Patricia Limousin Sobell Department of Motor Neuroscience & Movement Disorders, Unit of Functional Neurosurgery UCL Institute of Neurology Biography Publications Institution JoVE Articles Patricia Limousin has not added a biography. If you are Patricia Limousin and would like to personalize this page please email our Author Liaison for assistance. Publications Longterm Deep Brain Stimulation Withdrawal: Clinical Stability Despite Electrophysiological Instability Journal of the Neurological Sciences. Jul, 2014 | Pubmed ID: 24857354 Graphene-Based Electroresponsive Scaffolds As Polymeric Implants for On-Demand Drug Delivery Advanced Healthcare Materials. May, 2014 | Pubmed ID: 24799416 Long-term Outcome of Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease Using an MRI-guided and MRI-verified Approach Journal of Neurology, Neurosurgery, and Psychiatry. Apr, 2014 | Pubmed ID: 24790212 Motor and Cognitive Advantages Persist 12 Months After Exenatide Exposure in Parkinson's Disease Journal of Parkinson's Disease. Mar, 2014 | Pubmed ID: 24662192 A Randomized Controlled Pilot Study to Evaluate a Technology Platform for the Assisted Living of People with Dementia and Their Carers Journal of Alzheimer's Disease : JAD. 2014 | Pubmed ID: 24643137 Resting State Functional MRI in Parkinson's Disease: the Impact of Deep Brain Stimulation on 'effective' Connectivity Brain : a Journal of Neurology. Apr, 2014 | Pubmed ID: 24566670 Predictive Factors of Speech Intelligibility Following Subthalamic Nucleus Stimulation in Consecutive Patients with Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Apr, 2014 | Pubmed ID: 24532491 Women Pioneers in Basal Ganglia Surgery Parkinsonism & Related Disorders. Feb, 2014 | Pubmed ID: 24262870 Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease: Two Case Reports JAMA Neurology. Jan, 2014 | Pubmed ID: 24217017 Pallidal Stimulation for Primary Generalised Dystonia: Effect on Cognition, Mood and Quality of Life Journal of Neurology. Jan, 2014 | Pubmed ID: 24178706 Short and Long Term Outcome of Bilateral Pallidal Stimulation in Chorea-acanthocytosis PloS One. 2013 | Pubmed ID: 24223913 Phase Dependent Modulation of Tremor Amplitude in Essential Tremor Through Thalamic Stimulation Brain : a Journal of Neurology. Oct, 2013 | Pubmed ID: 24038075 The Nucleus Basalis of Meynert: a New Target for Deep Brain Stimulation in Dementia? Neuroscience and Biobehavioral Reviews. Dec, 2013 | Pubmed ID: 24035740 Subthalamic Nucleus Local Field Potential Activity During the Eriksen Flanker Task Reveals a Novel Role for Theta Phase During Conflict Monitoring The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2013 | Pubmed ID: 24027276 Dopamine Agonists Rather Than Deep Brain Stimulation Cause Reflection Impulsivity in Parkinson's Disease Journal of Parkinson's Disease. 2013 | Pubmed ID: 23938343 Pallidal Stimulation for Cervical Dystonia Does Not Correct Abnormal Temporal Discrimination Movement Disorders : Official Journal of the Movement Disorder Society. Nov, 2013 | Pubmed ID: 23853089 Adaptive Deep Brain Stimulation in Advanced Parkinson Disease Annals of Neurology. Sep, 2013 | Pubmed ID: 23852650 Genotype and Phenotype in Parkinson's Disease: Lessons in Heterogeneity from Deep Brain Stimulation Movement Disorders : Official Journal of the Movement Disorder Society. Sep, 2013 | Pubmed ID: 23818421 Complementary Roles of Different Oscillatory Activities in the Subthalamic Nucleus in Coding Motor Effort in Parkinsonism Experimental Neurology. Oct, 2013 | Pubmed ID: 23778147 Critical Evaluation of the Anatomical Location of the Barrington Nucleus: Relevance for Deep Brain Stimulation Surgery of Pedunculopontine Tegmental Nucleus Neuroscience. Sep, 2013 | Pubmed ID: 23732233 Exenatide and the Treatment of Patients with Parkinson's Disease The Journal of Clinical Investigation. Jun, 2013 | Pubmed ID: 23728174 α-Synucleinopathy Associated with G51D SNCA Mutation: a Link Between Parkinson's Disease and Multiple System Atrophy? Acta Neuropathologica. May, 2013 | Pubmed ID: 23404372 Image-guided and Image-verified Deep Brain Stimulation Movement Disorders : Official Journal of the Movement Disorder Society. Feb, 2013 | Pubmed ID: 23390009 The Glucocerobrosidase E326K Variant Predisposes to Parkinson's Disease, but Does Not Cause Gaucher's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Feb, 2013 | Pubmed ID: 23225227 The Risk of Hardware Infection in Deep Brain Stimulation Surgery is Greater at Impulse Generator Replacement Than at the Primary Procedure Stereotactic and Functional Neurosurgery. 