Pramod Upadhyaya Masonic Cancer Center University of Minnesota Biography Publications Institution JoVE Articles Pramod Upadhyaya has not added a biography. If you are Pramod Upadhyaya and would like to personalize this page please email our Author Liaison for assistance. Publications Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O(6)-Methylguanine and Lung Tumor in A/J Mice Journal of Medicinal Chemistry. Sep, 2017 | Pubmed ID: 28806079 Investigation of the Presence in Human Urine of Mercapturic Acids Derived from Phenanthrene, a Representative Polycyclic Aromatic Hydrocarbon Chemico-biological Interactions. Aug, 2017 | Pubmed ID: 28693886 Identification of 4-(3-Pyridyl)-4-oxobutyl-2'-deoxycytidine Adducts Formed in the Reaction of DNA with 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone: A Chemically Activated Form of Tobacco-Specific Carcinogens ACS Omega. Mar, 2017 | Pubmed ID: 28393135 Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines Chemical Research in Toxicology. Dec, 2016 | Pubmed ID: 27989137 Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O(6)-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice Chemical Research in Toxicology. Nov, 2016 | Pubmed ID: 27728767 Harnessing the Power of Cruciferous Vegetables: Developing a Biomarker for Brassica Vegetable Consumption Using Urinary 3,3'-Diindolylmethane Cancer Prevention Research (Philadelphia, Pa.). Oct, 2016 | Pubmed ID: 27538743 Honokiol Suppresses Lung Tumorigenesis by Targeting EGFR and Its Downstream Effectors Oncotarget. Sep, 2016 | Pubmed ID: 27458163 Multiclass Carcinogenic DNA Adduct Quantification in Formalin-Fixed Paraffin-Embedded Tissues by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry Analytical Chemistry. May, 2016 | Pubmed ID: 27043225 Clinical Trial of 2-Phenethyl Isothiocyanate As an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers Cancer Prevention Research (Philadelphia, Pa.). 05, 2016 | Pubmed ID: 26951845 Research on Cruciferous Vegetables, Indole-3-carbinol, and Cancer Prevention: A Tribute to Lee W. Wattenberg Molecular Nutrition & Food Research. Jun, 2016 | Pubmed ID: 26840393 DNA Adduct Formation from Metabolic 5'-Hydroxylation of the Tobacco-Specific Carcinogen N'-Nitrosonornicotine in Human Enzyme Systems and in Rats Chemical Research in Toxicology. Mar, 2016 | Pubmed ID: 26808005 Transcriptome Profiling in Oral Cavity and Esophagus Tissues from (S)-N'-nitrosonornicotine-treated Rats Reveals Candidate Genes Involved in Human Oral Cavity and Esophageal Carcinogenesis Molecular Carcinogenesis. Dec, 2016 | Pubmed ID: 26785143 Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification Drug Metabolism and Disposition: the Biological Fate of Chemicals. Mar, 2016 | Pubmed ID: 26744252 Analysis of O(6)-[4-(3-Pyridyl)-4-oxobut-1-yl]-2'-deoxyguanosine and Other DNA Adducts in Rats Treated with Enantiomeric or Racemic N'-Nitrosonornicotine Chemical Research in Toxicology. Jan, 2016 | Pubmed ID: 26633576 Comprehensive High-Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Chemical Research in Toxicology. Nov, 2015 | Pubmed ID: 26398225 Combinations of Indole-3-carbinol and Silibinin Suppress Inflammation-driven Mouse Lung Tumorigenesis by Modulating Critical Cell Cycle Regulators Carcinogenesis. Jun, 2015 | Pubmed ID: 25896445 RNA-sequencing Studies Identify Genes Differentially Regulated During Inflammation-driven Lung Tumorigenesis and Targeted by Chemopreventive Agents Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]. May, 2015 | Pubmed ID: 25795230 Quantitative Analysis of 3'-hydroxynorcotinine in Human Urine Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco. May, 2015 | Pubmed ID: 25324430 Intranasal Delivery of Liposomal Indole-3-carbinol Improves Its Pulmonary Bioavailability International Journal of Pharmaceutics. Dec, 