Naiming Zhou Institute of Biochemistry, College of Life Sciences Zhejiang University Biography Publications Institution JoVE Articles Naiming Zhou has not added a biography. If you are Naiming Zhou and would like to personalize this page please email our Author Liaison for assistance. Publications An Overview of Ca(2+) Mobilization Assays in GPCR Drug Discovery Expert Opinion on Drug Discovery. Mar, 2017 | Pubmed ID: 28277837 Activated Niacin Receptor HCA2 Inhibits Chemoattractant-mediated Macrophage Migration Via Gβγ/PKC/ERK1/2 Pathway and Heterologous Receptor Desensitization Scientific Reports. Feb, 2017 | Pubmed ID: 28186140 Identification and Functional Characterisation of 5-HT4 Receptor in Sea Cucumber Apostichopus Japonicus (Selenka) Scientific Reports. Jan, 2017 | Pubmed ID: 28059140 Agonist-Activated Bombyx Corazonin Receptor Is Internalized Via an Arrestin-Dependent and Clathrin-Independent Pathway Biochemistry. Jul, 2016 | Pubmed ID: 27348044 Agonist-mediated Activation of Bombyx Mori Diapause Hormone Receptor Signals to Extracellular Signal-regulated Kinases 1 and 2 Through Gq-PLC-PKC-dependent Cascade Insect Biochemistry and Molecular Biology. Aug, 2016 | Pubmed ID: 27318251 Quantitative Analysis of G-protein-coupled Receptor Internalization Using DnaE Intein-based Assay Methods in Cell Biology. 2016 | Pubmed ID: 26928549 Human Neuropeptide S Receptor Is Activated Via a Gαq Protein-biased Signaling Cascade by a Human Neuropeptide S Analog Lacking the C-terminal 10 Residues The Journal of Biological Chemistry. Apr, 2016 | Pubmed ID: 26865629 Agonist-induced Activation of Histamine H3 Receptor Signals to Extracellular Signal-regulated Kinases 1 and 2 Through PKC-, PLD-, and EGFR-dependent Mechanisms Journal of Neurochemistry. Apr, 2016 | Pubmed ID: 26826667 Novel 1-Phenyl-3-hydroxy-4-pyridinone Derivatives As Multifunctional Agents for the Therapy of Alzheimer's Disease ACS Chemical Neuroscience. Jan, 2016 | Pubmed ID: 26479744 Bombyx Mori Prothoracicostatic Peptide Receptor is Allosterically Activated Via a Gα(i/o)-protein-biased Signalling Cascade by Drosophila Sex Peptide The Biochemical Journal. Mar, 2015 | Pubmed ID: 25422933 Niacin Activates the PI3K/Akt Cascade Via PKC- and EGFR-transactivation-dependent Pathways Through Hydroxyl-carboxylic Acid Receptor 2 PloS One. 2014 | Pubmed ID: 25375133 Activation of BNGR-A24 by Direct Interaction with Tachykinin-related Peptides from the Silkworm Bombyx Mori Leads to the Gq- and Gs-coupled Signaling Cascades Biochemistry. Oct, 2014 | Pubmed ID: 25275886 Differential Requirements of Arrestin-3 and Clathrin for Ligand-dependent and -independent Internalization of Human G Protein-coupled Receptor 40 Cellular Signalling. Nov, 2014 | Pubmed ID: 25038452 Involvement of β-arrestin-2 and Clathrin in Agonist-mediated Internalization of the Human Cannabinoid CB2 Receptor Current Molecular Pharmacology. 2014 | Pubmed ID: 25023974 Melatonin Receptor Type 1 Signals to Extracellular Signal-regulated Kinase 1 and 2 Via Gi and Gs Dually Coupled Pathways in HEK-293 Cells Biochemistry. May, 2014 | Pubmed ID: 24724723 Activation of Bombyx Neuropeptide G Protein-coupled Receptor A4 Via a Gαi-dependent Signaling Pathway by Direct Interaction with Neuropeptide F from Silkworm, Bombyx Mori Insect Biochemistry and Molecular Biology. Feb, 2014 | Pubmed ID: 24374022 Activation of CAMP-response Element-binding Protein is Positively Regulated by PKA and Calcium-sensitive Calcineurin and Negatively by PKC in Insect Insect Biochemistry and Molecular Biology. Nov, 2013 | Pubmed ID: 24018109 The Second Intracellular Loop of the Human Cannabinoid CB2 Receptor Governs G Protein Coupling in Coordination with the Carboxyl Terminal Domain PloS One. 2013 | Pubmed ID: 23667597 Specific Activation of the G Protein-coupled Receptor BNGR-A21 by the Neuropeptide Corazonin from the Silkworm, Bombyx Mori, Dually Couples to the G(q) and G(s) Signaling Cascades The Journal of Biological Chemistry. Apr, 2013 | Pubmed ID: 23457297 Design, Synthesis and Biological Evaluation of Novel Piperazine Derivatives As CCR5 Antagonists PloS One. 2013 | Pubmed ID: 23308267 Identification and Characterization of Distinct C-terminal Domains of the Human Hydroxycarboxylic Acid Receptor-2 That Are Essential for Receptor Export, Constitutive Activity, Desensitization, and Internalization Molecular Pharmacology. Dec, 2012 | Pubmed ID: 