Ole Isacson Biography Publications JoVE Articles Ole Isacson has not added a biography. If you are Ole Isacson and would like to personalize this page please email our Author Liaison for assistance. Publications Sorting the Wheat from the Chaff in Dopamine Neuron-based Cell Therapies Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015 | Pubmed ID: 25848026 A Nurr1 Agonist Causes Neuroprotection in a Parkinson's Disease Lesion Model Primed with the Toll-Like Receptor 3 DsRNA Inflammatory Stimulant Poly(I:C) PloS One. 2015 | Pubmed ID: 25815475 Successful Function of Autologous IPSC-Derived Dopamine Neurons Following Transplantation in a Non-Human Primate Model of Parkinson's Disease Cell Stem Cell. Mar, 2015 | Pubmed ID: 25732245 Long-term Health of Dopaminergic Neuron Transplants in Parkinson's Disease Patients Cell Reports. Jun, 2014 | Pubmed ID: 24910427 ALS-associated Peripherin Spliced Transcripts Form Distinct Protein Inclusions That Are Neuroprotective Against Oxidative Stress Experimental Neurology. Nov, 2014 | Pubmed ID: 24907400 Widespread Neuron-specific Transgene Expression in Brain and Spinal Cord Following Synapsin Promoter-driven AAV9 Neonatal Intracerebroventricular Injection Neuroscience Letters. Jul, 2014 | Pubmed ID: 24882721 Progressive Axonal Transport and Synaptic Protein Changes Correlate with Behavioral and Neuropathological Abnormalities in the Heterozygous Q175 KI Mouse Model of Huntington's Disease Human Molecular Genetics. Sep, 2014 | Pubmed ID: 24728190 Motor Impairments, Striatal Degeneration, and Altered Dopamine-glutamate Interplay in Mice Lacking PSD-95 Journal of Neurogenetics. Mar-Jun, 2014 | Pubmed ID: 24702501 Advances in Stem-cell--generated Transplantation Therapy for Parkinson's Disease Expert Opinion on Biological Therapy. Apr, 2014 | Pubmed ID: 24437368 Enhanced Ubiquitin-dependent Degradation by Nedd4 Protects Against α-synuclein Accumulation and Toxicity in Animal Models of Parkinson's Disease Neurobiology of Disease. Apr, 2014 | Pubmed ID: 24388974 LRRK2 Mutations Cause Mitochondrial DNA Damage in IPSC-derived Neural Cells from Parkinson's Disease Patients: Reversal by Gene Correction Neurobiology of Disease. Feb, 2014 | Pubmed ID: 24148854 Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of HESC-, HiPSC-, and Non-human Primate IPSC-derived Dopaminergic Neurons Stem Cells (Dayton, Ohio). Aug, 2013 | Pubmed ID: 23666606 Characterization and Criteria of Embryonic Stem and Induced Pluripotent Stem Cells for a Dopamine Replacement Therapy Progress in Brain Research. 2012 | Pubmed ID: 23195423 Stem Cells for Parkinson's Disease: Advancing Science but Protecting Patients Movement Disorders : Official Journal of the Movement Disorder Society. Oct, 2012 | Pubmed ID: 23032987 Creation of an Open-access, Mutation-defined Fibroblast Resource for Neurological Disease Research PloS One. 2012 | Pubmed ID: 22952635 The Search for Genetic Mouse Models of Prodromal Parkinson's Disease Experimental Neurology. Oct, 2012 | Pubmed ID: 22819262 Pharmacological Rescue of Mitochondrial Deficits in IPSC-derived Neural Cells from Patients with Familial Parkinson's Disease Science Translational Medicine. Jul, 2012 | Pubmed ID: 22764206 α-Synuclein Overexpressing Transgenic Mice Show Internal Organ Pathology and Autonomic Deficits Neurobiology of Disease. Aug, 2012 | Pubmed ID: 22549133 Viral and Inflammatory Triggers of Neurodegenerative