R. Mark Henkelman Mouse Imaging Centre Hospital for Sick Children Biography Publications Institution JoVE Articles R. Mark Henkelman has not added a biography. If you are R. Mark Henkelman and would like to personalize this page please email our Author Liaison for assistance. Publications Preparation of Fixed Mouse Brains for MRI NeuroImage. Jan, 2012 | Pubmed ID: 22305951 Robust Method for 3D Arterial Spin Labeling in Mice Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Nov, 2011 | Pubmed ID: 22102489 Priming of Hypoxia-inducible Factor by Neuronal Nitric Oxide Synthase is Essential for Adaptive Responses to Severe Anemia Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21976486 Dosage-dependent Phenotypes in Models of 16p11.2 Lesions Found in Autism Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21969575 Genes into Geometry: Imaging for Mouse Development in 3D Current Opinion in Genetics & Development. Oct, 2011 | Pubmed ID: 21907568 Brain Abnormalities in a Neuroligin3 R451C Knockin Mouse Model Associated with Autism Autism Research : Official Journal of the International Society for Autism Research. Oct, 2011 | Pubmed ID: 21882360 Mice Lacking Caspase-2 Are Protected from Behavioral Changes, but Not Pathology, in the YAC128 Model of Huntington Disease Molecular Neurodegeneration. 2011 | Pubmed ID: 21854568 Iroquois Homeobox Gene 3 Establishes Fast Conduction in the Cardiac His-Purkinje Network Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011 | Pubmed ID: 21825130 Altered Palmitoylation and Neuropathological Deficits in Mice Lacking HIP14 Human Molecular Genetics. Oct, 2011 | Pubmed ID: 21775500 Semi-automatic Segmentation of Multiple Mouse Embryos in MR Images BMC Bioinformatics. 2011 | Pubmed ID: 21679425 Natural History of Disease in the YAC128 Mouse Reveals a Discrete Signature of Pathology in Huntington Disease Neurobiology of Disease. Jul, 2011 | Pubmed ID: 21458571 Multiple Developmental Programs Are Altered by Loss of Zic1 and Zic4 to Cause Dandy-Walker Malformation Cerebellar Pathogenesis Development (Cambridge, England). Mar, 2011 | Pubmed ID: 21307096 Chromatin Remodelling Complex Dosage Modulates Transcription Factor Function in Heart Development Nature Communications. 2011 | Pubmed ID: 21304516 Suppressor of Fused Controls Mid-hindbrain Patterning and Cerebellar Morphogenesis Via GLI3 Repressor The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2011 | Pubmed ID: 21289193 MRI Phenotyping of Genetically Altered Mice Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21279611 Correlation Between Local Hemodynamics and Lesion Distribution in a Novel Aortic Regurgitation Murine Model of Atherosclerosis Annals of Biomedical Engineering. May, 2011 | Pubmed ID: 21279441 Electrical Remodelling Precedes Heart Failure in an Endothelin-1-induced Model of Cardiomyopathy Cardiovascular Research. Feb, 2011 | Pubmed ID: 21062919 Maze Training in Mice Induces MRI-detectable Brain Shape Changes Specific to the Type of Learning NeuroImage. Feb, 2011 | Pubmed ID: 20932918 A Mouse Model of Heritable Cerebrovascular Disease PloS One. 2010 | Pubmed ID: 21217823 Comparative SNR for High-throughput Mouse Embryo MR Microscopy Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Jun, 2010 | Pubmed ID: 20512875 A Mouse Model of Down Syndrome Trisomic for All Human Chromosome 21 Syntenic Regions Human Molecular Genetics. Jul, 2010 | Pubmed ID: 20442137 Systems Biology Through Mouse Imaging Centers: Experience and New Directions Annual Review of Biomedical Engineering. Aug, 2010 | Pubmed ID: 20415591 Hedgehog Regulates Distinct Vascular Patterning Events Through VEGF-dependent and -independent Mechanisms Blood. Jul, 2010 | Pubmed ID: 20339091 Anatomical Phenotyping in a Mouse Model of Fragile X Syndrome with Magnetic Resonance Imaging NeuroImage. Nov, 2010 | Pubmed ID: 20304074 Aortic Regurgitation Dramatically Alters the Distribution of Atherosclerotic Lesions and Enhances Atherogenesis in Mice Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2010 | Pubmed ID: 20299687 Genetic Deletion or Pharmacological Inhibition of Dipeptidyl Peptidase-4 Improves Cardiovascular Outcomes After Myocardial Infarction in Mice Diabetes. Apr, 2010 | Pubmed ID: 20097729 Cerebral Asymmetries in 12-week-old C57Bl/6J Mice Measured by Magnetic Resonance Imaging