Peter Kleinebudde Institute of Pharmaceutics and Biopharmaceutics Heinrich-Heine University Biography Publications Institution JoVE Articles Peter Kleinebudde has not added a biography. If you are Peter Kleinebudde and would like to personalize this page please email our Author Liaison for assistance. Publications Influence of Storage Condition on Properties of MCC II-based Pellets with Theophylline-monohydrate European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Jun, 2014 | Pubmed ID: 24950003 Systematic Classification of Tablet Disintegrants by Water Uptake and Force Development Kinetics The Journal of Pharmacy and Pharmacology. Jun, 2014 | Pubmed ID: 24943882 Impact of Fillers on Dissolution Kinetic of Fenofibrate Dry Foams Pharmaceutical Development and Technology. Jun, 2014 | Pubmed ID: 24901031 Performance of Tablet Disintegrants: Impact of Storage Conditions and Relative Tablet Density Pharmaceutical Development and Technology. May, 2014 | Pubmed ID: 24848093 Tablet Disintegration Studied by High-resolution Real-time Magnetic Resonance Imaging Journal of Pharmaceutical Sciences. Jan, 2014 | Pubmed ID: 24475490 Preparing of Pellets by Extrusion/spheronization Using Different Types of Equipment and Process Conditions Drug Development and Industrial Pharmacy. Jun, 2014 | Pubmed ID: 23596971 Optimization of the Inter-tablet Coating Uniformity for an Active Coating Process at Lab and Pilot Scale International Journal of Pharmaceutics. Nov, 2013 | Pubmed ID: 24055439 In Situ Dissolution Analysis Using Coherent Anti-Stokes Raman Scattering (CARS) and Hyperspectral CARS Microscopy European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Nov, 2013 | Pubmed ID: 23994672 Influence of Process Parameters and Equipment on Dry Foam Formulation Properties Using Indomethacin As Model Drug International Journal of Pharmaceutics. Oct, 2013 | Pubmed ID: 23891743 Evaluation of Critical Process Parameters for Intra-tablet Coating Uniformity Using Terahertz Pulsed Imaging European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Nov, 2013 | Pubmed ID: 23872179 Influence of MCC II Fraction and Storage Conditions on Pellet Properties European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Nov, 2013 | Pubmed ID: 23872176 Assessment of Test Methods Evaluating Mucoadhesive Polymers and Dosage Forms: an Overview European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Nov, 2013 | Pubmed ID: 23851076 Oromucosal Film Preparations: Classification and Characterization Methods Expert Opinion on Drug Delivery. Sep, 2013 | Pubmed ID: 23768198 Critical Factors in the Measurement of Tablet Film Coatings Using Terahertz Pulsed Imaging Journal of Pharmaceutical Sciences. Jun, 2013 | Pubmed ID: 23681565 Development of a Raman Method to Follow the Evolution of Coating Thickness of Pellets Drug Development and Industrial Pharmacy. May, 2013 | Pubmed ID: 23662715 PAT-tools for Process Control in Pharmaceutical Film Coating Applications International Journal of Pharmaceutics. Dec, 2013 | Pubmed ID: 23380626 Experimental Analysis of Tablet Properties for Discrete Element Modeling of an Active Coating Process AAPS PharmSciTech. Mar, 2013 | Pubmed ID: 23354469 Monitoring of an Active Coating Process for Two-layer Tablets-model Development Strategies Journal of Pharmaceutical Sciences. Feb, 2013 | Pubmed ID: 23188659 Compaction Behavior of Isomalt After Roll Compaction Pharmaceutics. 