Diseases Science Translational Medicine. Feb, 2012 | Pubmed ID: 22344685 Clinical Translation of Stem Cells in Neurodegenerative Disorders Cell Stem Cell. Feb, 2012 | Pubmed ID: 22305565 Using Stem Cells and IPS Cells to Discover New Treatments for Parkinson's Disease Parkinsonism & Related Disorders. Jan, 2012 | Pubmed ID: 22166414 Transcript Expression Levels of Full-length Alpha-synuclein and Its Three Alternatively Spliced Variants in Parkinson's Disease Brain Regions and in a Transgenic Mouse Model of Alpha-synuclein Overexpression Molecular and Cellular Neurosciences. Feb, 2012 | Pubmed ID: 22155155 Oct4-induced Reprogramming is Required for Adult Brain Neural Stem Cell Differentiation into Midbrain Dopaminergic Neurons PloS One. 2011 | Pubmed ID: 21655272 Development of Histocompatible Primate-induced Pluripotent Stem Cells for Neural Transplantation Stem Cells (Dayton, Ohio). Jul, 2011 | Pubmed ID: 21608081 Functions of the Nigrostriatal Dopaminergic Synapse and the Use of Neurotransplantation in Parkinson's Disease Journal of Neurology. Aug, 2011 | Pubmed ID: 21544566 Opportunities for Neurorestorative Therapies in PD Using IPS and Stem Cells RinshÅ Shinkeigaku = Clinical Neurology. Nov, 2010 | Pubmed ID: 21921494 The Toll-like Receptor-3 Agonist Polyinosinic:polycytidylic Acid Triggers Nigrostriatal Dopaminergic Degeneration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2010 | Pubmed ID: 21123556 Global Gene Expression Profiling of Somatic Motor Neuron Populations with Different Vulnerability Identify Molecules and Pathways of Degeneration and Protection Brain : a Journal of Neurology. Aug, 2010 | Pubmed ID: 20826431 Being Too Inclusive About Synuclein Inclusions Nature Medicine. Sep, 2010 | Pubmed ID: 20823871 Differentiated Parkinson Patient-derived Induced Pluripotent Stem Cells Grow in the Adult Rodent Brain and Reduce Motor Asymmetry in Parkinsonian Rats Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20798034 The HAPP-YAC Transgenic Model Has Elevated UPS Activity in the Frontal Cortex Similar to Alzheimer's Disease and Down's Syndrome Journal of Neurochemistry. Sep, 2010 | Pubmed ID: 20698932 Differentiation of Human ES and Parkinson's Disease IPS Cells into Ventral Midbrain Dopaminergic Neurons Requires a High Activity Form of SHH, FGF8a and Specific Regionalization by Retinoic Acid Molecular and Cellular Neurosciences. Nov, 2010 | Pubmed ID: 20603216 The Transcription Factor Orthodenticle Homeobox 2 Influences Axonal Projections and Vulnerability of Midbrain Dopaminergic Neurons Brain : a Journal of Neurology. Jul, 2010 | Pubmed ID: 20573704 High Regulatability Favors Genetic Selection in SLC18A2, a Vesicular Monoamine Transporter Essential for Life FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2010 | Pubmed ID: 20181938 Functional Enhancement and Protection of Dopaminergic Terminals by RAB3B Overexpression Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 20007772 Cell Therapy Ahead for Parkinson's Disease Science (New York, N.Y.). Nov, 2009 | Pubmed ID: 19965408 Isolation and Culture of Ventral Mesencephalic Precursor Cells and Dopaminergic Neurons from Rodent Brains Current Protocols in Stem Cell Biology. Dec, 2009 | Pubmed ID: 19960452 Wnt1-lmx1a Forms a Novel Autoregulatory Loop and Controls Midbrain Dopaminergic Differentiation Synergistically with the SHH-FoxA2 Pathway Cell Stem Cell. Dec, 2009 | Pubmed ID: 19951692 No Evidence for Disease-like Processes in Fetal Transplants Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009 | Pubmed ID: 19805203 Molecular and Cellular Determinants for Generating ES-cell Derived Dopamine Neurons for Cell Therapy Advances in Experimental Medicine and Biology. 