Oliver Smithies Department of Pathology and Laboratory Medicine University of North Carolina at Chapel Hill Biography Publications Institution JoVE Articles Oliver Smithies has not added a biography. If you are Oliver Smithies and would like to personalize this page please email our Author Liaison for assistance. Publications Transforming Growth Factor β1 and Diabetic Nephropathy American Journal of Physiology. Renal Physiology. Dec, 2015 | Pubmed ID: 26719364 A Conversation with Oliver Smithies The Journal of Clinical Investigation. Nov, 2015 | Pubmed ID: 26524588 The Whole of a Scientific Career: an Interview with Oliver Smithies PLoS Genetics. May, 2015 | Pubmed ID: 26020970 Low TGFβ1 Expression Prevents and High Expression Exacerbates Diabetic Nephropathy in Mice Proceedings of the National Academy of Sciences of the United States of America. May, 2015 | Pubmed ID: 25902541 Endothelin-1 Critically Influences Cardiac Function Via Superoxide-MMP9 Cascade Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015 | Pubmed ID: 25848038 A Conversation with Oliver Smithies Annual Review of Physiology. 2015 | Pubmed ID: 25668016 Transforming Growth Factor Beta1 and Aldosterone Current Opinion in Nephrology and Hypertension. Mar, 2015 | Pubmed ID: 25587902 The Role of Transforming Growth Factor β1 in the Regulation of Blood Pressure Current Hypertension Reviews. 2014 | Pubmed ID: 25801626 Stable Oligomeric Clusters of Gold Nanoparticles: Preparation, Size Distribution, Derivatization, and Physical and Biological Properties Langmuir : the ACS Journal of Surfaces and Colloids. Nov, 2014 | Pubmed ID: 25317930 Colour Blindness: Still Too Many Red-green Figures Nature. Jun, 2014 | Pubmed ID: 24943948 The Smooth Muscle-selective RhoGAP GRAF3 is a Critical Regulator of Vascular Tone and Hypertension Nature Communications. 2013 | Pubmed ID: 24335996 Primary Aldosteronism and Impaired Natriuresis in Mice Underexpressing TGFβ1 Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23503843 Null Mutations at the P66 and Bradykinin 2 Receptor Loci Induce Divergent Phenotypes in the Diabetic Kidney American Journal of Physiology. Renal Physiology. Dec, 2012 | Pubmed ID: 23019230 Distribution of Histone3 Lysine 4 Trimethylation at T3-responsive Loci in the Heart During Reversible Changes in Gene Expression Gene Expression. 2012 | Pubmed ID: 22783727 How It All Began: a Personal History of Gel Electrophoresis Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22585472 The Kallikrein-kinin System in Diabetic Nephropathy Kidney International. Apr, 2012 | Pubmed ID: 22318421 ENOS Deficiency Acts Through Endothelin to Aggravate SFlt-1-induced Pre-eclampsia-like Phenotype Journal of the American Society of Nephrology : JASN. Apr, 2012 | Pubmed ID: 22282588 Quantification of Myocyte Chemotaxis: a Role for FAK in Regulating Directional Motility Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22222526 The Kallikrein-kinin System and Oxidative Stress Current Opinion in Nephrology and Hypertension. Jan, 2012 | Pubmed ID: 22048723 β-MyHC and Cardiac Hypertrophy: Size Does Matter Circulation Research. Sep, 2011 | Pubmed ID: 21885833 Mitochondrial DNA Polymerase Editing Mutation, PolgD257A, Reduces the Diabetic Phenotype of Akita Male Mice by Suppressing Appetite Proceedings of the National Academy of Sciences of the United States of America. May, 2011 | Pubmed ID: 21555558 A Modest Decrease in Endothelial NOS in Mice Comparable to That Associated with Human NOS3 Variants Exacerbates Diabetic Nephropathy Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011 | Pubmed ID: 21245338 Therapeutic Benefits in Thalassemic Mice Transplanted with Long-term-cultured Bone Marrow Cells Experimental Hematology. Mar, 2011 | Pubmed ID: 21184801 Reversible Epigenetic Modifications of the Two Cardiac Myosin Heavy Chain Genes During Changes in Expression Gene Expression. 