Shareen H. Doak In vitro Toxicology Group Swansea University Medical School Biography Publications Institution JoVE Articles Shareen H. Doak has not added a biography. If you are Shareen H. Doak and would like to personalize this page please email our Author Liaison for assistance. Publications Comparison of Passive-dosed and Solvent Spiked Exposures of Pro-carcinogen, Benzo[a]pyrene, to Human Lymphoblastoid Cell Line, MCL-5 Toxicology in Vitro : an International Journal Published in Association with BIBRA. Jun, 2020 | Pubmed ID: 32497684 Nanomaterials and Innate Immunity: A Perspective of the Current Status in Nanosafety Chemical Research in Toxicology. May, 2020 | Pubmed ID: 32307980 Use of in Vitro 3D Tissue Models in Genotoxicity Testing: Strategic Fit, Validation Status and Way Forward. Report of the Working Group from the 7 International Workshop on Genotoxicity Testing (IWGT) Mutation Research. Feb - Mar, 2020 | Pubmed ID: 32247552 Emerging Standards and Analytical Science for Nanoenabled Medical Products Annual Review of Analytical Chemistry (Palo Alto, Calif.). Feb, 2020 | Pubmed ID: 32084321 Horizon Scanning for Novel and Emerging in Vitro Mammalian Cell Mutagenicity Test Systems Mutation Research. 11, 2019 | Pubmed ID: 31699342 Genotoxicity Assessment of Nanomaterials: Recommendations on Best Practices, Assays, and Methods Toxicological Sciences : an Official Journal of the Society of Toxicology. 08, 2018 | Pubmed ID: 29701824 STEAP2 Knockdown Reduces the Invasive Potential of Prostate Cancer Cells Scientific Reports. 04, 2018 | Pubmed ID: 29674723 A Novel, Integrated in Vitro Carcinogenicity Test to Identify Genotoxic and Non-genotoxic Carcinogens Using Human Lymphoblastoid Cells Archives of Toxicology. Feb, 2018 | Pubmed ID: 29110037 Characterizing Nanoparticles in Biological Matrices: Tipping Points in Agglomeration State and Cellular Delivery In Vitro ACS Nano. 12, 2017 | Pubmed ID: 29072897 Aligning Nanotoxicology with the 3Rs: What is Needed to Realise the Short, Medium and Long-term Opportunities? Regulatory Toxicology and Pharmacology : RTP. Dec, 2017 | Pubmed ID: 29069581 Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways International Journal of Molecular Sciences. Jul, 2017 | Pubmed ID: 28703770 The Role of Intracellular Trafficking of CdSe/ZnS QDs on Their Consequent Toxicity Profile Journal of Nanobiotechnology. Jun, 2017 | Pubmed ID: 28619032 Choose Your Cell Model Wisely: The in Vitro Nanoneurotoxicity of Differentially Coated Iron Oxide Nanoparticles for Neural Cell Labeling Acta Biomaterialia. 06, 2017 | Pubmed ID: 28373085 Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice Frontiers in Surgery. 2017 | Pubmed ID: 28280722 Critical Review of the Current and Future Challenges Associated with Advanced in Vitro Systems Towards the Study of Nanoparticle (secondary) Genotoxicity Mutagenesis. 01, 2017 | Pubmed ID: 27815329 Is Nickel Chloride Really a Non-Genotoxic Carcinogen? Basic & Clinical Pharmacology & Toxicology. Sep, 2017 | Pubmed ID: 27748567 Factors Affecting the in Vitro Micronucleus Assay for Evaluation of Nanomaterials Mutagenesis. 01, 2017 | Pubmed ID: 27567283 Emerging Metrology for High-throughput Nanomaterial Genotoxicology Mutagenesis. 01, 2017 | Pubmed ID: 27565834 Genetic Toxicity Assessment of Engineered Nanoparticles Using a 3D in Vitro Skin Model (EpiDerm™) Particle and Fibre Toxicology. 