Sharon A. Tooze Molecular Cell Biology of Autophagy The Francis Crick Institute Biography Publications Institution JoVE Articles Sharon A. Tooze has not added a biography. If you are Sharon A. Tooze and would like to personalize this page please email our Author Liaison for assistance. Publications Autophagosome Membrane Expansion is Mediated by the N-terminus and -membrane Association of Human ATG8s ELife. Jun, 2023 | Pubmed ID: 37288820 Membrane Association of the ATG8 Conjugation Machinery Emerges As a Key Regulatory Feature for Autophagosome Biogenesis FEBS Letters. Jun, 2023 | Pubmed ID: 37259601 Loss of NDR1/2 Kinases Impairs Endomembrane Trafficking and Autophagy Leading to Neurodegeneration Life Science Alliance. Feb, 2023 | Pubmed ID: 36446521 ATG9A and ATG2A Form a Heteromeric Complex Essential for Autophagosome Formation Molecular Cell. Nov, 2022 | Pubmed ID: 36347259 Unraveling Membrane Properties at the Organelle-level with LipidDyn Computational and Structural Biotechnology Journal. 2022 | Pubmed ID: 35860415 Autophagy Coordinates Chondrocyte Development and Early Joint Formation in Zebrafish FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2021 | Pubmed ID: 34708458 Homozygous Missense Variants Cause a Congenital Disorder of Autophagy with Neurodevelopmental Impairments of Variable Clinical Severity and Disease Course Brain Communications. 2021 | Pubmed ID: 34557665 The Ingenious ULKs: Expanding the Repertoire of the ULK Complex with Phosphoproteomics Autophagy. Dec, 2021 | Pubmed ID: 34520329 Autophagy in Major Human Diseases The EMBO Journal. Oct, 2021 | Pubmed ID: 34459017 SAMM50 is a Receptor for Basal Piecemeal Mitophagy and Acts with SQSTM1/p62 in OXPHOS-induced Mitophagy Autophagy. Sep, 2021 | Pubmed ID: 34275433 ATG9A Protects the Plasma Membrane from Programmed and Incidental Permeabilization Nature Cell Biology. Aug, 2021 | Pubmed ID: 34257406 Phosphoproteomic Identification of ULK Substrates Reveals VPS15-dependent ULK/VPS34 Interplay in the Regulation of Autophagy The EMBO Journal. Jul, 2021 | Pubmed ID: 34121209 Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity Journal of Molecular Biology. Jul, 2021 | Pubmed ID: 34052024 SAMM50 Acts with P62 in Piecemeal Basal- and OXPHOS-induced Mitophagy of SAM and MICOS Components The Journal of Cell Biology. Aug, 2021 | Pubmed ID: 34037656 ATG4: More Than a Protease? Trends in Cell Biology. Jul, 2021 | Pubmed ID: 33972154 Membrane Supply and Remodeling During Autophagosome Biogenesis Current Opinion in Cell Biology. Aug, 2021 | Pubmed ID: 33930785 Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity Journal of Molecular Biology. Jun, 2021 | Pubmed ID: 33845085 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition) Autophagy. Feb, 2021 | Pubmed ID: 33634751 The Phosphatidylinositol 3-phosphate-binding Protein SNX4 Controls ATG9A Recycling and Autophagy Journal of Cell Science. Feb, 2021 | Pubmed ID: 33468622 Path to Autophagy Therapeutics with Beth Levine Nature Reviews. Molecular Cell Biology. Oct, 2020 | Pubmed ID: 32770126 Emerging Roles of ATG Proteins and Membrane Lipids in Autophagosome Formation Cell Discovery. 2020 | Pubmed ID: 32509328 The Golgi As an Assembly Line to the Autophagosome Trends in Biochemical Sciences. Jun, 2020 | Pubmed ID: 32307224 Twenty Years of Traffic Traffic (Copenhagen, Denmark). Jan, 2020 | Pubmed ID: 31854088 Axonal Autophagosome Maturation Defect Through Failure of ATG9A Sorting Underpins Pathology in AP-4 Deficiency Syndrome Autophagy. Mar, 2020 | Pubmed ID: 31142229 Expression of WIPI2B Counteracts Age-related Decline in Autophagosome Biogenesis in Neurons ELife. Jul, 2019 | Pubmed ID: 31309927 Autophagy, Inflammation, and Metabolism (AIM) Center in Its Second Year Autophagy. Oct, 2019 | Pubmed ID: 31234750 ATG9A Supplies PtdIns4P to the Autophagosome Initiation Site Autophagy. Sep, 2019 | Pubmed ID: 31204568 Molecular Determinants Regulating Selective Binding of Autophagy Adapters and Receptors to ATG8 Proteins Nature Communications. May, 2019 | Pubmed ID: 31053714 A Mutation in the Major Autophagy Gene, WIPI2, Associated with Global Developmental Abnormalities Brain : a Journal of Neurology. May, 2019 | Pubmed ID: 30968111 ATG9A Shapes the Forming Autophagosome Through Arfaptin 2 and Phosphatidylinositol 4-kinase IIIβ The Journal of Cell Biology. May, 2019 | Pubmed ID: 30917996 Suppression of Autophagy During Mitosis Via CUL4-RING Ubiquitin Ligases-mediated WIPI2 Polyubiquitination and Proteasomal Degradation Autophagy. Nov, 2019 | Pubmed ID: 30898011 Members of the Autophagy Class III