Roland Brosch Pathogenomique Mycobacterienne Integrée Institut Pasteur, Paris, France Biography Publications Institution JoVE Articles Roland Brosch has not added a biography. If you are Roland Brosch and would like to personalize this page please email our Author Liaison for assistance. Publications TBCAP; Tuberculosis Annotation Project Tuberculosis (Edinburgh, Scotland). Jan, 2013 | Pubmed ID: 23332402 Genomic Analysis of Smooth Tubercle Bacilli Provides Insights into Ancestry and Pathoadaptation of Mycobacterium Tuberculosis Nature Genetics. Feb, 2013 | Pubmed ID: 23291586 The ESX-5 Associated EccB-EccC Locus is Essential for Mycobacterium Tuberculosis Viability PloS One. 2012 | Pubmed ID: 23284869 ESX-1 Dependent Impairment of Autophagic Flux by Mycobacterium Tuberculosis in Human Dendritic Cells Autophagy. Sep, 2012 | Pubmed ID: 22885411 Multidrug-resistant Tuberculosis in Admitted Patients at a Tertiary Referral Hospital of Bangladesh PloS One. 2012 | Pubmed ID: 22808189 ESX-1-mediated Translocation to the Cytosol Controls Virulence of Mycobacteria Cellular Microbiology. Aug, 2012 | Pubmed ID: 22524898 Strong Immunogenicity and Cross-reactivity of Mycobacterium Tuberculosis ESX-5 Type VII Secretion: Encoded PE-PPE Proteins Predicts Vaccine Potential Cell Host & Microbe. Apr, 2012 | Pubmed ID: 22520463 Characterization of Mycobacterium Orygis As M. Tuberculosis Complex Subspecies Emerging Infectious Diseases. Apr, 2012 | Pubmed ID: 22469053 Disruption of the ESX-5 System of Mycobacterium Tuberculosis Causes Loss of PPE Protein Secretion, Reduction of Cell Wall Integrity and Strong Attenuation Molecular Microbiology. Mar, 2012 | Pubmed ID: 22340629 Phagosomal Rupture by Mycobacterium Tuberculosis Results in Toxicity and Host Cell Death PLoS Pathogens. Feb, 2012 | Pubmed ID: 22319448 Activation of the NLRP3 Inflammasome by Mycobacterium Tuberculosis is Uncoupled from Susceptibility to Active Tuberculosis European Journal of Immunology. Feb, 2012 | Pubmed ID: 22101787 P62 and NDP52 Proteins Target Intracytosolic Shigella and Listeria to Different Autophagy Pathways The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21646350 Deciphering the Role of IS6110 in a Highly Transmissible Mycobacterium Tuberculosis Beijing Strain, GC1237 Tuberculosis (Edinburgh, Scotland). Mar, 2011 | Pubmed ID: 21256084 ESAT-6 Secretion-independent Impact of ESX-1 Genes EspF and EspG1 on Virulence of Mycobacterium Tuberculosis The Journal of Infectious Diseases. Apr, 2011 | Pubmed ID: 21196469 Overexpression of Proinflammatory TLR-2-signalling Lipoproteins in Hypervirulent Mycobacterial Variants Cellular Microbiology. May, 2011 | Pubmed ID: 21143571 Entrapment of Intracytosolic Bacteria by Septin Cage-like Structures Cell Host & Microbe. Nov, 2010 | Pubmed ID: 21075354 Synthesis, Biological Activity, and Evaluation of the Mode of Action of Novel Antitubercular Benzofurobenzopyrans Substituted on A Ring European Journal of Medicinal Chemistry. Dec, 2010 | Pubmed ID: 20961671 High Content Phenotypic Cell-based Visual Screen Identifies Mycobacterium Tuberculosis Acyltrehalose-containing Glycolipids Involved in Phagosome Remodeling PLoS Pathogens. 