2010 | Pubmed ID: 21526716 Science Brick by Brick Nature. Oct, 2010 | Pubmed ID: 20944621 Heterogeneous Myocyte Enhancer Factor-2 (Mef2) Activation in Myocytes Predicts Focal Scarring in Hypertrophic Cardiomyopathy Proceedings of the National Academy of Sciences of the United States of America. Oct, 2010 | Pubmed ID: 20923879 Genetically Determined Angiotensin Converting Enzyme Level and Myocardial Tolerance to Ischemia FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2010 | Pubmed ID: 20667972 Loss of Bradykinin Signaling Does Not Accelerate the Development of Cardiac Dysfunction in Type 1 Diabetic Akita Mice Endocrinology. Aug, 2010 | Pubmed ID: 20501666 Lack of Both Bradykinin B1 and B2 Receptors Enhances Nephropathy, Neuropathy, and Bone Mineral Loss in Akita Diabetic Mice Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20479236 Normal Development of Mice Deficient in Beta 2M, MHC Class I Proteins, and CD8+ T Cells. 1990 Journal of Immunology (Baltimore, Md. : 1950). May, 2010 | Pubmed ID: 20410496 Genetic Variations in Peroxisome Proliferator-activated Receptor Gamma Expression Affect Blood Pressure Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009 | Pubmed ID: 19884495 Influence of Natriuretic Peptide Receptor-1 on Survival and Cardiac Hypertrophy During Development Biochimica Et Biophysica Acta. Dec, 2009 | Pubmed ID: 19782130 Mouse Models of Diabetic Nephropathy Journal of the American Society of Nephrology : JASN. Dec, 2009 | Pubmed ID: 19729434 Restoration of Podocyte Structure and Improvement of Chronic Renal Disease in Transgenic Mice Overexpressing Renin PloS One. 2009 | Pubmed ID: 19696925 Decreased Beta-adrenergic Responsiveness Following Hypertrophy Occurs Only in Cardiomyocytes That Also Re-express Beta-myosin Heavy Chain European Journal of Heart Failure. Jul, 2009 | Pubmed ID: 19553396 Gender-dependent Survival of Allogeneic Trophoblast Stem Cells in Liver Cell Transplantation. 2009 | Pubmed ID: 19523327 The Kallikrein-kinin System in Health and in Diseases of the Kidney Kidney International. May, 2009 | Pubmed ID: 19190676 RNA Repair Restores Hemoglobin Expression in IVS2-654 Thalassemic Mice Proceedings of the National Academy of Sciences of the United States of America. Jan, 2009 | Pubmed ID: 19164558 Tea with Dr Oliver Smithies, 2007 Nobel Laureate in Physiology and Medicine. Interview by Dr. Anthony Viera Journal of Clinical Hypertension (Greenwich, Conn.). Aug, 2008 | Pubmed ID: 18772647 Discordant On/off Switching of Gene Expression in Myocytes During Cardiac Hypertrophy in Vivo Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18755891 Turning Pages (Nobel Lecture) Chembiochem : a European Journal of Chemical Biology. Jun, 2008 | Pubmed ID: 18543237 Tissue-specific Regulation of ACE/ACE2 and AT1/AT2 Receptor Gene Expression by Oestrogen in Apolipoprotein E/oestrogen Receptor-alpha Knock-out Mice Experimental Physiology. May, 2008 | Pubmed ID: 18192335 Salt-sensitive Blood Pressure in Mice with Increased Expression of Aldosterone Synthase Hypertension. Jan, 2008 | Pubmed ID: 18039983 Conditional Deletion of Focal Adhesion Kinase Leads to Defects in Ventricular Septation and Outflow Tract Alignment Molecular and Cellular Biology. Aug, 2007 | Pubmed ID: 17526730 Receptor Activity-modifying Proteins 2 and 3 Have Distinct Physiological Functions from Embryogenesis to Old Age The Journal of Biological Chemistry. Jun, 2007 | Pubmed ID: 17470425 Bradykinin B1 and B2 Receptors Both Have Protective Roles in Renal Ischemia/reperfusion Injury Proceedings of the National Academy of Sciences of the United States of America. May, 2007 | Pubmed ID: 17452647 Early Cardiac Hypertrophy in Mice with Impaired Calmodulin Regulation of Cardiac Muscle Ca Release Channel The Journal of Clinical Investigation. May, 2007 | Pubmed ID: 17431507 Adrenomedullin Gene Expression Differences in Mice Do Not Affect Blood Pressure but Modulate Hypertension-induced Pathology in Males Proceedings of the National Academy of Sciences of the United States of America. Feb, 2007 | Pubmed ID: 17360661 Npr1-regulated Gene Pathways Contributing to