2009 | Pubmed ID: 19731556 CD15, CD24, and CD29 Define a Surface Biomarker Code for Neural Lineage Differentiation of Stem Cells Stem Cells (Dayton, Ohio). Dec, 2009 | Pubmed ID: 19725119 Lack of Functional Relevance of Isolated Cell Damage in Transplants of Parkinson's Disease Patients Journal of Neurology. Aug, 2009 | Pubmed ID: 19711122 The Blood-brain Barrier is Intact After Levodopa-induced Dyskinesias in Parkinsonian Primates--evidence from in Vivo Neuroimaging Studies Neurobiology of Disease. Sep, 2009 | Pubmed ID: 19501164 Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV Alpha-synucleinopathy The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2009 | Pubmed ID: 19295143 Parkinson's Disease Patient-derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors Cell. Mar, 2009 | Pubmed ID: 19269371 PSD-95 Uncouples Dopamine-glutamate Interaction in the D1/PSD-95/NMDA Receptor Complex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2009 | Pubmed ID: 19261890 Axon Guidance and Synaptic Maintenance: Preclinical Markers for Neurodegenerative Disease and Therapeutics Trends in Neurosciences. Mar, 2009 | Pubmed ID: 19162339 Future of Cell and Gene Therapies for Parkinson's Disease Annals of Neurology. Dec, 2008 | Pubmed ID: 19127583 ALS Model Glia Can Mediate Toxicity to Motor Neurons Derived from Human Embryonic Stem Cells Cell Stem Cell. Dec, 2008 | Pubmed ID: 19041769 Parthenogenetic Dopamine Neurons from Primate Embryonic Stem Cells Restore Function in Experimental Parkinson's Disease Brain : a Journal of Neurology. Aug, 2008 | Pubmed ID: 18669499 Compensatory Changes in the Ubiquitin-proteasome System, Brain-derived Neurotrophic Factor and Mitochondrial Complex II/III in YAC72 and R6/2 Transgenic Mice Partially Model Huntington's Disease Patients Human Molecular Genetics. Oct, 2008 | Pubmed ID: 18640989 Fate Mapping and Lineage Analyses Demonstrate the Production of a Large Number of Striatal Neuroblasts After Transforming Growth Factor Alpha and Noggin Striatal Infusions into the Dopamine-depleted Striatum Stem Cells (Dayton, Ohio). Sep, 2008 | Pubmed ID: 18556510 Nociceptin/orphanin FQ Receptor Blockade Attenuates MPTP-induced Parkinsonism Neurobiology of Disease. Jun, 2008 | Pubmed ID: 18413287 Dopamine Neurons Implanted into People with Parkinson's Disease Survive Without Pathology for 14 Years Nature Medicine. May, 2008 | Pubmed ID: 18391961 Neurons Derived from Reprogrammed Fibroblasts Functionally Integrate into the Fetal Brain and Improve Symptoms of Rats with Parkinson's Disease Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18391196 Embryonic Stem Cell-derived Pitx3-enhanced Green Fluorescent Protein Midbrain Dopamine Neurons Survive Enrichment by Fluorescence-activated Cell Sorting and Function in an Animal Model of Parkinson's Disease Stem Cells (Dayton, Ohio). Jun, 2008 | Pubmed ID: 18388307 Recent Advances in Cell-based Therapy for Parkinson Disease Neurosurgical Focus. 2008 | Pubmed ID: 18341409 Neuroinflammation Mediated by IL-1beta Increases Susceptibility of Dopamine Neurons to Degeneration in an Animal Model of Parkinson's Disease Journal of Neuroinflammation. 