Michael Brenowitz Department of Biochemistry Albert Einstein College of Medicine Biography Publications Institution JoVE Articles Michael Brenowitz has not added a biography. If you are Michael Brenowitz and would like to personalize this page please email our Author Liaison for assistance. Publications Spatial Arrangement of an RNA Zipcode Identifies MRNAs Under Post-transcriptional Control Genes & Development. Jan, 2012 | Pubmed ID: 22215810 Entropy-driven Binding of Picomolar Transition State Analogue Inhibitors to Human 5'-methylthioadenosine Phosphorylase Biochemistry. Nov, 2011 | Pubmed ID: 21985704 A Microfluidic Device That Generates Hydroxyl Radicals to Probe the Solvent Accessible Surface of Nucleic Acids Lab on a Chip. Oct, 2011 | Pubmed ID: 21863183 Introduction: Twenty Five Years of the Gibbs Conference on Biothermodynamics Biophysical Chemistry. Nov, 2011 | Pubmed ID: 21840113 RNA Molecules with Conserved Catalytic Cores but Variable Peripheries Fold Along Unique Energetically Optimized Pathways RNA (New York, N.Y.). Aug, 2011 | Pubmed ID: 21712400 Stability, Denaturation and Refolding of Mycobacterium Tuberculosis MfpA, a DNA Mimicking Protein That Confers Antibiotic Resistance Biophysical Chemistry. Nov, 2011 | Pubmed ID: 21605934 Decoy Strategies: the Structure of TL1A:DcR3 Complex Structure (London, England : 1993). Feb, 2011 | Pubmed ID: 21300286 Phenothiazines Inhibit S100A4 Function by Inducing Protein Oligomerization Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20421509 Conformational States of Human Purine Nucleoside Phosphorylase at Rest, at Work, and with Transition State Analogues Biochemistry. Mar, 2010 | Pubmed ID: 20108972 Biochemical and Structural Characterization of the Human TL1A Ectodomain Biochemistry. Aug, 2009 | Pubmed ID: 19522538 Complementing Global Measures of RNA Folding with Local Reports of Backbone Solvent Accessibility by Time Resolved Hydroxyl Radical Footprinting Methods (San Diego, Calif.). Oct, 2009 | Pubmed ID: 19426806 Evolutionary and Biophysical Relationships Among the Papillomavirus E2 Proteins Frontiers in Bioscience : a Journal and Virtual Library. 2009 | Pubmed ID: 19273107 PEGylation of Val-1(alpha) Destabilizes the Tetrameric Structure of Hemoglobin Biochemistry. Jan, 2009 | Pubmed ID: 19119852 Solution Structure and Refolding of the Mycobacterium Tuberculosis Pentapeptide Repeat Protein MfpA The Journal of Biological Chemistry. Dec, 2008 | Pubmed ID: 18977756 Energy Barriers, Pathways, and Dynamics During Folding of Large, Multidomain RNAs Current Opinion in Chemical Biology. Dec, 2008 | Pubmed ID: 18926923 Semiautomated and Rapid Quantification of Nucleic Acid Footprinting and Structure Mapping Experiments Nature Protocols. 2008 | Pubmed ID: 18772866 Function and Structural Organization of Mot1 Bound to a Natural Target Promoter The Journal of Biological Chemistry. Sep, 2008 | Pubmed ID: 18606810 High-throughput Single-nucleotide Structural Mapping by Capillary Automated Footprinting Analysis Nucleic Acids Research. Jun, 2008 | Pubmed ID: 18477638 Hinge Stiffness is a Barrier to RNA Folding Journal of Molecular Biology. Jun, 2008 | Pubmed ID: 18471829 Monitoring Structural Changes in Nucleic Acids with Single Residue Spatial and Millisecond Time Resolution by Quantitative Hydroxyl Radical Footprinting Nature Protocols. 2008 | Pubmed ID: 18274531 Evolution of GITRL Immune Function: Murine GITRL Exhibits Unique Structural and Biochemical Properties Within the TNF Superfamily Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18182486 Following Molecular Transitions with Single Residue Spatial and Millisecond Time Resolution Methods in Cell Biology. 2008 | Pubmed ID: 17964944 Assembly and Structural Properties of Glucocorticoid-induced TNF Receptor Ligand: Implications for Function Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18040044 DNA and Protein Footprinting Analysis of the Modulation of DNA Binding by the N-terminal Domain of the Saccharomyces Cerevisiae TATA Binding Protein Biochemistry. Sep, 2007 | Pubmed ID: 17683121 Distinct Contribution of Electrostatics, Initial Conformational Ensemble, and Macromolecular Stability in RNA Folding Proceedings of the National Academy of Sciences of the United States of America. Apr, 2007 | Pubmed ID: 17438287 Influence of the N-terminal Domain and Divalent Cations on Self-association and DNA Binding by the Saccharomyces Cerevisiae TATA Binding Protein Biochemistry. Apr, 2007 | Pubmed ID: 17378582 Influence of Intramolecular Cross-links on the Molecular, Structural and Functional Properties of PEGylated Haemoglobin The Biochemical Journal. Feb, 2007 | Pubmed ID: 17049048 Binding then Bending: a Mechanism for Wrapping DNA Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006 | Pubmed ID: 17159146 Following the Dynamics of Changes in Solvent Accessibility of 16 S and 23 S RRNA During Ribosomal Subunit Association Using Synchrotron-generated Hydroxyl Radicals Journal of Molecular Biology. Jun, 2006 | Pubmed ID: 16725154 Fast Fenton Footprinting: a Laboratory-based Method for the Time-resolved Analysis of DNA, RNA and Proteins Nucleic Acids Research. 