Sharon C-A. Chen Centre for Infectious Diseases and Microbiology-Public Health Westmead Hospital Biography Publications Institution JoVE Articles Sharon C-A. Chen has not added a biography. If you are Sharon C-A. Chen and would like to personalize this page please email our Author Liaison for assistance. Publications Genome Sequencing Links Persistent Outbreak of Legionellosis in Sydney to an Emerging Clone of Legionella Pneumophila ST211 Applied and Environmental Microbiology. Dec, 2017 | Pubmed ID: 29247056 Locally Acquired Mcr-1 in Escherichia Coli, Australia, 2011 and 2013 Emerging Infectious Diseases. 07, 2017 | Pubmed ID: 28628439 Challenges in Laboratory Detection of Fungal Pathogens in the Airways of Cystic Fibrosis Patients Mycopathologia. Jun, 2017 | Pubmed ID: 28589247 Molecular Epidemiology and Antifungal Susceptibility of Candida Glabrata in China (August 2009 to July 2014): A Multi-Center Study Frontiers in Microbiology. 2017 | Pubmed ID: 28588560 Pseudomonas Aeruginosa Inhibits the Growth of Scedosporium and Lomentospora In Vitro Mycopathologia. May, 2017 | Pubmed ID: 28512704 Laboratory Approach to the Diagnosis of Culture-Negative Infective Endocarditis Heart, Lung & Circulation. Aug, 2017 | Pubmed ID: 28372886 New Developments and Directions in the Clinical Application of the Echinocandins Archives of Toxicology. Apr, 2017 | Pubmed ID: 28180946 Identification and Antifungal Susceptibility Profiles of Candida Nivariensis and Candida Bracarensis in a Multi-Center Chinese Collection of Yeasts Frontiers in Microbiology. 2017 | Pubmed ID: 28154553 Transcriptome and Network Analyses in Saccharomyces Cerevisiae Reveal That Amphotericin B and Lactoferrin Synergy Disrupt Metal Homeostasis and Stress Response Scientific Reports. Jan, 2017 | Pubmed ID: 28079179 Verruconis Gallopava Cardiac and Endovascular Infection with Dissemination After Renal Transplantation: Case Report and Lessons Learned Medical Mycology Case Reports. Mar, 2017 | Pubmed ID: 28053851 16S-23S Internal Transcribed Spacer Region PCR and Sequencer-Based Capillary Gel Electrophoresis Has Potential As an Alternative to High Performance Liquid Chromatography for Identification of Slowly Growing Nontuberculous Mycobacteria PloS One. 2016 | Pubmed ID: 27749897 Problematic Dichotomization of Risk for Intensive Care Unit (ICU)-Acquired Invasive Candidiasis: Results Using a Risk-Predictive Model to Categorize 3 Levels of Risk From a Multicenter Prospective Cohort of Australian ICU Patients Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Dec, 2016 | Pubmed ID: 27601224 Mycological Testing of Clinical Samples in Australasian Pathology Laboratories: Wide Diversity and Room for Improvement Pathology. Oct, 2016 | Pubmed ID: 27567987 Antifungal Susceptibilities of Non-Aspergillus Filamentous Fungi Causing Invasive Infection in Australia: Support for Current Antifungal Guideline Recommendations International Journal of Antimicrobial Agents. Oct, 2016 | Pubmed ID: 27562696 Identification and Antifungal Susceptibility Profiles of Candida Haemulonii Species Complex Clinical Isolates from a Multicenter Study in China Journal of Clinical Microbiology. Nov, 2016 | Pubmed ID: 27535688 Safety, Clinical Effectiveness and Trough Plasma Concentrations of Intravenous Posaconazole in Patients with Haematological Malignancies And/or Undergoing Allogeneic Haematopoietic Stem Cell Transplantation: Off-trial Experience The Journal of Antimicrobial Chemotherapy. 