Peter Schuck National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health Dynamics of Macromolecular Assembly, Laboratory of Bioengineering and Physical Science Biography Publications Institution JoVE Articles Peter Schuck has not added a biography. If you are Peter Schuck and would like to personalize this page please email our Author Liaison for assistance. Publications Structural, Bioinformatic, and In Vivo Analyses of Two Treponema Pallidum Lipoproteins Reveal a Unique TRAP Transporter Journal of Molecular Biology. Jan, 2012 | Pubmed ID: 22306465 Density Contrast Sedimentation Velocity for the Determination of Protein Partial-specific Volumes PloS One. 2011 | Pubmed ID: 22028836 NBD-labeled Phospholipid Accelerates Apolipoprotein C-II Amyloid Fibril Formation but is Not Incorporated into Mature Fibrils Biochemistry. Nov, 2011 | Pubmed ID: 21985034 Malaria Vaccine Candidate: Design of a Multivalent Subunit α-helical Coiled Coil Poly-epitope Vaccine. Sep, 2011 | Pubmed ID: 21803099 Structure and Assembly Mechanism for Heteromeric Kainate Receptors Neuron. Jul, 2011 | Pubmed ID: 21791290 The Molecular Refractive Function of Lens γ-Crystallins Journal of Molecular Biology. Aug, 2011 | Pubmed ID: 21684289 Radiation Engineering of Optical Antennas for Maximum Field Enhancement Nano Letters. Jul, 2011 | Pubmed ID: 21648393 The Role of Macromolecular Crowding in the Evolution of Lens Crystallins with High Molecular Refractive Index Physical Biology. Aug, 2011 | Pubmed ID: 21566271 On the Distribution of Protein Refractive Index Increments Biophysical Journal. May, 2011 | Pubmed ID: 21539801 Editorial for the Special Issue of Methods "Modern Analytical Ultracentrifugation" Methods (San Diego, Calif.). May, 2011 | Pubmed ID: 21536133 Dimeric States of Neural- and Epithelial-cadherins Are Distinguished by the Rate of Disassembly Biochemistry. Apr, 2011 | Pubmed ID: 21375242 The Boundary Structure in the Analysis of Reversibly Interacting Systems by Sedimentation Velocity Methods (San Diego, Calif.). May, 2011 | Pubmed ID: 21315155 Extended Fujita Approach to the Molecular Weight Distribution of Polysaccharides and Other Polymeric Systems Methods (San Diego, Calif.). May, 2011 | Pubmed ID: 21276851 Biophysical Characterization of DNA and RNA Aptamer Interactions with Hen Egg Lysozyme International Journal of Biological Macromolecules. Apr, 2011 | Pubmed ID: 21167858 Macromol. Biosci. 7/2010 Macromolecular Bioscience. Jul, 2010 | Pubmed ID: 20632364 Cooperative Interactions at the SLP-76 Complex Are Critical for Actin Polymerization The EMBO Journal. Jul, 2010 | Pubmed ID: 20562827 Diffusion of the Reaction Boundary of Rapidly Interacting Macromolecules in Sedimentation Velocity Biophysical Journal. Jun, 2010 | Pubmed ID: 20513419 Accounting for Solvent Signal Offsets in the Analysis of Interferometric Sedimentation Velocity Data Macromolecular Bioscience. Jul, 2010 | Pubmed ID: 20480511 Sedimentation Patterns of Rapidly Reversible Protein Interactions Biophysical Journal. May, 2010 | Pubmed ID: 20441765 Phospholipids Enhance Nucleation but Not Elongation of Apolipoprotein C-II Amyloid Fibrils Journal of Molecular Biology. Jun, 2010 | Pubmed ID: 20433849 The Role of Mass Transport Limitation and Surface Heterogeneity in the Biophysical Characterization of Macromolecular Binding Processes by SPR Biosensing Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20217612 Some Statistical Properties of Differencing Schemes for Baseline Correction of Sedimentation Velocity Data Analytical Biochemistry. Jun, 2010 | Pubmed ID: 20206114 Direct Interaction of the Mouse Cytomegalovirus M152/gp40 Immunoevasin with RAE-1 Isoforms Biochemistry. Mar, 2010 | Pubmed ID: 20166740 On Computational Approaches for Size-and-shape Distributions from Sedimentation Velocity Analytical Ultracentrifugation European Biophysics Journal : EBJ. Jul, 2010 | Pubmed ID: 19806353 On the Analysis of Sedimentation Velocity in the Study of Protein Complexes European Biophysics Journal : EBJ. Oct, 2009 | Pubmed ID: 19644686 Energetics of Glutamate Receptor Ligand Binding Domain Dimer Assembly Are Modulated by Allosteric Ions Proceedings of the National Academy of Sciences of the United States of America. Jul, 2009 | Pubmed ID: 19617541 NanoPen: Dynamic, Low-power, and Light-actuated Patterning of Nanoparticles Nano Letters. Aug, 2009 | Pubmed ID: 19588985 Novel Chimpanzee/human Monoclonal Antibodies That Neutralize Anthrax Lethal Factor, and Evidence for Possible Synergy with Anti-protective Antigen Antibody Infection and Immunity. Sep, 2009 | Pubmed ID: 19528217 The N-terminal Domain of GluR6-subtype Glutamate Receptor Ion Channels Nature Structural & Molecular Biology. Jun, 2009 | Pubmed ID: 19465914 The C-terminal Domain of Plasmodium Falciparum Merozoite Surface Protein 3 Self-assembles into Alpha-helical Coiled Coil Tetramer Molecular and Biochemical Parasitology. Jun, 2009 | Pubmed ID: 19428662 Stability of Ligand-binding Domain Dimer Assembly Controls Kainate Receptor Desensitization The EMBO Journal. May, 2009 | Pubmed ID: 19339989 Autoinhibition of Arf GTPase-activating Protein Activity by the BAR Domain in ASAP1 The Journal of Biological Chemistry. Jan, 2009 | Pubmed ID: 19017632 Bayesian Analysis of Heterogeneity in the Distribution of Binding Properties of Immobilized Surface Sites Langmuir : the ACS Journal of Surfaces and Colloids. Oct, 2008 | Pubmed ID: 18816013 A Bayesian Approach for Quantifying Trace Amounts of Antibody Aggregates by Sedimentation Velocity Analytical Ultracentrifugation The AAPS Journal. Sep, 2008 | Pubmed ID: 18814037 Characterizing Protein-protein Interactions by Sedimentation Velocity Analytical Ultracentrifugation Current Protocols in Immunology / Edited by John E. Coligan ... [et Al.]. May, 2008 | Pubmed ID: 18491296 Humanized Monoclonal Antibodies Derived from Chimpanzee Fabs Protect Against Japanese Encephalitis Virus in Vitro and in Vivo Journal of Virology. Jul, 2008 | Pubmed ID: 18480437 Apolipoprotein C-II Amyloid Fibrils Assemble Via a Reversible Pathway That Includes Fibril Breaking and Rejoining Journal of Molecular Biology. Feb, 2008 | Pubmed ID: 18206908 A New Adaptive Grid-size Algorithm for the Simulation of Sedimentation Velocity Profiles in Analytical Ultracentrifugation Computer Physics Communications. Jan, 2008 | Pubmed ID: 18196178 Bacteriorhodopsin/amphipol Complexes: Structural and Functional Properties Biophysical Journal. May, 2008 | Pubmed ID: 18192360 Extended Polypeptide Linkers Establish the Spatial Architecture of a Pyruvate Dehydrogenase Multienzyme Complex Structure (London, England : 1993). Jan, 2008 | Pubmed ID: 18184587 Measuring Protein-protein Interactions by Equilibrium Sedimentation Current Protocols in Immunology / Edited by John E. Coligan ... [et Al.]. Nov, 2007 | Pubmed ID: 18432990 Two Interferons Alpha Influence Each Other During Their Interaction with the Extracellular Domain of Human Type Interferon Receptor Subunit 2 Biochemistry. Dec, 2007 | Pubmed ID: 18027911 Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, M153 The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17897947 Characterization of Chimpanzee/human Monoclonal Antibodies to Vaccinia Virus A33 Glycoprotein and Its Variola Virus Homolog in Vitro and in a Vaccinia Virus Mouse Protection Model Journal of Virology. Sep, 2007 | Pubmed ID: 17581986 Using Prior