Rick L. Tarleton Center for Tropical and Emerging Global Diseases University of Georgia Biography Publications Institution JoVE Articles Rick L. Tarleton has not added a biography. If you are Rick L. Tarleton and would like to personalize this page please email our Author Liaison for assistance. Publications High Variation in Immune Responses and Parasite Phenotypes in Naturally Acquired Trypanosoma Cruzi Infection in a Captive Non-human Primate Breeding Colony in Texas, USA PLoS Neglected Tropical Diseases. 03, 2021 | Pubmed ID: 33788859 Reduced Trypanosoma Cruzi-specific Humoral Response and Enhanced T Cell Immunity After Treatment Interruption with Benznidazole in Chronic Chagas Disease The Journal of Antimicrobial Chemotherapy. 05, 2021 | Pubmed ID: 33693664 A Flexible, Pan-species, Multi-antigen Platform for the Detection and Monitoring of SARS-CoV-2-specific Antibody Responses MedRxiv : the Preprint Server for Health Sciences. Jan, 2021 | Pubmed ID: 33532799 Strain-specific Genome Evolution in Trypanosoma Cruzi, the Agent of Chagas Disease PLoS Pathogens. 01, 2021 | Pubmed ID: 33508020 A Modified Drug Regimen Clears Active and Dormant Trypanosomes in Mouse Models of Chagas Disease Science Translational Medicine. 10, 2020 | Pubmed ID: 33115952 Cutting Edge: Augmenting Muscle MHC Expression Enhances Systemic Pathogen Control at the Expense of T Cell Exhaustion Journal of Immunology (Baltimore, Md. : 1950). 08, 2020 | Pubmed ID: 32591392 New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma Cruzi: Clinical, Parasitological, and Serological Assessment After Three Years of Follow-Up Antimicrobial Agents and Chemotherapy. 08, 2020 | Pubmed ID: 32571827 Chagas Disease Drug Discovery: Multiparametric Lead Optimization Against in Acylaminobenzothiazole Series Journal of Medicinal Chemistry. 11, 2019 | Pubmed ID: 31657555 Protozoan Persister-like Cells and Drug Treatment Failure Nature Reviews. Microbiology. 10, 2019 | Pubmed ID: 31444481 Drug Discovery for Kinetoplastid Diseases: Future Directions ACS Infectious Diseases. 02, 2019 | Pubmed ID: 30543391 Highly Competent, Non-exhausted CD8+ T Cells Continue to Tightly Control Pathogen Load Throughout Chronic Trypanosoma Cruzi Infection PLoS Pathogens. 11, 2018 | Pubmed ID: 30419010 Spontaneous Dormancy Protects During Extended Drug Exposure ELife. 03, 2018 | Pubmed ID: 29578409 Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins MBio. 11, 2017 | Pubmed ID: 29114029 The Significance of Discordant Serology in Chagas Disease: Enhanced T-Cell Immunity to in Serodiscordant Subjects Frontiers in Immunology. 2017 | Pubmed ID: 28966620 Recombination-driven Generation of the Largest Pathogen Repository of Antigen Variants in the Protozoan Trypanosoma Cruzi BMC Genomics. 09, 2016 | Pubmed ID: 27619017 Chagas Disease: A Solvable Problem, Ignored Trends in Molecular Medicine. Oct, 2016 | Pubmed ID: 27523778 Long-Term Immunity to Trypanosoma Cruzi in the Absence of Immunodominant Trans-Sialidase-Specific CD8+ T Cells Infection and Immunity. 09, 2016 | Pubmed ID: 27354447 A Framework for Ontology-based Question Answering with Application to Parasite Immunology Journal of Biomedical Semantics. 2015 | Pubmed ID: 26185615 CD8+ T Cells in Trypanosoma Cruzi Infection Seminars in Immunopathology. May, 2015 | Pubmed ID: 25921214 Chemokine Receptor 7 (CCR7)-expression and IFNγ Production Define Vaccine-specific Canine T-cell Subsets Veterinary Immunology and Immunopathology. Apr, 2015 | Pubmed ID: 25758065 CRISPR-Cas9-mediated Single-gene and Gene Family Disruption in Trypanosoma Cruzi MBio. Dec, 2014 | Pubmed ID: 25550322 Chagas Disease and the London Declaration on Neglected Tropical Diseases PLoS Neglected Tropical Diseases. Oct, 2014 | Pubmed ID: 25299701 The Trypanosoma Cruzi Flagellum is Discarded Via Asymmetric Cell Division Following Invasion and Provides Early Targets for Protective CD8⁺ T Cells Cell Host & Microbe. Oct, 2014 | Pubmed ID: 25299330 Frequency of IFNγ-producing T Cells Correlates with Seroreactivity and Activated T Cells During Canine Trypanosoma Cruzi Infection Veterinary Research. Jan, 2014 | Pubmed ID: 24456537 New, Combined, and Reduced Dosing Treatment Protocols Cure Trypanosoma Cruzi Infection in Mice The Journal of Infectious Diseases. Jan, 2014 | Pubmed ID: 23945371 Perpetual Expression of PAMPs Necessary for Optimal Immune Control and Clearance of a Persistent Pathogen Nature Communications. 