12, 2016 | Pubmed ID: 27521358 Performance of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Aspergillus, Scedosporium, and Fusarium Spp. in the Australian Clinical Setting Journal of Clinical Microbiology. Aug, 2016 | Pubmed ID: 27252460 Sequencer-Based Capillary Gel Electrophoresis (SCGE) Targeting the RDNA Internal Transcribed Spacer (ITS) Regions for Accurate Identification of Clinically Important Yeast Species PloS One. 2016 | Pubmed ID: 27105313 Concordance of Four Commercial Enzyme Immunoassay and Three Immunoblot Formats for the Detection of Lyme Borreliosis Antibodies in Human Serum: the Two-tier Approach Remains Pathology. Apr, 2016 | Pubmed ID: 27020501 Chaetomium Atrobrunneum and Aspergillus Fumigatus in Multiple Tracheal Aspirates: Copathogens or Symbiosis Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi. Apr, 2016 | Pubmed ID: 26880338 Accurate Identification of Common Pathogenic Nocardia Species: Evaluation of a Multilocus Sequence Analysis Platform and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry PloS One. 2016 | Pubmed ID: 26808813 Successful Treatment of Cryptococcus Neoformans Immune Reconstitution Inflammatory Syndrome in an Immunocompetent Host Using Thalidomide Medical Mycology Case Reports. Mar, 2015 | Pubmed ID: 27330941 Antibiotic Susceptibility of Diverse Mycobacterium Abscessus Complex Strains in New South Wales, Australia Pathology. Dec, 2015 | Pubmed ID: 26517625 What Assay is Optimal for the Diagnosis of Measles Virus Infection? An Evaluation of the Performance of a Measles Virus Real-time Reverse Transcriptase PCR Using the Cepheid SmartCycler(®) and Antigen Detection by Immunofluorescence Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. Sep, 2015 | Pubmed ID: 26305819 Editorial: Laboratory Preparedness for Ebolavirus Disease Pathology. Aug, 2015 | Pubmed ID: 26126052 Evaluation of Point-of-care Testing in Critically Unwell Patients: Comparison with Clinical Laboratory Analysers and Applicability to Patients with Ebolavirus Infection Pathology. Aug, 2015 | Pubmed ID: 26126049 Colonisation with Pneumocystis Jirovecii in Australian Infants Pathology. Aug, 2015 | Pubmed ID: 25938363 Contemporary Molecular Approaches in the Clinical Microbiology Laboratory: Progress and Pitfalls Pathology. Apr, 2015 | Pubmed ID: 25714589 Invasive Infections Due to Filamentous Fungi Other Than Aspergillus: Epidemiology and Determinants of Mortality Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. May, 2015 | Pubmed ID: 25677259 Candida Colonization As a Risk Marker for Invasive Candidiasis in Mixed Medical-surgical Intensive Care Units: Development and Evaluation of a Simple, Standard Protocol Journal of Clinical Microbiology. Apr, 2015 | Pubmed ID: 25673797 Rapid Microscopy and Use of Vital Dyes: Potential to Determine Viability of Cryptococcus Neoformans in the Clinical Laboratory PloS One. 2015 | Pubmed ID: 25625210 Antifungal Susceptibilities of Candida Glabrata Species Complex, Candida Krusei, Candida Parapsilosis Species Complex and Candida Tropicalis Causing Invasive Candidiasis in China: 3 Year National Surveillance The Journal of Antimicrobial Chemotherapy. Mar, 2015 | Pubmed ID: 25473027 Cystic Fibrosis and Bacterial Colonization Define the Sputum N-glycosylation Phenotype Glycobiology. Jan, 2015 | Pubmed ID: 25190359 A Chitin-like Component on Sclerotic Cells of Fonsecaea Pedrosoi Inhibits Dectin-1-mediated Murine Th17 Development by Masking β-glucans PloS One. 2014 | Pubmed ID: 25490199 Cryptococcus Gattii Infections Clinical Microbiology Reviews. Oct, 2014 | Pubmed ID: 25278580 Rapid and Accurate Direct Antibiotic Susceptibility Testing of Blood Culture Broths Using MALDI Sepsityper Combined with the BD Phoenix Automated System Journal of Medical Microbiology. Dec, 2014 | Pubmed ID: 25212759 Detection of Multiple Fungal Species in Blood Samples by Real-time PCR: an Interpretative Challenge Journal of Clinical Microbiology. Sep, 2014 | Pubmed ID: 25143424 Improved Identification of Rapidly Growing Mycobacteria by a 16S-23S Internal Transcribed Spacer Region PCR and Capillary Gel Electrophoresis PloS One. 2014 | Pubmed ID: 25013955 Clinical Utility of Caspofungin Eye Drops in Fungal Keratitis International Journal of Antimicrobial Agents. Aug, 2014 | Pubmed ID: 24933448 Clinical Utility of Aspergillus Galactomannan and PCR in Bronchoalveolar Lavage Fluid for the Diagnosis of Invasive Pulmonary Aspergillosis in Patients with Haematological Malignancies Diagnostic Microbiology and