2008 | Pubmed ID: 18304357 Neural Precursors Derived from Human Embryonic Stem Cells Maintain Long-term Proliferation Without Losing the Potential to Differentiate into All Three Neural Lineages, Including Dopaminergic Neurons Journal of Neurochemistry. Jan, 2008 | Pubmed ID: 17944878 Cell Therapy and Stem Cells in Animal Models of Motor Neuron Disorders The European Journal of Neuroscience. Oct, 2007 | Pubmed ID: 17897390 Reducing Amyloid Plaque Burden Via Ex Vivo Gene Delivery of an Abeta-degrading Protease: a Novel Therapeutic Approach to Alzheimer Disease PLoS Medicine. Aug, 2007 | Pubmed ID: 17760499 Inhibition of the Leucine-rich Repeat Protein LINGO-1 Enhances Survival, Structure, and Function of Dopaminergic Neurons in Parkinson's Disease Models Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17726113 An Endogenous Serine/threonine Protein Phosphatase Inhibitor, G-substrate, Reduces Vulnerability in Models of Parkinson's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2007 | Pubmed ID: 17670978 Immature and Neurally Differentiated Mouse Embryonic Stem Cells Do Not Express a Functional Fas/Fas Ligand System Stem Cells (Dayton, Ohio). Oct, 2007 | Pubmed ID: 17615270 Functional Analysis of Various Promoters in Lentiviral Vectors at Different Stages of in Vitro Differentiation of Mouse Embryonic Stem Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2007 | Pubmed ID: 17609656 Markers and Methods for Cell Sorting of Human Embryonic Stem Cell-derived Neural Cell Populations Stem Cells (Dayton, Ohio). Sep, 2007 | Pubmed ID: 17588935 In Vivo Evidence of D3 Dopamine Receptor Sensitization in Parkinsonian Primates and Rodents with L-DOPA-induced Dyskinesias Neurobiology of Disease. Aug, 2007 | Pubmed ID: 17588764 Inhibition of the Dopamine D1 Receptor Signaling by PSD-95 The Journal of Biological Chemistry. May, 2007 | Pubmed ID: 17369255 Proteasome Activator Enhances Survival of Huntington's Disease Neuronal Model Cells PloS One. 2007 | Pubmed ID: 17327906 Selection of Embryonic Stem Cell-derived Enhanced Green Fluorescent Protein-positive Dopamine Neurons Using the Tyrosine Hydroxylase Promoter is Confounded by Reporter Gene Expression in Immature Cell Populations Stem Cells (Dayton, Ohio). May, 2007 | Pubmed ID: 17234989 Enhanced Yield of Neuroepithelial Precursors and Midbrain-like Dopaminergic Neurons from Human Embryonic Stem Cells Using the Bone Morphogenic Protein Antagonist Noggin Stem Cells (Dayton, Ohio). Feb, 2007 | Pubmed ID: 17038668 Transplanted Dopamine Neurons Derived from Primate ES Cells Preferentially Innervate DARPP-32 Striatal Progenitors Within the Graft The European Journal of Neuroscience. Oct, 2006 | Pubmed ID: 17067292 What Are the Long-term Effects of Neural Grafting in Patients with Huntington's Disease? Nature Clinical Practice. Neurology. Sep, 2006 | Pubmed ID: 16932607 Neuroblast Protuberances in the Subventricular Zone of the Regenerative MRL/MpJ Mouse The Journal of Comparative Neurology. Oct, 2006 | Pubmed ID: 16927265 Axonal Growth Regulation of Fetal and Embryonic Stem Cell-derived Dopaminergic Neurons by Netrin-1 and Slits Stem Cells (Dayton, Ohio). Nov, 2006 | Pubmed ID: 16840550 Genetic Selection of Sox1GFP-expressing Neural Precursors Removes Residual Tumorigenic Pluripotent Stem Cells and Attenuates Tumor Formation After Transplantation Journal of Neurochemistry. Jun, 2006 | Pubmed