2014 | Pubmed ID: 25311179 Carcinogenicity and DNA Adduct Formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 Rats Carcinogenesis. Dec, 2014 | Pubmed ID: 25269804 Liquid Chromatography-electrospray Ionization-tandem Mass Spectrometry Quantitation of Urinary [pyridine-D4]4-hydroxy-4-(3-pyridyl)butanoic Acid, a Biomarker of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Metabolic Activation in Smokers Chemical Research in Toxicology. Sep, 2014 | Pubmed ID: 25098652 Dihydromethysticin from Kava Blocks Tobacco Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced Lung Tumorigenesis and Differentially Reduces DNA Damage in A/J Mice Carcinogenesis. Oct, 2014 | Pubmed ID: 25053626 Application of a High-resolution Mass-spectrometry-based DNA Adductomics Approach for Identification of DNA Adducts in Complex Mixtures Analytical Chemistry. Feb, 2014 | Pubmed ID: 24410521 Kava Blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced Lung Tumorigenesis in Association with Reducing O6-methylguanine DNA Adduct in A/J Mice Cancer Prevention Research (Philadelphia, Pa.). Jan, 2014 | Pubmed ID: 24403291 Urinary 3,3'-diindolylmethane: a Biomarker of Glucobrassicin Exposure and Indole-3-carbinol Uptake in Humans Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Feb, 2014 | Pubmed ID: 24357105 Quantitation of Pyridyloxobutyl-DNA Adducts in Tissues of Rats Treated Chronically with (R)- or (S)-N'-nitrosonornicotine (NNN) in a Carcinogenicity Study Chemical Research in Toxicology. Oct, 2013 | Pubmed ID: 24001146 Contamination of Deconjugation Enzymes Derived from Helix Pomatia with the Plant Bioactive Compounds 3,3'-diindolylmethane, 5-methoxypsoralen, and 8-methoxypsoralen Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Dec, 2013 | Pubmed ID: 23994708 (S)-N'-Nitrosonornicotine, a Constituent of Smokeless Tobacco, is a Powerful Oral Cavity Carcinogen in Rats Carcinogenesis. Sep, 2013 | Pubmed ID: 23671129 DNA Adducts in Aldehyde Dehydrogenase-positive Lung Stem Cells of A/J Mice Treated with the Tobacco Specific Lung Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Chemical Research in Toxicology. Apr, 2013 | Pubmed ID: 23477619 Chemoprevention of Lung Tumorigenesis by Intranasally Administered Diindolylmethane in A/J Mice Carcinogenesis. Apr, 2013 | Pubmed ID: 23239747 Levels of (S)-N'-nitrosonornicotine in U.S. Tobacco Products Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco. Jul, 2013 | Pubmed ID: 23212437 Formation and Repair of Pyridyloxobutyl DNA Adducts and Their Relationship to Tumor Yield in A/J Mice Chemical Research in Toxicology. Oct, 2012 | Pubmed ID: 22928598 The Sphingolipid Degradation Product Trans-2-hexadecenal Forms Adducts with DNA Biochemical and Biophysical Research Communications. Jul, 2012 | Pubmed ID: 22727907 Phenanthrene Metabolism in Smokers: Use of a Two-step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation The Journal of Pharmacology and Experimental Therapeutics. Sep, 2012 | Pubmed ID: 22674470 Indole-3-carbinol Inhibited Tobacco Smoke Carcinogen-induced Lung Adenocarcinoma in A/J Mice when Administered During the Post-initiation or Progression Phase of Lung Tumorigenesis Cancer Letters. Dec, 2011 | Pubmed ID: 21767909 Lung Tumorigenesis Suppressing Effects of a Commercial Kava Extract and Its Selected Compounds in A/J Mice The American Journal of Chinese Medicine. 