2013 | Pubmed ID: 24149620 Evidence for the Role of Vacuolar Soluble Pyrophosphatase and Inorganic Polyphosphate in Trypanosoma Cruzi Persistence Molecular Microbiology. Nov, 2013 | Pubmed ID: 24033456 A Systematic Review of High Quality Diagnostic Tests for Chagas Disease PLoS Neglected Tropical Diseases. 2012 | Pubmed ID: 23145201 Is Chagas Disease Really the "new HIV/AIDS of the Americas"? PLoS Neglected Tropical Diseases. 2012 | Pubmed ID: 23145193 Inhibitory Receptors Are Expressed by Trypanosoma Cruzi-specific Effector T Cells and in Hearts of Subjects with Chronic Chagas Disease PloS One. 2012 | Pubmed ID: 22574131 Transgenic Parasites Accelerate Drug Discovery Trends in Parasitology. Mar, 2012 | Pubmed ID: 22277131 Report of the 2nd Chagas Drug Discovery Consortium Meeting, Held on 3 November 2010; Atlanta GA, USA Expert Opinion on Drug Discovery. 09, 2011 | Pubmed ID: 22646217 Knockout of the Dhfr-ts Gene in Trypanosoma Cruzi Generates Attenuated Parasites Able to Confer Protection Against a Virulent Challenge PLoS Neglected Tropical Diseases. Dec, 2011 | Pubmed ID: 22180798 Methodological Advances in Drug Discovery for Chagas Disease Expert Opinion on Drug Discovery. Jun, 2011 | Pubmed ID: 21712965 Oral Exposure to Trypanosoma Cruzi Elicits a Systemic CD8⁺ T Cell Response and Protection Against Heterotopic Challenge Infection and Immunity. Aug, 2011 | Pubmed ID: 21628516 Widespread, Focal Copy Number Variations (CNV) and Whole Chromosome Aneuploidies in Trypanosoma Cruzi Strains Revealed by Array Comparative Genomic Hybridization BMC Genomics. 2011 | Pubmed ID: 21385342 In Vitro and in Vivo High-throughput Assays for the Testing of Anti-Trypanosoma Cruzi Compounds PLoS Neglected Tropical Diseases. Jul, 2010 | Pubmed ID: 20644616 CD8+ T Cells Specific for Immunodominant Trans-sialidase Epitopes Contribute to Control of Trypanosoma Cruzi Infection but Are Not Required for Resistance Journal of Immunology (Baltimore, Md. : 1950). Jul, 2010 | Pubmed ID: 20530265 Generation of Trypanosoma Cruzi-specific CD8+ T-cell Immunity is Unaffected by the Absence of Type I Interferon Signaling Infection and Immunity. Jul, 2010 | Pubmed ID: 20457790 Trypanosoma Cruzi-specific Immune Responses in Subjects from Endemic Areas of Chagas Disease of Argentina Microbes and Infection. May, 2010 | Pubmed ID: 20123034 Changes in Trypanosoma Cruzi-specific Immune Responses After Treatment: Surrogate Markers of Treatment Efficacy Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Dec, 2009 | Pubmed ID: 19877967 Chronic Human Infection with Trypanosoma Cruzi Drives CD4+ T Cells to Immune Senescence Journal of Immunology (Baltimore, Md. : 1950). Sep, 2009 | Pubmed ID: 19692645 The Steady-state Transcriptome of the Four Major Life-cycle Stages of Trypanosoma Cruzi BMC Genomics. 2009 | Pubmed ID: 19664227 CD8+ T Cells in Trypanosoma Cruzi Infection Current Opinion in Immunology. Aug, 2009 | Pubmed ID: 19646853 Insufficient TLR Activation Contributes to the Slow Development of CD8+ T Cell Responses in Trypanosoma Cruzi Infection Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009 | Pubmed ID: 19553540 Chromosome Level Assembly of the Hybrid Trypanosoma Cruzi Genome BMC Genomics. 2009 | Pubmed ID: 19486522 Evaluation of High Efficiency Gene Knockout Strategies for Trypanosoma Cruzi BMC Microbiology. May, 2009 | Pubmed ID: 19432966 Eliminating Chagas Disease: Challenges and a Roadmap BMJ (Clinical Research Ed.). Apr, 2009 | Pubmed ID: 19366739 HLA Class I-T Cell Epitopes from Trans-sialidase Proteins Reveal Functionally Distinct Subsets of CD8+ T Cells in Chronic Chagas Disease PLoS Neglected Tropical Diseases. 