Ramon Arens Department of Immunohematology and Blood Transfusion Leiden University Medical Center Biography Publications Institution JoVE Articles Ramon Arens has not added a biography. If you are Ramon Arens and would like to personalize this page please email our Author Liaison for assistance. Publications A Poly-neoantigen DNA Vaccine Synergizes with PD-1 Blockade to Induce T Cell-mediated Tumor Control Oncoimmunology. 2019 | Pubmed ID: 31646082 PD-L1 Blockade Engages Tumor-infiltrating Lymphocytes to Co-express Targetable Activating and Inhibitory Receptors Journal for Immunotherapy of Cancer. Aug, 2019 | Pubmed ID: 31412943 CD8+ T Cells Protect During Vein Graft Disease Development Frontiers in Cardiovascular Medicine. 2019 | Pubmed ID: 31263704 The Hallmarks of CMV-specific CD8 T-cell Differentiation Medical Microbiology and Immunology. Aug, 2019 | Pubmed ID: 30989333 Peripheral and Systemic Antigens Elicit an Expandable Pool of Resident Memory CD8 T Cells in the Bone Marrow European Journal of Immunology. Jun, 2019 | Pubmed ID: 30891737 T Cell Co-stimulation and Co-inhibition in Cardiovascular Disease: a Double-edged Sword Nature Reviews. Cardiology. Jun, 2019 | Pubmed ID: 30770894 Demarcated Thresholds of Tumor-specific CD8 T Cells Elicited by MCMV-based Vaccine Vectors Provide Robust Correlates of Protection Journal for Immunotherapy of Cancer. 01, 2019 | Pubmed ID: 30704520 Science Immunology. 12, 2018 | Pubmed ID: 30552101 : A Workflow for Visual and Quantitative Analysis of Flow and Mass Cytometry Data to Discover Immune Signatures and Correlations Computational and Structural Biotechnology Journal. 2018 | Pubmed ID: 30450167 Cytomegalovirus Infection and Progressive Differentiation of Effector-memory T Cells F1000Research. 2018 | Pubmed ID: 30345004 OX40 Stimulation Enhances Protective Immune Responses Induced After Vaccination With Attenuated Malaria Parasites Frontiers in Cellular and Infection Microbiology. 2018 | Pubmed ID: 30073152 FcγRI Expression on Macrophages is Required for Antibody-mediated Tumor Protection by Cytomegalovirus-based Vaccines Oncotarget. Jun, 2018 | Pubmed ID: 30034625 Impact of Congenital Cytomegalovirus Infection on Transcriptomes from Archived Dried Blood Spots in Relation to Long-term Clinical Outcome PloS One. 2018 | Pubmed ID: 30024899 A Flexible MHC Class I Multimer Loading System for Large-scale Detection of Antigen-specific T Cells The Journal of Experimental Medicine. 05, 2018 | Pubmed ID: 29666167 Features of Effective T Cell-Inducing Vaccines Against Chronic Viral Infections Frontiers in Immunology. 2018 | Pubmed ID: 29503649 Exhaustion and Inflation at Antipodes of T Cell Responses to Chronic Virus Infection Trends in Microbiology. 06, 2018 | Pubmed ID: 29249600 Human Plasmacytoid Dendritic Cells Acquire Phagocytic Capacity by TLR9 Ligation in the Presence of Soluble Factors Produced by Renal Epithelial Cells Kidney International. 02, 2018 | Pubmed ID: 29061332 The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose Frontiers in Immunology. 2017 | Pubmed ID: 29367854 CMV Immune Evasion and Manipulation of the Immune System with Aging GeroScience. 06, 2017 | Pubmed ID: 28647908 CD4 T Cell and NK Cell Interplay Key to Regression of MHC Class I Tumors Upon TLR7/8 Agonist Therapy Cancer Immunology Research. 08, 2017 | Pubmed ID: 28637878 Inhibition of 14q32 MicroRNA MiR-495 Reduces Lesion Formation, Intimal Hyperplasia and Plasma Cholesterol Levels in Experimental Restenosis Atherosclerosis. 