2010 | Pubmed ID: 20844580 High Content Screening Identifies Decaprenyl-phosphoribose 2' Epimerase As a Target for Intracellular Antimycobacterial Inhibitors PLoS Pathogens. Oct, 2009 | Pubmed ID: 19876393 Systematic Genetic Nomenclature for Type VII Secretion Systems PLoS Pathogens. Oct, 2009 | Pubmed ID: 19876390 [A Promising New Class of Antituberculous Molecules] Médecine Sciences : M/S. Aug-Sep, 2009 | Pubmed ID: 19765374 Mycobacterial PE, PPE and ESX Clusters: Novel Insights into the Secretion of These Most Unusual Protein Families Molecular Microbiology. Aug, 2009 | Pubmed ID: 19602151 Non Mycobacterial Virulence Genes in the Genome of the Emerging Pathogen Mycobacterium Abscessus PloS One. 2009 | Pubmed ID: 19543527 Myths and Misconceptions: the Origin and Evolution of Mycobacterium Tuberculosis Nature Reviews. Microbiology. Jul, 2009 | Pubmed ID: 19483712 Benzothiazinones Kill Mycobacterium Tuberculosis by Blocking Arabinan Synthesis Science (New York, N.Y.). May, 2009 | Pubmed ID: 19299584 Pathogenicity in the Tubercle Bacillus: Molecular and Evolutionary Determinants BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Apr, 2009 | Pubmed ID: 19274661 ESX/type VII Secretion Systems and Their Role in Host-pathogen Interaction Current Opinion in Microbiology. Feb, 2009 | Pubmed ID: 19155186 Functional Analysis of a Clonal Deletion in an Epidemic Strain of Mycobacterium Bovis Reveals a Role in Lipid Metabolism Microbiology (Reading, England). Dec, 2008 | Pubmed ID: 19047741 Insights from the Complete Genome Sequence of Mycobacterium Marinum on the Evolution of Mycobacterium Tuberculosis Genome Research. May, 2008 | Pubmed ID: 18403782 Control of M. Tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP PLoS Pathogens. Feb, 2008 | Pubmed ID: 18282096 Cutting-edge Science and the Future of Tuberculosis Control Bulletin of the World Health Organization. May, 2007 | Pubmed ID: 17639231 ESAT-6 from Mycobacterium Tuberculosis Dissociates from Its Putative Chaperone CFP-10 Under Acidic Conditions and Exhibits Membrane-lysing Activity Journal of Bacteriology. Aug, 2007 | Pubmed ID: 17557817 Genome Plasticity of BCG and Impact on Vaccine Efficacy Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007 | Pubmed ID: 17372194 "A Re-evaluation of M. Prototuberculosis": Continuing the Debate PLoS Pathogens. Sep, 2006 | Pubmed ID: 17009866 Horizontal Transfer of a Virulence Operon to the Ancestor of Mycobacterium Tuberculosis Molecular Biology and Evolution. Jun, 2006 | Pubmed ID: 16520338 Dissection of ESAT-6 System 1 of Mycobacterium Tuberculosis and Impact on Immunogenicity and Virulence Infection and Immunity. Jan, 2006 | Pubmed ID: 16368961 Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium Tuberculosis PLoS Pathogens. Sep, 2005 | Pubmed ID: 16201017 Tuberculosis: from Genome to Vaccine Expert Review of Vaccines. Aug, 2005 | Pubmed ID: 16117711 Functional Analysis of Early Secreted Antigenic Target-6, the Dominant T-cell Antigen of Mycobacterium Tuberculosis, Reveals Key Residues Involved in Secretion, Complex Formation, Virulence, and Immunogenicity The Journal of Biological Chemistry. Oct, 2005 | Pubmed ID: 16048998 Modulation of the Host Immune Response by a Transient Intracellular Stage of Mycobacterium Ulcerans: the Contribution of Endogenous Mycolactone Toxin Cellular Microbiology. Aug, 2005 | Pubmed ID: 16008585 Structure and Mechanism of the Alkyl Hydroperoxidase AhpC, a Key Element of the Mycobacterium Tuberculosis Defense System Against Oxidative Stress The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15886207 Influence of ESAT-6 Secretion System 1 (RD1) of Mycobacterium Tuberculosis on the Interaction Between