Cardiac Hypertrophy and Fibrosis Journal of Molecular Endocrinology. Feb, 2007 | Pubmed ID: 17293444 Angiotensin II Causes Hypertension and Cardiac Hypertrophy Through Its Receptors in the Kidney Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17090678 Disturbed Homeostasis in Sodium-restricted Mice Heterozygous and Homozygous for Aldosterone Synthase Gene Disruption Hypertension. Dec, 2006 | Pubmed ID: 17075030 Fibrosis, Not Cell Size, Delineates Beta-myosin Heavy Chain Reexpression During Cardiac Hypertrophy and Normal Aging in Vivo Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17068123 Reduced Maternal Expression of Adrenomedullin Disrupts Fertility, Placentation, and Fetal Growth in Mice The Journal of Clinical Investigation. Oct, 2006 | Pubmed ID: 16981008 Apop-1, a Novel Protein Inducing Cyclophilin D-dependent but Bax/Bak-related Channel-independent Apoptosis The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16782708 A DNA Insulator Prevents Repression of a Targeted X-linked Transgene but Not Its Random or Imprinted X Inactivation Proceedings of the National Academy of Sciences of the United States of America. Jun, 2006 | Pubmed ID: 16777957 Intermittent Pressure Overload Triggers Hypertrophy-independent Cardiac Dysfunction and Vascular Rarefaction The Journal of Clinical Investigation. Jun, 2006 | Pubmed ID: 16741575 Senescence-associated Phenotypes in Akita Diabetic Mice Are Enhanced by Absence of Bradykinin B2 Receptors The Journal of Clinical Investigation. May, 2006 | Pubmed ID: 16604193 Amino Acids As Modulators of Endothelium-derived Nitric Oxide American Journal of Physiology. Renal Physiology. Aug, 2006 | Pubmed ID: 16571593 Hydrops Fetalis, Cardiovascular Defects, and Embryonic Lethality in Mice Lacking the Calcitonin Receptor-like Receptor Gene Molecular and Cellular Biology. Apr, 2006 | Pubmed ID: 16537897 Kidney Function in Mice Lacking Aldosterone American Journal of Physiology. Renal Physiology. Jan, 2006 | Pubmed ID: 16118390 Isolating Gene-corrected Stem Cells Without Drug Selection Proceedings of the National Academy of Sciences of the United States of America. Nov, 2005 | Pubmed ID: 16258059 An Improved Technique for Tail-cuff Blood Pressure Measurements with Dark-tailed Mice Contemporary Topics in Laboratory Animal Science / American Association for Laboratory Animal Science. Sep, 2005 | Pubmed ID: 16138782 An Interview With... Oliver Smithies [interviewed by Magdalena Skipper] Nature Reviews. Genetics. May, 2005 | Pubmed ID: 15880879 Many Little Things: One Geneticist's View of Complex Diseases Nature Reviews. Genetics. May, 2005 | Pubmed ID: 15861211 Distinct Roles for the Kidney and Systemic Tissues in Blood Pressure Regulation by the Renin-angiotensin System The Journal of Clinical Investigation. Apr, 2005 | Pubmed ID: 15841186 Increased Susceptibility to Heart Failure in Response to Volume Overload in Mice Lacking Natriuretic Peptide Receptor-A Gene Cardiovascular Research. Apr, 2005 | Pubmed ID: 15769452 Homeostatic Responses in the Adrenal Cortex to the Absence of Aldosterone in Mice Endocrinology. Jun, 2005 | Pubmed ID: 15731365 Correction of Factor IX Deficiency in Mice by Embryonic Stem Cells Differentiated in Vitro Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15699326 Lifelong Genetic Minipumps Physiological Genomics. Jan, 2005 | Pubmed ID: 15585607 Ren1c Homozygous Null Mice Are Hypotensive and Polyuric, but Heterozygotes Are Indistinguishable from Wild-type Journal of the American Society of Nephrology : JASN. Jan, 2005 | Pubmed ID: 15563565 Complementation of Replication Origin Function in Mouse Embryonic Stem Cells by Human DNA Sequences Genomics. Sep, 2004 | Pubmed ID: 15498455 Three-dimensional Diffusion Tensor Microscopy of Fixed Mouse Hearts Magnetic Resonance in Medicine. Sep, 2004 | Pubmed ID: 15334561 Diabetic Nephropathy is Markedly Enhanced in Mice Lacking the Bradykinin B2 Receptor Proceedings of the National Academy of Sciences of the United States of America. Sep, 