Philip A. Barker Department of Neurology and Neurosurgery Montreal Neurological Institute, McGill University Biography Publications Institution JoVE Articles Philip A. Barker has not added a biography. If you are Philip A. Barker and would like to personalize this page please email our Author Liaison for assistance. Publications S100B Protein Activates a RAGE-dependent Autocrine Loop in Astrocytes: Implications for Its Role in the Propagation of Reactive Gliosis Journal of Neurochemistry. Jun, 2014 | Pubmed ID: 24923428 Neurotrophins in the Regulation of Cellular Survival and Death Handbook of Experimental Pharmacology. 2014 | Pubmed ID: 24668474 P75 Neurotrophin Receptor Cleavage by α- and γ-secretases is Required for Neurotrophin-mediated Proliferation of Brain Tumor-initiating Cells The Journal of Biological Chemistry. Mar, 2014 | Pubmed ID: 24519935 XIAP Regulates Caspase Activity in Degenerating Axons Cell Reports. Aug, 2013 | Pubmed ID: 23954782 Interaction and Antagonistic Roles of NF-κB and Hes6 in the Regulation of Cortical Neurogenesis Molecular and Cellular Biology. Jul, 2013 | Pubmed ID: 23689134 Wengen, the Sole Tumour Necrosis Factor Receptor in Drosophila, Collaborates with Moesin to Control Photoreceptor Axon Targeting During Development PloS One. 2013 | Pubmed ID: 23544124 ASPP1/2 Regulate P53-dependent Death of Retinal Ganglion Cells Through PUMA and Fas/CD95 Activation in Vivo The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2013 | Pubmed ID: 23365256 An Inactivating Caspase 11 Passenger Mutation Originating from the 129 Murine Strain in Mice Targeted for C-IAP1 The Biochemical Journal. Apr, 2012 | Pubmed ID: 22332634 Developing a Methodology for Carbon Isotope Analysis of Lacustrine Diatoms Rapid Communications in Mass Spectrometry : RCM. Jun, 2011 | Pubmed ID: 21594931 Trk-dependent ADAM17 Activation Facilitates Neurotrophin Survival Signaling FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2011 | Pubmed ID: 21411748 Stress-induced Expression of the P75 Neurotrophin Receptor is Regulated by O-GlcNAcylation of the Sp1 Transcription Factor Journal of Neurochemistry. Feb, 2011 | Pubmed ID: 21105874 TRPC Channels Underlie Cholinergic Plateau Potentials and Persistent Activity in Entorhinal Cortex Hippocampus. Apr, 2011 | Pubmed ID: 20082292 The P75NTR Intracellular Domain Generated by Neurotrophin-induced Receptor Cleavage Potentiates Trk Signaling Journal of Cell Science. Jul, 2010 | Pubmed ID: 20530577 LGI1 is a Nogo Receptor 1 Ligand That Antagonizes Myelin-based Growth Inhibition The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2010 | Pubmed ID: 20463223 De Novo Mutations in the Gene Encoding the Synaptic Scaffolding Protein SHANK3 in Patients Ascertained for Schizophrenia Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20385823 ProNGF Induces TNFalpha-dependent Death of Retinal Ganglion Cells Through a P75NTR Non-cell-autonomous Signaling Pathway Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133718 Cellular Inhibitors of Apoptosis CIAP1 and CIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2 Immunity. Jun, 2009 | Pubmed ID: 19464198 Excitotoxic Death of Retinal Neurons in Vivo Occurs Via a Non-cell-autonomous Mechanism The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2009 | Pubmed ID: 19403821 A P75(NTR) Pivoting Paradigm Propels Perspicacity Neuron. Apr, 2009 | Pubmed ID: 19376060 Vasculature Guides Migrating Neuronal Precursors in the Adult Mammalian Forebrain Via Brain-derived Neurotrophic Factor Signaling The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2009 | Pubmed ID: 19339612 Nuclear Factor Kappa B Signaling Regulates Neuronal Morphology and Cocaine Reward The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2009 | Pubmed ID: 19295158 Whither ProBDNF? Nature Neuroscience. Feb, 2009 | Pubmed ID: 19172162 Observations on the Function of Nuclear Factor Kappa B (NF-kappaB) in the Survival of Adult Primary Sensory Neurons After Nerve Injury Molecular and Cellular Neurosciences. Feb, 2009 | Pubmed ID: 19049877 Mutations in the Calcium-related Gene IL1RAPL1 Are Associated with Autism Human Molecular Genetics. Dec, 2008 | Pubmed ID: 18801879 Edar and Troy Signalling Pathways Act Redundantly to Regulate Initiation of Hair Follicle Development Human Molecular Genetics. Nov, 2008 | Pubmed ID: 18689798 Apoptotic Sensitivity of Murine IAP-deficient Cells The Biochemical Journal. Oct, 2008 | Pubmed ID: 18684108 CIAP1 and CIAP2 Facilitate Cancer Cell Survival by Functioning As E3 Ligases That Promote RIP1 Ubiquitination Molecular Cell. Jun, 2008 | Pubmed ID: 18570872 Soluble Adenylyl Cyclase is Not Required for Axon Guidance to Netrin-1 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2008 | Pubmed ID: 18400890 Proneurotrophins Require Endocytosis and Intracellular Proteolysis to Induce TrkA Activation