Muthiah Manoharan Alnylam Pharmaceuticals, Inc. Biography Publications Institution JoVE Articles Muthiah Manoharan has not added a biography. If you are Muthiah Manoharan and would like to personalize this page please email our Author Liaison for assistance. Publications Angewandte Chemie (International Ed. in English). Jul, 2012 | Pubmed ID: 22782619 Molecularly Self-assembled Nucleic Acid Nanoparticles for Targeted in Vivo SiRNA Delivery Nature Nanotechnology. 2012 | Pubmed ID: 22659608 RNA (New York, N.Y.). Mar, 2012 | Pubmed ID: 22294662 Mechanistic Insights into LDL Nanoparticle-mediated SiRNA Delivery Bioconjugate Chemistry. Jan, 2012 | Pubmed ID: 22142191 Experimental Neurology. Jan, 2012 | Pubmed ID: 22119622 MicroRNA-194 is a Target of Transcription Factor 1 (Tcf1, HNF1α) in Adult Liver and Controls Expression of Frizzled-6 Hepatology (Baltimore, Md.). Jan, 2012 | Pubmed ID: 21887698 Bioconjugate Chemistry. Aug, 2011 | Pubmed ID: 21755983 Angewandte Chemie (International Ed. in English). Mar, 2011 | Pubmed ID: 21351337 Nucleic Acids Research. Jun, 2011 | Pubmed ID: 21345934 The Journal of Organic Chemistry. Mar, 2011 | Pubmed ID: 21299239 Nucleic Acids Research. Apr, 2011 | Pubmed ID: 21183463 Chemistry & Biology. Dec, 2010 | Pubmed ID: 21168770 Organic Letters. Dec, 2010 | Pubmed ID: 21049912 Nucleic Acids Research. Nov, 2010 | Pubmed ID: 20610434 Analytical Biochemistry. Oct, 2010 | Pubmed ID: 20599656 Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20534471 Targeted Delivery of RNAi Therapeutics with Endogenous and Exogenous Ligand-based Mechanisms Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2010 | Pubmed ID: 20461061 Organic Letters. May, 2010 | Pubmed ID: 20420425 Nucleic Acids Research. Aug, 2010 | Pubmed ID: 20403811 Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2010 | Pubmed ID: 20170694 Analytical Biochemistry. Jun, 2010 | Pubmed ID: 20156415 Rational Design of Cationic Lipids for SiRNA Delivery Nature Biotechnology. Feb, 2010 | Pubmed ID: 20081866 Antimicrobial Agents and Chemotherapy. Sep, 2009 | Pubmed ID: 19506055 Chemical Communications (Cambridge, England). Apr, 2009 | Pubmed ID: 19333476 Development of Lipidoid-siRNA Formulations for Systemic Delivery to the Liver Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2009 | Pubmed ID: 19259063 Durable Protection from Herpes Simplex Virus-2 Transmission Following Intravaginal Application of SiRNAs Targeting Both a Viral and Host Gene Cell Host & Microbe. Jan, 2009 | Pubmed ID: 19154990 Oligonucleotides. Mar, 2009 | Pubmed ID: 19093781 Therapeutic RNAi Targeting PCSK9 Acutely Lowers Plasma Cholesterol in Rodents and LDL Cholesterol in Nonhuman Primates Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008 | Pubmed ID: 18695239 A Combinatorial Library of Lipid-like Materials for Delivery of RNAi Therapeutics Nature Biotechnology. May, 2008 | Pubmed ID: 18438401 Journal of Medicinal Chemistry. May, 2008 | Pubmed ID: 18399648 A Viral MicroRNA Functions As an Orthologue of Cellular MiR-155 Nature. Dec, 2007 | Pubmed ID: 18075594 Effective RNAi-mediated Gene Silencing Without Interruption of the Endogenous MicroRNA Pathway Nature. Oct, 2007 | Pubmed ID: 17898712 Nucleic Acids Research. 2007 | Pubmed ID: 17881374 Nature Biotechnology. Oct, 2007 | Pubmed ID: 17873866 Specificity, Duplex Degradation and Subcellular Localization of Antagomirs Nucleic Acids Research. 2007 | Pubmed ID: 17439965 Cell. Apr, 2007 | Pubmed ID: 17382377 Nucleosides, Nucleotides & Nucleic Acids. 