2013 | Pubmed ID: 23207787 Frequency Specific Activity in Subthalamic Nucleus Correlates with Hand Bradykinesia in Parkinson's Disease Experimental Neurology. Feb, 2013 | Pubmed ID: 23178580 The Influence of Deep Brain Stimulation Intensity and Duration on Symptoms Evolution in an OFF Stimulation Dystonia Study Brain Stimulation. Jul, 2013 | Pubmed ID: 23088851 Deep Brain Stimulation As a Treatment for Chorea-acanthocytosis Journal of Neurology. Jan, 2013 | Pubmed ID: 23086180 Subthalamic Nucleus Gamma Oscillations Mediate a Switch from Automatic to Controlled Processing: a Study of Random Number Generation in Parkinson's Disease NeuroImage. Jan, 2013 | Pubmed ID: 22960249 Parkinson's Disease, Insulin Resistance and Novel Agents of Neuroprotection Brain : a Journal of Neurology. Feb, 2013 | Pubmed ID: 22344583 Therapeutic Subthalamic Nucleus Deep Brain Stimulation Reverses Cortico-thalamic Coupling During Voluntary Movements in Parkinson's Disease PloS One. 2012 | Pubmed ID: 23300524 Image-verified Deep Brain Stimulation Reduces Risk and Cost with No Apparent Impact on Efficacy Movement Disorders : Official Journal of the Movement Disorder Society. Oct, 2012 | Pubmed ID: 23032691 THAP1 Mutations and Dystonia Phenotypes: Genotype Phenotype Correlations Movement Disorders : Official Journal of the Movement Disorder Society. Sep, 2012 | Pubmed ID: 22903657 Subthalamic Nucleus Activity Optimizes Maximal Effort Motor Responses in Parkinson's Disease Brain : a Journal of Neurology. Sep, 2012 | Pubmed ID: 22858550 Movement-related Changes in Local and Long-range Synchronization in Parkinson's Disease Revealed by Simultaneous Magnetoencephalography and Intracranial Recordings The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2012 | Pubmed ID: 22855804 Alpha Oscillations in the Pedunculopontine Nucleus Correlate with Gait Performance in Parkinsonism Brain : a Journal of Neurology. Jan, 2012 | Pubmed ID: 22232591 Screening for VPS35 Mutations in Parkinson's Disease Neurobiology of Aging. Apr, 2012 | Pubmed ID: 22154191 Doorway-provoked Freezing of Gait in Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Apr, 2012 | Pubmed ID: 21997389 Deep Brain Stimulation in the Treatment of Chorea Movement Disorders : Official Journal of the Movement Disorder Society. Mar, 2012 | Pubmed ID: 21997283 Reducing Hemorrhagic Complications in Functional Neurosurgery: a Large Case Series and Systematic Literature Review Journal of Neurosurgery. Jan, 2012 | Pubmed ID: 21905798 Treatment of Dysarthria Following Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Nov, 2011 | Pubmed ID: 21953693 Urinary Incontinence Following Deep Brain Stimulation of the Pedunculopontine Nucleus Acta Neurochirurgica. Dec, 2011 | Pubmed ID: 21927820 MRI-guided Subthalamic Nucleus Deep Brain Stimulation Without Microelectrode Recording: Can We Dispense with Surgery Under Local Anaesthesia? Stereotactic and Functional Neurosurgery. 2011 | Pubmed ID: 21921673 A Gamma Band Specific Role of the Subthalamic Nucleus in Switching During Verbal Fluency Tasks in Parkinson's Disease Experimental Neurology. Dec, 2011 | Pubmed ID: 21872587 Clinical Safety of Brain Magnetic Resonance Imaging with Implanted Deep Brain Stimulation Hardware: Large Case Series and Review of the Literature World Neurosurgery. Jul-Aug, 2011 | Pubmed ID: 21839969 Functional Magnetic Resonance Imaging Exploration of Combined Hand and Speech Movements in Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Oct, 2011 | Pubmed ID: 21714000 Shaping Reversibility? Long-term Deep Brain Stimulation in Dystonia: the Relationship Between Effects on Electrophysiology and Clinical Symptoms Brain : a Journal of Neurology. Jul, 2011 | Pubmed ID: 21705425 