Peggy S. Lai Division of Pulmonary and Critical Care Massachusetts General Hospital Biography Publications Institution JoVE Articles Peggy S. Lai Dr. Peggy Lai is a an Assistant Professor of Medicine at HMS, a physician in the Division of Pulmonary and Critical Care Medicine at MGH, and a Research Associate in the Department of Environmental Health at the Harvard T.H. Chan School of Public Health. Her research group (https://www.lai-lab.com/) performs clinical and translational research at the intersection of environmental exposures, the human microbiome, and lung disease. Her work is supported by grants from the National Institutes of Health, the American Lung Association, the American Thoracic Society, and a Transformative Scholars Award from the MGH Department of Medicine.Dr. Lai earned her MD at Columbia University College of Physicians and Surgeons and her MPH from the Harvard T.H. Chan School of Public Health. She completed her Internal Medicine Residency at New York Presbyterian - Weill Cornell and her Pulmonary and Critical Care fellowship at Massachusetts General Hospital, Brigham and Women's Hospital, and Beth Israel Deaconess Medical Center in Boston. Publications Detection of Food Allergens in School and Home Environments of Elementary Students The Journal of Allergy and Clinical Immunology. In Practice. Jun, 2021 | Pubmed ID: 34174494 Notch4 Signaling Limits Regulatory T-cell-mediated Tissue Repair and Promotes Severe Lung Inflammation in Viral Infections Immunity. 06, 2021 | Pubmed ID: 33915108 Preventing Asthma in High Risk Kids (PARK) with Omalizumab: Design, Rationale, Methods, Lessons Learned and Adaptation Contemporary Clinical Trials. 01, 2021 | Pubmed ID: 33242697 Asthma Prevalence and Mold Levels in US Northeastern Schools The Journal of Allergy and Clinical Immunology. In Practice. 03, 2021 | Pubmed ID: 33091637 Occupational and Environmental Contributions to Lung Disease Clinics in Chest Medicine. 12, 2020 | Pubmed ID: 33153699 Indoor Microbial Exposures and Chronic Lung Disease: From Microbial Toxins to the Microbiome Clinics in Chest Medicine. 12, 2020 | Pubmed ID: 33153695 Impact of DNA Extraction Method on Variation in Human and Built Environment Microbial Community and Functional Profiles Assessed by Shotgun Metagenomics Sequencing Frontiers in Microbiology. Month, 2020 | Pubmed ID: 32528434 Gut Carriage of Antimicrobial Resistance Genes in Women Exposed to Small-scale Poultry Farms in Rural Uganda: A Feasibility Study PloS One. Month, 2020 | Pubmed ID: 32525954 Differential Effect of School-Based Pollution Exposure in Children With Asthma Born Prematurely Chest. 10, 2020 | Pubmed ID: 32450239 Obesity May Enhance the Adverse Effects of NO Exposure in Urban Schools on Asthma Symptoms in Children The Journal of Allergy and Clinical Immunology. 10, 2020 | Pubmed ID: 32197971 Proximity to Major Roadways and Asthma Symptoms in the School Inner-City Asthma Study The Journal of Allergy and Clinical Immunology. 01, 2020 | Pubmed ID: 31557500 Pulmonary Infarction Due to Paget-Schroetter Syndrome and Nephrotic Syndrome The American Journal of Case Reports. Nov, 2019 | Pubmed ID: 31727870 Personal Carbon Monoxide Exposure, Respiratory Symptoms, and the Potentially Modifying Roles of Sex and HIV Infection in Rural Uganda: a Cohort Study Environmental Health : a Global Access Science Source. 08, 2019 | Pubmed ID: 31429759 The Nasal Methylome As a Biomarker of Asthma and Airway Inflammation in Children Nature Communications. 07, 2019 | Pubmed ID: 31300640 Association Between Fungal Spore Exposure in Inner-city Schools and Asthma Morbidity Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. 06, 2019 | Pubmed ID: 30904580 Impact of Occupational Exposure on Human Microbiota Current Opinion in Allergy and Clinical Immunology. 04, 2019 | Pubmed ID: 30507717 The Classroom Microbiome and Asthma Morbidity in Children Attending 3 Inner-city Schools The Journal of Allergy and Clinical Immunology. 06, 2018 | Pubmed ID: 29518428 Nitrogen Dioxide Exposure in School Classrooms of Inner-city Children with Asthma The Journal of Allergy and Clinical Immunology. 06, 2018 | Pubmed ID: 28988796 Gene-environment Interaction Between an IL4R Variant and School Endotoxin Exposure Contributes to Asthma Symptoms in Inner-city Children The Journal of Allergy and Clinical Immunology. 