-7 Cleavage of Perlecan/HSPG2 Complexed with Semaphorin 3A Supports FAK-Mediated Stromal Invasion by Prostate Cancer Cells Scientific Reports. 05, 2018 | Pubmed ID: 29740048 Bottom-up Assembly of Salivary Gland Microtissues for Assessing Myoepithelial Cell Function Biomaterials. Oct, 2017 | Pubmed ID: 28734180 Inflammatory Breast Cancer: a Model for Investigating Cluster-based Dissemination NPJ Breast Cancer. 2017 | Pubmed ID: 28649661 Primary Salivary Human Stem/Progenitor Cells Undergo Microenvironment-Driven Acinar-Like Differentiation in Hyaluronate Hydrogel Culture Stem Cells Translational Medicine. 01, 2017 | Pubmed ID: 28170182 Tuning Hydrogel Properties to Promote the Assembly of Salivary Gland Spheroids in 3D ACS Biomaterials Science & Engineering. Dec, 2016 | Pubmed ID: 27990487 Sustained Delivery of Recombinant Human Bone Morphogenetic Protein-2 from Perlecan Domain I - Functionalized Electrospun Poly (ε-caprolactone) Scaffolds for Bone Regeneration Journal of Experimental Orthopaedics. Dec, 2016 | Pubmed ID: 27714703 Heralding a New Paradigm in 3D Tumor Modeling Biomaterials. 11, 2016 | Pubmed ID: 27639438 Neuronal Trans-Differentiation in Prostate Cancer Cells The Prostate. Oct, 2016 | Pubmed ID: 27403603 Tumor Budding: The Name is EMT. Partial EMT Journal of Clinical Medicine. Apr, 2016 | Pubmed ID: 27136592 Ultrahigh-throughput Generation and Characterization of Cellular Aggregates in Laser-ablated Microwells of Poly(dimethylsiloxane) RSC Advances. Jan, 2016 | Pubmed ID: 26998251 Biomaterials-based Strategies for Salivary Gland Tissue Regeneration Biomaterials Science. Apr, 2016 | Pubmed ID: 26878077 Perlecan/HSPG2 and Matrilysin/MMP-7 As Indices of Tissue Invasion: Tissue Localization and Circulating Perlecan Fragments in a Cohort of 288 Radical Prostatectomy Patients Oncotarget. Mar, 2016 | Pubmed ID: 26862737 A 3D In vitro Model of Patient-derived Prostate Cancer Xenograft for Controlled Interrogation of In vivo Tumor-stromal Interactions Biomaterials. Jan, 2016 | Pubmed ID: 26599623 Single Molecule Force Measurements of Perlecan/HSPG2: A Key Component of the Osteocyte Pericellular Matrix Matrix Biology : Journal of the International Society for Matrix Biology. Mar, 2016 | Pubmed ID: 26546708 Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures Advanced Healthcare Materials. Aug, 2015 | Pubmed ID: 26059746 Three-dimensional (3D) Culture of Bone-derived Human 786-O Renal Cell Carcinoma Retains Relevant Clinical Characteristics of Bone Metastases Cancer Letters. Aug, 2015 | Pubmed ID: 26004343 Evolution of the Perlecan/HSPG2 Gene and Its Activation in Regenerating Nematostella Vectensis PloS One. 2015 | Pubmed ID: 25876075 Prostate Cancer and Neuroendocrine Differentiation: More Neuronal, Less Endocrine? Frontiers in Oncology. 2015 | Pubmed ID: 25785244 Three-dimensional in Vitro Tumor Models for Cancer Research and Drug Evaluation Biotechnology Advances. Nov, 2014 | Pubmed ID: 25116894 Deficiency in Perlecan/HSPG2 During Bone Development Enhances Osteogenesis and Decreases Quality of Adult Bone in Mice Calcified Tissue International. Jul, 2014 | Pubmed ID: 24798737 Hydrogel-based 3D Model of Patient-derived Prostate Xenograft Tumors Suitable for Drug Screening Molecular Pharmaceutics. Jul, 2014 | Pubmed ID: 24779589 Transcriptional Activation by NFκB Increases Perlecan/HSPG2 Expression in the Desmoplastic Prostate Tumor Microenvironment Journal of Cellular Biochemistry. Jul, 2014 | Pubmed ID: 24700612 RANK- and C-Met-mediated Signal Network Promotes Prostate Cancer Metastatic Colonization Endocrine-related Cancer. Apr, 2014 | Pubmed ID: 24478054 A Hydrogel-based Tumor Model for the Evaluation of Nanoparticle-based Cancer Therapeutics Biomaterials. Mar, 2014 | Pubmed ID: 24447463 Hyaluronan: a Simple Polysaccharide with Diverse Biological Functions Acta Biomaterialia. Apr, 2014 | Pubmed ID: 24361428 P62/SQSTM1 is Required for Cell Survival of Apoptosis-resistant Bone Metastatic Prostate Cancer Cell Lines The Prostate. Feb, 2014 | Pubmed ID: 24122957 Perlecan-containing Pericellular Matrix Regulates Solute Transport and Mechanosensing Within the Osteocyte Lacunar-canalicular System Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Apr, 2014 | Pubmed ID: 24115222 Border Patrol: Insights into the Unique Role of Perlecan/heparan Sulfate Proteoglycan 2 at Cell and Tissue Borders Matrix Biology : Journal of the International Society for Matrix Biology. Feb, 2014 | Pubmed ID: 24001398 A Novel in Vivo Model for Evaluating Functional Restoration of a Tissue-engineered Salivary Gland The Laryngoscope. Feb, 2014 | Pubmed ID: 23832678 Chaperone Properties of Pdia3 Participate in Rapid Membrane Actions of 1α,25-dihydroxyvitamin D3 Molecular Endocrinology (Baltimore, Md.). Jul, 2013 | Pubmed ID: 23660595 Modeling Ewing Sarcoma Tumors in Vitro with 3D Scaffolds Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23576741 Implantable Three-dimensional Salivary Spheroid Assemblies Demonstrate Fluid and Protein Secretory Responses to Neurotransmitters Tissue Engineering. Part A. Jul, 2013 | Pubmed ID: 23442148 Hyaluronan (HA) Interacting Proteins RHAMM and Hyaluronidase Impact Prostate Cancer Cell Behavior and Invadopodia Formation in 3D HA-based Hydrogels PloS One. 2012 | Pubmed ID: 23166824 Recreating the Tumor Microenvironment in a Bilayer, Hyaluronic Acid Hydrogel Construct for the Growth of Prostate Cancer Spheroids Biomaterials. Dec, 2012 | Pubmed ID: 22999468 Improved Cellular Specificity of Plasmonic Nanobubbles Versus Nanoparticles in Heterogeneous Cell Systems PloS One. 2012 | Pubmed ID: 22509318 Injectable Perlecan Domain 1-hyaluronan Microgels Potentiate the Cartilage Repair Effect of BMP2 in a Murine Model of Early Osteoarthritis Biomedical Materials (Bristol, England). Apr, 2012 | Pubmed ID: 22455987 Interleukin-6: a Bone Marrow Stromal Cell Paracrine Signal That Induces Neuroendocrine Differentiation and Modulates Autophagy in Bone Metastatic PCa Cells Autophagy. Apr, 2012 | Pubmed ID: 22441019 Hyaluronic Acid-Based Hydrogels: from a Natural Polysaccharide to Complex Networks Soft Matter. 2012 | Pubmed ID: 22419946 A Control Engineering Approach to Understanding the TGF-β Paradox in Cancer Journal of the Royal Society, Interface. Jun, 2012 | Pubmed ID: 22188767 Co-culture of Osteocytes and Neurons on a Unique Patterned Surface Biointerphases. Dec, 2011 | Pubmed ID: 22239813 Rainbow Plasmonic Nanobubbles: Synergistic Activation of Gold Nanoparticle Clusters Journal of Nanomedicine & Nanotechnology. Jan, 2011 | Pubmed ID: 21804947 A New Assay for Functional Screening of BRCA2 Linker Region Mutations Identifies Variants That Alter Chemoresistance to Cisplatin Experimental Cell Research. Sep, 2011 | Pubmed ID: 21741379 Association of the α(2)δ(1) Subunit with Ca(v)3.2 Enhances Membrane Expression and Regulates Mechanically Induced ATP Release in MLO-Y4 Osteocytes Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Sep, 2011 | Pubmed ID: 21638318 Tumor Necrosis Factor-α Treatment of HepG2 Cells Mobilizes a Cytoplasmic Pool of ERp57/1,25D₃-MARRS to the Nucleus Journal of Cellular Biochemistry. Sep, 2011 | Pubmed ID: 21598303 Tunable Plasmonic Nanoprobes for Theranostics