Functional Imaging of Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Aug, 2011 | Pubmed ID: 21674623 Patients' Perceptions of Life Shift After Deep Brain Stimulation for Primary Dystonia--A Qualitative Study Movement Disorders : Official Journal of the Movement Disorder Society. Sep, 2011 | Pubmed ID: 21626564 Deep Brain Stimulation Effects in Dystonia: Time Course of Electrophysiological Changes in Early Treatment Movement Disorders : Official Journal of the Movement Disorder Society. Aug, 2011 | Pubmed ID: 21547950 Deep Brain Stimulation for Gilles De La Tourette Syndrome: a Case Series Targeting Subregions of the Globus Pallidus Internus Movement Disorders : Official Journal of the Movement Disorder Society. Aug, 2011 | Pubmed ID: 21538528 Targeting of the Pedunculopontine Nucleus by an MRI-guided Approach: a Cadaver Study Journal of Neural Transmission (Vienna, Austria : 1996). Oct, 2011 | Pubmed ID: 21484277 Skewering the Subthalamic Nucleus Via a Parietal Approach Stereotactic and Functional Neurosurgery. 2011 | Pubmed ID: 21293165 Gender Distribution of Patients with Parkinson's Disease Treated with Subthalamic Deep Brain Stimulation; a Review of the 2000-2009 Literature Parkinsonism & Related Disorders. Mar, 2011 | Pubmed ID: 21195012 An Approach to Deep Brain Stimulation for Severe Treatment-refractory Tourette Syndrome: the UK Perspective British Journal of Neurosurgery. Feb, 2011 | Pubmed ID: 21158507 Effects of Medication and Subthalamic Nucleus Deep Brain Stimulation on Tongue Movements in Speakers with Parkinson's Disease Using Electropalatography: a Pilot Study Clinical Linguistics & Phonetics. Mar, 2011 | Pubmed ID: 21158488 Resting Oscillatory Cortico-subthalamic Connectivity in Patients with Parkinson's Disease Brain : a Journal of Neurology. Feb, 2011 | Pubmed ID: 21147836 Improving Targeting in Image-guided Frame-based Deep Brain Stimulation Neurosurgery. Dec, 2010 | Pubmed ID: 21099570 Minimizing Brain Shift in Stereotactic Functional Neurosurgery Neurosurgery. Sep, 2010 | Pubmed ID: 20679927 Self-perception of Speech Changes in Patients with Parkinson's Disease Following Deep Brain Stimulation of the Subthalamic Nucleus International Journal of Speech-language Pathology. Oct, 2010 | Pubmed ID: 20602580 Insights into the Neural Control of Locomotion from Walking Through Doorways in Parkinson's Disease Neuropsychologia. Jul, 2010 | Pubmed ID: 20519135 Value of Subthalamic Nucleus Local Field Potentials Recordings in Predicting Stimulation Parameters for Deep Brain Stimulation in Parkinson's Disease Journal of Neurology, Neurosurgery, and Psychiatry. Aug, 2010 | Pubmed ID: 20466699 Patient-specific Model-based Investigation of Speech Intelligibility and Movement During Deep Brain Stimulation Stereotactic and Functional Neurosurgery. 2010 | Pubmed ID: 20460952 Optimized Beamforming for Simultaneous MEG and Intracranial Local Field Potential Recordings in Deep Brain Stimulation Patients NeuroImage. May, 2010 | Pubmed ID: 20056156 Frequency-specific Effects of Stimulation of the Subthalamic Area in Treated Parkinson's Disease Patients Neuroreport. Jul, 2009 | Pubmed ID: 19525877 Early and Marked Benefit with GPi DBS for Lubag Syndrome Presenting with Rapidly Progressive Life-threatening Dystonia Movement Disorders : Official Journal of the Movement Disorder Society. Aug, 2009 | Pubmed ID: 19514062 Resonance in Subthalamo-cortical Circuits in Parkinson's Disease Brain : a Journal of Neurology. Aug, 2009 | Pubmed ID: 19369488 Avoiding the Ventricle: a Simple Step to Improve Accuracy of Anatomical Targeting During Deep Brain Stimulation Journal of Neurosurgery. Jun, 2009 | Pubmed ID: 19301961 Effects of Contact Location and Voltage Amplitude on Speech and Movement in Bilateral Subthalamic Nucleus Deep Brain Stimulation Movement Disorders : Official Journal of the Movement Disorder Society. Dec, 2008 | Pubmed ID: 18785648 Stereotactic Localization of the Human Pedunculopontine Nucleus: Atlas-based Coordinates and Validation of a Magnetic Resonance Imaging Protocol for Direct Localization Brain : a Journal of Neurology. Jun, 2008 | Pubmed ID: 18467343 Deep Brain Stimulation for Parkinson's Disease Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Apr, 2008 | Pubmed ID: 18394572 Cortical Evoked Potentials from Pallidal Stimulation in Patients with Primary Generalized Dystonia Movement Disorders : Official Journal of the Movement Disorder Society. Jan, 2008 | Pubmed ID: 18044698 Effects of Low-frequency Stimulation of the Subthalamic Nucleus on Movement in Parkinson's Disease Experimental Neurology. Jan, 2008 | Pubmed ID: 17950279 Acute Severe Depression Induced by Intraoperative Stimulation of the Substantia Nigra: a Case Report Parkinsonism & Related Disorders. 