2007 | Pubmed ID: 17365794 ACS Chemical Biology. Apr, 2006 | Pubmed ID: 17163665 Nature Chemical Biology. Dec, 2006 | Pubmed ID: 17108989 Journal of Medicinal Chemistry. Apr, 2006 | Pubmed ID: 16610796 Biochemistry. Apr, 2006 | Pubmed ID: 16566588 Nature. May, 2006 | Pubmed ID: 16565705 Silencing of MicroRNAs in Vivo with 'antagomirs' Nature. Dec, 2005 | Pubmed ID: 16258535 Journal of Medicinal Chemistry. Oct, 2005 | Pubmed ID: 16220989 Nucleic Acids Research. 2005 | Pubmed ID: 16170156 Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-ribonucleic Acid Modifications Biochemistry. Jun, 2005 | Pubmed ID: 15966728 Nature Medicine. Mar, 2005 | Pubmed ID: 15723075 Methods in Enzymology. 2005 | Pubmed ID: 15644187 Nucleic Acids Research. 2004 | Pubmed ID: 15602001 Current Opinion in Chemical Biology. Dec, 2004 | Pubmed ID: 15556399 Journal of the American Chemical Society. Nov, 2004 | Pubmed ID: 15547979 Nature. Nov, 2004 | Pubmed ID: 15538359 The Journal of Gene Medicine. Oct, 2004 | Pubmed ID: 15386737 Nucleic Acids Research. 2004 | Pubmed ID: 15247346 2'-O-[2-(guanidinium)ethyl]-modified Oligonucleotides: Stabilizing Effect on Duplex and Triplex Structures Organic Letters. Jun, 2004 | Pubmed ID: 15176796 Nucleic Acids Research. 2004 | Pubmed ID: 14762210 Nucleic Acids Research. Supplement (2001). 2003 | Pubmed ID: 14510407 Evaluation of C-5 Propynyl Pyrimidine-containing Oligonucleotides in Vitro and in Vivo Antisense & Nucleic Acid Drug Development. 2003 | Pubmed ID: 12954113 Organic Letters. Aug, 2003 | Pubmed ID: 12916967 Organic Letters. Jun, 2003 | Pubmed ID: 12790517 Nucleic Acids Research. Apr, 2003 | Pubmed ID: 12682357 Journal of the American Chemical Society. Mar, 2003 | Pubmed ID: 12603111 2'-O-[2-(amino)-2-oxoethyl] Oligonucleotides Organic Letters. Feb, 2003 | Pubmed ID: 12583729 Bioconjugate Chemistry. Jan-Feb, 2003 | Pubmed ID: 12526688 RNA (New York, N.Y.). Dec, 2002 | Pubmed ID: 12515389 Angewandte Chemie (International Ed. in English). Jan, 2002 | Pubmed ID: 12491456 High-affinity Peptide Nucleic Acid Oligomers Containing Tricyclic Cytosine Analogues Organic Letters. Dec, 2002 | Pubmed ID: 12465896 Improving Antisense Oligonucleotide Binding to Human Serum Albumin: Dramatic Effect of Ibuprofen Conjugation Chembiochem : a European Journal of Chemical Biology. Dec, 2002 | Pubmed ID: 12465035 Nature Biotechnology. Dec, 2002 | Pubmed ID: 12426578 2'-O-[2-(methylthio)ethyl]-modified Oligonucleotide: an Analogue of 2'-O-[2-(methoxy)-ethyl]-modified Oligonucleotide with Improved Protein Binding Properties and High Binding Affinity to Target RNA Biochemistry. Oct, 2002 | Pubmed ID: 12269806 The Journal of Pharmacology and Experimental Therapeutics. Aug, 2002 | Pubmed ID: 12130724 Antisense & Nucleic Acid Drug Development. Apr, 2002 | Pubmed ID: 12074364 European Journal of Biochemistry / FEBS. May, 2002 | Pubmed ID: 12027896 Biochemistry. Jan, 2002 | Pubmed ID: 11802733 The Journal of Organic Chemistry. Jan, 2002 | Pubmed ID: 11798305 ورم في المثانة Orthotopic النموذجي وتقييم المعالجة سارنا داخل المثانة Moo Rim Kang*1, Glen Yang*1, Klaus Charisse2, Hila Epstein-Barash2, Muthiah Manoharan2, Long-Cheng Li1 1Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, 2Alnylam Pharmaceuticals, Inc. JoVE 4207 Medicine
ورم في المثانة Orthotopic النموذجي وتقييم المعالجة سارنا داخل المثانة Moo Rim Kang*1, Glen Yang*1, Klaus Charisse2, Hila Epstein-Barash2, Muthiah Manoharan2, Long-Cheng Li1 1Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, 2Alnylam Pharmaceuticals, Inc. JoVE 4207 Medicine