Qun Lu Department of Anatomy and Cell Biology, Brody School of Medicine East Carolina University Biography Publications Institution JoVE Articles Qun Lu has not added a biography. If you are Qun Lu and would like to personalize this page please email our Author Liaison for assistance. Publications Nanoarchitecture and Molecular Interactions of Epithelial Cell Junction Proteins Revealed by Super-resolution Microscopy Annals of the New York Academy of Sciences. Jul, 2022 | Pubmed ID: 35819053 TRPV4: En RhoA To a Cure? BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. 06, 2022 | Pubmed ID: 35441721 The Effect of Exercise on Early Sensorimotor Performance Alterations in the 3xTg-AD Model of Alzheimer's Disease Neuroscience Research. May, 2022 | Pubmed ID: 35033583 Pharmacological Modulators of Small GTPases of Rho Family in Neurodegenerative Diseases Frontiers in Cellular Neuroscience. 2021 | Pubmed ID: 34054432 Selective Axonal Translation of the MRNA Isoform Encoding Prenylated Cdc42 Supports Axon Growth Journal of Cell Science. 04, 2021 | Pubmed ID: 33674450 Intratumor δ-catenin Heterogeneity Driven by Genomic Rearrangement Dictates Growth Factor Dependent Prostate Cancer Progression Oncogene. 05, 2020 | Pubmed ID: 32313227 Tight Junction Protein Claudin-7 Is Essential for Intestinal Epithelial Stem Cell Self-Renewal and Differentiation Cellular and Molecular Gastroenterology and Hepatology. 2020 | Pubmed ID: 31874254 Therapeutic Effect of Y-27632 on Tumorigenesis and Cisplatin-Induced Peripheral Sensory Loss Through RhoA-NF-κB Molecular Cancer Research : MCR. 09, 2019 | Pubmed ID: 31189689 Claudin-7 Modulates Cell-matrix Adhesion That Controls Cell Migration, Invasion and Attachment of Human HCC827 Lung Cancer Cells Oncology Letters. Mar, 2019 | Pubmed ID: 30854065 Inhibition of Cdc42-intersectin Interaction by Small Molecule ZCL367 Impedes Cancer Cell Cycle Progression, Proliferation, Migration, and Tumor Growth Cancer Biology & Therapy. 2019 | Pubmed ID: 30849276 The Effects of Exercise on Hypothalamic Neurodegeneration of Alzheimer's Disease Mouse Model PloS One. 2018 | Pubmed ID: 29293568 Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview Journal of Clinical Medicine. Dec, 2017 | Pubmed ID: 29271928 Rho GTPases As Therapeutic Targets in Alzheimer's Disease Alzheimer's Research & Therapy. Dec, 2017 | Pubmed ID: 29246246 Cdc42 Signaling Pathway Inhibition As a Therapeutic Target in Ras- Related Cancers Current Medicinal Chemistry. 2017 | Pubmed ID: 28571533 Genetic Alterations of δ-catenin/NPRAP/Neurojungin (CTNND2): Functional Implications in Complex Human Diseases Human Genetics. 10, 2016 | Pubmed ID: 27380241 Early Alterations in Blood and Brain RANTES and MCP-1 Expression and the Effect of Exercise Frequency in the 3xTg-AD Mouse Model of Alzheimer's Disease Neuroscience Letters. Jan, 2016 | Pubmed ID: 26547034 A Non-tight Junction Function of Claudin-7-Interaction with Integrin Signaling in Suppressing Lung Cancer Cell Proliferation and Detachment Molecular Cancer. Jun, 2015 | Pubmed ID: 26081244 δ-Catenin, a Wnt/β-catenin Modulator, Reveals Inducible Mutagenesis Promoting Cancer Cell Survival Adaptation and Metabolic Reprogramming Oncogene. Mar, 2015 | Pubmed ID: 24727894 Amelioration of Cisplatin-induced Experimental Peripheral Neuropathy by a Small Molecule Targeting P75 NTR Neurotoxicology. Dec, 2014 | Pubmed ID: 25277379 δ-Catenin As a Potential Cancer Biomarker Pathology International. May, 2014 | Pubmed ID: 24888779 VASP Activation Via the Gα13/RhoA/PKA Pathway Mediates Cucurbitacin-B-induced Actin Aggregation and Cofilin-actin Rod Formation PloS One. 2014 | Pubmed ID: 24691407 Cytotoxicity of Cyclometalated Platinum Complexes Based on Tridentate NCN and CNN-coordinating Ligands: Remarkable Coordination Dependence Journal of Inorganic Biochemistry. May, 2014 | Pubmed ID: 24531534 C-Src-mediated Phosphorylation