Michael A Hough Diamond Light Source Ltd Harwell Science and Innovation Campus Biography Publications Institution JoVE Articles Michael A Hough has not added a biography. If you are Michael A Hough and would like to personalize this page please email our Author Liaison for assistance. Publications Beyond the Coupled Distortion Model: Structural Analysis of the Single Domain Cupredoxin AcoP, a Green Mononuclear Copper Centre with Original Features Dalton Transactions (Cambridge, England : 2003). Jan, 2024 | Pubmed ID: 38170898 New Insights into Controlling Radical Migration Pathways in Heme Enzymes Gained from the Study of a Dye-decolorising Peroxidase Chemical Science. Nov, 2023 | Pubmed ID: 38020392 The CCP4 Suite: Integrative Software for Macromolecular Crystallography Acta Crystallographica. Section D, Structural Biology. Jun, 2023 | Pubmed ID: 37259835 Protein-to-structure Pipeline for Ambient-temperature in Situ Crystallography at VMXi IUCrJ. Jul, 2023 | Pubmed ID: 37199504 A Heme Pocket Aromatic Quadrupole Modulates Gas Binding to Cytochrome C'-β: Implications for NO Sensors The Journal of Biological Chemistry. Jun, 2023 | Pubmed ID: 37100286 Perspective: Structure Determination of Protein-ligand Complexes at Room Temperature Using X-ray Diffraction Approaches Frontiers in Molecular Biosciences. 2023 | Pubmed ID: 36756363 Serial Femtosecond Crystallography Reveals the Role of Water in the One- or Two-Electron Redox Chemistry of Compound I in the Catalytic Cycle of the B-Type Dye-Decolorizing Peroxidase DtpB ACS Catalysis. Nov, 2022 | Pubmed ID: 36366763 Serial Femtosecond Crystallography Approaches to Understanding Catalysis in Iron Enzymes Current Opinion in Structural Biology. Dec, 2022 | Pubmed ID: 36274419 Complementarity of Neutron, XFEL and Synchrotron Crystallography for Defining the Structures of Metalloenzymes at Room Temperature IUCrJ. Sep, 2022 | Pubmed ID: 36071813 Crystal Structure of Thermally Stable Homodimeric Cytochrome C'-β from Thermus Thermophilus Acta Crystallographica. Section F, Structural Biology Communications. Jun, 2022 | Pubmed ID: 35647678 Aspartate or Arginine? Validated Redox State X-ray Structures Elucidate Mechanistic Subtleties of Fe = O Formation in Bacterial Dye-decolorizing Peroxidases Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Oct, 2021 | Pubmed ID: 34477969 Serial Synchrotron and XFEL Crystallography for Studies of Metalloprotein Catalysis Current Opinion in Structural Biology. Dec, 2021 | Pubmed ID: 34455163 Serial Femtosecond Zero Dose Crystallography Captures a Water-Free Distal Heme Site in a Dye-Decolorising Peroxidase to Reveal a Catalytic Role for an Arginine in Fe =O Formation Angewandte Chemie (International Ed. in English). 11, 2020 | Pubmed ID: 32780931 Successful Sample Preparation for Serial Crystallography Experiments Journal of Applied Crystallography. Dec, 2019 | Pubmed ID: 31798361 High-throughput Structures of Protein-ligand Complexes at Room Temperature Using Serial Femtosecond Crystallography IUCrJ. Nov, 2019 | Pubmed ID: 31709063 Dose-resolved Serial Synchrotron and XFEL Structures of Radiation-sensitive Metalloproteins IUCrJ. Jul, 2019 | Pubmed ID: 31316799 Resolving Polymorphs and Radiation-driven Effects in Microcrystals Using Fixed-target Serial Synchrotron Crystallography Acta Crystallographica. Section D, Structural Biology. Feb, 2019 | Pubmed ID: 30821704 Enzyme Catalysis Captured Using Multiple Structures from One Crystal at Varying Temperatures IUCrJ. May, 2018 | Pubmed ID: 29755744 Advancing Protein Structure Analysis for Drug Development (Video) | JoVE James Sandy1, Halina Mikolajek1,2, Amy J. Thompson1, Juan Sanchez-Weatherby1, Michael A Hough1,2 1Diamond Light Source Ltd, Harwell Science and Innovation Campus, 2Research Complex at Harwell, Harwell Science and Innovation Campus JoVE 65964 Biochemistry
Advancing Protein Structure Analysis for Drug Development (Video) | JoVE James Sandy1, Halina Mikolajek1,2, Amy J. Thompson1, Juan Sanchez-Weatherby1, Michael A Hough1,2 1Diamond Light Source Ltd, Harwell Science and Innovation Campus, 2Research Complex at Harwell, Harwell Science and Innovation Campus JoVE 65964 Biochemistry