2008 | Pubmed ID: 17561432 The Physiological Effects of Pallidal Deep Brain Stimulation in Dystonia IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society. Jun, 2007 | Pubmed ID: 17601185 Pallidal Stimulation Modifies After-effects of Paired Associative Stimulation on Motor Cortex Excitability in Primary Generalised Dystonia Experimental Neurology. Jul, 2007 | Pubmed ID: 17498697 Excessive Synchronization of Basal Ganglia Neurons at 20 Hz Slows Movement in Parkinson's Disease Experimental Neurology. May, 2007 | Pubmed ID: 17335810 Deep Brain Stimulation of the Subthalamic Nucleus: a Two-edged Sword Current Biology : CB. Nov, 2006 | Pubmed ID: 17113373 Changes in Blink Reflex Excitability After Globus Pallidus Internus Stimulation for Dystonia Movement Disorders : Official Journal of the Movement Disorder Society. Oct, 2006 | Pubmed ID: 17058185 Deep Brain Stimulation for Parkinson's Disease: Surgical Issues Movement Disorders : Official Journal of the Movement Disorder Society. Jun, 2006 | Pubmed ID: 16810673 Intra-operative Recordings of Local Field Potentials Can Help Localize the Subthalamic Nucleus in Parkinson's Disease Surgery Experimental Neurology. Mar, 2006 | Pubmed ID: 16403500 Sensory Timing Cues Improve Akinesia of Grasping Movements in Parkinson's Disease: a Comparison to the Effects of Subthalamic Nucleus Stimulation Movement Disorders : Official Journal of the Movement Disorder Society. Feb, 2006 | Pubmed ID: 16161152 Reciprocal Interactions Between Oscillatory Activities of Different Frequencies in the Subthalamic Region of Patients with Parkinson's Disease The European Journal of Neuroscience. Jul, 2005 | Pubmed ID: 16029215 Frequency Dependent Effects of Subthalamic Nucleus Stimulation in Parkinson's Disease Neuroscience Letters. Jul 1-8, 2005 | Pubmed ID: 15911112 The Beneficial Effects of Subthalamic Nucleus Stimulation on Manipulative Finger Force Control in Parkinson's Disease Experimental Neurology. Jun, 2005 | Pubmed ID: 15869945 Stimulation Through Electrodes Implanted Near the Subthalamic Nucleus Activates Projections to Motor Areas of Cerebral Cortex in Patients with Parkinson's Disease The European Journal of Neuroscience. Mar, 2005 | Pubmed ID: 15813949 The Myth of Microelectrode Recording in Ensuring a Precise Location of the DBS Electrode Within the Sensorimotor Part of the Subthalamic Nucleus Movement Disorders : Official Journal of the Movement Disorder Society. Jul, 2004 | Pubmed ID: 15254958 Event-related Beta Desynchronization in Human Subthalamic Nucleus Correlates with Motor Performance Brain : a Journal of Neurology. Apr, 2004 | Pubmed ID: 14960502 Five-year Follow-up of Bilateral Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease The New England Journal of Medicine. Nov, 2003 | Pubmed ID: 14614167 السيطرة على مرض باركنسون مع التكيف تحفيز الدماغ العميق Simon Little1, Alek Pogosyan1, Spencer Neal2, Ludvic Zrinzo2, Marwan Hariz2, Thomas Foltynie2, Patricia Limousin2, Peter Brown1 1Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, 2Sobell Department of Motor Neuroscience & Movement Disorders, Unit of Functional Neurosurgery, UCL Institute of Neurology JoVE 51403 Medicine
السيطرة على مرض باركنسون مع التكيف تحفيز الدماغ العميق Simon Little1, Alek Pogosyan1, Spencer Neal2, Ludvic Zrinzo2, Marwan Hariz2, Thomas Foltynie2, Patricia Limousin2, Peter Brown1 1Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, 2Sobell Department of Motor Neuroscience & Movement Disorders, Unit of Functional Neurosurgery, UCL Institute of Neurology JoVE 51403 Medicine