2011 | Pubmed ID: 21721153 Metabolism of [D10]phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration The Journal of Pharmacology and Experimental Therapeutics. Jul, 2011 | Pubmed ID: 21515812 Evolution of Research on the DNA Adduct Chemistry of N-nitrosopyrrolidine and Related Aldehydes Chemical Research in Toxicology. Jun, 2011 | Pubmed ID: 21480629 Enhanced Inhibition of Lung Adenocarcinoma by Combinatorial Treatment with Indole-3-carbinol and Silibinin in A/J Mice Carcinogenesis. Apr, 2011 | Pubmed ID: 21273642 Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides Chemical Research in Toxicology. Feb, 2011 | Pubmed ID: 21184614 Inhibition of Lung Carcinogenesis and Critical Cancer-related Signaling Pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, Indole-3-carbinol and Myo-inositol, Alone and in Combination Carcinogenesis. Sep, 2010 | Pubmed ID: 20603442 Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes Drug Metabolism and Disposition: the Biological Fate of Chemicals. Sep, 2010 | Pubmed ID: 20547966 Formation and Distribution of NNK Metabolites in an Isolated Perfused Rat Lung Drug Metabolism and Disposition: the Biological Fate of Chemicals. May, 2010 | Pubmed ID: 20159989 Inhibition of Vinyl Carbamate-induced Pulmonary Adenocarcinoma by Indole-3-carbinol and Myo-inositol in A/J Mice Carcinogenesis. Feb, 2010 | Pubmed ID: 19625346 Analysis of Pyridyloxobutyl and Pyridylhydroxybutyl DNA Adducts in Extrahepatic Tissues of F344 Rats Treated Chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol Chemical Research in Toxicology. May, 2009 | Pubmed ID: 19358518 Comparative Levels of O6-methylguanine, Pyridyloxobutyl-, and Pyridylhydroxybutyl-DNA Adducts in Lung and Liver of Rats Treated Chronically with the Tobacco-specific Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jun, 2009 | Pubmed ID: 19324941 Dose-dependent Inhibition of Tobacco Smoke Carcinogen-induced Lung Tumorigenesis in A/J Mice by Indole-3-carbinol Cancer Prevention Research (Philadelphia, Pa.). Dec, 2008 | Pubmed ID: 19139007 Chemopreventive Effect of Kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Plus Benzo[a]pyrene-induced Lung Tumorigenesis in A/J Mice Cancer Prevention Research (Philadelphia, Pa.). Nov, 2008 | Pubmed ID: 19138990 Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and Myo-inositol Inhibit Tobacco Carcinogen-induced Lung Adenocarcinoma in Mice Cancer Prevention Research (Philadelphia, Pa.). Sep, 2008 | Pubmed ID: 19138972 Identification of Adducts Formed in the Reactions of 5'-acetoxy-N'-nitrosonornicotine with Deoxyadenosine, Thymidine, and DNA Chemical Research in Toxicology. Nov, 2008 | Pubmed ID: 18821782 Expression Différentielle Des MicroARN Dans Les Premières Phases De Transformation Néoplasique Dans Les Poumons De Rats F344 Traités Chroniquement Avec Le Cancérogène 4 Tabac - (méthylnitrosamino) -1 - (3-pyridyl)-1-butanone Carcinogenesis. Dec, 2008 | Pubmed ID: 18780894 Extensive Metabolic Activation of the Tobacco-specific Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in Smokers Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Jul, 2008 | Pubmed ID: 18628430 Quantitation of Pyridylhydroxybutyl-DNA Adducts in Liver and Lung of F-344 Rats Treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol Chemical Research in Toxicology. Jul, 2008 | Pubmed ID: 18570389 Formation of Formaldehyde Adducts in the Reactions of DNA and Deoxyribonucleosides with Alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA) Chemical Research in Toxicology. Mar, 2008 | Pubmed ID: 18205321 Chemopreventive Agents Modulate the Protein Expression Profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Plus Benzo[a]pyrene-induced Lung Tumors in A/J Mice Carcinogenesis. Mar, 2008 | Pubmed ID: 18192687 Indole-3-carbinol Inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Plus Benzo(a)pyrene-induced Lung Tumorigenesis in A/J Mice and Modulates Carcinogen-induced Alterations in Protein Levels Cancer Research. Jul, 2007 | Pubmed ID: 17616712 Investigation of the Reaction of Myosmine with Sodium Nitrite in Vitro and in Rats Chemical Research in Toxicology. Mar, 2007 | Pubmed ID: 17291014 Quantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-L-cysteine in Human Urine: Comparison