02, 2018 | Pubmed ID: 28943468 Epidemiology of Antibiotic-resistant Wound Infections from Six Countries in Africa BMJ Global Health. Month, 2017 | Pubmed ID: 29588863 Impact of Environmental Microbiota on Human Microbiota of Workers in Academic Mouse Research Facilities: An Observational Study PloS One. Month, 2017 | Pubmed ID: 28704437 Reply The Journal of Allergy and Clinical Immunology. In Practice. Jul - Aug, 2017 | Pubmed ID: 28689836 The School Inner-City Asthma Intervention Study: Design, Rationale, Methods, and Lessons Learned Contemporary Clinical Trials. 09, 2017 | Pubmed ID: 28619649 Association Between Allergen Exposure in Inner-City Schools and Asthma Morbidity Among Students JAMA Pediatrics. 01, 2017 | Pubmed ID: 27893060 Effect of Pre-operative Anaemia on Post-operative Complications in Low-Resource Settings World Journal of Surgery. Mar, 2017 | Pubmed ID: 27837236 School Environmental Intervention to Reduce Particulate Pollutant Exposures for Children with Asthma The Journal of Allergy and Clinical Immunology. In Practice. Jan - Feb, 2017 | Pubmed ID: 27641483 Modeling Indoor Particulate Exposures in Inner-city School Classrooms Journal of Exposure Science & Environmental Epidemiology. 09, 2017 | Pubmed ID: 27599884 Retrospective Review of the Anaesthetic Management of Maxillectomies and Mandibulectomies for Benign Tumours in Sub-Saharan Africa PloS One. Month, 2016 | Pubmed ID: 27788172 Imaging Phenotype of Occupational Endotoxin-Related Lung Function Decline Environmental Health Perspectives. 09, 2016 | Pubmed ID: 27138294 Time-Limited Trials of Intensive Care for Critically Ill Patients With Cancer: How Long Is Long Enough? JAMA Oncology. Jan, 2016 | Pubmed ID: 26469222 School Endotoxin Exposure and Asthma Morbidity in Inner-city Children Chest. Nov, 2015 | Pubmed ID: 26087201 Alternate Methods of Nasal Epithelial Cell Sampling for Airway Genomic Studies The Journal of Allergy and Clinical Immunology. Oct, 2015 | Pubmed ID: 26037550 Endotoxin and Gender Modify Lung Function Recovery After Occupational Organic Dust Exposure: a 30-year Study Occupational and Environmental Medicine. Aug, 2015 | Pubmed ID: 25666844 Gender Differences in the Effect of Occupational Endotoxin Exposure on Impaired Lung Function and Death: the Shanghai Textile Worker Study Occupational and Environmental Medicine. Feb, 2014 | Pubmed ID: 24297825 What is the Clinical Significance of Pulmonary Hypertension in Acute Respiratory Distress Syndrome? A Review Minerva Anestesiologica. May, 2014 | Pubmed ID: 24193181 Exposures to Molds in School Classrooms of Children with Asthma Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology. Nov, 2013 | Pubmed ID: 24112429 Why Activated Protein C Was Not Successful in Severe Sepsis and Septic Shock: Are We Still Tilting at Windmills? Current Infectious Disease Reports. Oct, 2013 | Pubmed ID: 23925482 Integrating Murine Gene Expression Studies to Understand Obstructive Lung Disease Due to Chronic Inhaled Endotoxin PloS One. Month, 2013 | Pubmed ID: 23675439 Dynamic Data During Hypotensive Episode Improves Mortality Predictions Among Patients with Sepsis and Hypotension Critical Care Medicine. Apr, 2013 | Pubmed ID: 23385106 Long-term Respiratory Health Effects in Textile Workers Current Opinion in Pulmonary Medicine. Mar, 2013 | Pubmed ID: 23361196 An Updated Meta-analysis to Understand the Variable Efficacy of Drotrecogin Alfa (activated) in Severe Sepsis and Septic Shock Minerva Anestesiologica. Jan, 2013 | Pubmed ID: 23174922 Chronic Endotoxin Exposure Produces Airflow Obstruction and Lung Dendritic Cell Expansion American Journal of Respiratory Cell and Molecular Biology. Aug, 2012 | Pubmed ID: 22517795 Design and Development of a Model to Study the Effect of Supplemental Oxygen on the Cystic Fibrosis Airway Microbiome Jacob Vieira1, Tara Gallagher2, Hui-Yu Sui1, Sirus Jesudasen3, Katrine Whiteson2, George A. O'Toole4, Kurt Hanselmann5, Peggy S. Lai1 1Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, 2Department of Molecular Biology & Biochemistry, University of California, Irvine, 3Department of Medicine, Massachusetts General Hospital, 4Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, 5Swiss i-research and teaching institute JoVE 62888 Medicine
Design and Development of a Model to Study the Effect of Supplemental Oxygen on the Cystic Fibrosis Airway Microbiome Jacob Vieira1, Tara Gallagher2, Hui-Yu Sui1, Sirus Jesudasen3, Katrine Whiteson2, George A. O'Toole4, Kurt Hanselmann5, Peggy S. Lai1 1Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, 2Department of Molecular Biology & Biochemistry, University of California, Irvine, 3Department of Medicine, Massachusetts General Hospital, 4Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, 5Swiss i-research and teaching institute JoVE 62888 Medicine