of δ-catenin Increases Its Protein Stability and the Ability of Inducing Nuclear Distribution of β-catenin Biochimica Et Biophysica Acta. Apr, 2014 | Pubmed ID: 24412473 Claudins in Intestines: Distribution and Functional Significance in Health and Diseases Tissue Barriers. Jul, 2013 | Pubmed ID: 24478939 The Claudin Family of Proteins in Human Malignancy: a Clinical Perspective Cancer Management and Research. Nov, 2013 | Pubmed ID: 24232410 14-3-3É›/ζ Affects the Stability of δ-catenin and Regulates δ-catenin-induced Dendrogenesis FEBS Open Bio. 2013 | Pubmed ID: 23772369 Claudin-7 Increases Chemosensitivity to Cisplatin Through the Upregulation of Caspase Pathway in Human NCI-H522 Lung Cancer Cells Cancer Science. May, 2013 | Pubmed ID: 23433123 Small Molecule Targeting Cdc42-intersectin Interaction Disrupts Golgi Organization and Suppresses Cell Motility Proceedings of the National Academy of Sciences of the United States of America. Jan, 2013 | Pubmed ID: 23284167 δ-Catenin Promotes E-cadherin Processing and Activates β-catenin-mediated Signaling: Implications on Human Prostate Cancer Progression Biochimica Et Biophysica Acta. Jan, 2012 | Pubmed ID: 22261283 Inflammation and Disruption of the Mucosal Architecture in Claudin-7-deficient Mice Gastroenterology. Feb, 2012 | Pubmed ID: 22044670 Claudin-7 Inhibits Human Lung Cancer Cell Migration and Invasion Through ERK/MAPK Signaling Pathway Experimental Cell Research. Aug, 2011 | Pubmed ID: 21641901 Hydroxycamptothecin-loaded Fe3O4 Nanoparticles Induce Human Lung Cancer Cell Apoptosis Through Caspase-8 Pathway Activation and Disrupt Tight Junctions Cancer Science. Jun, 2011 | Pubmed ID: 21435100 Fe3O4 Nanoparticles with Daunorubicin Induce Apoptosis Through Caspase 8-PARP Pathway and Inhibit K562 Leukemia Cell-induced Tumor Growth in Vivo Nanomedicine : Nanotechnology, Biology, and Medicine. Oct, 2011 | Pubmed ID: 21333751 Human Homolog of Drosophila Hairy and Enhancer of Split 1, Hes1, Negatively Regulates δ-catenin (CTNND2) Expression in Cooperation with E2F1 in Prostate Cancer Molecular Cancer. Nov, 2010 | Pubmed ID: 21106062 Alzheimer's Disease-linked Presenilin Mutation (PS1M146L) Induces Filamin Expression and γ-secretase Independent Redistribution Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20847418 δ-Catenin Dysregulation in Cancer: Interactions with E-cadherin and Beyond The Journal of Pathology. Oct, 2010 | Pubmed ID: 20715154 Delta-catenin/NPRAP: A New Member of the Glycogen Synthase Kinase-3beta Signaling Complex That Promotes Beta-catenin Turnover in Neurons Journal of Neuroscience Research. Aug, 2010 | Pubmed ID: 20623542 Pro-oncogenic and Anti-oncogenic Pathways: Opportunities and Challenges of Cancer Therapy Future Oncology (London, England). Apr, 2010 | Pubmed ID: 20373871 Delta-catenin Affects the Localization and Stability of P120-catenin by Competitively Interacting with E-cadherin Molecules and Cells. Mar, 2010 | Pubmed ID: 20108168 Isoform- and Dose-sensitive Feedback Interactions Between Paired Box 6 Gene and Delta-catenin in Cell Differentiation and Death Experimental Cell Research. Apr, 2010 | Pubmed ID: 20074565 Rho Kinase Inhibitor Y-27632 Facilitates Recovery from Experimental Peripheral Neuropathy Induced by Anti-cancer Drug Cisplatin Neurotoxicology. Mar, 2010 | Pubmed ID: 20060419 Renal Salt Wasting and Chronic Dehydration in Claudin-7-deficient Mice American Journal of Physiology. Renal Physiology. Jan, 2010 | Pubmed ID: 19759267 Xenopus Delta-catenin is Essential in Early Embryogenesis and is Functionally Linked to Cadherins and Small GTPases Journal of Cell Science. Nov, 2009 | Pubmed ID: 19843587 GSK-3 Phosphorylates Delta-catenin and Negatively Regulates Its Stability Via Ubiquitination/proteosome-mediated Proteolysis The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19706605 Analysis of Claudin Genes in Pediatric Patients with Bartter's Syndrome Annals of the New York Academy of Sciences. May, 2009 | Pubmed ID: 19538297 Signaling Through Rho GTPase Pathway As Viable Drug Target Current Medicinal Chemistry. 