Knowledge in the Determination of Macromolecular Size-distributions by Analytical Ultracentrifugation Biomacromolecules. Jun, 2007 | Pubmed ID: 17521163 Single-walled Tubulin Ring Polymers Biopolymers. Aug 5-15, 2007 | Pubmed ID: 17480000 Superantigen Natural Affinity Maturation Revealed by the Crystal Structure of Staphylococcal Enterotoxin G and Its Binding to T-cell Receptor Vbeta8.2 Proteins. Jul, 2007 | Pubmed ID: 17427250 Studying Multisite Binary and Ternary Protein Interactions by Global Analysis of Isothermal Titration Calorimetry Data in SEDPHAT: Application to Adaptor Protein Complexes in Cell Signaling Protein Science : a Publication of the Protein Society. Jan, 2007 | Pubmed ID: 17192587 Probing the Functional Heterogeneity of Surface Binding Sites by Analysis of Experimental Binding Traces and the Effect of Mass Transport Limitation Biophysical Journal. Mar, 2007 | Pubmed ID: 17158569 Conformational Restriction Blocks Glutamate Receptor Desensitization Nature Structural & Molecular Biology. Dec, 2006 | Pubmed ID: 17115050 Oligomerization of Signaling Complexes by the Multipoint Binding of GRB2 to Both LAT and SOS1 Nature Structural & Molecular Biology. Sep, 2006 | Pubmed ID: 16906159 Variable Dimerization of the Ly49A Natural Killer Cell Receptor Results in Differential Engagement of Its MHC Class I Ligand Journal of Molecular Biology. Sep, 2006 | Pubmed ID: 16899255 Macromolecular Size-and-shape Distributions by Sedimentation Velocity Analytical Ultracentrifugation Biophysical Journal. Jun, 2006 | Pubmed ID: 16565040 Quaternary Structure and Cleavage Specificity of a Poxvirus Holliday Junction Resolvase The Journal of Biological Chemistry. Apr, 2006 | Pubmed ID: 16513635 Crystal Structure of Group A Streptococcus Mac-1: Insight into Dimer-mediated Specificity for Recognition of Human IgG Structure (London, England : 1993). Feb, 2006 | Pubmed ID: 16472742 Efficient Neutralization of Anthrax Toxin by Chimpanzee Monoclonal Antibodies Against Protective Antigen The Journal of Infectious Diseases. Mar, 2006 | Pubmed ID: 16453257 Chimpanzee/human MAbs to Vaccinia Virus B5 Protein Neutralize Vaccinia and Smallpox Viruses and Protect Mice Against Vaccinia Virus Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16436502 Influence of Temperature on the Conformation of Canine Plasminogen: an Analytical Ultracentrifugation and Dynamic Light Scattering Study Biochemistry. Oct, 2005 | Pubmed ID: 16185080 Dissection of Merozoite Surface Protein 3, a Representative of a Family of Plasmodium Falciparum Surface Proteins, Reveals an Oligomeric and Highly Elongated Molecule The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16135515 Regulation of ASAP1 by Phospholipids is Dependent on the Interface Between the PH and Arf GAP Domains Cellular Signalling. Oct, 2005 | Pubmed ID: 16038802 Self-association and Ligand-induced Conformational Changes of Iron Regulatory Proteins 1 and 2 Biochemistry. Jun, 2005 | Pubmed ID: 15938636 A Mechanism for Assembly of Complexes of Vitronectin and Plasminogen Activator Inhibitor-1 from Sedimentation Velocity Analysis The Journal of Biological Chemistry. Aug, 2005 | Pubmed ID: 15905170 Sedimentation Velocity Analysis of Heterogeneous Protein-protein Interactions: Lamm Equation Modeling and Sedimentation Coefficient Distributions C(s) Biophysical Journal. Jul, 2005 | Pubmed ID: 15863475 Sedimentation Velocity Analysis of Heterogeneous Protein-protein Interactions: Sedimentation Coefficient Distributions C(s) and Asymptotic Boundary Profiles from Gilbert-Jenkins Theory Biophysical Journal. Jul, 2005 | Pubmed ID: 15863474 Eukaryotic RNases H1 Act Processively by Interactions Through the Duplex RNA-binding Domain Nucleic Acids Research. 