Michael D. Cahalan Physiology and Biophysics University of California, Irvine Biography Publications Institution JoVE Articles Michael D. Cahalan has not added a biography. If you are Michael D. Cahalan and would like to personalize this page please email our Author Liaison for assistance. Publications CD95 Triggers Orai1-mediated Localized Ca2+ Entry, Regulates Recruitment of Protein Kinase C (PKC) β2, and Prevents Death-inducing Signaling Complex Formation Proceedings of the National Academy of Sciences of the United States of America. Nov, 2011 | Pubmed ID: 22065776 Subunit Stoichiometry of Human Orai1 and Orai3 Channels in Closed and Open States Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21987805 Mutations in Orai1 Transmembrane Segment 1 Cause STIM1-independent Activation of Orai1 Channels at Glycine 98 and Channel Closure at Arginine 91 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21987804 Analysis of Transient Migration Behavior of Natural Killer Cells Imaged in Situ and in Vitro Integrative Biology : Quantitative Biosciences from Nano to Macro. Jul, 2011 | Pubmed ID: 21687858 Imaging Transplant Rejection: a New View Nature Medicine. Jun, 2011 | Pubmed ID: 21647143 Immunoimaging: Studying Immune System Dynamics Using Two-photon Microscopy Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285279 In Vivo Lymph Node Imaging Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285268 In Situ Lymph Node Imaging Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285267 Induction of an Immune Response for Imaging Antigen-presenting Cell/T-cell Interactions Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285266 General Approach to Adoptive Transfer and Cell Labeling for Immunoimaging Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285265 Protein Kinase D Orchestrates the Activation of DRAK2 in Response to TCR-induced Ca2+ Influx and Mitochondrial Reactive Oxygen Generation Journal of Immunology (Baltimore, Md. : 1950). Jan, 2011 | Pubmed ID: 21148796 Mzb1 Protein Regulates Calcium Homeostasis, Antibody Secretion, and Integrin Activation in Innate-like B Cells Immunity. Nov, 2010 | Pubmed ID: 21093319 Cell Biology. How to STIMulate Calcium Channels Science (New York, N.Y.). Oct, 2010 | Pubmed ID: 20929798 Selective and Site-specific Mobilization of Dermal Dendritic Cells and Langerhans Cells by Th1- and Th2-polarizing Adjuvants Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20404167 The Immunological Synapse: a Dynamic Platform for Local Signaling Journal of Clinical Immunology. May, 2010 | Pubmed ID: 20390326 NK Cell Patrolling and Elimination of Donor-derived Dendritic Cells Favor Indirect Alloreactivity Journal of Immunology (Baltimore, Md. : 1950). Mar, 2010 | Pubmed ID: 20139277 The Functional Network of Ion Channels in T Lymphocytes Immunological Reviews. Sep, 2009 | Pubmed ID: 19754890 STIMulating Store-operated Ca(2+) Entry Nature Cell Biology. Jun, 2009 | Pubmed ID: 19488056 A Functional Single-nucleotide Polymorphism in the TRPC6 Gene Promoter Associated with Idiopathic Pulmonary Arterial Hypertension Circulation. May, 2009 | Pubmed ID: 19380626 Imaging of Effector Memory T Cells During a Delayed-type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block Immunity. Oct, 2008 | Pubmed ID: 18835197 Quantum Dots for Tracking Dendritic Cells and Priming an Immune Response in Vitro and in Vivo PloS One. 2008 | Pubmed ID: 18820727 The CRAC Channel Consists of a Tetramer Formed by Stim-induced Dimerization of Orai Dimers Nature. Nov, 2008 | Pubmed ID: 18820677 Store-dependent and -independent Modes Regulating Ca2+ Release-activated Ca2+ Channel Activity of Human Orai1 and Orai3 The Journal of Biological Chemistry. Jun, 2008 | Pubmed ID: 18420579 Orai1 and STIM1 Move to the Immunological Synapse and Are Up-regulated During T Cell Activation Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18250319 Choreography of Cell Motility and Interaction Dynamics Imaged by Two-photon Microscopy in Lymphoid Organs Annual Review of Immunology. 