of Prostate Cancer Theranostics. Jan, 2011 | Pubmed ID: 21547151 Perlecan/Hspg2 Deficiency Alters the Pericellular Space of the Lacunocanalicular System Surrounding Osteocytic Processes in Cortical Bone Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Mar, 2011 | Pubmed ID: 20814969 Facteurs Paracrines Produites Par Les Cellules Stromales De La Moelle Osseuse Induisent L'apoptose Et Différenciation Neuroendocrine Dans Les Cellules De Cancer De La Prostate The Prostate. Feb, 2011 | Pubmed ID: 20665531 Amphiphilic Block Co-polyesters Bearing Pendant Cyclic Ketal Groups As Nanocarriers for Controlled Release of Camptothecin Journal of Biomaterials Science. Polymer Edition. 2011 | Pubmed ID: 20594408 Hierarchically Structured, Hyaluronic Acid-based Hydrogel Matrices Via the Covalent Integration of Microgels into Macroscopic Networks Soft Matter. Jun, 2010 | Pubmed ID: 20936090 The in Vivo Performance of Plasmonic Nanobubbles As Cell Theranostic Agents in Zebrafish Hosting Prostate Cancer Xenografts Biomaterials. Oct, 2010 | Pubmed ID: 20630586 Biofunctionalization of Electrospun PCL-based Scaffolds with Perlecan Domain IV Peptide to Create a 3-D Pharmacokinetic Cancer Model Biomaterials. Jul, 2010 | Pubmed ID: 20417554 Effect of HIP/ribosomal Protein L29 Deficiency on Mineral Properties of Murine Bones and Teeth Bone. Jul, 2010 | Pubmed ID: 20362701 Perlecan Domain IV Peptide Stimulates Salivary Gland Cell Assembly in Vitro Tissue Engineering. Part A. Nov, 2009 | Pubmed ID: 19382872 Osteogenic Differentiation of Rat Bone Marrow Stromal Cells Cultured on Arg-Gly-Asp Modified Hydrogels Without Dexamethasone and Beta-glycerol Phosphate Biomaterials. Jun, 2005 | Pubmed ID: 15621255 Modulation of Differentiation and Mineralization of Marrow Stromal Cells Cultured on Biomimetic Hydrogels Modified with Arg-Gly-Asp Containing Peptides Journal of Biomedical Materials Research. Part A. Jun, 2004 | Pubmed ID: 15127400 Attachment, Proliferation, and Migration of Marrow Stromal Osteoblasts Cultured on Biomimetic Hydrogels Modified with an Osteopontin-derived Peptide Biomaterials. Feb, 2004 | Pubmed ID: 14609678 Viabilité améliorée pour les cultures Hydrogel 3D Ex vivo de xénogreffes dérivées du patient dans une plate-forme microfluidique perfusée Lindsey K. Sablatura1, Kristin M. Bircsak2, Peter Shepherd3, Karla Queiroz4, Mary C. Farach-Carson1,5,6, Pamela E. Constantinou1,7, Anthony Saleh2, Nora Navone3, Daniel A. Harrington1,5,6 1Department of BioSciences, Rice University, 2Mimetas US Inc, 3Department of Genitourinary Medical Oncology Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, 4Mimetas B.V., 5Department of Bioengineering, Rice University, 6Department of Diagnostic and Biomedical Sciences, The University of Texas Health Science Center, 7Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center JoVE 60872 Cancer Research
Viabilité améliorée pour les cultures Hydrogel 3D Ex vivo de xénogreffes dérivées du patient dans une plate-forme microfluidique perfusée Lindsey K. Sablatura1, Kristin M. Bircsak2, Peter Shepherd3, Karla Queiroz4, Mary C. Farach-Carson1,5,6, Pamela E. Constantinou1,7, Anthony Saleh2, Nora Navone3, Daniel A. Harrington1,5,6 1Department of BioSciences, Rice University, 2Mimetas US Inc, 3Department of Genitourinary Medical Oncology Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, 4Mimetas B.V., 5Department of Bioengineering, Rice University, 6Department of Diagnostic and Biomedical Sciences, The University of Texas Health Science Center, 7Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center JoVE 60872 Cancer Research