2012 | Pubmed ID: 24300366 Validation of Terahertz Coating Thickness Measurements Using X-ray Microtomography Molecular Pharmaceutics. Dec, 2012 | Pubmed ID: 23116336 Application of Mixtures of Polymeric Carriers for Dissolution Enhancement of Oxeglitazar Using Hot-melt Extrusion International Journal of Pharmaceutics. Dec, 2012 | Pubmed ID: 23073606 Application of Artificial Neural Networks (ANNs) and Genetic Programming (GP) for Prediction of Drug Release from Solid Lipid Matrices International Journal of Pharmaceutics. Oct, 2012 | Pubmed ID: 22728260 Pellet Layering: Scale-up Considerations Using Different Kinds of Processing Equipment Drug Development and Industrial Pharmacy. Dec, 2012 | Pubmed ID: 22452570 Application of Mixtures of Polymeric Carriers for Dissolution Enhancement of Fenofibrate Using Hot-melt Extrusion International Journal of Pharmaceutics. Jun, 2012 | Pubmed ID: 22440149 Prediction of Dissolution Time and Coating Thickness of Sustained Release Formulations Using Raman Spectroscopy and Terahertz Pulsed Imaging European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Apr, 2012 | Pubmed ID: 22245221 Drug Release from Extruded Solid Lipid Matrices: Theoretical Predictions and Independent Experiments European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Jan, 2012 | Pubmed ID: 22008146 Roll Compaction/dry Granulation: Comparison Between Roll Mill and Oscillating Granulator in Dry Granulation Pharmaceutical Development and Technology. Jan-Feb, 2012 | Pubmed ID: 20731538 From Mini to Micro Scale-Feasibility of Raman Spectroscopy As a Process Analytical Tool (PAT) Pharmaceutics. 2011 | Pubmed ID: 24309305 Melt Extruded Helical Waxy Matrices As a New Sustained Drug Delivery System European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Nov, 2011 | Pubmed ID: 21827851 Development of Mini-tablets with 1mm and 2mm Diameter International Journal of Pharmaceutics. Sep, 2011 | Pubmed ID: 21726616 Development of a Taste-masked Generic Ibuprofen Suspension: Top-down Approach Guided by Electronic Tongue Measurements Journal of Pharmaceutical Sciences. May, 2011 | Pubmed ID: 21607955 Analysis of Matrix Dosage Forms During Dissolution Testing Using Raman Microscopy Journal of Pharmaceutical Sciences. May, 2011 | Pubmed ID: 21560128 Dissolution from Solid Lipid Extrudates Containing Release Modifiers International Journal of Pharmaceutics. Jun, 2011 | Pubmed ID: 21515350 Suitability of a Flat Die Press for the Manufacture of Pharmaceutical Pellets by Extrusion/spheronization Drug Development and Industrial Pharmacy. Apr, 2011 | Pubmed ID: 21446830 A Comparative Study on Two Electronic Tongues for Pharmaceutical Formulation Development Journal of Pharmaceutical and Biomedical Analysis. May, 2011 | Pubmed ID: 21353433 Suitability of κ-carrageenan Pellets for the Formulation of Multiparticulate Tablets with Modified Release International Journal of Pharmaceutics. May, 2011 | Pubmed ID: 21335073 Taste Sensing Systems (electronic Tongues) for Pharmaceutical Applications International Journal of Pharmaceutics. Sep, 2011 | Pubmed ID: 21094230 Solid Lipid Extrusion with Small Die Diameters--electrostatic Charging, Taste Masking and Continuous Production European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Jan, 2011 | Pubmed ID: 20940049 Increased Compactibility of Acetames After Roll Compaction European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Jan, 2011 | Pubmed ID: 20932904 Evaluation of Predictive Models for Stable Solid Solution Formation Journal of Pharmaceutical Sciences. Feb, 2011 | Pubmed ID: 20803574 Rational Development of Taste Masked Oral Liquids Guided by an Electronic Tongue International Journal of Pharmaceutics. Nov, 2010 | Pubmed ID: 20816732 Pharmaceutical Review Articles: from Good to Great Pharmaceutical Development and Technology. Sep-Oct, 2010 | Pubmed ID: 20735298 Analysis of Pellet Properties with Use of Artificial Neural Networks European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Nov, 2010 | Pubmed ID: 20659554 Validation of Raman Spectroscopic Procedures in Agreement with ICH Guideline Q2 with Considering the Transfer to Real Time Monitoring of an Active Coating Process Journal of Pharmaceutical and Biomedical Analysis. Dec, 2010 | Pubmed ID: 20638213 Improvement of Dissolution