Nicholas D. P. Cosford Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center Sanford Burnham Prebys Medical Discovery Institute Biography Publications Institution JoVE Articles Nicholas D. P. Cosford has not added a biography. If you are Nicholas D. P. Cosford and would like to personalize this page please email our Author Liaison for assistance. Publications A Cellular Target Engagement Assay for the Characterization of SHP2 (PTPN11) Phosphatase Inhibitors The Journal of Biological Chemistry. Feb, 2020 | Pubmed ID: 31953320 Conservation of Structure, Function and Inhibitor Binding in UNC-51-like Kinase 1 and 2 (ULK1/2) The Biochemical Journal. 03, 2019 | Pubmed ID: 30782972 A Combination of Flow and Batch Mode Processes for the Efficient Preparation of MGlu Receptor Negative Allosteric Modulators (NAMs) Tetrahedron. Jun, 2018 | Pubmed ID: 30705468 Autophagy in Cancer: Regulation by Small Molecules Trends in Pharmacological Sciences. 12, 2018 | Pubmed ID: 30454769 Metabotropic Glutamate Receptor 5 As a Target for the Treatment of Depression and Smoking: Robust Preclinical Data but Inconclusive Clinical Efficacy Biological Psychiatry. 06, 2018 | Pubmed ID: 29628194 Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a Potent and Orally Bioavailable Tissue-nonspecific Alkaline Phosphatase (TNAP) Inhibitor Bioorganic & Medicinal Chemistry Letters. 01, 2018 | Pubmed ID: 29174347 Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[C]methoxyphenyl) Quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2 ACS Chemical Neuroscience. 09, 2017 | Pubmed ID: 28565908 Inducing Death in Tumor Cells: Roles of the Inhibitor of Apoptosis Proteins F1000Research. 2017 | Pubmed ID: 28529715 An Integrated Chemical Biology Approach Reveals the Mechanism of Action of HIV Replication Inhibitors Bioorganic & Medicinal Chemistry. 12, 2017 | Pubmed ID: 28442262 Continuous-flow Synthesis of Highly Functionalized Imidazo-oxadiazoles Facilitated by Microfluidic Extraction Beilstein Journal of Organic Chemistry. 2017 | Pubmed ID: 28326132 Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production Frontiers in Pharmacology. 2017 | Pubmed ID: 28261092 Characterization of Potent SMAC Mimetics That Sensitize Cancer Cells to TNF Family-Induced Apoptosis PloS One. 2016 | Pubmed ID: 27617834 Direct Inhibition of C-Myc-Max Heterodimers by Celastrol and Celastrol-inspired Triterpenoids Oncotarget. Oct, 2015 | Pubmed ID: 26474287 BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency Cell Host & Microbe. Sep, 2015 | Pubmed ID: 26355217 Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1 Journal of Biomolecular Screening. Dec, 2015 | Pubmed ID: 26265713 Bewertung des zellulären Zielengagements durch SHP2 (PTPN11) Phosphatase-Inhibitoren Lester J. Lambert1, Celeste Romero1, Douglas J. Sheffler1, Maria Celeridad1, Nicholas D. P. Cosford1, Lutz Tautz1 1Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute JoVE 61457 Cancer Research
Bewertung des zellulären Zielengagements durch SHP2 (PTPN11) Phosphatase-Inhibitoren Lester J. Lambert1, Celeste Romero1, Douglas J. Sheffler1, Maria Celeridad1, Nicholas D. P. Cosford1, Lutz Tautz1 1Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute JoVE 61457 Cancer Research