2005 | Pubmed ID: 15831789 Characterization of DC-SIGN/R Interaction with Human Immunodeficiency Virus Type 1 Gp120 and ICAM Molecules Favors the Receptor's Role As an Antigen-capturing Rather Than an Adhesion Receptor Journal of Virology. Apr, 2005 | Pubmed ID: 15795245 Cooperative Behavior of Escherichia Coli Cell-division Protein FtsZ Assembly Involves the Preferential Cyclization of Long Single-stranded Fibrils Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15684053 Targeted Lysis of HIV-infected Cells by Natural Killer Cells Armed and Triggered by a Recombinant Immunoglobulin Fusion Protein: Implications for Immunotherapy Virology. Feb, 2005 | Pubmed ID: 15680414 Exposure of Acidic Residues As a Danger Signal for Recognition of Fibrinogen and Other Macromolecules by Integrin AlphaXbeta2 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15665082 Studying Multiprotein Complexes by Multisignal Sedimentation Velocity Analytical Ultracentrifugation Proceedings of the National Academy of Sciences of the United States of America. Jan, 2005 | Pubmed ID: 15613487 Measuring Protein Interactions by Optical Biosensors Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [et Al.]. May, 2004 | Pubmed ID: 18228444 Case Histories Illustrating the Utility of Sertindole in Clinical Practice CNS Drugs. 2004 | Pubmed ID: 15461314 SDR Grafting of a Murine Antibody Using Multiple Human Germline Templates to Minimize Its Immunogenicity Molecular Immunology. Jul, 2004 | Pubmed ID: 15261458 Crystal Structure of the C-terminal Peptidoglycan-binding Domain of Human Peptidoglycan Recognition Protein Ialpha The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15140887 Assessing Reproducibility for Interval Data in Health-related Quality of Life Questionnaires: Which Coefficient Should Be Used? Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation. Apr, 2004 | Pubmed ID: 15130022 Calculating Sedimentation Coefficient Distributions by Direct Modeling of Sedimentation Velocity Concentration Profiles Methods in Enzymology. 2004 | Pubmed ID: 15081688 Binding Specificity of Multiprotein Signaling Complexes is Determined by Both Cooperative Interactions and Affinity Preferences Biochemistry. Apr, 2004 | Pubmed ID: 15065860 A Model for Sedimentation in Inhomogeneous Media. II. Compressibility of Aqueous and Organic Solvents Biophysical Chemistry. Mar, 2004 | Pubmed ID: 15043930 A Model for Sedimentation in Inhomogeneous Media. I. Dynamic Density Gradients from Sedimenting Co-solutes Biophysical Chemistry. Mar, 2004 | Pubmed ID: 15043929 Sedimentation Equilibrium Analysis of Protein Interactions with Global Implicit Mass Conservation Constraints and Systematic Noise Decomposition Analytical Biochemistry. Mar, 2004 | Pubmed ID: 15003564 In Vitro Affinity Maturation of a Specificity-determining Region-grafted Humanized Anticarcinoma Antibody: Isolation and Characterization of Minimally Immunogenic High-affinity Variants Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2003 | Pubmed ID: 14654532 Variable MHC Class I Engagement by Ly49 Natural Killer Cell Receptors Demonstrated by the Crystal Structure of Ly49C Bound to H-2K(b) Nature Immunology. Dec, 2003 | Pubmed ID: 14595439 Minimizing Immunogenicity of the SDR-grafted Humanized Antibody CC49 by Genetic Manipulation of the Framework Residues Molecular Immunology. Oct, 2003 | Pubmed ID: 14522015 Reversible and Fast Association Equilibria of a Molecular Chaperone, Gp57A, of Bacteriophage T4 Biophysical Journal. Oct, 2003 | Pubmed ID: 14507723 On the Analysis of Protein Self-association by Sedimentation Velocity Analytical Ultracentrifugation Analytical Biochemistry. Sep, 2003 | Pubmed ID: 12895474 The 'smallest Real Difference' As a Measure of Sensitivity to Change: a Critical Analysis International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation. Jun, 2003 | Pubmed ID: 12799601 Alanine-scanning Mutations in Domain 4 of Anthrax Toxin Protective Antigen Reveal Residues Important for Binding to the Cellular Receptor and to a Neutralizing Monoclonal Antibody The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12771151 Combined Affinity and Rate Constant Distributions of Ligand Populations from Experimental Surface Binding Kinetics and Equilibria Biophysical Journal. Jun, 2003 | Pubmed ID: 12770910 Inhibition of Hemostasis by a High Affinity Biogenic Amine-binding Protein from the Saliva of a Blood-feeding Insect The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12464610 Differences in the Binding Capacity of Human Apolipoprotein E3 and E4 to Size-fractionated Lipid Emulsions European Journal of Biochemistry / FEBS. Dec, 2002 | Pubmed ID: 12444983 Grafting of "abbreviated" Complementarity-determining Regions Containing Specificity-determining Residues Essential for Ligand Contact to Engineer a Less Immunogenic Humanized Monoclonal Antibody Journal of Immunology (Baltimore, Md. : 1950). Sep, 2002 | Pubmed ID: 12218124 Surface Plasmon Resonance-based Competition Assay to Assess the Sera Reactivity of Variants of Humanized Antibodies Journal of Immunological Methods. Oct, 2002 | Pubmed ID: 12215388 Modern Analytical Ultracentrifugation in Protein Science: a Tutorial Review Protein Science : a Publication of the Protein Society. Sep, 2002 | Pubmed ID: 12192063 Epidemiology Research Lancet. Jul, 2002 | Pubmed ID: 12133688 Analysis of a Temperature-sensitive Mutant Rotavirus Indicates That NSP2 Octamers Are the Functional Form of the Protein Journal of Virology. Jul, 2002 | Pubmed ID: 12072508 Mass Spectrometry After Capture and Small-volume Elution of Analyte from a Surface Plasmon Resonance Biosensor Analytical Chemistry. May, 2002 | Pubmed ID: 12033305 Quantifying the Energetics of Cooperativity in a Ternary Protein Complex Biochemistry. Apr, 2002 | Pubmed ID: 11955066 Size-distribution Analysis of Proteins by Analytical Ultracentrifugation: Strategies and Application to Model Systems Biophysical Journal. Feb, 2002 | Pubmed ID: 11806949 Biochemical and Biological Characterization of a Dodecameric CD4-Ig Fusion Protein: Implications for Therapeutic and Vaccine Strategies The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11805109 Elucidating Kinetic and Thermodynamic Constants for Interaction of G Protein Subunits and Receptors by Surface Plasmon Resonance Spectroscopy Methods in Enzymology. 2002 | Pubmed ID: 11771379 Rethinking Informed Consent The Yale Law Journal. Jan, 1994 | Pubmed ID: 11659806 The Social Utility of Surrogacy Harvard Journal of Law & Public Policy. 1990 | Pubmed ID: 11649283 Some Reflections on the Baby M Case The Georgetown Law Journal. Jun, 1988 | Pubmed ID: 11649251 Malpractice Liability and the Rationing of Care Texas Law Review. Nov, 1981 | Pubmed ID: 11650624 Assembly, Loading, and Alignment of an Analytical Ultracentrifuge Sample Cell Andrea Balbo1, Huaying Zhao1, Patrick H. Brown1, Peter Schuck1 1National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Dynamics of Macromolecular Assembly, Laboratory of Bioengineering and Physical Science JoVE 1530 Biology
Assembly, Loading, and Alignment of an Analytical Ultracentrifuge Sample Cell Andrea Balbo1, Huaying Zhao1, Patrick H. Brown1, Peter Schuck1 1National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Dynamics of Macromolecular Assembly, Laboratory of Bioengineering and Physical Science JoVE 1530 Biology