2009 | Pubmed ID: 19355891 Methodology to Obtain a Mixed Sural Nerve Recording in Mice American Journal of Physical Medicine & Rehabilitation / Association of Academic Physiatrists. Jul, 2009 | Pubmed ID: 19325459 Delta-Catenin Promotes Prostate Cancer Cell Growth and Progression by Altering Cell Cycle and Survival Gene Profiles Molecular Cancer. 2009 | Pubmed ID: 19284555 Increased DJ-1 Expression Under Oxidative Stress and in Alzheimer's Disease Brains Molecular Neurodegeneration. Feb, 2009 | Pubmed ID: 19243613 Identification of Extracellular Delta-catenin Accumulation for Prostate Cancer Detection The Prostate. Mar, 2009 | Pubmed ID: 19116988 Increased Nucleotide Polymorphic Changes in the 5'-untranslated Region of Delta-catenin (CTNND2) Gene in Prostate Cancer Oncogene. Jan, 2009 | Pubmed ID: 18978817 Small Molecule, Non-peptide P75 Ligands Inhibit Abeta-induced Neurodegeneration and Synaptic Impairment PloS One. 2008 | Pubmed ID: 18978948 E-Cadherin Negatively Modulates Delta-catenin-induced Morphological Changes and RhoA Activity Reduction by Competing with P190RhoGEF for Delta-catenin Biochemical and Biophysical Research Communications. Dec, 2008 | Pubmed ID: 18930028 Anti-cancer Drug Induced Neurotoxicity and Identification of Rho Pathway Signaling Modulators As Potential Neuroprotectants Neurotoxicology. Jul, 2008 | Pubmed ID: 18539332 Identification of E2F1 As a Positive Transcriptional Regulator for Delta-catenin Biochemical and Biophysical Research Communications. May, 2008 | Pubmed ID: 18302937 Delta-catenin-induced Dendritic Morphogenesis. An Essential Role of P190RhoGEF Interaction Through Akt1-mediated Phosphorylation The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 17993462 WNK4 Phosphorylates Ser(206) of Claudin-7 and Promotes Paracellular Cl(-) Permeability FEBS Letters. Aug, 2007 | Pubmed ID: 17651736 Presenilin-1 Inhibits Delta-catenin-induced Cellular Branching and Promotes Delta-catenin Processing and Turnover Biochemical and Biophysical Research Communications. Dec, 2006 | Pubmed ID: 17097608 Increased Expression of Delta-catenin/neural Plakophilin-related Armadillo Protein is Associated with the Down-regulation and Redistribution of E-cadherin and P120ctn in Human Prostate Cancer Human Pathology. Oct, 2005 | Pubmed ID: 16226102 Overexpression of Claudin-7 Decreases the Paracellular Cl- Conductance and Increases the Paracellular Na+ Conductance in LLC-PK1 Cells Journal of Cell Science. Jun, 2005 | Pubmed ID: 15928046 Abl Tyrosine Kinase Promotes Dendrogenesis by Inducing Actin Cytoskeletal Rearrangements in Cooperation with Rho Family Small GTPases in Hippocampal Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2004 | Pubmed ID: 15456825 Association of Nonreceptor Tyrosine Kinase C-yes with Tight Junction Protein Occludin by Coimmunoprecipitation Assay Methods in Molecular Biology (Clifton, N.J.). 2003 | Pubmed ID: 12616717 Dendrite-like Process Formation and Cytoskeletal Remodeling Regulated by Delta-catenin Expression Experimental Cell Research. May, 2002 | Pubmed ID: 11969288 Nonreceptor Tyrosine Kinase C-Yes Interacts with Occludin During Tight Junction Formation in Canine Kidney Epithelial Cells Molecular Biology of the Cell. Apr, 2002 | Pubmed ID: 11950934 Tredimensjonal kultur av Murine Colonic krypter for å studere intestinal stamcellefunksjon ex vivo Amna N. Naser1, Qun Lu1, Yan-Hua Chen1 1Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University JoVE 64534 Cancer Research
Tredimensjonal kultur av Murine Colonic krypter for å studere intestinal stamcellefunksjon ex vivo Amna N. Naser1, Qun Lu1, Yan-Hua Chen1 1Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University JoVE 64534 Cancer Research