Behavior for Poorly Water-soluble Drug by Application of Cyclodextrin in Extrusion Process: Comparison Between Melt Extrusion and Wet Extrusion AAPS PharmSciTech. Jun, 2010 | Pubmed ID: 20496019 Two-step Solid Lipid Extrusion As a Process to Modify Dissolution Behavior AAPS PharmSciTech. Mar, 2010 | Pubmed ID: 20309654 Compression Behaviour of Kappa-carrageenan Pellets International Journal of Pharmaceutics. May, 2010 | Pubmed ID: 20100553 Role of Surface Free Energy and Spreading Coefficient in the Formulation of Active Agent-layered Pellets European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Feb, 2010 | Pubmed ID: 19931611 Continuous Granulation with a Twin-screw Extruder: Impact of Material Throughput Pharmaceutical Development and Technology. Sep-Oct, 2010 | Pubmed ID: 19921959 Performance Qualification of an Electronic Tongue Based on ICH Guideline Q2 Journal of Pharmaceutical and Biomedical Analysis. Feb, 2010 | Pubmed ID: 19853397 Feasibility of Raman Spectroscopy As PAT Tool in Active Coating Drug Development and Industrial Pharmacy. Feb, 2010 | Pubmed ID: 19778159 Effect of Lubricant on Spreading of Coating Liquid on Surface of Tablets Containing Pancreatin Pharmaceutical Development and Technology. Jul-Aug, 2010 | Pubmed ID: 19772392 Investigating the Relationship Between Drug Distribution in Solid Lipid Matrices and Dissolution Behaviour Using Raman Spectroscopy and Mapping Journal of Pharmaceutical Sciences. Mar, 2010 | Pubmed ID: 19691104 Investigating Dissolution Performance Critical Areas on Coated Tablets: a Case Study Using Terahertz Pulsed Imaging Journal of Pharmaceutical Sciences. Jan, 2010 | Pubmed ID: 19569058 Investigating the Principles of Recrystallization from Glyceride Melts AAPS PharmSciTech. 2009 | Pubmed ID: 19862628 Influence of the Composition of Glycerides on the Solid-state Behaviour and the Dissolution Profiles of Solid Lipid Extrudates International Journal of Pharmaceutics. Nov, 2009 | Pubmed ID: 19782882 Influence of Structural Variations on Drug Release from Lipid/polyethylene Glycol Matrices European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jul, 2009 | Pubmed ID: 19406229 Monitoring the Film Coating Unit Operation and Predicting Drug Dissolution Using Terahertz Pulsed Imaging Journal of Pharmaceutical Sciences. Dec, 2009 | Pubmed ID: 19367620 Tailor-made Dissolution Profiles by Extruded Matrices Based on Lipid Polyethylene Glycol Mixtures Journal of Controlled Release : Official Journal of the Controlled Release Society. Aug, 2009 | Pubmed ID: 19358867 Improved Bioavailability of Darunavir by Use of Kappa-carrageenan Versus Microcrystalline Cellulose As Pelletisation Aid European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Aug, 2009 | Pubmed ID: 19303929 Chemical Imaging of Oral Solid Dosage Forms and Changes Upon Dissolution Using Coherent Anti-Stokes Raman Scattering Microscopy Analytical Chemistry. Mar, 2009 | Pubmed ID: 19209888 Spheronization of Small Extrudates Containing Kappa-carrageenan Journal of Pharmaceutical Sciences. Oct, 2009 | Pubmed ID: 19130471 Mechanism of Drug Release from Polymethacrylate-based Extrudates and Milled Strands Prepared by Hot-melt Extrusion European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Feb, 2009 | Pubmed ID: 18951978 Theme Issue "Solid State and Solid Dosage Forms" European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Jan, 2009 | Pubmed ID: 18817869 Terahertz Pulsed Imaging As an Analytical Tool for Sustained-release Tablet Film Coating European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Jan, 2009 | Pubmed ID: 18647650 Understanding the Solid-state Behaviour of Triglyceride Solid Lipid Extrudates and Its Influence on Dissolution European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Jan, 2009 | Pubmed ID: 18588976 Evaluation of the Composition of the Binder