Seppo Parkkila Faculty of Medicine and Health Technology Tampere University Biography Publications Institution JoVE Articles Seppo Parkkila has not added a biography. If you are Seppo Parkkila and would like to personalize this page please email our Author Liaison for assistance. Publications Phytochemicals As Modulators of Long Non-Coding RNAs and Inhibitors of Cancer-Related Carbonic Anhydrases International Journal of Molecular Sciences. Jun, 2019 | Pubmed ID: 31208095 Catalytically Inactive Carbonic Anhydrase-related Proteins Enhance Transport of Lactate by MCT1 FEBS Open Bio. Jul, 2019 | Pubmed ID: 31033227 Discovery of New Organoselenium Compounds As Antileishmanial Agents Bioorganic Chemistry. May, 2019 | Pubmed ID: 30743174 Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan with Amino Acids and Amines Metabolites. Feb, 2019 | Pubmed ID: 30717275 R-Ras Regulates Vascular Permeability, but Not Overall Healing in Skin Wounds Experimental Dermatology. Feb, 2019 | Pubmed ID: 30489650 Sulfonamide Inhibition Studies of a New β-Carbonic Anhydrase from the Pathogenic Protozoan International Journal of Molecular Sciences. Dec, 2018 | Pubmed ID: 30544802 Cloning, Characterization and Anion Inhibition Studies of a β-Carbonic Anhydrase from the Pathogenic Protozoan Molecules (Basel, Switzerland). Nov, 2018 | Pubmed ID: 30486513 Carbonic Anhydrase Inhibitors As Novel Drugs Against Mycobacterial β-Carbonic Anhydrases: An Update on and Studies Molecules (Basel, Switzerland). Nov, 2018 | Pubmed ID: 30413024 Toll-like Receptors 2, 4 and 9 and Hypoxia Markers HIF-1alpha and CAIX in Pancreatic Intraepithelial Neoplasia APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Nov, 2018 | Pubmed ID: 30357962 Carbonic Anhydrases II, IX, and XII in Barrett's Esophagus and Adenocarcinoma Virchows Archiv : an International Journal of Pathology. Nov, 2018 | Pubmed ID: 30066203 Activation Studies with Amines and Amino Acids of the α-carbonic Anhydrase from the Pathogenic Protozoan Trypanosoma Cruzi Bioorganic & Medicinal Chemistry. 08, 2018 | Pubmed ID: 30007565 Weak HIF-1alpha Expression Indicates Poor Prognosis in Resectable Pancreatic Ductal Adenocarcinoma World Journal of Surgical Oncology. Jul, 2018 | Pubmed ID: 29973215 Nitroimidazole-based Inhibitors DTP338 and DTP348 Are Safe for Zebrafish Embryos and Efficiently Inhibit the Activity of Human CA IX in Xenopus Oocytes Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2018 | Pubmed ID: 29909747 Involvement of β-Carbonic Anhydrase Genes in Bacterial Genomic Islands and Their Horizontal Transfer to Protists Applied and Environmental Microbiology. 08, 2018 | Pubmed ID: 29802189 Carbonic Anhydrase Related Protein Expression in Astrocytomas and Oligodendroglial Tumors BMC Cancer. May, 2018 | Pubmed ID: 29792187 Activation Studies with Amines and Amino Acids of the β-carbonic Anhydrase from the Pathogenic Protozoan Leishmania Donovani Chagasi Bioorganic Chemistry. 08, 2018 | Pubmed ID: 29689418 An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas Reinhardtii Metabolites. Mar, 2018 | Pubmed ID: 29534024 Surveillance and Diagnosis of Zoonotic Foodborne Parasites Food Science & Nutrition. 01, 2018 | Pubmed ID: 29387356 Identification and Characterization of a Novel Zebrafish (Danio Rerio) Pentraxin-carbonic Anhydrase PeerJ. 2017 | Pubmed ID: 29230365 β-CA-specific Inhibitor Dithiocarbamate Fc14-584B: a Novel Antimycobacterial Agent with Potential to Treat Drug-resistant Tuberculosis Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2017 | Pubmed ID: 28629306 Role of Carbonic Anhydrases in Skin Wound Healing Experimental & Molecular Medicine. 