Ming-Rong Zhang Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology Biography Publications Institution JoVE Articles Ming-Rong Zhang has not added a biography. If you are Ming-Rong Zhang and would like to personalize this page please email our Author Liaison for assistance. Publications Small-animal PET Study for Noninvasive Quantification of Transmembrane AMPA Receptor Regulatory Protein -8 (TARP -8) in the Brain Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jan, 2023 | Pubmed ID: 36655318 Two Pathways Differentially Linking Tau Depositions, Oxidative Stress, and Neuronal Loss to Apathetic Phenotypes in Progressive Supranuclear Palsy Journal of the Neurological Sciences. Jan, 2023 | Pubmed ID: 36473346 Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia Schizophrenia Bulletin. Dec, 2022 | Pubmed ID: 36458958 An Optimized Reference Tissue Method for Quantification of Tau Protein Depositions in Diverse Neurodegenerative Disorders by PET with F-PM-PBB3 (F-APN-1607) NeuroImage. Dec, 2022 | Pubmed ID: 36427751 Dynamic Imaging Analysis Reveals Auger Electron-emitting Radio-cisplatin Induces DNA Damage Depending on the Cell Cycle Biochemical and Biophysical Research Communications. Dec, 2022 | Pubmed ID: 36410278 Assessment of Cholesterol Homeostasis in the Living Human Brain Science Translational Medicine. Oct, 2022 | Pubmed ID: 36197966 Precise Quantitative Evaluation of Pharmacokinetics of Cisplatin Using a Radio-platinum Tracer in Tumor-bearing Mice Nuclear Medicine Communications. Nov, 2022 | Pubmed ID: 36120823 Acetamidobenzoxazolone Scaffold As a Promising Translocator Protein (18 kDa, TSPO) Marker for Neuroinflammation Imaging: Advancement in Last Decennial Period Drug Development Research. Nov, 2022 | Pubmed ID: 36074736 A Machine Learning-Based Approach to Discrimination of Tauopathies Using [ F]PM-PBB3 PET Images Movement Disorders : Official Journal of the Movement Disorder Society. Nov, 2022 | Pubmed ID: 36054492 High-Contrast Imaging of α-Synuclein Pathologies in Living Patients with Multiple System Atrophy Movement Disorders : Official Journal of the Movement Disorder Society. Oct, 2022 | Pubmed ID: 36041211 C-Labeled Radiotracer for Noninvasive and Quantitative Assessment of the Thiocyanate Efflux System in the Brain Bioconjugate Chemistry. Sep, 2022 | Pubmed ID: 35951365 A Quantitative in Vivo Imaging Platform for Tracking Pathological Tau Depositions and Resultant Neuronal Death in a Mouse Model European Journal of Nuclear Medicine and Molecular Imaging. Nov, 2022 | Pubmed ID: 35798978 Imaging of Transmembrane AMPA Receptor Regulatory Proteins by Positron Emission Tomography Journal of Medicinal Chemistry. Jul, 2022 | Pubmed ID: 35762919 PEIGel: A Biocompatible and Injectable Scaffold with Innate Immune Adjuvanticity for Synergized Local Immunotherapy Materials Today. Bio. Jun, 2022 | Pubmed ID: 35637855 In Vitro Tumor Cell-Binding Assay to Select High-Binding Antibody and Predict Therapy Response for Personalized Cu-Intraperitoneal Radioimmunotherapy Against Peritoneal Dissemination of Pancreatic Cancer: A Feasibility Study International Journal of Molecular Sciences. May, 2022 | Pubmed ID: 35628616 Scandium Triflate-Catalyzed -[F]Fluoroalkylation of Aryl- Or Heteroaryl-Amines with [F]Epifluorohydrin Under Mild Conditions Organic Letters. Jun, 2022 | Pubmed ID: 35613453 PET-based Classification of Corticobasal Syndrome Parkinsonism & Related Disorders. May, 2022 | Pubmed