Roosmarijn E. Vandenbroucke

Publications

• Choroid Plexus-derived Extracellular Vesicles Exhibit Brain Targeting Characteristics
  Biomaterials. Nov, 2022  |   Pubmed ID: 36302306
• A Mouse Model of Hepatic Encephalopathy: Bile Duct Ligation Induces Brain Ammonia Overload, Glial Cell Activation and Neuroinflammation
  Scientific Reports. Oct, 2022  |   Pubmed ID: 36266427
• Differential Plasticity and Fate of Brain-resident and Recruited Macrophages During the Onset and Resolution of Neuroinflammation
  Immunity. Nov, 2022  |   Pubmed ID: 36228615
• Recent Insights into Viral Infections As a Trigger and Accelerator in Alzheimer's Disease
  Drug Discovery Today. Aug, 2022  |   Pubmed ID: 35987492
• Biomarker and Therapeutic Potential of Peripheral Extracellular Vesicles in Alzheimer's Disease
  Advanced Drug Delivery Reviews. Nov, 2022  |   Pubmed ID: 35952829
• Targeting Gliovascular Connexins Prevents Inflammatory Blood-brain Barrier Leakage and Astrogliosis
  JCI Insight. Aug, 2022  |   Pubmed ID: 35881483
• High-Precision Isotopic Analysis of Cu and Fe Multi-Collector Inductively Coupled Plasma-Mass Spectrometry Reveals Lipopolysaccharide-Induced Inflammatory Effects in Blood Plasma and Brain Tissues
  Frontiers in Chemistry. 2022  |   Pubmed ID: 35783204
• Astrocyte-targeted Gene Delivery of Interleukin 2 Specifically Increases Brain-resident Regulatory T Cell Numbers and Protects Against Pathological Neuroinflammation
  Nature Immunology. Jun, 2022  |   Pubmed ID: 35618831
• The Tremendous Biomedical Potential of Bacterial Extracellular Vesicles
  Trends in Biotechnology. Oct, 2022  |   Pubmed ID: 35581020
• Fighting Fire with Fire: The Immune System Might Be Key in Our Fight Against Alzheimer's Disease
  Drug Discovery Today. May, 2022  |   Pubmed ID: 35032668
• The Impact of Systemic Inflammation on Alzheimer's Disease Pathology
  Frontiers in Immunology. 2021  |   Pubmed ID: 35069578
• Anti-Inflammatory Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Pathology in Niemann-Pick Type C Disease
  Biomedicines. Dec, 2021  |   Pubmed ID: 34944681
• Special DelEVery: Extracellular Vesicles As Promising Delivery Platform to the Brain
  Biomedicines. Nov, 2021  |   Pubmed ID: 34829963
• Gastric Infection Partially Protects Against Neurotoxicity in A 6-OHDA Parkinson's Disease Mouse Model
  International Journal of Molecular Sciences. Oct, 2021  |   Pubmed ID: 34768765
• Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C
  Frontiers in Cellular Neuroscience. 2021  |   Pubmed ID: 34720883
• Low-grade Peripheral Inflammation Affects Brain Pathology in the Appmouse Model of Alzheimer's Disease
  Acta Neuropathologica Communications. Oct, 2021  |   Pubmed ID: 34620254
• Amelioration of Systemic Inflammation Via the Display of Two Different Decoy Protein Receptors on Extracellular Vesicles
  Nature Biomedical Engineering. Sep, 2021  |   Pubmed ID: 34616047
• The Neurogliovascular Unit in Hepatic Encephalopathy
  JHEP Reports : Innovation in Hepatology. Oct, 2021  |   Pubmed ID: 34611619
• Extracellular Vesicles: A Double-Edged Sword in Sepsis
  Pharmaceuticals (Basel, Switzerland). Aug, 2021  |   Pubmed ID: 34451925
• The Power of Imaging to Understand Extracellular Vesicle Biology in Vivo
  Nature Methods. Sep, 2021  |   Pubmed ID: 34446922
• Importance of Extracellular Vesicle Secretion at the Blood-cerebrospinal Fluid Interface in the Pathogenesis of Alzheimer's Disease
  Acta Neuropathologica Communications. Aug, 2021  |   Pubmed ID: 34425919
• Effect of Endotoxemia Induced by Intraperitoneal Injection of Lipopolysaccharide on the Mg Isotopic Composition of Biofluids and Tissues in Mice