22962331 Identification and Characterization of ZEL-H16 As a Novel Agonist of the Histamine H3 Receptor PloS One. 2012 | Pubmed ID: 22870296 An Update of Novel Screening Methods for GPCR in Drug Discovery Expert Opinion on Drug Discovery. Sep, 2012 | Pubmed ID: 22716301 アルツハイマー病に対するマルチターゲット主導のリガンドの検索:アセチルコリンエステラーゼ、H₃RとBACE 1阻害活性を持つキノキサリン系ハイブリッド化合物の発見 Bioorganic & Medicinal Chemistry. Dec, 2011 | Pubmed ID: 22019465 Identification and Functional Characterization of Two Orphan G-protein-coupled Receptors for Adipokinetic Hormones from Silkworm Bombyx Mori The Journal of Biological Chemistry. Dec, 2011 | Pubmed ID: 22009754 Distinct Kinetic and Spatial Patterns of Protein Kinase C (PKC)- and Epidermal Growth Factor Receptor (EGFR)-dependent Activation of Extracellular Signal-regulated Kinases 1 and 2 by Human Nicotinic Acid Receptor GPR109A The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21768093 Development of a Novel DnaE Intein-based Assay for Quantitative Analysis of G-protein-coupled Receptor Internalization Analytical Biochemistry. Oct, 2011 | Pubmed ID: 21726524 Identification of Distinct C-terminal Domains of the Bombyx Adipokinetic Hormone Receptor That Are Essential for Receptor Export, Phosphorylation and Internalization Cellular Signalling. Sep, 2011 | Pubmed ID: 21536126 Identification and Characterization of INCB9471, an Allosteric Noncompetitive Small-molecule Antagonist of C-C Chemokine Receptor 5 with Potent Inhibitory Activity Against Monocyte Migration and HIV-1 Infection The Journal of Pharmacology and Experimental Therapeutics. Jul, 2011 | Pubmed ID: 21459966 Bombyx Adipokinetic Hormone Receptor Activates Extracellular Signal-regulated Kinase 1 and 2 Via G Protein-dependent PKA and PKC but β-arrestin-independent Pathways Biochemistry. Dec, 2010 | Pubmed ID: 21126059 Functional Characterization of a Naturally Occurring Trans-splicing Intein from Synechococcus Elongatus in a Mammalian Cell System Analytical Biochemistry. Dec, 2010 | Pubmed ID: 20727340 The G Protein-coupled Receptors in the Silkworm, Bombyx Mori Insect Biochemistry and Molecular Biology. Aug, 2010 | Pubmed ID: 20685615 Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives As Beta-amyloid Peptide Aggregation Inhibitors Journal of Medicinal Chemistry. Aug, 2010 | Pubmed ID: 20684593 Internalization of the Human Nicotinic Acid Receptor GPR109A is Regulated by G(i), GRK2, and Arrestin3 The Journal of Biological Chemistry. Jul, 2010 | Pubmed ID: 20460384 An Enzyme-linked Immunosorbent Assay to Compare the Affinity of Chemical Compounds for β-amyloid Peptide As a Monomer Analytical and Bioanalytical Chemistry. Mar, 2010 | Pubmed ID: 20135308 Molecular and Functional Characterization of Adipokinetic Hormone Receptor and Its Peptide Ligands in Bombyx Mori FEBS Letters. May, 2009 | Pubmed ID: 19345219 A DEAD Box Protein Facilitates HIV-1 Replication As a Cellular Co-factor of Rev Virology. Dec, 2004 | Pubmed ID: 15567440 The N-terminal Domain of APJ, a CNS-based Coreceptor for HIV-1, is Essential for Its Receptor Function and Coreceptor Activity Virology. Dec, 2003 | Pubmed ID: 14675627 Structural and Functional Study of the Apelin-13 Peptide, an Endogenous Ligand of the HIV-1 Coreceptor, APJ Biochemistry. Sep, 2003 | Pubmed ID: 12939143 Binding of ALX40-4C to APJ, a CNS-based Receptor, Inhibits Its Utilization As a Co-receptor by HIV-1 Virology. Jul, 2003 | Pubmed ID: 12890632 Cell-cell Fusion and Internalization of the CNS-based, HIV-1 Co-receptor, APJ Virology. Mar, 2003 | Pubmed ID: 12667811 Exploring the Stereochemistry of CXCR4-peptide Recognition and Inhibiting HIV-1 Entry with D-peptides Derived from Chemokines The Journal of Biological Chemistry. May, 2002 | Pubmed ID: 11880384 共焦点顕微鏡により、リガンド活性化Gタンパク質共役型受容体内在化の検出 Jingwen Yang1, Yunjun Yan1, Xiaowei Xiang1, Yuchao Xu1, Naiming Zhou2, Tianming Wang1 1National Engineering Research Center of Marine Facilities Aquaculture, Marine Science College, Zhejiang Ocean University, 2Institute of Biochemistry, College of Life Sciences, Zhejiang University JoVE 55514 Biology
共焦点顕微鏡により、リガンド活性化Gタンパク質共役型受容体内在化の検出 Jingwen Yang1, Yunjun Yan1, Xiaowei Xiang1, Yuchao Xu1, Naiming Zhou2, Tianming Wang1 1National Engineering Research Center of Marine Facilities Aquaculture, Marine Science College, Zhejiang Ocean University, 2Institute of Biochemistry, College of Life Sciences, Zhejiang University JoVE 55514 Biology