ID: 16696855 Neural Precursors Derived from Embryonic Stem Cells, but Not Those from Fetal Ventral Mesencephalon, Maintain the Potential to Differentiate into Dopaminergic Neurons After Expansion in Vitro Stem Cells (Dayton, Ohio). Jun, 2006 | Pubmed ID: 16543488 Specific MicroRNAs Modulate Embryonic Stem Cell-derived Neurogenesis Stem Cells (Dayton, Ohio). Apr, 2006 | Pubmed ID: 16357340 Stromal Cell-derived Inducing Activity, Nurr1, and Signaling Molecules Synergistically Induce Dopaminergic Neurons from Mouse Embryonic Stem Cells Stem Cells (Dayton, Ohio). Mar, 2006 | Pubmed ID: 16123386 Insights into Parkinson's Disease Models and Neurotoxicity Using Non-invasive Imaging Toxicology and Applied Pharmacology. Sep, 2005 | Pubmed ID: 15979668 Long-term Survival of Dopamine Neurons Derived from Parthenogenetic Primate Embryonic Stem Cells (cyno-1) After Transplantation Stem Cells (Dayton, Ohio). Aug, 2005 | Pubmed ID: 15941857 Cell Type-specific Gene Expression of Midbrain Dopaminergic Neurons Reveals Molecules Involved in Their Vulnerability and Protection Human Molecular Genetics. Jul, 2005 | Pubmed ID: 15888489 Cell Type Analysis of Functional Fetal Dopamine Cell Suspension Transplants in the Striatum and Substantia Nigra of Patients with Parkinson's Disease Brain : a Journal of Neurology. Jul, 2005 | Pubmed ID: 15872020 Abnormal APP, Cholinergic and Cognitive Function in Ts65Dn Down's Model Mice Experimental Neurology. Jun, 2005 | Pubmed ID: 15869949 Stem Cells May Reshape the Prospect of Parkinson's Disease Therapy Brain Research. Molecular Brain Research. Mar, 2005 | Pubmed ID: 15790528 Netrin-1 and Slit-2 Regulate and Direct Neurite Growth of Ventral Midbrain Dopaminergic Neurons Molecular and Cellular Neurosciences. Mar, 2005 | Pubmed ID: 15737744 Context-dependent Neuronal Differentiation and Germ Layer Induction of Smad4-/- and Cripto-/- Embryonic Stem Cells Molecular and Cellular Neurosciences. Mar, 2005 | Pubmed ID: 15737733 The Homeodomain Transcription Factor Pitx3 Facilitates Differentiation of Mouse Embryonic Stem Cells into AHD2-expressing Dopaminergic Neurons Molecular and Cellular Neurosciences. Feb, 2005 | Pubmed ID: 15691706 Mapping Dopamine Function in Primates Using Pharmacologic Magnetic Resonance Imaging The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2004 | Pubmed ID: 15509742 Intrastriatal Transforming Growth Factor Alpha Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells Without Differentiation into Dopaminergic Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2004 | Pubmed ID: 15483111 Region-specific Cell Grafting into Cervical and Lumbar Spinal Cord in Rat: a Qualitative and Quantitative Stereological Study Experimental Neurology. Nov, 2004 | Pubmed ID: 15473986 Generalized Brain and Skin Proteasome Inhibition in Huntington's Disease Annals of Neurology. Sep, 2004 | Pubmed ID: 15349858 Selective COX-2 Inhibition Prevents Progressive Dopamine Neuron Degeneration in a Rat Model of Parkinson's Disease Journal of Neuroinflammation. May, 2004 | Pubmed ID: 15285796 Problems and Solutions for Circuits and Synapses in Parkinson's Disease Neuron. Jul, 2004 | Pubmed ID: 15260952 Temporally Induced Nurr1 Can Induce a Non-neuronal Dopaminergic Cell Type in Embryonic Stem Cell Differentiation The European Journal of Neuroscience. Mar, 2004 | Pubmed ID: 15016073 Estrogen Alters Amyloid Precursor Protein As Well As Dendritic and Cholinergic Markers in a Mouse Model of Down Syndrome Hippocampus. 