05, 2017 | Pubmed ID: 28524177 Carbonic Anhydrase II: a Novel Biomarker for Pseudomyxoma Peritonei APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Mar, 2017 | Pubmed ID: 28233447 Anti-carbonic Anhydrase Autoantibodies and Serum Beta-2 Microglobulin Correlate with the ClinESSDAI Score in Patients with Sjögren's Syndrome Clinical and Experimental Rheumatology. Mar-Apr, 2017 | Pubmed ID: 28079504 Fluorinated Benzenesulfonamide Anticancer Inhibitors of Carbonic Anhydrase IX Exhibit Lower Toxic Effects on Zebrafish Embryonic Development Than Ethoxzolamide Drug and Chemical Toxicology. Jul, 2017 | Pubmed ID: 27600313 Carbonic Anhydrase Enzymes II, VII, IX and XII in Colorectal Carcinomas World Journal of Gastroenterology. Sep, 2016 | Pubmed ID: 27688658 Identification and Inhibition of Carbonic Anhydrases from Nematodes Journal of Enzyme Inhibition and Medicinal Chemistry. 2016 | Pubmed ID: 27557594 Altered Gene Expression in the Lower Respiratory Tract of Car6 (-/-) Mice Transgenic Research. 10, 2016 | Pubmed ID: 27209317 Carbonic Anhydrase IX Deposits Are Associated with Increased Ascending Aortic Dilatation Scandinavian Cardiovascular Journal : SCJ. Jun, 2016 | Pubmed ID: 27157093 Horizontal Transfer of β-carbonic Anhydrase Genes from Prokaryotes to Protozoans, Insects, and Nematodes Parasites & Vectors. Mar, 2016 | Pubmed ID: 26983858 Innovative Molecular Diagnosis of Trichinella Species Based on β-carbonic Anhydrase Genomic Sequence Microbial Biotechnology. Mar, 2016 | Pubmed ID: 26639312 Discovery of 1,1'-Biphenyl-4-sulfonamides As a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors Journal of Medicinal Chemistry. Nov, 2015 | Pubmed ID: 26497049 Ascaris Lumbricoides β Carbonic Anhydrase: a Potential Target Enzyme for Treatment of Ascariasis Parasites & Vectors. Sep, 2015 | Pubmed ID: 26385556 β Carbonic Anhydrase is Required for Female Fertility in Drosophila Melanogaster Frontiers in Zoology. 2015 | Pubmed ID: 26300950 Inactivation of Ca10a and Ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish PloS One. 2015 | Pubmed ID: 26218428 The β-carbonic Anhydrase from the Malaria Mosquito Anopheles Gambiae is Highly Inhibited by Sulfonamides Bioorganic & Medicinal Chemistry. May, 2015 | Pubmed ID: 25882523 Beta Carbonic Anhydrases: Novel Targets for Pesticides and Anti-parasitic Agents in Agriculture and Livestock Husbandry Parasites & Vectors. Aug, 2014 | Pubmed ID: 25174433 The Role of Carbonic Anhydrase VI in Bitter Taste Perception: Evidence from the Car6⁻/⁻ Mouse Model Journal of Biomedical Science. Aug, 2014 | Pubmed ID: 25134447 Sulfonamide Inhibition Studies of the β Carbonic Anhydrase from Drosophila Melanogaster Bioorganic & Medicinal Chemistry Letters. Jul, 2014 | Pubmed ID: 24852120 Expression Patterns and Subcellular Localization of Carbonic Anhydrases Are Developmentally Regulated During Tooth Formation PloS One. 2014 | Pubmed ID: 24789143 Hsp27 and Its Expression Pattern in Diffusely Infiltrating Astrocytomas Histology and Histopathology. Sep, 2014 | Pubmed ID: 24599602 Bioinformatic Analysis of Beta Carbonic Anhydrase Sequences from Protozoans and Metazoans Parasites & Vectors. Jan, 2014 | Pubmed ID: 24447594 Anion Inhibition Studies of the α-carbonic Anhydrase from the Protozoan Pathogen Trypanosoma Cruzi, the Causative Agent of Chagas Disease Bioorganic & Medicinal Chemistry. Aug, 2013 | Pubmed ID: 23790722 Cloning, Characterization, and Sulfonamide and Thiol Inhibition Studies of an α-carbonic Anhydrase from Trypanosoma Cruzi, the Causative Agent of Chagas Disease Journal of Medicinal Chemistry. Feb, 2013 | Pubmed ID: 23391336 Characterization, Bioinformatic Analysis and Dithiocarbamate Inhibition Studies of Two New α-carbonic Anhydrases, CAH1 and CAH2, from the Fruit Fly Drosophila Melanogaster Bioorganic & Medicinal Chemistry. Mar, 2013 | Pubmed ID: 22989910 Serendipitous Fragment-based Drug Discovery: Ketogenic Diet Metabolites and Statins Effectively Inhibit Several Carbonic Anhydrases Chemical Communications (Cambridge, England). Apr, 2012 | Pubmed ID: 22382897 Characterization of Non-specific Cytotoxic Cell Receptor Protein 1: a New Member of the Lectin-type Subfamily of