2008 | Pubmed ID: 18173372 Class IA Phosphoinositide 3-kinase Modulates Basal Lymphocyte Motility in the Lymph Node Journal of Immunology (Baltimore, Md. : 1950). Aug, 2007 | Pubmed ID: 17675487 Ca2+ Signals in CD4+ T Cells During Early Contacts with Antigen-bearing Dendritic Cells in Lymph Node Journal of Immunology (Baltimore, Md. : 1950). Aug, 2007 | Pubmed ID: 17641025 Natural Killer Cells Actively Patrol Peripheral Lymph Nodes Forming Stable Conjugates to Eliminate MHC-mismatched Targets Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007 | Pubmed ID: 17609379 Molecular Basis of the CRAC Channel Cell Calcium. Aug, 2007 | Pubmed ID: 17482674 Molecular Identification of the CRAC Channel by Altered Ion Selectivity in a Mutant of Orai Nature. Sep, 2006 | Pubmed ID: 16921385 Enhancement of Capillary Leakage and Restoration of Lymphocyte Egress by a Chiral S1P1 Antagonist in Vivo Nature Chemical Biology. Aug, 2006 | Pubmed ID: 16829954 Imaging the Choreography of Lymphocyte Trafficking and the Immune Response Current Opinion in Immunology. Aug, 2006 | Pubmed ID: 16765574 Genome-wide RNAi Screen of Ca(2+) Influx Identifies Genes That Regulate Ca(2+) Release-activated Ca(2+) Channel Activity Proceedings of the National Academy of Sciences of the United States of America. Jun, 2006 | Pubmed ID: 16751269 The Sense of Place in the Immune System Nature Immunology. Apr, 2006 | Pubmed ID: 16550194 Sphingosine 1-phosphate Type 1 Receptor Agonism Inhibits Transendothelial Migration of Medullary T Cells to Lymphatic Sinuses Nature Immunology. Dec, 2005 | Pubmed ID: 16273098 Close Encounters of the First and Second Kind: T-DC and T-B Interactions in the Lymph Node Seminars in Immunology. Dec, 2005 | Pubmed ID: 16263308 Charge Screening by Internal PH and Polyvalent Cations As a Mechanism for Activation, Inhibition, and Rundown of TRPM7/MIC Channels The Journal of General Physiology. Nov, 2005 | Pubmed ID: 16260839 STIM1 is a Ca2+ Sensor That Activates CRAC Channels and Migrates from the Ca2+ Store to the Plasma Membrane Nature. Oct, 2005 | Pubmed ID: 16208375 STIM1, an Essential and Conserved Component of Store-operated Ca2+ Channel Function The Journal of Cell Biology. May, 2005 | Pubmed ID: 15866891 Antigen-engaged B Cells Undergo Chemotaxis Toward the T Zone and Form Motile Conjugates with Helper T Cells PLoS Biology. Jun, 2005 | Pubmed ID: 15857154 Channel Function is Dissociated from the Intrinsic Kinase Activity and Autophosphorylation of TRPM7/ChaK1 The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15781465 STOP! In the Name of Positive Selection Nature Immunology. Feb, 2005 | Pubmed ID: 15662438 Imaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes The Journal of Experimental Medicine. Oct, 2004 | Pubmed ID: 15466619 K+ Channels As Targets for Specific Immunomodulation Trends in Pharmacological Sciences. May, 2004 | Pubmed ID: 15120495 A Store-operated Calcium Channel in Drosophila S2 Cells The Journal of General Physiology. Feb, 2004 | Pubmed ID: 14744989 T Cell Repertoire Scanning is Promoted by Dynamic Dendritic Cell Behavior and Random T Cell Motility in the Lymph Node Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14722354 SK3-1C, a Dominant-negative Suppressor of SKCa and IKCa Channels The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14638680 Regulation of Membrane Trafficking and Subcellular Organization of Endocytic Compartments Revealed with FM1-43 in Resting and Activated Human T Cells Experimental Cell Research. Nov, 2003 | Pubmed ID: 14597416 A Stochastic View of Lymphocyte Motility and Trafficking Within the Lymph Node Immunological Reviews. Oct, 2003 | Pubmed ID: 12969316 