Piotr E. Marszalek Mechanical Engineering and Materials Science Duke University Biography Publications Institution JoVE Articles Piotr E. Marszalek has not added a biography. If you are Piotr E. Marszalek and would like to personalize this page please email our Author Liaison for assistance. Publications Unraveling the Mechanical Unfolding Pathways of a Multidomain Protein: Phosphoglycerate Kinase Biophysical Journal. Jul, 2018 | Pubmed ID: 29972811 AFM-Based Single-Molecule Force Spectroscopy of Proteins Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29956225 Endonuclease-independent DNA Mismatch Repair Processes on the Lagging Strand DNA Repair. 08, 2018 | Pubmed ID: 29929046 Relevance of the Speed and Direction of Pulling in Simple Modular Proteins Journal of Chemical Theory and Computation. Jun, 2018 | Pubmed ID: 29771510 Warhammers for Peaceful Times Biophysical Journal. 01, 2018 | Pubmed ID: 29320677 Competing Pathways and Multiple Folding Nuclei in a Large Multidomain Protein, Luciferase Biophysical Journal. May, 2017 | Pubmed ID: 28494954 A 'Semi-Protected Oligonucleotide Recombination' Assay for DNA Mismatch Repair in Vivo Suggests Different Modes of Repair for Lagging Strand Mismatches Nucleic Acids Research. May, 2017 | Pubmed ID: 28053122 Can Dissipative Properties of Single Molecules Be Extracted from a Force Spectroscopy Experiment? Biophysical Journal. Sep, 2016 | Pubmed ID: 27653475 Single-molecule Force Spectroscopy Reveals the Calcium Dependence of the Alternative Conformations in the Native State of a βγ-Crystallin Protein The Journal of Biological Chemistry. 08, 2016 | Pubmed ID: 27378818 Modular, Nondegenerate Polyprotein Scaffolds for Atomic Force Spectroscopy Biomacromolecules. 07, 2016 | Pubmed ID: 27276010 Structure and Specificity of the RNA-guided Endonuclease Cas9 During DNA Interrogation, Target Binding and Cleavage Nucleic Acids Research. Mar, 2016 | Pubmed ID: 26578578 Atomic Force Microscopy Captures the Initiation of Methyl-directed DNA Mismatch Repair DNA Repair. Nov, 2015 | Pubmed ID: 26466357 Structure and Specificity of the RNA-guided Endonuclease Cas9 During DNA Interrogation, Target Binding and Cleavage Nucleic Acids Research. Oct, 2015 | Pubmed ID: 26384421 Direct Observation of Multimer Stabilization in the Mechanical Unfolding Pathway of a Protein Undergoing Oligomerization ACS Nano. Feb, 2015 | Pubmed ID: 25639698 Capturing the Mechanical Unfolding Pathway of a Large Protein with Coiled-coil Probes Angewandte Chemie (International Ed. in English). Dec, 2014 | Pubmed ID: 25339429 Chaperones Rescue Luciferase Folding by Separating Its Domains The Journal of Biological Chemistry. Oct, 2014 | Pubmed ID: 25160632 Unraveling the Mysteries of Chaperone Interactions of the Myosin Head Biophysical Journal. Aug, 2014 | Pubmed ID: 25099791 Single Molecule Mechanical Manipulation for Studying Biological Properties of Proteins, DNA, and Sugars Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. May-Jun, 2014 | Pubmed ID: 24347439 Improving Single Molecule Force Spectroscopy Through Automated Real-time Data Collection and Quantification of Experimental Conditions Ultramicroscopy. Jan, 2014 | Pubmed ID: 24001740 Origin of Overstretching Transitions in Single-stranded Nucleic Acids Physical Review Letters. Nov, 2013 | Pubmed ID: 24237568 Effects of Ligand Binding on the Mechanical Properties of Ankyrin Repeat Protein Gankyrin PLoS Computational Biology. 2013 | Pubmed ID: 23341763 Atomic Force Microscopy Captures Folded Ribosome Bound Nascent Chains Chemical Communications (Cambridge, England). Dec, 2012 | Pubmed ID: 23051696 Mutation of Conserved Histidines Alters Tertiary Structure and Nanomechanics of Consensus Ankyrin Repeats The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22514283 Mechanical Anisotropy of Ankyrin Repeats Biophysical Journal. Mar, 2012 | Pubmed ID: 22404934 Stretching Single Polysaccharides and Proteins Using Atomic Force Microscopy Chemical Society Reviews. May, 2012 | Pubmed ID: 22331199 A Nanoscale Force Probe for Gauging Intermolecular Interactions Angewandte Chemie (International Ed. in English). Feb, 2012 | Pubmed ID: 22253141 Nanomechanics of Streptavidin Hubs for Molecular Materials Advanced Materials (Deerfield Beach, Fla.). Dec, 2011 | Pubmed ID: 22102445 Atomic Force Microscopy Captures MutS Tetramers Initiating DNA Mismatch Repair The EMBO Journal. Jun, 2011 | Pubmed ID: 21666597 Inhibitor Binding