Michael Chorny Department of Pediatrics, Division of Cardiology The Children's Hospital of Philadelphia, University of Pennsylvania Biography Publications Institution JoVE Articles Michael Chorny has not added a biography. If you are Michael Chorny and would like to personalize this page please email our Author Liaison for assistance. Publications Targeting to Endothelial Cells Augments the Protective Effect of Novel Dual Bioactive Antioxidant/anti-inflammatory Nanoparticles Molecular Pharmaceutics. Jul, 2014 | Pubmed ID: 24877560 Real-time Analysis of Composite Magnetic Nanoparticle Disassembly in Vascular Cells and Biomimetic Media Proceedings of the National Academy of Sciences of the United States of America. Mar, 2014 | Pubmed ID: 24591603 Endothelial Targeting of Nanocarriers Loaded with Antioxidant Enzymes for Protection Against Vascular Oxidative Stress and Inflammation Biomaterials. Apr, 2014 | Pubmed ID: 24480537 Modulation of NO and ROS Production by AdiNOS Transduced Vascular Cells Through Supplementation with L-Arg and BH4: Implications for Gene Therapy of Restenosis Atherosclerosis. Sep, 2013 | Pubmed ID: 23958248 Adenoviral Vector Tethering to Metal Surfaces Via Hydrolyzable Cross-linkers for the Modulation of Vector Release and Transduction Biomaterials. Sep, 2013 | Pubmed ID: 23777912 Site-specific Gene Delivery to Stented Arteries Using Magnetically Guided Zinc Oleate-based Nanoparticles Loaded with Adenoviral Vectors FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2013 | Pubmed ID: 23407712 Antioxidant Enzymes Reduce DNA Damage and Early Activation of Valvular Interstitial Cells in Aortic Valve Sclerosis Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2013 | Pubmed ID: 23241403 Magnetically Targeted Delivery of Therapeutic Agents to Injured Blood Vessels for Prevention of In-stent Restenosis Methodist DeBakey Cardiovascular Journal. Jan, 2012 | Pubmed ID: 22891107 Formulation and in Vitro Characterization of Composite Biodegradable Magnetic Nanoparticles for Magnetically Guided Cell Delivery Pharmaceutical Research. May, 2012 | Pubmed ID: 22274555 Magnetic Nanoparticles for Targeted Vascular Delivery IUBMB Life. Aug, 2011 | Pubmed ID: 21721100 Endothelial Delivery of Antioxidant Enzymes Loaded into Non-polymeric Magnetic Nanoparticles Journal of Controlled Release : Official Journal of the Controlled Release Society. Aug, 2010 | Pubmed ID: 20483366 Targeting Stents with Local Delivery of Paclitaxel-loaded Magnetic Nanoparticles Using Uniform Fields Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20404175 Site-specific Gene Therapy for Cardiovascular Disease Current Opinion in Drug Discovery & Development. Mar, 2010 | Pubmed ID: 20205054 Magnetically Responsive Biodegradable Nanoparticles Enhance Adenoviral Gene Transfer in Cultured Smooth Muscle and Endothelial Cells Molecular Pharmaceutics. Sep-Oct, 2009 | Pubmed ID: 19496618 Site-specific Analgesia with Sustained Release Liposomes Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009 | Pubmed ID: 19416926 A New Double Emulsion Solvent Diffusion Technique for Encapsulating Hydrophilic Molecules in PLGA Nanoparticles Journal of Controlled Release : Official Journal of the Controlled Release Society. Jan, 2009 | Pubmed ID: 18848962 Single and Double Emulsion Manufacturing Techniques of an Amphiphilic Drug in PLGA Nanoparticles: Formulations of Mithramycin and Bioactivity Journal of Pharmaceutical Sciences. Apr, 2009 | Pubmed ID: 18704956 Predicting in Vivo Efficacy of Potential Restenosis Therapies by Cell Culture Studies: Species-dependent Susceptibility of Vascular Smooth Muscle Cells The Open Cardiovascular Medicine Journal. 2008 | Pubmed ID: 18949101 High Field Gradient Targeting of Magnetic Nanoparticle-loaded Endothelial Cells to the Surfaces of Steel Stents Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18182491 Magnetically Driven Plasmid DNA Delivery with Biodegradable Polymeric Nanoparticles FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2007 | Pubmed ID: 17403937 Adenoviral Gene Vector Tethering to Nanoparticle Surfaces Results in Receptor-independent Cell Entry and Increased Transgene Expression Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2006 | Pubmed ID: 16807119 Site-specific Delivery of Dexamethasone from Biodegradable Implants Reduces Formation of Pericardial Adhesions in Rabbits Journal of Biomedical Materials Research. Part A. Aug, 2006 | Pubmed ID: 16628712 Locally Delivered Nanoencapsulated Tyrphostin (AGL-2043) Reduces Neointima Formation in Balloon-injured Rat Carotid and Stented Porcine Coronary Arteries Biomaterials. Feb, 2005 | Pubmed ID: 15275819 Tyrphostin AGL-2043 Eluting Stent Reduces Neointima Formation in Porcine Coronary Arteries Cardiovascular Research. Oct, 2004 | Pubmed ID: 15364624 Long-term Stability Study of L-adrenaline Injections: Kinetics of Sulfonation and Racemization Pathways of Drug Degradation Journal of Pharmaceutical Sciences. Apr, 2004 | Pubmed ID: 14999733 Development and Validation of a Stability-indicating High Performance Liquid Chromatographic Assay for Benoxinate Journal of Pharmaceutical and Biomedical Analysis. Apr, 2003 | Pubmed ID: 12852462 Inhibition of Aortic Allograft Vasculopathy by Local Delivery of Platelet-derived Growth Factor Receptor Tyrosine-kinase Blocker AG-1295 Transplantation. Nov, 2002 | Pubmed ID: 12451275 Study of the Drug Release Mechanism from Tyrphostin AG-1295-loaded Nanospheres by in Situ and External Sink Methods Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2002 | Pubmed ID: 12387948 Lipophilic Drug Loaded Nanospheres Prepared by Nanoprecipitation: Effect of Formulation Variables on Size, Drug Recovery and Release Kinetics Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2002 | Pubmed ID: 12387947 Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers Ilia Fishbein1, Scott P. Forbes1, Richard F. Adamo1, Michael Chorny1, Robert J. Levy1, Ivan S. Alferiev1 1Department of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, University of Pennsylvania JoVE 51653 Medicine
Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers Ilia Fishbein1, Scott P. Forbes1, Richard F. Adamo1, Michael Chorny1, Robert J. Levy1, Ivan S. Alferiev1 1Department of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, University of Pennsylvania JoVE 51653 Medicine