Real-time Imaging of Lymphocytes in Vivo Current Opinion in Immunology. Aug, 2003 | Pubmed ID: 12900266 Polyvalent Cations As Permeant Probes of MIC and TRPM7 Pores Biophysical Journal. Apr, 2003 | Pubmed ID: 12668438 Autonomous T Cell Trafficking Examined in Vivo with Intravital Two-photon Microscopy Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12601158 MIC Channels Are Inhibited by Internal Divalent Cations but Not ATP Biophysical Journal. Feb, 2003 | Pubmed ID: 12547774 A Novel Fluorescent Toxin to Detect and Investigate Kv1.3 Channel Up-regulation in Chronically Activated T Lymphocytes The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12511563 Two-photon Tissue Imaging: Seeing the Immune System in a Fresh Light Nature Reviews. Immunology. Nov, 2002 | Pubmed ID: 12415310 Two-photon Imaging in Intact Lymphoid Tissue Advances in Experimental Medicine and Biology. 2002 | Pubmed ID: 12405205 Distinct Properties of CRAC and MIC Channels in RBL Cells The Journal of General Physiology. Aug, 2002 | Pubmed ID: 12149283 Two-photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node Science (New York, N.Y.). Jun, 2002 | Pubmed ID: 12016203 The Ins and Outs of Polycystin-2 As a Calcium Release Channel Nature Cell Biology. Mar, 2002 | Pubmed ID: 11875447 Modulation of Mouse Paneth Cell Alpha-defensin Secretion by MIKCa1, a Ca2+-activated, Intermediate Conductance Potassium Channel The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11724775 التصوير ثنائي الفوتون الخلوية ديناميكية في الحبل الشوكي ماوس Jason G. Weinger1, Milton L. Greenberg2, Melanie P. Matheu4, Ian Parker3, Craig M. Walsh1, Thomas E. Lane5, Michael D. Cahalan2 1Molecular Biology and Biochemistry, University of California, Irvine, 2Physiology and Biophysics, University of California, Irvine, 3Neurobiology and Behavior, University of California, Irvine, 4University of California San Francisco Diabetes Center, University of California, San Francisco, 5Pathology, University of Utah JoVE 52580 Neuroscience عزل خلايا CD4 + T من الغدد الليمفاوية باستخدام الماوس Miltenyi MACS تنقية Melanie P. Matheu1, Michael D. Cahalan1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 409 Biology تشريح و 2 الفوتون التصوير من العقد الليمفاوية الطرفية في الفئران Melanie P. Matheu1, Ian Parker2, Michael D. Cahalan1 1Department of Physiology and Biophysics, University of California, Irvine (UCI), 2Department of Neurobiology and Behaviour, University of California, Irvine (UCI) JoVE 265 Biology تنقية DNA البلازميد من المستعمرات البكتيرية باستخدام Miniprep Qiagen كيت Shenyuan Zhang1, Michael D. Cahalan1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 247 Biology
التصوير ثنائي الفوتون الخلوية ديناميكية في الحبل الشوكي ماوس Jason G. Weinger1, Milton L. Greenberg2, Melanie P. Matheu4, Ian Parker3, Craig M. Walsh1, Thomas E. Lane5, Michael D. Cahalan2 1Molecular Biology and Biochemistry, University of California, Irvine, 2Physiology and Biophysics, University of California, Irvine, 3Neurobiology and Behavior, University of California, Irvine, 4University of California San Francisco Diabetes Center, University of California, San Francisco, 5Pathology, University of Utah JoVE 52580 Neuroscience
عزل خلايا CD4 + T من الغدد الليمفاوية باستخدام الماوس Miltenyi MACS تنقية Melanie P. Matheu1, Michael D. Cahalan1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 409 Biology
تشريح و 2 الفوتون التصوير من العقد الليمفاوية الطرفية في الفئران Melanie P. Matheu1, Ian Parker2, Michael D. Cahalan1 1Department of Physiology and Biophysics, University of California, Irvine (UCI), 2Department of Neurobiology and Behaviour, University of California, Irvine (UCI) JoVE 265 Biology
تنقية DNA البلازميد من المستعمرات البكتيرية باستخدام Miniprep Qiagen كيت Shenyuan Zhang1, Michael D. Cahalan1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 247 Biology