09, 2016 | Pubmed ID: 27613375 Opinion of the Scientific Committee on Consumer Safety (SCCS) - Opinion on the Use of 2,2'-methylene-bis-(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) (nano) - S79 - In Cosmetic Products Regulatory Toxicology and Pharmacology : RTP. Apr, 2016 | Pubmed ID: 26776753 Empirical Analysis of BMD Metrics in Genetic Toxicology Part I: in Vitro Analyses to Provide Robust Potency Rankings and Support MOA Determinations Mutagenesis. 05, 2016 | Pubmed ID: 26687511 Genotoxic Capacity of Cd/Se Semiconductor Quantum Dots with Differing Surface Chemistries Mutagenesis. Jan, 2016 | Pubmed ID: 26275419 Cell Type-dependent Changes in CdSe/ZnS Quantum Dot Uptake and Toxic Endpoints Toxicological Sciences : an Official Journal of the Society of Toxicology. Apr, 2015 | Pubmed ID: 25601991 Real-time Reverse-transcription Polymerase Chain Reaction: Technical Considerations for Gene Expression Analysis Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22147577 In Vitro Genotoxicity Testing Strategy for Nanomaterials and the Adaptation of Current OECD Guidelines Mutation Research. Jun, 2012 | Pubmed ID: 21971291 Confounding Experimental Considerations in Nanogenotoxicology Mutagenesis. Jul, 2009 | Pubmed ID: 19351890 No-observed Effect Levels Are Associated with Up-regulation of MGMT Following MMS Exposure Mutation Research. Dec, 2008 | Pubmed ID: 18992265 High-resolution Imaging Using a Novel Atomic Force Microscope and Confocal Laser Scanning Microscope Hybrid Instrument: Essential Sample Preparation Aspects Histochemistry and Cell Biology. Nov, 2008 | Pubmed ID: 18719934 Aneuploidy in Upper Gastro-intestinal Tract Cancers--a Potential Prognostic Marker? Mutation Research. Mar, 2008 | Pubmed ID: 18093868 Bone Morphogenic Factor Gene Dosage Abnormalities in Prostatic Intraepithelial Neoplasia and Prostate Cancer Cancer Genetics and Cytogenetics. Jul, 2007 | Pubmed ID: 17656261 Mechanistic Influences for Mutation Induction Curves After Exposure to DNA-reactive Carcinogens Cancer Research. Apr, 2007 | Pubmed ID: 17440105 Generation of Locus-specific Probes for Interphase Fluorescence in Situ Hybridisation--application in Barrett's Esophagus Experimental and Molecular Pathology. Aug, 2004 | Pubmed ID: 15215047 Differential Expression of the MAD2, BUB1 and HSP27 Genes in Barrett's Oesophagus-their Association with Aneuploidy and Neoplastic Progression Mutation Research. Mar, 2004 | Pubmed ID: 15013707 Utilisation of the STEAP Protein Family in a Diagnostic Setting May Provide a More Comprehensive Prognosis of Prostate Cancer PloS One. | Pubmed ID: 31393902 In Vitro Detection of in Vitro Secondary Mechanisms of Genotoxicity Induced by Engineered Nanomaterials Particle and Fibre Toxicology. | Pubmed ID: 30760282 Investigating FlowSight® Imaging Flow Cytometry As a Platform to Assess Chemically Induced Micronuclei Using Human Lymphoblastoid Cells in Vitro Mutagenesis. | Pubmed ID: 30204902 דגמי כבד תלת-ממדיים מתקדמים לבדיקות גנוטוקסיות במבחנה בעקבות חשיפה ננו-חומרית לטווח ארוך Samantha V. Llewellyn1, Gillian E. Conway1, Ume-Kulsoom Shah1, Stephen J. Evans1, Gareth J.S. Jenkins1, Martin J.D. Clift1, Shareen H. Doak1 1In vitro Toxicology Group, Swansea University Medical School JoVE 61141 Bioengineering
דגמי כבד תלת-ממדיים מתקדמים לבדיקות גנוטוקסיות במבחנה בעקבות חשיפה ננו-חומרית לטווח ארוך Samantha V. Llewellyn1, Gillian E. Conway1, Ume-Kulsoom Shah1, Stephen J. Evans1, Gareth J.S. Jenkins1, Martin J.D. Clift1, Shareen H. Doak1 1In vitro Toxicology Group, Swansea University Medical School JoVE 61141 Bioengineering