Bridges in Matrix Granules Prepared with a Small-scale High-shear Granulator Journal of Pharmaceutical and Biomedical Analysis. Nov, 2008 | Pubmed ID: 18774256 Solid Lipid Extrudates As Sustained-release Matrices: the Effect of Surface Structure on Drug Release Properties European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Nov, 2008 | Pubmed ID: 18765281 Controlled Release of Active As a Consequence of the Die Diameter in Solid Lipid Extrusion Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2008 | Pubmed ID: 18725256 Controlled Release Solid Dosage Forms Using Combinations of (meth)acrylate Copolymers Pharmaceutical Development and Technology. 2008 | Pubmed ID: 18720248 The 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (PBP Meeting) April 7-10, 2008, Barcelona, Spain AAPS PharmSciTech. 2008 | Pubmed ID: 18618267 Studies on the Reduction of Tensile Strength of Tablets After Roll Compaction/dry Granulation European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Sep, 2008 | Pubmed ID: 18511247 Impact of Screw Elements on Continuous Granulation with a Twin-screw Extruder Journal of Pharmaceutical Sciences. Nov, 2008 | Pubmed ID: 18300301 The Behavior of Different Carrageenans in Pelletization by Extrusion/spheronization Pharmaceutical Development and Technology. 2008 | Pubmed ID: 18300097 Applications of Terahertz Pulsed Imaging to Sustained-release Tablet Film Coating Quality Assessment and Dissolution Performance Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2008 | Pubmed ID: 18291547 Properties of Pellets Manufactured by Wet Extrusion/spheronization Process Using Kappa-carrageenan: Effect of Process Parameters AAPS PharmSciTech. 2007 | Pubmed ID: 18181555 Comparison of Different Dry Binders for Roll Compaction/dry Granulation Pharmaceutical Development and Technology. 2007 | Pubmed ID: 17963152 Influence of Chitosan Type on the Properties of Extruded Pellets with Low Amount of Microcrystalline Cellulose AAPS PharmSciTech. 2007 | Pubmed ID: 17915814 Solid Lipid Extrusion of Sustained Release Dosage Forms European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Sep, 2007 | Pubmed ID: 17481868 Abrasion of Tablets During Scale-up: the Influence of Different Crushing Forces in Laboratory and Production Perforated Pan Coaters European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Sep, 2007 | Pubmed ID: 17475452 Effect of Drying on Extruded Pellets Based on Kappa-carrageenan European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jun, 2007 | Pubmed ID: 17448646 Comparison of a Laboratory and a Production Coating Spray Gun with Respect to Scale-up AAPS PharmSciTech. 2007 | Pubmed ID: 17408226 Roll Compaction/dry Granulation: Effect of Raw Material Particle Size on Granule and Tablet Properties International Journal of Pharmaceutics. Jun, 2007 | Pubmed ID: 17324537 Use of Chitosan-alginate As Alternative Pelletization Aid to Microcrystalline Cellulose in Extrusion/spheronization Journal of Pharmaceutical Sciences. Sep, 2007 | Pubmed ID: 17286294 Comparison Study of Laboratory and Production Spray Guns in Film Coating: Effect of Pattern Air and Nozzle Diameter Pharmaceutical Development and Technology. 2006 | Pubmed ID: 17101513 Influence of Scale-up on the Abrasion of Tablets in a Pan Coater European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Nov, 2006 | Pubmed ID: 16875807 Mathematical Modeling of an Aqueous Film Coating Process in a Bohle Lab-Coater: Part 2: Application of the Model AAPS PharmSciTech. 2006 | Pubmed ID: 16796360 Mathematical Modeling of an Aqueous Film Coating Process in a Bohle Lab-Coater, Part 1: Development of the Model AAPS PharmSciTech. 