2003 | Pubmed ID: 14750653 Mapping of Brain Function After MPTP-induced Neurotoxicity in a Primate Parkinson's Disease Model NeuroImage. Oct, 2003 | Pubmed ID: 14568476 The Production and Use of Cells As Therapeutic Agents in Neurodegenerative Diseases The Lancet. Neurology. Jul, 2003 | Pubmed ID: 12849120 Orphan Nuclear Receptor Nurr1 Directly Transactivates the Promoter Activity of the Tyrosine Hydroxylase Gene in a Cell-specific Manner Journal of Neurochemistry. May, 2003 | Pubmed ID: 12694388 Toward Full Restoration of Synaptic and Terminal Function of the Dopaminergic System in Parkinson's Disease by Stem Cells Annals of Neurology. 2003 | Pubmed ID: 12666105 Regional Alterations in Amyloid Precursor Protein and Nerve Growth Factor Across Age in a Mouse Model of Down's Syndrome Neuroscience Research. Apr, 2003 | Pubmed ID: 12657457 Altered Proteasomal Function in Sporadic Parkinson's Disease Experimental Neurology. Jan, 2003 | Pubmed ID: 12504866 Genetic Engineering of Mouse Embryonic Stem Cells by Nurr1 Enhances Differentiation and Maturation into Dopaminergic Neurons The European Journal of Neuroscience. Nov, 2002 | Pubmed ID: 12453046 Regulation of Dopamine Cell Type and Transmitter Function in Fetal and Stem Cell Transplantation for Parkinson's Disease Progress in Brain Research. 2002 | Pubmed ID: 12432781 Proteasome Inhibition Causes Nigral Degeneration with Inclusion Bodies in Rats Neuroreport. Aug, 2002 | Pubmed ID: 12167769 Spatial Memory Testing Decreases Hippocampal Amyloid Precursor Protein in Young, but Not Aged, Female Rats Neuroscience Letters. Aug, 2002 | Pubmed ID: 12123857 Selective Loss of 20S Proteasome Alpha-subunits in the Substantia Nigra Pars Compacta in Parkinson's Disease Neuroscience Letters. Jul, 2002 | Pubmed ID: 12095645 Models of Repair Mechanisms for Future Treatment Modalities of Parkinson's Disease Brain Research Bulletin. Apr, 2002 | Pubmed ID: 12031282 Herpes Simplex Virus/adeno-associated Virus Hybrid Vectors for Gene Transfer to Neurons. Preparation and Use Methods in Molecular Medicine. 2002 | Pubmed ID: 11987795 A Direct Role of the Homeodomain Proteins Phox2a/2b in Noradrenaline Neurotransmitter Identity Determination Journal of Neurochemistry. Mar, 2002 | Pubmed ID: 11948255 Analysis of Different Promoter Systems for Efficient Transgene Expression in Mouse Embryonic Stem Cell Lines Stem Cells (Dayton, Ohio). 2002 | Pubmed ID: 11897870 Cortico-hippocampal APP and NGF Levels Are Dynamically Altered by Cholinergic Muscarinic Antagonist or M1 Agonist Treatment in Normal Mice The European Journal of Neuroscience. Feb, 2002 | Pubmed ID: 11876777 Alzheimer's Disease and Down's Syndrome: Roles of APP, Trophic Factors and ACh Trends in Neurosciences. Feb, 2002 | Pubmed ID: 11814559 Embryonic Stem Cells Develop into Functional Dopaminergic Neurons After Transplantation in a Parkinson Rat Model Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11782534 Ole Isacson: Development of New Therapies for Parkinson's Disease JoVE 189 Biology ES pochodzące z komórek nabłonka Cell Cultures Shreeya Karki1, Jan Pruszak1, Ole Isacson1, Kai C Sonntag1 1McLean Hospital, Harvard Medical School JoVE 118 Biology
ES pochodzące z komórek nabłonka Cell Cultures Shreeya Karki1, Jan Pruszak1, Ole Isacson1, Kai C Sonntag1 1McLean Hospital, Harvard Medical School JoVE 118 Biology