  Frontiers in Medicine. 2021  |   Pubmed ID: 34368182
• Profiling of Extracellular Small RNAs Highlights a Strong Bias Towards Non-Vesicular Secretion
  Cells. Jun, 2021  |   Pubmed ID: 34207405
• Single-cell Profiling of Myeloid Cells in Glioblastoma Across Species and Disease Stage Reveals Macrophage Competition and Specialization
  Nature Neuroscience. Apr, 2021  |   Pubmed ID: 33782623
• and the Potential Role in Neurological Disorders: There Is More Than
  Frontiers in Immunology. 2020  |   Pubmed ID: 33633723
• Extracellular Vesicles in Alzheimer's and Parkinson's Disease: Small Entities with Large Consequences
  Cells. Nov, 2020  |   Pubmed ID: 33203181
• High-precision Isotopic Analysis of Mg and Ca in Biological Samples Using Multi-collector ICP-mass Spectrometry After Their Sequential Chromatographic Isolation - Application to the Characterization of the Body Distribution of Mg and Ca Isotopes in Mice
  Analytica Chimica Acta. Sep, 2020  |   Pubmed ID: 32892933
• Tightening the Retinal Glia Limitans Attenuates Neuroinflammation After Optic Nerve Injury
  Glia. Dec, 2020  |   Pubmed ID: 32645232
• Microglial Activation Arises After Aggregation of Phosphorylated-tau in a Neuron-specific P301S Tauopathy Mouse Model
  Neurobiology of Aging. May, 2020  |   Pubmed ID: 32008854
• A Study of Cecal Ligation and Puncture-Induced Sepsis in Tissue-Specific Tumor Necrosis Factor Receptor 1-Deficient Mice
  Frontiers in Immunology. 2019  |   Pubmed ID: 31787972
• Biological Membranes in EV Biogenesis, Stability, Uptake, and Cargo Transfer: an ISEV Position Paper Arising from the ISEV Membranes and EVs Workshop
  Journal of Extracellular Vesicles. 2019  |   Pubmed ID: 31762963
• Blocking Connexin43 Hemichannels Protects Mice Against Tumour Necrosis Factor-induced Inflammatory Shock
  Scientific Reports. 11, 2019  |   Pubmed ID: 31719598
• Interferons: A Molecular Switch Between Damage and Repair in Ageing and Alzheimer's Disease
  Mechanisms of Ageing and Development. Oct, 2019  |   Pubmed ID: 31541624
• Immunogenicity and Protection Efficacy of a Naked Self-Replicating MRNA-Based Zika Virus Vaccine
  Vaccines. Aug, 2019  |   Pubmed ID: 31450775
• Choroid Plexus-derived MiR-204 Regulates the Number of Quiescent Neural Stem Cells in the Adult Brain
  The EMBO Journal. Sep, 2019  |   Pubmed ID: 31304985
• A Single-cell Atlas of Mouse Brain Macrophages Reveals Unique Transcriptional Identities Shaped by Ontogeny and Tissue Environment
  Nature Neuroscience. Jun, 2019  |   Pubmed ID: 31061494
• Choroid Plexus Tumor Necrosis Factor Receptor 1: A New Neuroinflammatory Piece of the Complex Alzheimer's Disease Puzzle
  Neural Regeneration Research. Jul, 2019  |   Pubmed ID: 30804238
• The N-terminal P.(Ser38Cys) TIMP3 Mutation Underlying Sorsby Fundus Dystrophy is a Founder Mutation Disrupting an Intramolecular Disulfide Bond
  Human Mutation. May, 2019  |   Pubmed ID: 30668888
• Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis
  Shock (Augusta, Ga.). Aug, 2019  |   Pubmed ID: 30124596
• A New Venue of TNF Targeting
  International Journal of Molecular Sciences. May, 2018  |   Pubmed ID: 29751683
• Glucocorticoid Receptor Dimers Control Intestinal STAT1 and TNF-induced Inflammation in Mice
  The Journal of Clinical Investigation. Aug, 2018  |   Pubmed ID: 29746256
• Counteracting the Effects of TNF Receptor-1 Has Therapeutic Potential in Alzheimer's Disease
  EMBO Molecular Medicine. Apr, 2018  |   Pubmed ID: 29472246