Mycobacteria and the Host Immune System Journal of Immunology (Baltimore, Md. : 1950). Mar, 2005 | Pubmed ID: 15749894 Common Evolutionary Origin for the Unstable Virulence Plasmid PMUM Found in Geographically Diverse Strains of Mycobacterium Ulcerans Journal of Bacteriology. Mar, 2005 | Pubmed ID: 15716437 ESAT-6 Proteins: Protective Antigens and Virulence Factors? Trends in Microbiology. Nov, 2004 | Pubmed ID: 15488391 Enhanced Protection Against Tuberculosis by Vaccination with Recombinant Mycobacterium Microti Vaccine That Induces T Cell Immunity Against Region of Difference 1 Antigens The Journal of Infectious Diseases. Jul, 2004 | Pubmed ID: 15195250 Cell Envelope Protein PPE68 Contributes to Mycobacterium Tuberculosis RD1 Immunogenicity Independently of a 10-kilodalton Culture Filtrate Protein and ESAT-6 Infection and Immunity. Apr, 2004 | Pubmed ID: 15039340 Macro-array and Bioinformatic Analyses Reveal Mycobacterial 'core' Genes, Variation in the ESAT-6 Gene Family and New Phylogenetic Markers for the Mycobacterium Tuberculosis Complex Microbiology (Reading, England). Feb, 2004 | Pubmed ID: 14766927 Genotypic Analysis of Mycobacterium Tuberculosis in Bangladesh and Prevalence of the Beijing Strain Journal of Clinical Microbiology. Feb, 2004 | Pubmed ID: 14766836 Giant Plasmid-encoded Polyketide Synthases Produce the Macrolide Toxin of Mycobacterium Ulcerans Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004 | Pubmed ID: 14736915 Recombinant BCG Exporting ESAT-6 Confers Enhanced Protection Against Tuberculosis Nature Medicine. May, 2003 | Pubmed ID: 12692540 Is Mycobacterium Africanum Subtype II (Uganda I and Uganda II) a Genetically Well-defined Subspecies of the Mycobacterium Tuberculosis Complex? Journal of Clinical Microbiology. Mar, 2003 | Pubmed ID: 12624085 Loss of RD1 Contributed to the Attenuation of the Live Tuberculosis Vaccines Mycobacterium Bovis BCG and Mycobacterium Microti Molecular Microbiology. Nov, 2002 | Pubmed ID: 12410828 Bacterial Artificial Chromosome-based Comparative Genomic Analysis Identifies Mycobacterium Microti As a Natural ESAT-6 Deletion Mutant Infection and Immunity. Oct, 2002 | Pubmed ID: 12228284 Rapid and Simple Approach for Identification of Mycobacterium Tuberculosis Complex Isolates by PCR-based Genomic Deletion Analysis Journal of Clinical Microbiology. Jul, 2002 | Pubmed ID: 12089245 Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen Genomes and Human Health. Mycobacterial Genomics Transactions of the Royal Society of Tropical Medicine and Hygiene. Jan-Feb, 2002 | Pubmed ID: 11925980 Encellete Målinger av vacuolar Rupture forårsaket av intracellulære patogener Charlotte Keller*1, Nora Mellouk*1, Anne Danckaert2, Roxane Simeone3, Roland Brosch3, Jost Enninga1, Alexandre Bobard1 1Dynamique des Interactions Hôte Pathogène, Institut Pasteur, Paris, France, 2Imagopole, Institut Pasteur, Paris, France, 3Pathogenomique Mycobacterienne Integrée, Institut Pasteur, Paris, France JoVE 50116 Immunology and Infection
Encellete Målinger av vacuolar Rupture forårsaket av intracellulære patogener Charlotte Keller*1, Nora Mellouk*1, Anne Danckaert2, Roxane Simeone3, Roland Brosch3, Jost Enninga1, Alexandre Bobard1 1Dynamique des Interactions Hôte Pathogène, Institut Pasteur, Paris, France, 2Imagopole, Institut Pasteur, Paris, France, 3Pathogenomique Mycobacterienne Integrée, Institut Pasteur, Paris, France JoVE 50116 Immunology and Infection