F-box Proteins PloS One. 2011 | Pubmed ID: 22087255 Oral Colonization by Streptococcus Mutans and Caries Development is Reduced Upon Deletion of Carbonic Anhydrase VI Expression in Saliva Biochimica Et Biophysica Acta. Dec, 2011 | Pubmed ID: 21945428 Acetaldehyde-derived Modifications on Cytosolic Human Carbonic Anhydrases Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2011 | Pubmed ID: 21679053 Novel Carbonic Anhydrase Autoantibodies and Renal Manifestations in Patients with Primary Sjogren's Syndrome Rheumatology (Oxford, England). Aug, 2011 | Pubmed ID: 21427176 Characterization of the First Beta-class Carbonic Anhydrase from an Arthropod (Drosophila Melanogaster) and Phylogenetic Analysis of Beta-class Carbonic Anhydrases in Invertebrates BMC Biochemistry. Jul, 2010 | Pubmed ID: 20659325 Global Transcriptional Response to Carbonic Anhydrase IX Deficiency in the Mouse Stomach BMC Genomics. Jun, 2010 | Pubmed ID: 20573196 Carbonic Anhydrases II and XII Are Up-regulated in Osteoclast-like Cells in Advanced Human Atherosclerotic Plaques-Tampere Vascular Study Annals of Medicine. Jul, 2010 | Pubmed ID: 20509747 Analysis of a Shortened Form of Human Carbonic Anhydrase VII Expressed in Vitro Compared to the Full-length Enzyme Biochimie. Aug, 2010 | Pubmed ID: 20493921 The Tumour-associated Carbonic Anhydrases CA II, CA IX and CA XII in a Group of Medulloblastomas and Supratentorial Primitive Neuroectodermal Tumours: an Association of CA IX with Poor Prognosis BMC Cancer. Apr, 2010 | Pubmed ID: 20398423 Phylogeny and Expression of Carbonic Anhydrase-related Proteins BMC Molecular Biology. Mar, 2010 | Pubmed ID: 20356370 Specific Expression Profile and Prognostic Significance of Peroxiredoxins in Grade II-IV Astrocytic Brain Tumors BMC Cancer. Mar, 2010 | Pubmed ID: 20307276 The Most Recently Discovered Carbonic Anhydrase, CA XV, is Expressed in the Thick Ascending Limb of Henle and in the Collecting Ducts of Mouse Kidney PloS One. Mar, 2010 | Pubmed ID: 20224780 Carbonic Anhydrase II. A Novel Biomarker for Gastrointestinal Stromal Tumors Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. May, 2010 | Pubmed ID: 20081808 Crystal Structure of the Catalytic Domain of the Tumor-associated Human Carbonic Anhydrase IX Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009 | Pubmed ID: 19805286 Global Transcriptional Response to Hfe Deficiency and Dietary Iron Overload in Mouse Liver and Duodenum PloS One. Sep, 2009 | Pubmed ID: 19787063 The Protein Tyrosine Kinase Inhibitors Imatinib and Nilotinib Strongly Inhibit Several Mammalian Alpha-carbonic Anhydrase Isoforms Bioorganic & Medicinal Chemistry Letters. Aug, 2009 | Pubmed ID: 19527930 Expression of Iron-related Genes in Human Brain and Brain Tumors BMC Neuroscience. Apr, 2009 | Pubmed ID: 19386095 Cloning, Expression, Post-translational Modifications and Inhibition Studies on the Latest Mammalian Carbonic Anhydrase Isoform, CA XV Journal of Medicinal Chemistry. Feb, 2009 | Pubmed ID: 19193158 Modification of Carbonic Anhydrase II with Acetaldehyde, the First Metabolite of Ethanol, Leads to Decreased Enzyme Activity BMC Biochemistry. Nov, 2008 | Pubmed ID: 19036170 Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes The Journal of Biological Chemistry. Oct, 2008 | Pubmed ID: 18703501 Significance of PH Regulation and Carbonic Anhydrases in Tumour Progression and Implications for Diagnostic and Therapeutic Approaches BJU International. Jun, 2008 | Pubmed ID: 18430117 Identification of an Alternatively Spliced Isoform of Carbonic Anhydrase XII in Diffusely Infiltrating Astrocytic Gliomas Neuro-oncology. Apr, 2008 | Pubmed ID: 18322268 The Calcium-binding Protein S100P in Normal and Malignant Human Tissues BMC Clinical Pathology. Feb, 2008 | Pubmed ID: 18282279 Carbonic Anhydrase IX in Oligodendroglial Brain Tumors BMC Cancer. Jan, 2008 | Pubmed ID: 18173856 Effects of Iron Loading on Muscle: Genome-wide MRNA Expression Profiling in the Mouse BMC Genomics. Oct, 2007 | Pubmed ID: 17949489 Characterization and Inhibition of the Recently Discovered Carbonic Anhydrase Isoforms CA XIII, XIV and XV Current Topics in Medicinal Chemistry. 