with Glutathione-S-transferase Genotypes in Smokers Chemical Research in Toxicology. Sep, 2006 | Pubmed ID: 16978029 Identification of Adducts Formed in the Reaction of 5'-acetoxy-N'-nitrosonornicotine with Deoxyguanosine and DNA Chemical Research in Toxicology. Mar, 2006 | Pubmed ID: 16544948 Identification of O2-substituted Pyrimidine Adducts Formed in Reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- Amino)-1-(3-pyridyl)-1-butanol with DNA Chemical Research in Toxicology. May, 2004 | Pubmed ID: 15144215 Stereoselective Metabolism and Tissue Retention in Rats of the Individual Enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), Metabolites of the Tobacco-specific Nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Carcinogenesis. Jul, 2004 | Pubmed ID: 14988218 Endogenous 5-methylcytosine Protects Neighboring Guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the Tobacco Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Biochemistry. Jan, 2004 | Pubmed ID: 14717610 Characterization of N-glucuronidation of the Lung Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in Human Liver: Importance of UDP-glucuronosyltransferase 1A4 Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jan, 2004 | Pubmed ID: 14709623 Stereospecific Deuterium Substitution Attenuates the Tumorigenicity and Metabolism of the Tobacco-specific Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Chemical Research in Toxicology. Jun, 2003 | Pubmed ID: 12807363 Identification of Adducts Formed by Pyridyloxobutylation of Deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a Chemically Activated Form of Tobacco Specific Carcinogens Chemical Research in Toxicology. May, 2003 | Pubmed ID: 12755591 Effects of Benzyl Isothiocyanate and 2-phenethyl Isothiocyanate on Benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Metabolism in F-344 Rats Carcinogenesis. Mar, 2003 | Pubmed ID: 12663513 Identification of Adducts Produced by the Reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with Deoxyguanosine and DNA Chemical Research in Toxicology. Feb, 2003 | Pubmed ID: 12588189 Benzyl Isothiocyanate: an Effective Inhibitor of Polycyclic Aromatic Hydrocarbon Tumorigenesis in A/J Mouse Lung Cancer Letters. Dec, 2002 | Pubmed ID: 12359355 Metabolism and Pharmacokinetics of N'-nitrosonornicotine in the Patas Monkey Drug Metabolism and Disposition: the Biological Fate of Chemicals. Oct, 2002 | Pubmed ID: 12228188 Inhibition of Lung Tumorigenesis in A/J Mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and Myo-inositol, Individually and in Combination Carcinogenesis. Sep, 2002 | Pubmed ID: 12189187 Effects of Benzyl Isothiocyanate and Phenethyl Isothiocyanate on DNA Adduct Formation by a Mixture of Benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J Mouse Lung Carcinogenesis. Sep, 2002 | Pubmed ID: 12189184 Analysis of N- and O-glucuronides of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in Human Urine Chemical Research in Toxicology. Apr, 2002 | Pubmed ID: 11952341 Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in Bile Duct-cannulated Rats: Stereoselective Metabolism and Tissue Distribution Carcinogenesis. Jan, 2002 | Pubmed ID: 11756238 Une méthode générale pour la détection des Nitrosamide Formation du métabolisme In Vitro des Nitrosamines par Cytochrome P450s Erik S. Carlson1,2, Pramod Upadhyaya2, Stephen S. Hecht2 1Department of Pharmacology, University of Minnesota, 2Masonic Cancer Center, University of Minnesota JoVE 56312 Cancer Research
Une méthode générale pour la détection des Nitrosamide Formation du métabolisme In Vitro des Nitrosamines par Cytochrome P450s Erik S. Carlson1,2, Pramod Upadhyaya2, Stephen S. Hecht2 1Department of Pharmacology, University of Minnesota, 2Masonic Cancer Center, University of Minnesota JoVE 56312 Cancer Research