06, 2017 | Pubmed ID: 28445809 Enforced OX40 Stimulation Empowers Booster Vaccines to Induce Effective CD4 and CD8 T Cell Responses Against Mouse Cytomegalovirus Infection Frontiers in Immunology. 2017 | Pubmed ID: 28265272 The Importance of Correctly Timing Cancer Immunotherapy Expert Opinion on Biological Therapy. 01, 2017 | Pubmed ID: 27802061 Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors PLoS Pathogens. Dec, 2016 | Pubmed ID: 27977791 Wnt Signaling As Master Regulator of T-Lymphocyte Responses: Implications for Transplant Therapy Transplantation. Dec, 2016 | Pubmed ID: 27861287 Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination Frontiers in Immunology. 2016 | Pubmed ID: 27656185 The Breadth of Synthetic Long Peptide Vaccine-Induced CD8+ T Cell Responses Determines the Efficacy Against Mouse Cytomegalovirus Infection PLoS Pathogens. 09, 2016 | Pubmed ID: 27637068 Tumor Eradication by Cisplatin Is Sustained by CD80/86-Mediated Costimulation of CD8+ T Cells Cancer Research. 10, 2016 | Pubmed ID: 27569212 Vaccination During Myeloid Cell Depletion by Cancer Chemotherapy Fosters Robust T Cell Responses Science Translational Medicine. Apr, 2016 | Pubmed ID: 27075626 Vaccines for Established Cancer: Overcoming the Challenges Posed by Immune Evasion Nature Reviews. Cancer. Apr, 2016 | Pubmed ID: 26965076 Viral Persistence Induces Antibody Inflation Without Altering Antibody Avidity Journal of Virology. May, 2016 | Pubmed ID: 26889035 In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity Immunity. Feb, 2016 | Pubmed ID: 26872694 Murine Cytomegalovirus (CMV) Infection Via the Intranasal Route Offers a Robust Model of Immunity Upon Mucosal CMV Infection The Journal of General Virology. Jan, 2016 | Pubmed ID: 26555192 Cytomegalovirus- and Epstein-Barr Virus-Induced T-Cell Expansions in Young Children Do Not Impair Naive T-cell Populations or Vaccination Responses: The Generation R Study The Journal of Infectious Diseases. Jan, 2016 | Pubmed ID: 26142434 The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8+ T Cells Journal of Immunology (Baltimore, Md. : 1950). Nov, 2015 | Pubmed ID: 26453748 Abatacept Decreases Disease Activity in a Absence of CD4(+) T Cells in a Collagen-induced Arthritis Model Arthritis Research & Therapy. Aug, 2015 | Pubmed ID: 26290328 The Viral Context Instructs the Redundancy of Costimulatory Pathways in Driving CD8(+) T Cell Expansion ELife. Aug, 2015 | Pubmed ID: 26263500 Therapeutic Cancer Vaccines The Journal of Clinical Investigation. Sep, 2015 | Pubmed ID: 26214521 New Approaches in Vaccine-based Immunotherapy for Human Papillomavirus-induced Cancer Current Opinion in Immunology. Aug, 2015 | Pubmed ID: 26001120 Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression Cancer Immunology Research. Sep, 2015 | Pubmed ID: 25888578 5(th) International Workshop on CMV and Immunosenescence - A Shadow of Cytomegalovirus Infection on Immunological Memory European Journal of Immunology. Apr, 2015 | Pubmed ID: 25857239 Enhanced CD8 T Cell Responses Through GITR-mediated Costimulation Resolve Chronic Viral Infection PLoS Pathogens. Mar, 2015 | Pubmed ID: 25738498 CD55 Deposited on Synovial Collagen Fibers Protects from Immune Complex-mediated Arthritis Arthritis Research & Therapy. Jan, 2015 | Pubmed ID: 25596646 Vaccine-induced Tumor Necrosis Factor-producing T Cells Synergize with Cisplatin to Promote Tumor Cell Death Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2015 | Pubmed ID: 25501579 The Activation of the Adaptive Immune System: Cross-talk Between Antigen-presenting Cells, T Cells and B