NeuroImage. Apr, 2010 | Pubmed ID: 20026229 Lunatic Fringe-mediated Notch Signaling is Required for Lung Alveogenesis American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2010 | Pubmed ID: 19897741 Reptilian Heart Development and the Molecular Basis of Cardiac Chamber Evolution Nature. Sep, 2009 | Pubmed ID: 19727199 Measurement of Cerebral Blood Volume in Mouse Brain Regions Using Micro-computed Tomography NeuroImage. Oct, 2009 | Pubmed ID: 19362597 Regionally Reduced Brain Volume, Altered Serotonin Neurochemistry, and Abnormal Behavior in Mice Null for the Circadian Rhythm Output Gene Magel2 American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. Dec, 2009 | Pubmed ID: 19199291 GLP-1R Agonist Liraglutide Activates Cytoprotective Pathways and Improves Outcomes After Experimental Myocardial Infarction in Mice Diabetes. Apr, 2009 | Pubmed ID: 19151200 Trading off SNR and Resolution in MR Images NMR in Biomedicine. Jun, 2009 | Pubmed ID: 19123210 Acoustic and Kinetic Behaviour of Definity in Mice Exposed to High Frequency Ultrasound Ultrasound in Medicine & Biology. Feb, 2009 | Pubmed ID: 18950930 P73 Regulates Neurodegeneration and Phospho-tau Accumulation During Aging and Alzheimer's Disease Neuron. Sep, 2008 | Pubmed ID: 18786355 Three-dimensional Analysis of Vascular Development in the Mouse Embryo PloS One. 2008 | Pubmed ID: 18682734 Longitudinal Neuroanatomical Changes Determined by Deformation-based Morphometry in a Mouse Model of Alzheimer's Disease NeuroImage. Aug, 2008 | Pubmed ID: 18547819 Cortical Thickness Measured from MRI in the YAC128 Mouse Model of Huntington's Disease NeuroImage. Jun, 2008 | Pubmed ID: 18387826 Tbx5-dependent Pathway Regulating Diastolic Function in Congenital Heart Disease Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18378906 Optimization of the SNR-resolution Tradeoff for Registration of Magnetic Resonance Images Human Brain Mapping. Oct, 2008 | Pubmed ID: 17957707 Automated Deformation Analysis in the YAC128 Huntington Disease Mouse Model NeuroImage. Jan, 2008 | Pubmed ID: 17942324 Combined Magnetic Resonance and Bioluminescence Imaging of Live Mice Journal of Biomedical Optics. May-Jun, 2007 | Pubmed ID: 17614726 Noninvasive Ultrasonic Measurement of Regional and Local Pulse-wave Velocity in Mice Ultrasound in Medicine & Biology. Sep, 2007 | Pubmed ID: 17561330 Behavioral Phenotypes of Disc1 Missense Mutations in Mice Neuron. May, 2007 | Pubmed ID: 17481393 Resolution Improvement in Emission Optical Projection Tomography Physics in Medicine and Biology. May, 2007 | Pubmed ID: 17473351 MR Technology for Biological Studies in Mice NMR in Biomedicine. May, 2007 | Pubmed ID: 17451169 4D Cardiac MRI in the Mouse NMR in Biomedicine. May, 2007 | Pubmed ID: 17451168 Mouse Behavioral Mutants Have Neuroimaging Abnormalities Human Brain Mapping. Jun, 2007 | Pubmed ID: 17437292 Morphological and Functional Evaluation of Murine Heterotopic Cardiac Grafts Using Ultrasound Biomicroscopy Ultrasound in Medicine & Biology. Jun, 2007 | Pubmed ID: 17434663 Sexual Dimorphism Revealed in the Structure of the Mouse Brain Using Three-dimensional Magnetic Resonance Imaging NeuroImage. May, 2007 | Pubmed ID: 17408971 Magnetic Resonance Imaging with Ultrashort TE (UTE) PULSE Sequences: Technical Considerations Journal of Magnetic Resonance Imaging : JMRI. Feb, 2007 | Pubmed ID: 17260388 Hemodynamics in the Mouse Aortic Arch As Assessed by MRI, Ultrasound, and Numerical Modeling American Journal of Physiology. Heart and Circulatory Physiology. Feb, 2007 | Pubmed ID: 17012350 Presentation of 3D Isotropic Imaging Data for Optimal Viewing Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Dec, 2006 | Pubmed ID: 17075854 High-grade Glioma Formation Results from Postnatal Pten Loss or Mutant Epidermal Growth Factor Receptor Expression in a Transgenic Mouse Glioma Model Cancer Research. Aug, 2006 | Pubmed ID: 16885338 Tbx5-dependent Rheostatic Control of Cardiac Gene Expression and Morphogenesis Developmental Biology. Sep, 2006 | Pubmed ID: 16870172 Using Metamaterial Yokes in NMR Measurements Journal of Magnetic Resonance (San Diego, Calif. : 1997). Oct, 2006 | Pubmed ID: 16859941 In Vivo Magnetic Resonance Imaging and Semiautomated Image Analysis Extend the Brain Phenotype for Cdf/cdf Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2006 | Pubmed ID: 16641223 Retrospective Gating for Mouse Cardiac MRI Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Mar, 2006 | Pubmed ID: 16450339 Anatomical Phenotyping in the Brain and Skull of a Mutant Mouse by Magnetic Resonance Imaging and Computed Tomography Physiological Genomics. Jan, 2006 | Pubmed ID: 16410543 Neuroanatomical Differences Between Mouse Strains As Shown by High-resolution 3D MRI NeuroImage. Jan, 2006 | Pubmed ID: 16084741 Disease Phenotyping: Structural and Functional Readouts Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progrès Des Recherches Pharmaceutiques. 