2007 | Pubmed ID: 17504134 Carbonic Anhydrase II in the Endothelium of Glial Tumors: a Potential Target for Therapy Neuro-oncology. Jul, 2007 | Pubmed ID: 17435181 A Systematic Quantification of Carbonic Anhydrase Transcripts in the Mouse Digestive System BMC Molecular Biology. Mar, 2007 | Pubmed ID: 17362527 Expression of Membrane-bound Carbonic Anhydrases IV, IX, and XIV in the Mouse Heart The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Dec, 2006 | Pubmed ID: 16924128 Carbonic Anhydrase Activators: Activation of Isozyme XIII with Amino Acids and Amines Bioorganic & Medicinal Chemistry Letters. Aug, 2006 | Pubmed ID: 16730978 Expression of Carbonic Anhydrases IX and XII During Mouse Embryonic Development BMC Developmental Biology. May, 2006 | Pubmed ID: 16719910 Expression of Carbonic Anhydrase IX in Astrocytic Tumors Predicts Poor Prognosis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2006 | Pubmed ID: 16428489 Carbonic Anhydrase Gene Expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) Mice The Journal of Physiology. Mar, 2006 | Pubmed ID: 16396925 Expression of Carbonic Anhydrases II, IV, VII, VIII and XII in Rat Brain After Kainic Acid Induced Status Epilepticus Neurochemistry International. Jan, 2006 | Pubmed ID: 16271802 Carbonic Anhydrase Isozyme-II-deficient Mice Lack the Duodenal Bicarbonate Secretory Response to Prostaglandin E2 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2005 | Pubmed ID: 16217040 Characterization of CA XV, a New GPI-anchored Form of Carbonic Anhydrase The Biochemical Journal. Nov, 2005 | Pubmed ID: 16083424 Expression of Von Hippel-Lindau Tumor Suppressor and Tumor-associated Carbonic Anhydrases IX and XII in Normal and Neoplastic Colorectal Mucosa World Journal of Gastroenterology. May, 2005 | Pubmed ID: 15849821 Expression of a Novel Carbonic Anhydrase, CA XIII, in Normal and Neoplastic Colorectal Mucosa BMC Cancer. Apr, 2005 | Pubmed ID: 15836783 Carbonic Anhydrases in Normal Gastrointestinal Tract and Gastrointestinal Tumours World Journal of Gastroenterology. Jan, 2005 | Pubmed ID: 15633208 Hepatic and Extrahepatic Expression of the New Iron Regulatory Protein Hemojuvelin Haematologica. Dec, 2004 | Pubmed ID: 15590393 Transmembrane Carbonic Anhydrase Isozymes IX and XII in the Female Mouse Reproductive Organs Reproductive Biology and Endocrinology : RB&E. Oct, 2004 | Pubmed ID: 15488153 Carbonic Anhydrase Inhibitors. Inhibition of Cytosolic Isozyme XIII with Aromatic and Heterocyclic Sulfonamides: a Novel Target for the Drug Design Bioorganic & Medicinal Chemistry Letters. Jul, 2004 | Pubmed ID: 15203157 Expression of Hypoxia-inducible, Membrane-bound Carbonic Anhydrase Isozyme XII in Mouse Tissues The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology. Mar, 2004 | Pubmed ID: 14983512 Carbonic Anhydrase Isozymes IX and XII in Gastric Tumors World Journal of Gastroenterology. Jul, 2003 | Pubmed ID: 12854129 The Plasma Membrane Carbonic Anhydrase in Murine Hepatocytes Identified As Isozyme XIV BMC Gastroenterology. May, 2002 | Pubmed ID: 12033992 Zebrafish 배아를 이용한 화학 화합물의 독성에 대한 신속한 평가 Ashok Aspatwar1, Milka Marjut Hammaren1, Mataleena Parikka1,2, Seppo Parkkila1,3 1Faculty of Medicine and Health Technology, Tampere University, 2Oral and Maxillofacial Unit, Tampere University Hospital, 3Fimlab Ltd, Tampere University Hospital JoVE 59315 Medicine
Zebrafish 배아를 이용한 화학 화합물의 독성에 대한 신속한 평가 Ashok Aspatwar1, Milka Marjut Hammaren1, Mataleena Parikka1,2, Seppo Parkkila1,3 1Faculty of Medicine and Health Technology, Tampere University, 2Oral and Maxillofacial Unit, Tampere University Hospital, 3Fimlab Ltd, Tampere University Hospital JoVE 59315 Medicine