ID: 35533530 A Novel Monoacylglycerol Lipase-targeted F-labeled Probe for Positron Emission Tomography Imaging of Brown Adipose Tissue in the Energy Network Acta Pharmacologica Sinica. Nov, 2022 | Pubmed ID: 35513432 Rapid 'on-column' Preparation of Hydrogen [C]cyanide from [C]methyl Iodide [C]formaldehyde Chemical Science. Mar, 2022 | Pubmed ID: 35432866 Correction To: First‑in‑human in Vivo Imaging and Quantification of Monoacylglycerol Lipase in the Brain: a PET Study with F‑T‑401 European Journal of Nuclear Medicine and Molecular Imaging. Jul, 2022 | Pubmed ID: 35403863 Development of Novel Pt-Labeled Hoechst33258: Pt Is More Suitable Than In for Targeting DNA Journal of Medicinal Chemistry. Apr, 2022 | Pubmed ID: 35358392 Synthesis of [C]carbonyl-labeled Cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate ([C-carbonyl]PK68) As a Potential PET Tracer for Receptor-interacting Protein 1 Kinase EJNMMI Radiopharmacy and Chemistry. Mar, 2022 | Pubmed ID: 35290562 Identification and Quantitative Structure-activity Relationship Assessment of Trace Chemical Impurities Contained in the Therapeutic Formulation of [Cu]Cu-ATSM Nuclear Medicine and Biology. 2022 | Pubmed ID: 35168008 Automated Radiosynthesis of [ C]MTP38-a Phosphodiesterase 7 Imaging Tracer-using [ C]hydrogen Cyanide for Clinical Applications Journal of Labelled Compounds & Radiopharmaceuticals. May, 2022 | Pubmed ID: 35122288 Development of a Stable Peptide-Based PET Tracer for Detecting CD133-Expressing Cancer Cells ACS Omega. Jan, 2022 | Pubmed ID: 35036703 First-in-human in Vivo Imaging and Quantification of Monoacylglycerol Lipase in the Brain: a PET Study with F-T-401 European Journal of Nuclear Medicine and Molecular Imaging. Jul, 2022 | Pubmed ID: 35022846 Brain 5-HT Receptor Binding and Its Neural Network Related to Behavioral Inhibition System Brain Imaging and Behavior. Jun, 2022 | Pubmed ID: 35006540 Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine Neurotoxicity Research. Feb, 2022 | Pubmed ID: 34981453 Quantification of Monoacylglycerol Lipase and Its Occupancy by an Exogenous Ligand in Rhesus Monkey Brains Using [F]T-401 and PET Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Apr, 2022 | Pubmed ID: 34727758 Characterization and Stabilization of a New Cu-Labeled Anti-EGFR Antibody NCAB001 for the Early Detection of Pancreatic Cancer with Positron Emission Tomography Pharmaceutics. Dec, 2021 | Pubmed ID: 35056963 Off-tumor IDO1 Target Engagements Determine the Cancer-immune Set Point and Predict the Immunotherapeutic Efficacy Journal for Immunotherapy of Cancer. Jun, 2021 | Pubmed ID: 34148865 Synthesis and Preliminary Evaluation of Novel C-labeled GluN2B-selective NMDA Receptor Negative Allosteric Modulators Acta Pharmacologica Sinica. Mar, 2021 | Pubmed ID: 32661351 [C]phosgene: Synthesis and Application for Development of PET Radiotracers Nuclear Medicine and Biology. Jan, 2021 | Pubmed ID: 32546396 Harnessing the PD-L1 Interface Peptide for Positron Emission Tomography Imaging of the PD-1 Immune Checkpoint RSC Chemical Biology. Oct, 2020 | Pubmed ID: 34458761 Radiosynthesis and Evaluation of 4-(6-[F]Fluoro-4-(5-isopropoxy-1-indazol-3-yl)pyridin-2-yl)morpholine As a Novel Radiotracer Candidate Targeting Leucine-rich Repeat Kinase 2 RSC Medicinal Chemistry. Jun, 2020 | Pubmed ID: 33479667 3-(Cyclopropylmethyl)-7-((4-(4-[C]methoxyphenyl)piperidin-1-yl)methyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine: Synthesis and Preliminary Evaluation for PET Imaging of Metabotropic Glutamate Receptor Subtype 2 Bioorganic & Medicinal Chemistry Letters. Dec, 2020 | Pubmed ID: 32941990 Synthesis and Preliminary Evaluation of 4-hydroxy-6-(3-[C]methoxyphenethyl)pyridazin-3(2H)-one, a C-labeled D-amino Acid Oxidase (DAAO) Inhibitor for PET Imaging Bioorganic & Medicinal Chemistry Letters. Aug, 2020 | Pubmed ID: 32631531 Marriage of Black Phosphorus and Cu As Effective Photothermal Agents for PET-guided Combination Cancer Therapy Nature Communications. Jun, 2020 | Pubmed ID: 32513979 Radiosynthesis of [thiocarbonyl-C]disulfiram and Its First PET Study in Mice Bioorganic & Medicinal Chemistry Letters. Mar, 2020 | Pubmed ID: 32014383 Synthesis and Evaluation of 6-(C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for Imaging γ-8 Dependent Transmembrane AMPA Receptor Regulatory Protein by PET Bioorganic & Medicinal Chemistry Letters. Feb, 2020 | Pubmed ID: 31879207 I-IITM and At-AITM: Two Novel Small-Molecule Radiopharmaceuticals Targeting Oncoprotein Metabotropic Glutamate Receptor 1 Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Feb, 2020 | Pubmed ID: 31451486 PET Imaging on Neurofunctional Changes After Optogenetic Stimulation in a Rat Model of Panic Disorder Frontiers of Medicine. Oct, 2019 | Pubmed ID: 31321611 Radiosynthesis and Evaluation of a Novel Monoacylglycerol Lipase Radiotracer: 1,1,1,3,3,3-hexafluoropropan-2-yl-3-(1-benzyl-1H-pyrazol-3-yl)azetidine-1-[C]carboxylate Bioorganic & Medicinal Chemistry. Aug, 2019 | Pubmed ID: 31278005 Correction: Developing Native Peptide-based Radiotracers for PD-L1 PET Imaging and Improving Imaging Contrast by Pegylation Chemical Communications (Cambridge, England). Apr, 2019 | Pubmed ID: 30855058 Developing Native Peptide-based Radiotracers for PD-L1 PET Imaging and Improving Imaging Contrast by Pegylation Chemical Communications (Cambridge, England). Apr, 2019 | Pubmed ID: 30810133 Synthesis and Evaluation of 4-(2-fluoro-4-[C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide for PET Imaging of the Metabotropic Glutamate Receptor 2 in the Rat Brain Bioorganic & Medicinal Chemistry. Feb, 2019 | Pubmed ID: 30611634 Unexpected Decrease in in Vivo Binding of [H]QNB in the Mouse Cerebral Cortex in the Developing Brain - A Comparison with [C]NMPB Nuclear Medicine and Biology. Dec, 2018 | Pubmed ID: 30380462 Synthesis of Two Novel [F]fluorobenzene-containing Radiotracers Via Spirocyclic Iodonium Ylides and Positron Emission Tomography Imaging of Translocator Protein (18 KDa) in Ischemic Brain Organic & Biomolecular Chemistry. Sep, 2018 | Pubmed ID: 30206613 Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression Lulu Zhang*1, Siqi Zhang*2, Wenyu Wu1, Xingkai Wang2, Jieting Shen2, Dongyuan Wang4, Kuan Hu*2,3, Ming-Rong Zhang*3, Feng Wang*1, Rui Wang*2 1Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, 2State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 3Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology JoVE 65047 Cancer Research
Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression Lulu Zhang*1, Siqi Zhang*2, Wenyu Wu1, Xingkai Wang2, Jieting Shen2, Dongyuan Wang4, Kuan Hu*2,3, Ming-Rong Zhang*3, Feng Wang*1, Rui Wang*2 1Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, 2State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 3Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology JoVE 65047 Cancer Research