Sergei Sukharev Department of Biology University of Maryland Biography Publications Institution JoVE Articles Sergei Sukharev has not added a biography. If you are Sergei Sukharev and would like to personalize this page please email our Author Liaison for assistance. Publications Activation of Bacterial Channel MscL in Mechanically Stimulated Droplet Interface Bilayers Scientific Reports. 2015 | Pubmed ID: 26348441 Effects of Lys to Glu Mutations in GsMTx4 on Membrane Binding, Peptide Orientation, and Self-association Propensity, As Analyzed by Molecular Dynamics Simulations Biochimica Et Biophysica Acta. Nov, 2015 | Pubmed ID: 26342676 Membrane Affinity of Platensimycin and Its Dialkylamine Analogs International Journal of Molecular Sciences. 2015 | Pubmed ID: 26247942 Catalytic Role of the Substrate Defines Specificity of Therapeutic L-Asparaginase Journal of Molecular Biology. Aug, 2015 | Pubmed ID: 26142822 Properties of Diphytanoyl Phospholipids at the Air-water Interface Langmuir : the ACS Journal of Surfaces and Colloids. Jan, 2015 | Pubmed ID: 25474305 The Cytoplasmic Cage Domain of the Mechanosensitive Channel MscS is a Sensor of Macromolecular Crowding The Journal of General Physiology. May, 2014 | Pubmed ID: 24778428 The Glutaminase Activity of L-asparaginase is Not Required for Anticancer Activity Against ASNS-negative Cells Blood. Jun, 2014 | Pubmed ID: 24659632 The Mechanoelectrical Response of the Cytoplasmic Membrane of Vibrio Cholerae The Journal of General Physiology. Jul, 2013 | Pubmed ID: 23797422 Molecular Force Transduction by Ion Channels: Diversity and Unifying Principles Journal of Cell Science. Jul, 2012 | Pubmed ID: 22797911 Effects on Membrane Lateral Pressure Suggest Permeation Mechanisms for Bacterial Quorum Signaling Molecules Biochemistry. Aug, 2011 | Pubmed ID: 21736305 The Pathway and Spatial Scale for MscS Inactivation The Journal of General Physiology. Jul, 2011 | Pubmed ID: 21670207 Adaptive MscS Gating in the Osmotic Permeability Response in E. Coli: the Question of Time Biochemistry. May, 2011 | Pubmed ID: 21456519 Structural Models of TREK Channels and Their Gating Mechanism Channels (Austin, Tex.). Jan-Feb, 2011 | Pubmed ID: 21084863 Analyses of Gating Thermodynamics and Effects of Deletions in the Mechanosensitive Channel TREK-1: Comparisons with Structural Models Channels (Austin, Tex.). Jan-Feb, 2011 | Pubmed ID: 21057213 Effects of GsMTx4 on Bacterial Mechanosensitive Channels in Inside-out Patches from Giant Spheroplasts Biophysical Journal. Nov, 2010 | Pubmed ID: 21044584 Mechanosensitive Channels in Microbes Annual Review of Microbiology. 2010 | Pubmed ID: 20825352 Adaptive Behavior of Bacterial Mechanosensitive Channels is Coupled to Membrane Mechanics The Journal of General Physiology. Jun, 2010 | Pubmed ID: 20513760 Gadolinium Ions Block Mechanosensitive Channels by Altering the Packing and Lateral Pressure of Anionic Lipids Biophysical Journal. Mar, 2010 | Pubmed ID: 20303859 The Tension-transmitting 'clutch' in the Mechanosensitive Channel MscS Nature Structural & Molecular Biology. Apr, 2010 | Pubmed ID: 20208543 State-stabilizing Interactions in Bacterial Mechanosensitive Channel Gating and Adaptation The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19383606 The Membrane Lateral Pressure-perturbing Capacity of Parabens and Their Effects on the Mechanosensitive Channel Directly Correlate with Hydrophobicity Biochemistry. Oct, 2008 | Pubmed ID: 18795793 Mechanosensitive Channel MscS in the Open State: Modeling of the Transition, Explicit