2004 | Pubmed ID: 15326315 A GammaGT-AT1A Receptor Transgene Protects Renal Cortical Structure in AT1 Receptor-deficient Mice Physiological Genomics. Aug, 2004 | Pubmed ID: 15306694 E-prostanoid-3 Receptors Mediate the Proinflammatory Actions of Prostaglandin E2 in Acute Cutaneous Inflammation Journal of Immunology (Baltimore, Md. : 1950). Jul, 2004 | Pubmed ID: 15240726 Renin Cells Are Precursors for Multiple Cell Types That Switch to the Renin Phenotype when Homeostasis is Threatened Developmental Cell. May, 2004 | Pubmed ID: 15130496 Altering the Expression in Mice of Genes by Modifying Their 3' Regions Developmental Cell. Apr, 2004 | Pubmed ID: 15068798 Human Genetics, Animal Models and Computer Simulations for Studying Hypertension Trends in Genetics : TIG. Mar, 2004 | Pubmed ID: 15036807 Cardiac Hypertrophy and Sudden Death in Mice with a Genetically Clamped Renin Transgene Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 14978280 Physiological Impact of Increased Expression of the AT1 Angiotensin Receptor Hypertension. Oct, 2003 | Pubmed ID: 12963678 Induction of Hepatic Differentiation in Embryonic Stem Cells by Co-culture with Embryonic Cardiac Mesoderm Surgery. Aug, 2003 | Pubmed ID: 12947317 Natriuretic Peptide Receptor A Mediates Renal Sodium Excretory Responses to Blood Volume Expansion American Journal of Physiology. Renal Physiology. Oct, 2003 | Pubmed ID: 12824076 Minireview: Computer Simulations of Blood Pressure Regulation by the Renin-angiotensin System Endocrinology. Jun, 2003 | Pubmed ID: 12746272 Why the Kidney Glomerulus Does Not Clog: a Gel Permeation/diffusion Hypothesis of Renal Function Proceedings of the National Academy of Sciences of the United States of America. Apr, 2003 | Pubmed ID: 12655073 Targeted Disruption of Hsp70.1 Sensitizes to Osmotic Stress EMBO Reports. Sep, 2002 | Pubmed ID: 12189176 A Genetically Clamped Renin Transgene for the Induction of Hypertension Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002 | Pubmed ID: 12034874 Genotype/age Interactions on Aggressive Behavior in Gonadally Intact Estrogen Receptor Beta Knockout (betaERKO) Male Mice Hormones and Behavior. May, 2002 | Pubmed ID: 11971662 Multiple Roles of Adrenomedullin Revealed by Animal Models Microscopy Research and Technique. Apr, 2002 | Pubmed ID: 11921356 Molecular Phenotyping for Analyzing Subtle Genetic Effects in Mice: Application to an Angiotensinogen Gene Titration Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002 | Pubmed ID: 11904385 Impaired T Cell Function in RANTES-deficient Mice Clinical Immunology (Orlando, Fla.). Mar, 2002 | Pubmed ID: 11890717 Posttranscriptional Compensation for Heterozygous Disruption of the Kidney-specific NaK2Cl Cotransporter Gene Journal of the American Society of Nephrology : JASN. Mar, 2002 | Pubmed ID: 11856763 Interactions Between Endothelial Nitric Oxide Synthase and Sex Hormones in Vascular Protection in Mice The Journal of Clinical Investigation. Feb, 2002 | Pubmed ID: 11854327 Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor Beta Science (New York, N.Y.). Jan, 2002 | Pubmed ID: 11799247 Targeted Disruption of the Gene for Natriuretic Peptide Receptor-A Worsens Hypoxia-induced Cardiac Hypertrophy American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2002 | Pubmed ID: 11748047 Ortam Koşullarında Altın Nanopartiküller Kararlı Oligomerik Kümeleri Boyut Kontrollü Sentezi için Basit Bir Yöntem Marlon Lawrence1, Anze Testen1, Tilen Koklic2, Oliver Smithies1 1Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 2Condensed Matter Physics Department, Laboratory of Biophysics, Jozef Stefan Institute JoVE 53388 Chemistry
Ortam Koşullarında Altın Nanopartiküller Kararlı Oligomerik Kümeleri Boyut Kontrollü Sentezi için Basit Bir Yöntem Marlon Lawrence1, Anze Testen1, Tilen Koklic2, Oliver Smithies1 1Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 2Condensed Matter Physics Department, Laboratory of Biophysics, Jozef Stefan Institute JoVE 53388 Chemistry