2008 | Pubmed ID: 18846233 High Throughput Selection of Effective Serodiagnostics for Trypanosoma Cruzi Infection PLoS Neglected Tropical Diseases. 2008 | Pubmed ID: 18841200 Stable CD8+ T Cell Memory During Persistent Trypanosoma Cruzi Infection Journal of Immunology (Baltimore, Md. : 1950). Aug, 2008 | Pubmed ID: 18684955 Drug-induced Cure Drives Conversion to a Stable and Protective CD8+ T Central Memory Response in Chronic Chagas Disease Nature Medicine. May, 2008 | Pubmed ID: 18425131 The Challenges of Chagas Disease-- Grim Outlook or Glimmer of Hope PLoS Medicine. Dec, 2007 | Pubmed ID: 18162039 TGF-beta Regulates Pathology but Not Tissue CD8+ T Cell Dysfunction During Experimental Trypanosoma Cruzi Infection European Journal of Immunology. Oct, 2007 | Pubmed ID: 17823982 Immune System Recognition of Trypanosoma Cruzi Current Opinion in Immunology. Aug, 2007 | Pubmed ID: 17651955 A Semi-quantitative GeLC-MS Analysis of Temporal Proteome Expression in the Emerging Nosocomial Pathogen Ochrobactrum Anthropi Genome Biology. 2007 | Pubmed ID: 17567905 CD8+ T-Cell Responses to Trypanosoma Cruzi Are Highly Focused on Strain-variant Trans-sialidase Epitopes PLoS Pathogens. Aug, 2006 | Pubmed ID: 16879036 New Approaches in Vaccine Development for Parasitic Infections Cellular Microbiology. Oct, 2005 | Pubmed ID: 16153238 A Heuristic Method for Assigning a False-discovery Rate for Protein Identifications from Mascot Database Search Results Molecular & Cellular Proteomics : MCP. Jun, 2005 | Pubmed ID: 15703444 Antigen-specific T Cells Maintain an Effector Memory Phenotype During Persistent Trypanosoma Cruzi Infection Journal of Immunology (Baltimore, Md. : 1950). Feb, 2005 | Pubmed ID: 15661921 Inducible Nitric Oxide Synthase is Not Essential for Control of Trypanosoma Cruzi Infection in Mice Infection and Immunity. Jul, 2004 | Pubmed ID: 15213153 TcruziDB: an Integrated Trypanosoma Cruzi Genome Resource Nucleic Acids Research. Jan, 2004 | Pubmed ID: 14681430 Chagas Disease: a Role for Autoimmunity? Trends in Parasitology. Oct, 2003 | Pubmed ID: 14519582 Microarray Profiling of Gene Expression During Trypomastigote to Amastigote Transition in Trypanosoma Cruzi Molecular and Biochemical Parasitology. Sep, 2003 | Pubmed ID: 12967712 Genetic Immunization with LYT1 or a Pool of Trans-sialidase Genes Protects Mice from Lethal Trypanosoma Cruzi Infection Vaccine. Jun, 2003 | Pubmed ID: 12798651 Rapid Quantitation of Trypanosoma Cruzi in Host Tissue by Real-time PCR Molecular and Biochemical Parasitology. Jun, 2003 | Pubmed ID: 12798506 Cutting Edge: Dysfunctional CD8+ T Cells Reside in Nonlymphoid Tissues During Chronic Trypanosoma Cruzi Infection Journal of Immunology (Baltimore, Md. : 1950). Mar, 2003 | Pubmed ID: 12594245 Genetic Immunization Elicits Antigen-specific Protective Immune Responses and Decreases Disease Severity in Trypanosoma Cruzi Infection Infection and Immunity. Oct, 2002 | Pubmed ID: 12228281 Vaccination with Trypomastigote Surface Antigen 1-encoding Plasmid DNA Confers Protection Against Lethal Trypanosoma Cruzi Infection Infection and Immunity. Nov, 1998 | Pubmed ID: 9784506 Imaging 3D quantitativo di cellule infette da Trypanosoma cruzi, amastigoti dormienti e cellule T in organi chiarificati intatti Fernando Sanchez-Valdez1, Ángel M. Padilla1, Juan M. Bustamante1, Caleb W. D. Hawkins1, Rick L. Tarleton1,2 1Center for Tropical and Emerging Global Diseases, University of Georgia, 2Department of Cellular Biology, University of Georgia JoVE 63919 Immunology and Infection
Imaging 3D quantitativo di cellule infette da Trypanosoma cruzi, amastigoti dormienti e cellule T in organi chiarificati intatti Fernando Sanchez-Valdez1, Ángel M. Padilla1, Juan M. Bustamante1, Caleb W. D. Hawkins1, Rick L. Tarleton1,2 1Center for Tropical and Emerging Global Diseases, University of Georgia, 2Department of Cellular Biology, University of Georgia JoVE 63919 Immunology and Infection