2006 | Pubmed ID: 16796359 Use of Kappa-carrageenan As Alternative Pelletisation Aid to Microcrystalline Cellulose in Extrusion/spheronisation. I. Influence of Type and Fraction of Filler European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. May, 2006 | Pubmed ID: 16326085 Use of Kappa-carrageenan As Alternative Pelletisation Aid to Microcrystalline Cellulose in Extrusion/spheronisation. II. Influence of Drug and Filler Type European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. May, 2006 | Pubmed ID: 16325384 Coprocessing of Powdered Cellulose and Magnesium Carbonate: Direct Tableting Versus Tableting After Roll Compaction/dry Granulation Pharmaceutical Development and Technology. 2005 | Pubmed ID: 16176015 Studies of the Retrogradation Process for Various Starch Gels Using Raman Spectroscopy Carbohydrate Research. Nov, 2005 | Pubmed ID: 16168973 Preliminary Assessment of Carrageenan As Excipient for Extrusion/spheronisation European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Jan, 2005 | Pubmed ID: 15567309 Roll Compaction/dry Granulation: Pharmaceutical Applications European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Sep, 2004 | Pubmed ID: 15296958 How Do Roll Compaction/dry Granulation Affect the Tableting Behaviour of Inorganic Materials? Microhardness of Ribbons and Mercury Porosimetry Measurements of Tablets European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jul, 2004 | Pubmed ID: 15196589 Properties of Microcrystalline Cellulose and Powder Cellulose After Extrusion/spheronization As Studied by Fourier Transform Raman Spectroscopy and Environmental Scanning Electron Microscopy AAPS PharmSci. Nov, 2003 | Pubmed ID: 15198519 Disintegrating Pellets from a Water-insoluble Pectin Derivative Produced by Extrusion/spheronisation European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Nov, 2003 | Pubmed ID: 14602179 Pediatric Drug Formulations of Sodium Benzoate: II. Coated Granules with a Lipophilic Binder European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Sep, 2003 | Pubmed ID: 12957640 Pediatric Drug Formulations of Sodium Benzoate: I. Coated Granules with a Hydrophilic Binder European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Sep, 2003 | Pubmed ID: 12957639 How Do Roll Compaction/dry Granulation Affect the Tableting Behaviour of Inorganic Materials? Comparison of Four Magnesium Carbonates European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jul, 2003 | Pubmed ID: 12885393 Coating Uniformity and Coating Efficiency in a Bohle Lab-Coater Using Oval Tablets European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Jul, 2003 | Pubmed ID: 12837475 Coating Uniformity: Influence of Atomizing Air Pressure Pharmaceutical Development and Technology. 2003 | Pubmed ID: 12665196 Development of Fast-disintegrating Pellets in a Rotary Processor Drug Development and Industrial Pharmacy. Nov, 2002 | Pubmed ID: 12476866 Quantum Chemical Descriptors in the Formulation of Pectin Pellets Produced by Extrusion/spheronisation European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Aug, 2002 | Pubmed ID: 12128168 Pectinic Acid, a Novel Excipient for Production of Pellets by Extrusion/spheronisation: Preliminary Studies European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Jul, 2002 | Pubmed ID: 12084508 Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution Andrew L. Fussell1, Peter Kleinebudde2, Jennifer Herek1, Clare J. Strachan3, Herman L. Offerhaus1 1Optical Sciences Group, MESA+ Institute, University of Twente, 2Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine University, 3Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki JoVE 51847 Engineering
Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution Andrew L. Fussell1, Peter Kleinebudde2, Jennifer Herek1, Clare J. Strachan3, Herman L. Offerhaus1 1Optical Sciences Group, MESA+ Institute, University of Twente, 2Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine University, 3Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki JoVE 51847 Engineering