Cells Immunology Letters. Dec, 2014 | Pubmed ID: 25455596 T Cell Factor 1 Represses CD8+ Effector T Cell Formation and Function Journal of Immunology (Baltimore, Md. : 1950). Dec, 2014 | Pubmed ID: 25355919 Enhanced Cross-presentation and Improved CD8+ T Cell Responses After Mannosylation of Synthetic Long Peptides in Mice PloS One. 2014 | Pubmed ID: 25137039 New Advances in CMV and Immunosenescence Experimental Gerontology. Jul, 2014 | Pubmed ID: 24703889 Viral Inoculum Dose Impacts Memory T-cell Inflation European Journal of Immunology. Apr, 2014 | Pubmed ID: 24356925 Local Immunomodulation for Cancer Therapy: Providing Treatment Where Needed Oncoimmunology. Nov, 2013 | Pubmed ID: 24490127 Nodular Inflammatory Foci Are Sites of T Cell Priming and Control of Murine Cytomegalovirus Infection in the Neonatal Lung PLoS Pathogens. 2013 | Pubmed ID: 24348257 The Distinct Role of T Cell Costimulation in Antiviral Immunity Current Opinion in Virology. Aug, 2013 | Pubmed ID: 23850168 Lysine Acetyltransferase PCAF is a Key Regulator of Arteriogenesis Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2013 | Pubmed ID: 23788761 Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-cell-dependent Tumor Eradication and Decreases Risk of Toxic Side Effects Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2013 | Pubmed ID: 23788581 Prospects of Combinatorial Synthetic Peptide Vaccine-based Immunotherapy Against Cancer Seminars in Immunology. Apr, 2013 | Pubmed ID: 23706598 CD27-CD70 Costimulation Controls T Cell Immunity During Acute and Persistent Cytomegalovirus Infection Journal of Virology. Jun, 2013 | Pubmed ID: 23576505 Predicting the Efficacy of Cancer Vaccines by Evaluating T-cell Responses Oncoimmunology. Jan, 2013 | Pubmed ID: 23482345 Vaccine-induced Effector-memory CD8+ T Cell Responses Predict Therapeutic Efficacy Against Tumors Journal of Immunology (Baltimore, Md. : 1950). Oct, 2012 | Pubmed ID: 22914049 Polyfunctional CD4+ T Cell Responses to Immunodominant Epitopes Correlate with Disease Activity of Virulent Salmonella PloS One. 2012 | Pubmed ID: 22912884 Rational Design of Vaccines: Learning from Immune Evasion Mechanisms of Persistent Viruses and Tumors Advances in Immunology. 2012 | Pubmed ID: 22449784 Local Activation of CD8 T Cells and Systemic Tumor Eradication Without Toxicity Via Slow Release and Local Delivery of Agonistic CD40 Antibody Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2011 | Pubmed ID: 21389097 Differential B7-CD28 Costimulatory Requirements for Stable and Inflationary Mouse Cytomegalovirus-specific Memory CD8 T Cell Populations Journal of Immunology (Baltimore, Md. : 1950). Apr, 2011 | Pubmed ID: 21357256 Immunotherapy for Persistent Viral Infections and Associated Disease Trends in Immunology. Mar, 2011 | Pubmed ID: 21227751 Visualisation et quantification des données de cytométrie à haute dimension à l'aide de Cytofast et des méthodes de clustering en amont FlowSOM et Cytosplore Guillaume Beyrend1, Koen Stam2, Ferry Ossendorp1, Ramon Arens1 1Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2Department of Parasitology, Leiden University Medical Center JoVE 60525 Immunology and Infection
Visualisation et quantification des données de cytométrie à haute dimension à l'aide de Cytofast et des méthodes de clustering en amont FlowSOM et Cytosplore Guillaume Beyrend1, Koen Stam2, Ferry Ossendorp1, Ramon Arens1 1Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2Department of Parasitology, Leiden University Medical Center JoVE 60525 Immunology and Infection