• Correction To: Current Research into Brain Barriers and the Delivery of Therapeutics for Neurological Diseases: a Report on CNS Barrier Congress London, UK, 2017
  Fluids and Barriers of the CNS. 01, 2018  |   Pubmed ID: 29329565
• The Choroid Plexus Epithelium As a Novel Player in the Stomach-brain Axis During Helicobacter Infection
  Brain, Behavior, and Immunity. Mar, 2018  |   Pubmed ID: 29258921
• Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis
  Critical Care Medicine. Jan, 2018  |   Pubmed ID: 29095202
• Current Research into Brain Barriers and the Delivery of Therapeutics for Neurological Diseases: a Report on CNS Barrier Congress London, UK, 2017
  Fluids and Barriers of the CNS. Nov, 2017  |   Pubmed ID: 29110676
• TNFR1 Inhibition with a Nanobody Protects Against EAE Development in Mice
  Scientific Reports. Oct, 2017  |   Pubmed ID: 29057962
• Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor
  Gastroenterology. Oct, 2017  |   Pubmed ID: 28642198
• A Hidden Epithelial Barrier in the Brain with a Central Role in Regulating Brain Homeostasis. Implications for Aging
  Annals of the American Thoracic Society. Dec, 2016  |   Pubmed ID: 28005425
• MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment
  International Journal of Molecular Sciences. Nov, 2016  |   Pubmed ID: 27809288
• Mouse Models of Ageing and Their Relevance to Disease
  Mechanisms of Ageing and Development. Dec, 2016  |   Pubmed ID: 27717883
• Sizing Nanomaterials in Bio-fluids by CFRAP Enables Protein Aggregation Measurements and Diagnosis of Bio-barrier Permeability
  Nature Communications. Sep, 2016  |   Pubmed ID: 27653841
• Identification of a Novel Mechanism of Blood-brain Communication During Peripheral Inflammation Via Choroid Plexus-derived Extracellular Vesicles
  EMBO Molecular Medicine. Oct, 2016  |   Pubmed ID: 27596437
• With Mouse Age Comes Wisdom: A Review and Suggestions of Relevant Mouse Models for Age-related Conditions
  Mechanisms of Ageing and Development. Dec, 2016  |   Pubmed ID: 27450180
• Caloric Restriction: Beneficial Effects on Brain Aging and Alzheimer's Disease
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Aug, 2016  |   Pubmed ID: 27240590
• The Choroid Plexus-cerebrospinal Fluid Interface in Alzheimer's Disease: More Than Just a Barrier
  Neural Regeneration Research. Apr, 2016  |   Pubmed ID: 27212900
• Efficient Analysis of Mouse Genome Sequences Reveal Many Nonsense Variants
  Proceedings of the National Academy of Sciences of the United States of America. May, 2016  |   Pubmed ID: 27147605
• The Effect of Aging on Brain Barriers and the Consequences for Alzheimer's Disease Development
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Aug, 2016  |   Pubmed ID: 27143113
• Nanobodies As Therapeutics: Big Opportunities for Small Antibodies
  Drug Discovery Today. Jul, 2016  |   Pubmed ID: 27080147
• Comparing Exosome-like Vesicles with Liposomes for the Functional Cellular Delivery of Small RNAs
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2016  |   Pubmed ID: 27072025
• Into Rather Unexplored Terrain-transcellular Transport Across the Blood-brain Barrier
  Glia. Jul, 2016  |   Pubmed ID: 26852907
• Topical Imiquimod Yields Systemic Effects Due to Unintended Oral Uptake
  Scientific Reports. Jan, 2016  |   Pubmed ID: 26818707
• Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8
  Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2016  |   Pubmed ID: 26775809
• Endothelial LRP1 Transports Amyloid-β(1-42) Across the Blood-brain Barrier
  The Journal of Clinical Investigation. Jan, 2016  |   Pubmed ID: 26619118
• Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases
  Mediators of Inflammation. 2015  |   Pubmed ID: 26538832
• Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 As TNF Sheddase
  Mediators of Inflammation. 2015  |   Pubmed ID: 26451076
• Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2015  |   Pubmed ID: 26377465
• Hematopoietic Plakophilin-3 Regulates Acute Tissue-specific and Systemic Inflammation in Mice
  European Journal of Immunology. Oct, 2015  |   Pubmed ID: 26173741
• Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice
  Immunity. Jul, 2015  |   Pubmed ID: 26163370
• Therapeutic Implications of the Choroid Plexus-cerebrospinal Fluid Interface in Neuropsychiatric Disorders
  Brain, Behavior, and Immunity. Nov, 2015  |   Pubmed ID: 26116435
• Glucocorticoid-induced MicroRNA-511 Protects Against TNF by Down-regulating TNFR1
  EMBO Molecular Medicine. Aug, 2015  |   Pubmed ID: 25995337
• Clinical Implications of Leukocyte Infiltration at the Choroid Plexus in (neuro)inflammatory Disorders
  Drug Discovery Today. Aug, 2015  |   Pubmed ID: 25979470
• Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2015  |   Pubmed ID: 25911755
• Generation and Characterization of Small Single Domain Antibodies Inhibiting Human Tumor Necrosis Factor Receptor 1
  The Journal of Biological Chemistry. Feb, 2015  |   Pubmed ID: 25538244
• An Inflammatory Triangle in Psoriasis: TNF, Type I IFNs and IL-17
  Cytokine & Growth Factor Reviews. Feb, 2015  |   Pubmed ID: 25434285
• Is There New Hope for Therapeutic Matrix Metalloproteinase Inhibition?
  Nature Reviews. Drug Discovery. Dec, 2014  |   Pubmed ID: 25376097
• Tauroursodeoxycholic Acid Inhibits Experimental Colitis by Preventing Early Intestinal Epithelial Cell Death
  Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2014  |   Pubmed ID: 25310532
• Choose Your Models Wisely: How Different Murine Bone Marrow-derived Dendritic Cell Protocols Influence the Success of Nanoparticulate Vaccines in Vitro
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2014  |   Pubmed ID: 24960224
• A New Angle on Blood-CNS Interfaces: a Role for Connexins?
  FEBS Letters. Apr, 2014  |   Pubmed ID: 24631535
• An Acute Phase Protein Ready to Go Therapeutic for Sepsis
  EMBO Molecular Medicine. Jan, 2014  |   Pubmed ID: 24408964
• Antisense Oligonucleotides Against TNFR1 Prevent Toxicity of TNF/IFNγ Treatment in Mouse Tumor Models
  International Journal of Cancer. Aug, 2014  |   Pubmed ID: 24382818
• Mice Overexpressing β-1,4-Galactosyltransferase I Are Resistant to TNF-induced Inflammation and DSS-induced Colitis
  PloS One. 2013  |   Pubmed ID: 24339869
• Matrix Metalloproteinase 13 Modulates Intestinal Epithelial Barrier Integrity in Inflammatory Diseases by Activating TNF
  EMBO Molecular Medicine. Jul, 2013  |   Pubmed ID: 23723167
• Safe TNF-based Antitumor Therapy Following P55TNFR Reduction in Intestinal Epithelium
  The Journal of Clinical Investigation. Jun, 2013  |   Pubmed ID: 23676465
• Treatment of TNF Mediated Diseases by Selective Inhibition of Soluble TNF or TNFR1
  Cytokine & Growth Factor Reviews. 2011  |   Pubmed ID: 21962830
• Matrix Metalloproteinases As Drug Targets in Ischemia/reperfusion Injury
  Drug Discovery Today. Sep, 2011  |   Pubmed ID: 21745586
• The First MMP in Sepsis
  EMBO Molecular Medicine. Jul, 2011  |   Pubmed ID: 21591260
• Matrix Metalloproteinase8 Has a Central Role in Inflammatory Disorders and Cancer Progression
  Cytokine & Growth Factor Reviews. Apr, 2011  |   Pubmed ID: 21388856
• The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2010  |   Pubmed ID: 20010917