The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18299325 Photic Injury Promotes Cleavage of P75NTR by TACE and Nuclear Trafficking of the P75 Intracellular Domain Molecular and Cellular Neurosciences. Dec, 2007 | Pubmed ID: 17904861 Atmospheric Science. The Monsoon's Past Science (New York, N.Y.). Jun, 2007 | Pubmed ID: 17540892 Something Old, Something New: BDNF-induced Neuron Survival Requires TRPC Channel Function Nature Neuroscience. May, 2007 | Pubmed ID: 17453053 Stabilization of P73 by Nuclear IkappaB Kinase-alpha Mediates Cisplatin-induced Apoptosis The Journal of Biological Chemistry. Jun, 2007 | Pubmed ID: 17452332 Hypo-osmolar Stress Induces P75NTR Expression by Activating Sp1-dependent Transcription The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2007 | Pubmed ID: 17287525 High Affinity Not in the Vicinity? Neuron. Jan, 2007 | Pubmed ID: 17196523 The Epilepsy Gene LGI1 Encodes a Secreted Glycoprotein That Binds to the Cell Surface Human Molecular Genetics. Dec, 2006 | Pubmed ID: 17067999 Ligand-dependent Cleavage of the P75 Neurotrophin Receptor is Necessary for NRIF Nuclear Translocation and Apoptosis in Sympathetic Neurons Neuron. Apr, 2006 | Pubmed ID: 16630834 AEG3482 is an Antiapoptotic Compound That Inhibits Jun Kinase Activity and Cell Death Through Induced Expression of Heat Shock Protein 70 Chemistry & Biology. Feb, 2006 | Pubmed ID: 16492569 Tumor Necrosis Factor-alpha Triggers Mucus Production in Airway Epithelium Through an IkappaB Kinase Beta-dependent Mechanism The Journal of Biological Chemistry. Oct, 2005 | Pubmed ID: 16123045 P75 Neurotrophin Receptor Reduces Ligand-induced Trk Receptor Ubiquitination and Delays Trk Receptor Internalization and Degradation EMBO Reports. Oct, 2005 | Pubmed ID: 16113645 Getting RIP'd Stunts Your Growth Neuron. Jun, 2005 | Pubmed ID: 15953410 Nuclear Factor-kappaB Induced by Doxorubicin is Deficient in Phosphorylation and Acetylation and Represses Nuclear Factor-kappaB-dependent Transcription in Cancer Cells Cancer Research. May, 2005 | Pubmed ID: 15899819 Characterization of the C-Jun N-terminal Kinase-BimEL Signaling Pathway in Neuronal Apoptosis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2004 | Pubmed ID: 15470142 TRAF6-dependent NF-kB Transcriptional Activity During Mouse Development Developmental Dynamics : an Official Publication of the American Association of Anatomists. Sep, 2004 | Pubmed ID: 15305292 P75NTR is Positively Promiscuous: Novel Partners and New Insights Neuron. May, 2004 | Pubmed ID: 15157416 Protein Kinase A Activation Promotes Plasma Membrane Insertion of DCC from an Intracellular Pool: A Novel Mechanism Regulating Commissural Axon Extension The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2004 | Pubmed ID: 15044543 A Pro-apoptotic Fragment of the P75 Neurotrophin Receptor is Expressed in P75NTRExonIV Null Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2004 | Pubmed ID: 14985432 The P75 Neurotrophin Receptor: Multiple Interactors and Numerous Functions Progress in Brain Research. 2004 | Pubmed ID: 14699954 Apoptosis Induced by P75NTR Overexpression Requires Jun Kinase-dependent Phosphorylation of Bad The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2003 | Pubmed ID: 14673001 K252a and CEP1347 Are Neuroprotective Compounds That Inhibit Mixed-lineage Kinase-3 and Induce Activation of Akt and ERK The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12388555 NRAGE, a P75 Neurotrophin Receptor-interacting Protein, Induces Caspase Activation and Cell Death Through a JNK-dependent Mitochondrial Pathway The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12376548 Constitutive Nuclear Factor-kappa B Activity is Required for Central Neuron Survival The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2002 | Pubmed ID: 12351721 Expression Analysis of a Novel P75(NTR) Signaling Protein, Which Regulates Cell Cycle Progression and Apoptosis Mechanisms of Development. Sep, 2002 | Pubmed ID: 12204258 Neurotrophin Signaling Through the P75 Neurotrophin Receptor Progress in Neurobiology. Jun, 2002 | Pubmed ID: 12169297 Retrograde Signaling by the Neurotrophins Follows a Well-worn Trk Trends in Neurosciences. Aug, 2002 | Pubmed ID: 12127743 The MAGE Proteins: Emerging Roles in Cell Cycle Progression, Apoptosis, and Neurogenetic Disease Journal of Neuroscience Research. Mar, 2002 | Pubmed ID: 11891783 Production and Isolation of Axons from Sensory Neurons for Biochemical Analysis Using Porous Filters Nicolas Unsain1, Kristen N. Heard1, Julia M. Higgins1, Philip A. Barker1 1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University JoVE 51795 Neuroscience
Production and Isolation of Axons from Sensory Neurons for Biochemical Analysis Using Porous Filters Nicolas Unsain1, Kristen N. Heard1, Julia M. Higgins1, Philip A. Barker1 1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University JoVE 51795 Neuroscience