Phosphatidylinositol 3-kinase Complex I Interact with GABARAP and GABARAPL1 Via LIR Motifs Autophagy. Aug, 2019 | Pubmed ID: 30767700 MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma Cancer Research. Apr, 2019 | Pubmed ID: 30765601 Autophagy Pathway Mapping to Elucidate the Function of Novel Autophagy Regulators Identified by High-Throughput Screening Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30610711 Identification and Validation of Novel Autophagy Regulators Using an Endogenous Readout SiGENOME Screen Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30610710 MTOR Independent Alteration in ULK1 Ser758 Phosphorylation Following Chronic LRRK2 Kinase Inhibition Bioscience Reports. Apr, 2018 | Pubmed ID: 29563162 SNAREing an ARP Requires a LIR The Journal of Cell Biology. Mar, 2018 | Pubmed ID: 29449316 A Molecular Perspective of Mammalian Autophagosome Biogenesis The Journal of Biological Chemistry. Apr, 2018 | Pubmed ID: 29371398 Control of GABARAP-mediated Autophagy by the Golgi Complex, Centrosome and Centriolar Satellites Biology of the Cell. Jan, 2018 | Pubmed ID: 28990689 Autophagy Pathway: Cellular and Molecular Mechanisms Autophagy. 2018 | Pubmed ID: 28933638 Vps34 PI 3-kinase Inactivation Enhances Insulin Sensitivity Through Reprogramming of Mitochondrial Metabolism Nature Communications. Nov, 2017 | Pubmed ID: 29180704 Centrosome to Autophagosome Signaling: Specific GABARAP Regulation by Centriolar Satellites Autophagy. 2017 | Pubmed ID: 29099272 Membrane Dynamics and Organelle Biogenesis-lipid Pipelines and Vesicular Carriers BMC Biology. 10, 2017 | Pubmed ID: 29089042 Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy Current Biology : CB. Jul, 2017 | Pubmed ID: 28712572 Molecular Definitions of Autophagy and Related Processes The EMBO Journal. Jul, 2017 | Pubmed ID: 28596378 Editorial Overview: Celebrating the Advances in Cell Biology from China Traffic (Copenhagen, Denmark). Jun, 2017 | Pubmed ID: 28513089 Molecular Pathways Controlling Autophagy in Pancreatic Cancer Frontiers in Oncology. 2017 | Pubmed ID: 28316954 ATG4B Contains a C-terminal LIR Motif Important for Binding and Efficient Cleavage of Mammalian Orthologs of Yeast Atg8 Autophagy. May, 2017 | Pubmed ID: 28287329 Quantifying Autophagic Structures in Mammalian Cells Using Confocal Microscopy Methods in Enzymology. 2017 | Pubmed ID: 28253957 A Switch from Canonical to Noncanonical Autophagy Shapes B Cell Responses Science (New York, N.Y.). Feb, 2017 | Pubmed ID: 28183981 Fundamental Mechanisms Deliver the Nobel Prize to Ohsumi Traffic (Copenhagen, Denmark). Feb, 2017 | Pubmed ID: 28097732 Molecular Mechanisms of Autophagy-Part B Journal of Molecular Biology. Feb, 2017 | Pubmed ID: 28087262 So Long Tom! Traffic (Copenhagen, Denmark). Jan, 2017 | Pubmed ID: 28008716 Autophagy Captures the Nobel Prize Cell. Dec, 2016 | Pubmed ID: 27912049 Rabs and GAPs in Starvation-induced Autophagy Small GTPases. Oct, 2016 | Pubmed ID: 27669114 An SiRNA Screen for ATG Protein Depletion Reveals the Extent of the Unconventional Functions of the Autophagy Proteome in Virus Replication The Journal of Cell Biology. Aug, 2016 | Pubmed ID: 27573464 TBC1D14 Sets the TRAPP for ATG9 Autophagy. Jul, 2016 | Pubmed ID: 27171758 TBC1D14 and TRAPP - Regulating Autophagy Through ATG9 Cell Cycle (Georgetown, Tex.). Jul, 2016 | Pubmed ID: 27105289 Digesting the Expanding Mechanisms of Autophagy Trends in Cell Biology. Aug, 2016 | Pubmed ID: 27050762 Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival Scientific Reports. 2016 | Pubmed ID: 26987296 GABARAP Activates ULK1 and Traffics from the Centrosome Dependent on Golgi Partners WAC and GOLGA2/GM130 Autophagy. May, 2016 | Pubmed ID: 26986052 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition) Autophagy. Jan, 2016 | Pubmed ID: 26799652 TBC1D14 Regulates Autophagy Via the TRAPP Complex and ATG9 Traffic The EMBO Journal. Feb, 2016 | Pubmed ID: 26711178 Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130 Molecular Cell. Dec, 2015 | Pubmed ID: 26687599 Imaging ATG9A, a Multi-Spanning Membrane Protein (Video) | JoVE Alexander R. van Vliet*1,2, Stefano De Tito*1, Eugenia Almacellas*1, Sharon A. Tooze1 1Molecular Cell Biology of Autophagy, The Francis Crick Institute, 2MRC Laboratory of Molecular Biology JoVE 65349 Biology
Imaging ATG9A, a Multi-Spanning Membrane Protein (Video) | JoVE Alexander R. van Vliet*1,2, Stefano De Tito*1, Eugenia Almacellas*1, Sharon A. Tooze1 1Molecular Cell Biology of Autophagy, The Francis Crick Institute, 2MRC Laboratory of Molecular Biology JoVE 65349 Biology