2005 | Pubmed ID: 16329257 Magnetic Resonance Imaging for Detection and Analysis of Mouse Phenotypes NMR in Biomedicine. Nov, 2005 | Pubmed ID: 16206127 Gradient Hysteresis in MRI and NMR Experiments Journal of Magnetic Resonance (San Diego, Calif. : 1997). Dec, 2005 | Pubmed ID: 16188476 Correction of Artefacts in Optical Projection Tomography Physics in Medicine and Biology. Oct, 2005 | Pubmed ID: 16177495 A Gja1 Missense Mutation in a Mouse Model of Oculodentodigital Dysplasia Development (Cambridge, England). Oct, 2005 | Pubmed ID: 16155213 T1, T2 Relaxation and Magnetization Transfer in Tissue at 3T Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Sep, 2005 | Pubmed ID: 16086319 Abnormal Cardiac Inflow Patterns During Postnatal Development in a Mouse Model of Holt-Oram Syndrome American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2005 | Pubmed ID: 15849237 Imaging Articular Cartilage Under Compression--cartilage Elastography Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. May, 2005 | Pubmed ID: 15844160 Tbx20 Dose-dependently Regulates Transcription Factor Networks Required for Mouse Heart and Motoneuron Development Development (Cambridge, England). May, 2005 | Pubmed ID: 15843409 Identification of Human Brain Tumour Initiating Cells Nature. Nov, 2004 | Pubmed ID: 15549107 Baf60c is Essential for Function of BAF Chromatin Remodelling Complexes in Heart Development Nature. Nov, 2004 | Pubmed ID: 15525990 Multiple Mouse Biological Loading and Monitoring System for MRI Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Oct, 2004 | Pubmed ID: 15389955 Foxh1 is Essential for Development of the Anterior Heart Field Developmental Cell. Sep, 2004 | Pubmed ID: 15363409 Angiopoietin-1 Causes Reversible Degradation of the Portal Microcirculation in Mice: Implications for Treatment of Liver Disease The American Journal of Pathology. Sep, 2004 | Pubmed ID: 15331413 Comprehensive Transthoracic Cardiac Imaging in Mice Using Ultrasound Biomicroscopy with Anatomical Confirmation by Magnetic Resonance Imaging Physiological Genomics. Jul, 2004 | Pubmed ID: 15114000 MicroCT Scanner Performance and Considerations for Vascular Specimen Imaging Medical Physics. Feb, 2004 | Pubmed ID: 15000616 Ultrasound-guided Left-ventricular Catheterization: a Novel Method of Whole Mouse Perfusion for Microimaging Laboratory Investigation; a Journal of Technical Methods and Pathology. Mar, 2004 | Pubmed ID: 14704721 High-resolution Longitudinal Screening with Magnetic Resonance Imaging in a Murine Brain Cancer Model Neoplasia (New York, N.Y.). Nov-Dec, 2003 | Pubmed ID: 14965447 Multiple-mouse MRI Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Jan, 2003 | Pubmed ID: 12509832 Orientational Diffusion Reflects Fiber Structure Within a Voxel Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Sep, 2002 | Pubmed ID: 12210909 Pulse-wave Velocity Measured in One Heartbeat Using MR Tagging Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Jul, 2002 | Pubmed ID: 12111938 Why Does MTR Change with Neuronal Depolarization? Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Mar, 2002 | Pubmed ID: 11870833 Multiple-mouse Neuroanatomical Magnetic Resonance Imaging Jun Dazai*1, Shoshana Spring*1, Lindsay S. Cahill1, R. Mark Henkelman1,2 1Mouse Imaging Centre, Hospital for Sick Children, 2Department of Medical Biophysics and Medical Imaging, University of Toronto JoVE 2497 Neuroscience
Multiple-mouse Neuroanatomical Magnetic Resonance Imaging Jun Dazai*1, Shoshana Spring*1, Lindsay S. Cahill1, R. Mark Henkelman1,2 1Mouse Imaging Centre, Hospital for Sick Children, 2Department of Medical Biophysics and Medical Imaging, University of Toronto JoVE 2497 Neuroscience