Punam Malik Division of Experimental Hematology and Cancer Biology Cincinnati Children's Hospital Medical Center Biography Publications Institution JoVE Articles Punam Malik has not added a biography. If you are Punam Malik and would like to personalize this page please email our Author Liaison for assistance. Publications Foamy Virus Vector Carries a Strong Insulator in Its Long Terminal Repeat Which Reduces Its Genotoxic Potential Journal of Virology. Jan, 2018 | Pubmed ID: 29046446 Placenta Growth Factor Mediated Gene Regulation in Sickle Cell Disease Blood Reviews. Jan, 2018 | Pubmed ID: 28823762 Erratum To: Patient Perspectives on Gene Transfer Therapy for Sickle Cell Disease Advances in Therapy. Sep, 2017 | Pubmed ID: 28770518 Patient Perspectives on Gene Transfer Therapy for Sickle Cell Disease Advances in Therapy. Aug, 2017 | Pubmed ID: 28717861 Losartan for the Nephropathy of Sickle Cell Anemia: A Phase-2, Multicenter Trial American Journal of Hematology. Sep, 2017 | Pubmed ID: 28589652 Association Between Diffuse Myocardial Fibrosis and Diastolic Dysfunction in Sickle Cell Anemia Blood. 07, 2017 | Pubmed ID: 28507082 A Reappraisal of the Mechanisms Underlying the Cardiac Complications of Sickle Cell Anemia Pediatric Blood & Cancer. Nov, 2017 | Pubmed ID: 28453224 KIT Blockade is Sufficient for Donor Hematopoietic Stem Cell Engraftment in Fanconi Anemia Mice Blood. 02, 2017 | Pubmed ID: 27998889 CRISPR/Cas9 in Allergic and Immunologic Diseases Expert Review of Clinical Immunology. Jan, 2017 | Pubmed ID: 27687572 Purification of Baculovirus Vectors Using Heparin Affinity Chromatography Molecular Therapy. Methods & Clinical Development. 2016 | Pubmed ID: 27933303 Gene Therapy for Hemoglobin Disorders - a Mini-review Journal of Rare Diseases Research & Treatment. 2016 | Pubmed ID: 27891535 Production and Purification of High-titer Foamy Virus Vector for the Treatment of Leukocyte Adhesion Deficiency Molecular Therapy. Methods & Clinical Development. 2016 | Pubmed ID: 27722179 The Potential of Gene Therapy Approaches for the Treatment of Hemoglobinopathies: Achievements and Challenges Therapeutic Advances in Hematology. Oct, 2016 | Pubmed ID: 27695619 Activated Transcription Factor 3 in Association with Histone Deacetylase 6 Negatively Regulates MicroRNA 199a2 Transcription by Chromatin Remodeling and Reduces Endothelin-1 Expression Molecular and Cellular Biology. Nov, 2016 | Pubmed ID: 27573019 Sickle Cell Anemia Mice Develop a Unique Cardiomyopathy with Restrictive Physiology Proceedings of the National Academy of Sciences of the United States of America. 08, 2016 | Pubmed ID: 27503873 High Level of Perforin Expression Is Required for Effective Correction of Hemophagocytic Lymphohistiocytosis Human Gene Therapy. 10, 2016 | Pubmed ID: 27471778 Gene Therapy for Hemoglobinopathies: Tremendous Successes and Remaining Caveats Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2016 | Pubmed ID: 27081721 Cardiomyopathy With Restrictive Physiology in Sickle Cell Disease JACC. Cardiovascular Imaging. Mar, 2016 | Pubmed ID: 26897687 Placenta Growth Factor Augments Airway Hyperresponsiveness Via Leukotrienes and IL-13 The Journal of Clinical Investigation. Feb, 2016 | Pubmed ID: 26690703 Peroxisome Proliferator-activated Receptor-α-mediated Transcription of MiR-301a and MiR-454 and Their Host Gene SKA2 Regulates Endothelin-1 and PAI-1 Expression in Sickle Cell Disease Bioscience Reports. Oct, 2015 | Pubmed ID: 26460070 Genetic Diminution of Circulating Prothrombin Ameliorates Multiorgan Pathologies in Sickle Cell Disease Mice Blood. Oct, 2015 | Pubmed ID: 26286849 Erythropoietin-mediated Expression of Placenta Growth Factor is Regulated Via Activation of Hypoxia-inducible Factor-1α and Post-transcriptionally by MiR-214 in Sickle Cell Disease The Biochemical Journal. Jun, 2015 | Pubmed ID: 25876995 Vasculopathy-associated Hyperangiotensinemia Mobilizes Haematopoietic Stem Cells/progenitors Through Endothelial AT₂R and Cytoskeletal Dysregulation Nature Communications. 2015 | Pubmed ID: 25574809 Perforin Gene Transfer into Hematopoietic Stem Cells Improves Immune Dysregulation in Murine Models of Perforin Deficiency Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2015 | Pubmed ID: 25523759 MicroRNA 648 Targets ET-1 MRNA and is Cotranscriptionally Regulated with MICAL3 by PAX5 Molecular and Cellular Biology. Feb, 2015 | Pubmed ID: 25403488 Pigtailed Macaques As a Model to Study Long-term Safety of Lentivirus Vector-mediated Gene Therapy for Hemoglobinopathies Molecular Therapy. Methods & Clinical Development. 