Increases the Mechanical Stability of Staphylococcal Nuclease Biophysical Journal. Feb, 2011 | Pubmed ID: 21320455 Full Reconstruction of a Vectorial Protein Folding Pathway by Atomic Force Microscopy and Molecular Dynamics Simulations The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 20870713 Separating DNA with Different Topologies by Atomic Force Microscopy in Comparison with Gel Electrophoresis The Journal of Physical Chemistry. B. Sep, 2010 | Pubmed ID: 20799746 Fast and Forceful Refolding of Stretched Alpha-helical Solenoid Proteins Biophysical Journal. Jun, 2010 | Pubmed ID: 20550922 Mechanical Unfolding of an Ankyrin Repeat Protein Biophysical Journal. Apr, 2010 | Pubmed ID: 20371329 Equilibrium Sampling for Biomolecules Under Mechanical Tension Biophysical Journal. Feb, 2010 | Pubmed ID: 20159170 Nanomechanical Fingerprints of Gamma Radiation Damage to DNA Journal of Nanoscience and Nanotechnology. Dec, 2009 | Pubmed ID: 19908788 Detecting Solvent-driven Transitions of Poly(A) to Double-stranded Conformations by Atomic Force Microscopy Biophysical Journal. Apr, 2009 | Pubmed ID: 19348773 UVA Generates Pyrimidine Dimers in DNA Directly Biophysical Journal. Feb, 2009 | Pubmed ID: 19186150 Minimizing Pulling Geometry Errors in Atomic Force Microscope Single Molecule Force Spectroscopy Biophysical Journal. Oct, 2008 | Pubmed ID: 18641069 Nanoscale Detection of Ionizing Radiation Damage to DNA by Atomic Force Microscopy Small (Weinheim an Der Bergstrasse, Germany). Feb, 2008 | Pubmed ID: 18247386 Measuring Protein Mechanics by Atomic Force Microscopy CSH Protocols. Dec, 2007 | Pubmed ID: 21357003 Measuring Polysaccharide Mechanics by Atomic Force Microscopy CSH Protocols. Dec, 2007 | Pubmed ID: 21357002 Construction of a Single-axis Molecular Puller for Measuring Polysaccharide and Protein Mechanics by Atomic Force Microscopy CSH Protocols. Dec, 2007 | Pubmed ID: 21357001 Direct Measurements of Base Stacking Interactions in DNA by Single-molecule Atomic-force Spectroscopy Physical Review Letters. Jul, 2007 | Pubmed ID: 17678193 Detecting Ultraviolet Damage in Single DNA Molecules by Atomic Force Microscopy Biophysical Journal. Sep, 2007 | Pubmed ID: 17483180 Nanomechanical Fingerprints of UV Damage to DNA Small (Weinheim an Der Bergstrasse, Germany). May, 2007 | Pubmed ID: 17393552 Pulling Geometry-induced Errors in Single Molecule Force Spectroscopy Measurements Biophysical Journal. May, 2007 | Pubmed ID: 17324999 A Stochastic, Cantilever Approach to the Evaluation of Solution Phase Thermodynamic Quantities Proceedings of the National Academy of Sciences of the United States of America. Feb, 2007 | Pubmed ID: 17307881 Direct Detection of the Formation of V-amylose Helix by Single Molecule Force Spectroscopy Journal of the American Chemical Society. Jul, 2006 | Pubmed ID: 16848474 Simulating Force-induced Conformational Transitions in Polysaccharides with the SMD Replica Exchange Method Biophysical Journal. Sep, 2006 | Pubmed ID: 16829559 Identification of Sugar Isomers by Single-molecule Force Spectroscopy Journal of the American Chemical Society. May, 2006 | Pubmed ID: 16637601 Nanospring Behaviour of Ankyrin Repeats Nature. Mar, 2006 | Pubmed ID: 16415852 Direct Detection of Inter-residue Hydrogen Bonds in Polysaccharides by Single-molecule Force Spectroscopy Angewandte Chemie (International Ed. in English). Apr, 2005 | Pubmed ID: 15786525 Molecular Dynamics Simulations of Forced Conformational Transitions in 1,6-linked Polysaccharides Biophysical Journal. Sep, 2004 | Pubmed ID: 15345528 Elastic Properties of Single Amylose Chains in Water: a Quantum Mechanical and AFM Study Journal of the American Chemical Society. Jul, 2004 | Pubmed ID: 15264836 Nanomechanical Control of Glucopyranose Rotamers Journal of the American Chemical Society. May, 2004 | Pubmed ID: 15149204 The Force-driven Conformations of Heparin Studied with Single Molecule Force Microscopy Biophysical Journal. Oct, 2003 | Pubmed ID: 14507732 Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope Zackary N. Scholl1, Qing Li1, Eric Josephs1, Dimitra Apostolidou1, Piotr E. Marszalek1 1Mechanical Engineering and Materials Science, Duke University JoVE 55989 Biochemistry
Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope Zackary N. Scholl1, Qing Li1, Eric Josephs1, Dimitra Apostolidou1, Piotr E. Marszalek1 1Mechanical Engineering and Materials Science, Duke University JoVE 55989 Biochemistry