2006 | Pubmed ID: 16582097 Local Kinetic Measures of Macromolecular Structure Reveal Partitioning Among Multiple Parallel Pathways from the Earliest Steps in the Folding of a Large RNA Molecule Journal of Molecular Biology. May, 2006 | Pubmed ID: 16574145 Snf2/Swi2-related ATPase Mot1 Drives Displacement of TATA-binding Protein by Gripping DNA The EMBO Journal. Apr, 2006 | Pubmed ID: 16541100 Indirect Readout of DNA Sequence by Papillomavirus E2 Proteins Depends Upon Net Cation Uptake Journal of Molecular Biology. Apr, 2006 | Pubmed ID: 16513133 Concordant Exploration of the Kinetics of RNA Folding from Global and Local Perspectives Journal of Molecular Biology. Jan, 2006 | Pubmed ID: 16303138 Perturbation of the Hierarchical Folding of a Large RNA by the Destabilization of Its Scaffold's Tertiary Structure Journal of Molecular Biology. Nov, 2005 | Pubmed ID: 16242711 Overproduction of Alpha Chains Provides a Proton-insensitive Component to the Bluefish Hemoglobin System The Journal of Biological Chemistry. Dec, 2005 | Pubmed ID: 16166086 Catching RNA Polymerase in the Act of Binding: Intermediates in Transcription Illuminated by Synchrotron Footprinting Proceedings of the National Academy of Sciences of the United States of America. Mar, 2005 | Pubmed ID: 15781859 Principles of RNA Compaction: Insights from the Equilibrium Folding Pathway of the P4-P6 RNA Domain in Monovalent Cations Journal of Molecular Biology. Nov, 2004 | Pubmed ID: 15491606 Monovalent Ion-mediated Folding of the Tetrahymena Thermophila Ribozyme Journal of Molecular Biology. Oct, 2004 | Pubmed ID: 15364572 Semi-automated, Single-band Peak-fitting Analysis of Hydroxyl Radical Nucleic Acid Footprint Autoradiograms for the Quantitative Analysis of Transitions Nucleic Acids Research. 2004 | Pubmed ID: 15319447 Comparison of the Effect of Water Release on the Interaction of the Saccharomyces Cerevisiae TATA Binding Protein (TBP) with "TATA Box" Sequences Composed of Adenosine or Inosine Biophysical Journal. Jan, 2004 | Pubmed ID: 14695279 Quaternary Solution Structures of Galectins-1, -3, and -7 Glycobiology. Mar, 2004 | Pubmed ID: 14693909 An Alternative Route for the Folding of Large RNAs: Apparent Two-state Folding by a Group II Intron Ribozyme Journal of Molecular Biology. Dec, 2003 | Pubmed ID: 14636593 Multiple Monovalent Ion-dependent Pathways for the Folding of the L-21 Tetrahymena Thermophila Ribozyme Journal of Molecular Biology. Apr, 2003 | Pubmed ID: 12691754 Solution Structure and Interdomain Interactions of the Saccharomyces Cerevisiae "TATA Binding Protein" (TBP) Probed by Radiolytic Protein Footprinting Biochemistry. Apr, 2003 | Pubmed ID: 12667055 Probing the Structural Dynamics of Nucleic Acids by Quantitative Time-resolved and Equilibrium Hydroxyl Radical "footprinting" Current Opinion in Structural Biology. Oct, 2002 | Pubmed ID: 12464318 Monovalent Cations Mediate Formation of Native Tertiary Structure of the Tetrahymena Thermophila Ribozyme Nature Structural Biology. Dec, 2002 | Pubmed ID: 12434149 Solution Structural Studies of the Saccharomyces Cerevisiae TATA Binding Protein (TBP) Biochemistry. Jul, 2002 | Pubmed ID: 12135378 Linkage of Monovalent and Divalent Ion Binding in the Folding of the P4-P6 Domain of the Tetrahymena Ribozyme Biochemistry. May, 2002 | Pubmed ID: 11980483 Concerted Binding and Bending of DNA by Escherichia Coli Integration Host Factor Journal of Molecular Biology. Feb, 2002 | Pubmed ID: 11827473 Productive Folding to the Native State by a Group II Intron Ribozyme Journal of Molecular Biology. Jan, 2002 | Pubmed ID: 11786013 Monitoring Equilibrium Changes in RNA Structure by 'Peroxidative' and 'Oxidative' Hydroxyl Radical Footprinting Ravichandra Bachu*1, Frances-Camille S. Padlan*2, Sara Rouhanifard2, Michael Brenowitz2, Jörg C. Schlatterer2 1Department of Chemistry, Hunter College, 2Department of Biochemistry, Albert Einstein College of Medicine JoVE 3244 Biology
Monitoring Equilibrium Changes in RNA Structure by 'Peroxidative' and 'Oxidative' Hydroxyl Radical Footprinting Ravichandra Bachu*1, Frances-Camille S. Padlan*2, Sara Rouhanifard2, Michael Brenowitz2, Jörg C. Schlatterer2 1Department of Chemistry, Hunter College, 2Department of Biochemistry, Albert Einstein College of Medicine JoVE 3244 Biology