2014 | Pubmed ID: 26052523 Peroxisome Proliferator-activated Receptor-α-mediated Transcription of MiR-199a2 Attenuates Endothelin-1 Expression Via Hypoxia-inducible Factor-1α The Journal of Biological Chemistry. Dec, 2014 | Pubmed ID: 25389292 Pulmonary Macrophage Transplantation Therapy Nature. Oct, 2014 | Pubmed ID: 25274301 Gene Therapy for Hemoglobinopathies: the State of the Field and the Future Hematology/oncology Clinics of North America. Apr, 2014 | Pubmed ID: 24589262 Use of Induced Pluripotent Stem Cells to Recapitulate Pulmonary Alveolar Proteinosis Pathogenesis American Journal of Respiratory and Critical Care Medicine. Jan, 2014 | Pubmed ID: 24279752 G9a/GLP-dependent Histone H3K9me2 Patterning During Human Hematopoietic Stem Cell Lineage Commitment Genes & Development. Nov, 2012 | Pubmed ID: 23105005 Stem Cell Selection in Vivo Using Foamy Vectors Cures Canine Pyruvate Kinase Deficiency PloS One. 2012 | Pubmed ID: 23028826 Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease: an Update on Management TheScientificWorldJournal. 2012 | Pubmed ID: 22924029 Biomarkers for Early Detection of Sickle Nephropathy American Journal of Hematology. Jul, 2011 | Pubmed ID: 21630304 Involvement of MiR-30c and MiR-301a in Immediate Induction of Plasminogen Activator Inhibitor-1 by Placental Growth Factor in Human Pulmonary Endothelial Cells The Biochemical Journal. Mar, 2011 | Pubmed ID: 21175428 Genetic Therapy for Beta-thalassemia: from the Bench to the Bedside Hematology. American Society of Hematology. Education Program. 2010 | Pubmed ID: 21239833 Therapy for Beta-globinopathies: a Brief Review and Determinants for Successful and Safe Correction Annals of the New York Academy of Sciences. Aug, 2010 | Pubmed ID: 20712770 Genetic Correction of Sickle Cell Anemia and Beta-thalassemia: Progress and New Perspective TheScientificWorldJournal. Apr, 2010 | Pubmed ID: 20419277 Placenta Growth Factor (PlGF), a Novel Inducer of Plasminogen Activator Inhibitor-1 (PAI-1) in Sickle Cell Disease (SCD) The Journal of Biological Chemistry. May, 2010 | Pubmed ID: 20351105 High Levels of Placenta Growth Factor in Sickle Cell Disease Promote Pulmonary Hypertension Blood. Jul, 2010 | Pubmed ID: 20335221 Reprogramming Erythroid Cells for Lysosomal Enzyme Production Leads to Visceral and CNS Cross-correction in Mice with Hurler Syndrome Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009 | Pubmed ID: 19903883 The 3' Region of the Chicken Hypersensitive Site-4 Insulator Has Properties Similar to Its Core and is Required for Full Insulator Activity PloS One. Sep, 2009 | Pubmed ID: 19746166 Genotoxic Potential of Lineage-specific Lentivirus Vectors Carrying the Beta-globin Locus Control Region Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2009 | Pubmed ID: 19707188 A Novel Human Gamma-globin Gene Vector for Genetic Correction of Sickle Cell Anemia in a Humanized Sickle Mouse Model: Critical Determinants for Successful Correction Blood. Aug, 2009 | Pubmed ID: 19474450 Mechanism of Reduction in Titers from Lentivirus Vectors Carrying Large Inserts in the 3'LTR Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2009 | Pubmed ID: 19384292 Placenta Growth Factor Induces 5-lipoxygenase-activating Protein to Increase Leukotriene Formation in Sickle Cell Disease Blood. Jan, 2009 | Pubmed ID: 18945963 Nf1 Mutation Expands an EGFR-dependent Peripheral Nerve Progenitor That Confers Neurofibroma Tumorigenic Potential Cell Stem Cell. Dec, 2008 | Pubmed ID: 19041782 Placenta Growth Factor Augments Endothelin-1 and Endothelin-B Receptor Expression Via Hypoxia-inducible Factor-1 Alpha Blood. Aug, 2008 | Pubmed ID: 18411415 Efficient Transduction of Pigtailed Macaque Hematopoietic Repopulating Cells with HIV-based Lentiviral Vectors Blood. Jun, 2008 | Pubmed ID: 18388180 Produktion og oprensning af Baculovirus for genterapi ansøgning Md Nasimuzzaman1,2, Johannes C.M. van der Loo1,2,3, Punam Malik1,2 1Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, 2University of Cincinnati College of Medicine, 3Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia JoVE 57019 Genetics
Produktion og oprensning af Baculovirus for genterapi ansøgning Md Nasimuzzaman1,2, Johannes C.M. van der Loo1,2,3, Punam Malik1,2 1Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, 2University of Cincinnati College of Medicine, 3Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia JoVE 57019 Genetics