Simulations, and Experimental Measurements of Conductance The Journal of General Physiology. Jul, 2008 | Pubmed ID: 18591417 Characterization of the Resting MscS: Modeling and Analysis of the Closed Bacterial Mechanosensitive Channel of Small Conductance Biophysical Journal. Feb, 2008 | Pubmed ID: 17981908 Straightening and Sequential Buckling of the Pore-lining Helices Define the Gating Cycle of MscS Nature Structural & Molecular Biology. Dec, 2007 | Pubmed ID: 18037888 2,2,2-Trifluoroethanol Changes the Transition Kinetics and Subunit Interactions in the Small Bacterial Mechanosensitive Channel MscS Biophysical Journal. Apr, 2007 | Pubmed ID: 17277184 Capping Transmembrane Helices of MscL with Aromatic Residues Changes Channel Response to Membrane Stretch Biochemistry. Sep, 2005 | Pubmed ID: 16156671 Explicit Channel Conductance: Can It Be Computed? Biophysical Journal. Jun, 2005 | Pubmed ID: 15764668 Gain-of-function Mutations Reveal Expanded Intermediate States and a Sequential Action of Two Gates in MscL The Journal of General Physiology. Feb, 2005 | Pubmed ID: 15684093 The "dashpot" Mechanism of Stretch-dependent Gating in MscS The Journal of General Physiology. Feb, 2005 | Pubmed ID: 15657299 Mechanosensitive Channels: What Can We Learn from 'simple' Model Systems? Trends in Neurosciences. Jun, 2004 | Pubmed ID: 15165739 Water Dynamics and Dewetting Transitions in the Small Mechanosensitive Channel MscS Biophysical Journal. May, 2004 | Pubmed ID: 15111405 Gating of the Large Mechanosensitive Channel in Situ: Estimation of the Spatial Scale of the Transition from Channel Population Responses Biophysical Journal. May, 2004 | Pubmed ID: 15111402 Mechanosensitive Channels: Multiplicity of Families and Gating Paradigms Science's STKE : Signal Transduction Knowledge Environment. Feb, 2004 | Pubmed ID: 14872099 On the Conformation of the COOH-terminal Domain of the Large Mechanosensitive Channel MscL The Journal of General Physiology. Mar, 2003 | Pubmed ID: 12601086 A Large Iris-like Expansion of a Mechanosensitive Channel Protein Induced by Membrane Tension Nature Structural Biology. Sep, 2002 | Pubmed ID: 12172538 Purification of the Small Mechanosensitive Channel of Escherichia Coli (MscS): the Subunit Structure, Conduction, and Gating Characteristics in Liposomes Biophysical Journal. Jul, 2002 | Pubmed ID: 12080120 רב תכליתיים, Micropipette מבוסס שיטה להתאגדות וגירוי של ערוצים בקטריאלי Mechanosensitive יון בbilayers ממשק אגל Joseph S. Najem1, Myles D. Dunlap2, Anthony Yasmann3, Eric C. Freeman4, John W. Grant5, Sergei Sukharev3, Donald J. Leo4 1Department of Mechanical Engineering, Virginia Polytechnic Institute and State University, 2School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, 3Department of Biology, University of Maryland, 4College of Engineering, University of Georgia, 5Department of Engineering Sciences and Mechanics, Virginia Polytechnic Institute and State University JoVE 53362 Biology
רב תכליתיים, Micropipette מבוסס שיטה להתאגדות וגירוי של ערוצים בקטריאלי Mechanosensitive יון בbilayers ממשק אגל Joseph S. Najem1, Myles D. Dunlap2, Anthony Yasmann3, Eric C. Freeman4, John W. Grant5, Sergei Sukharev3, Donald J. Leo4 1Department of Mechanical Engineering, Virginia Polytechnic Institute and State University, 2School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, 3Department of Biology, University of Maryland, 4College of Engineering, University of Georgia, 5Department of Engineering Sciences and Mechanics, Virginia Polytechnic Institute and State University JoVE 53362 Biology