Infectious Disease. Mar, 2014 | Pubmed ID: 24768294 Functional Disruption of Yeast Metacaspase, Mca1, Leads to Miltefosine Resistance and Inability to Mediate Miltefosine-induced Apoptotic Effects Fungal Genetics and Biology : FG & B. Jun, 2014 | Pubmed ID: 24731805 Candida Quercitrusa Candidemia: Investigation of Three Clustered Cases and Mycological Characteristics of This Novel Species Journal of Clinical Microbiology. Apr, 2014 | Pubmed ID: 24696025 Echinocandins in the Treatment of Candidaemia and Invasive Candidiasis: Clinical and Economic Perspectives International Journal of Antimicrobial Agents. Mar, 2014 | Pubmed ID: 24670423 A Loop-mediated Isothermal Amplification (LAMP) Assay for Strongyloides Stercoralis in Stool That Uses a Visual Detection Method with SYTO-82 Fluorescent Dye The American Journal of Tropical Medicine and Hygiene. Feb, 2014 | Pubmed ID: 24323513 Thermomyces Lanuginosus Infective Endocarditis: Case Report and a Review of Endocarditis Due to Uncommon Moulds Medical Mycology Case Reports. Sep, 2013 | Pubmed ID: 24432243 Fungal Infections and Treatment in Cystic Fibrosis Current Opinion in Pulmonary Medicine. Nov, 2013 | Pubmed ID: 24060984 Rapid Identification of Gram-negative Organisms from Blood Culture Bottles Using a Modified Extraction Method and MALDI-TOF Mass Spectrometry Diagnostic Microbiology and Infectious Disease. Oct, 2013 | Pubmed ID: 23891220 Post-transplant Pneumocystis Jirovecii Pneumonia-a Re-emerged Public Health Problem? Kidney International. Jun, 2013 | Pubmed ID: 23739237 Current Status of Matrix-assisted Laser Desorption Ionisation-time of Flight Mass Spectrometry in the Clinical Microbiology Laboratory Pathology. Jan, 2013 | Pubmed ID: 23255029 Clinical Utility of the Cryptococcal Antigen Lateral Flow Assay in a Diagnostic Mycology Laboratory PloS One. 2012 | Pubmed ID: 23166705 In Vitro Susceptibilities of Yeast Species to Fluconazole and Voriconazole As Determined by the 2010 National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study Journal of Clinical Microbiology. Dec, 2012 | Pubmed ID: 23035204 Multicenter Study of Posaconazole Therapeutic Drug Monitoring: Exposure-response Relationship and Factors Affecting Concentration Antimicrobial Agents and Chemotherapy. Nov, 2012 | Pubmed ID: 22890761 Multicenter Study of Voriconazole Pharmacokinetics and Therapeutic Drug Monitoring Antimicrobial Agents and Chemotherapy. Sep, 2012 | Pubmed ID: 22751544 Sporotrichosis (Sporothrix Schenckii Infection) in the New South Wales Mid-north Coast, 2000-2010 The Medical Journal of Australia. May, 2012 | Pubmed ID: 22621152 Pneumonia and Lung Infections Due to Emerging and Unusual Fungal Pathogens Seminars in Respiratory and Critical Care Medicine. Dec, 2011 | Pubmed ID: 22167398 Seeking Clarity Within Cloudy Effluents: Differentiating Fungal from Bacterial Peritonitis in Peritoneal Dialysis Patients PloS One. 2011 | Pubmed ID: 22145033 Nosocomial Pneumocystis Jirovecii Pneumonia: Lessons from a Cluster in Kidney Transplant Recipients Transplantation. Dec, 2011 | Pubmed ID: 22129760 Matrix-assisted Laser Desorption Ionization-time of Flight Mass Spectrometry Identification of Yeasts is Contingent on Robust Reference Spectra PloS One. 2011 | Pubmed ID: 22022438 Three-locus Identification, Genotyping, and Antifungal Susceptibilities of Medically Important Trichosporon Species from China Journal of Clinical Microbiology. Nov, 2011 | Pubmed ID: 21900517 Identification of Bacteria in Blood Culture Broths Using Matrix-assisted Laser Desorption-ionization Sepsityper™ and Time of Flight Mass Spectrometry PloS One. 2011 | Pubmed ID: 21858058 Direct Effects of Non-antifungal Agents Used in Cancer Chemotherapy and Organ Transplantation on the Development and Virulence of Candida and Aspergillus Species Virulence. Jul-Aug, 2011 | Pubmed ID: 21701255 Defining Reference Sequences for Nocardia Species by Similarity and Clustering Analyses of 16S RRNA Gene Sequence Data PloS One. 2011 | Pubmed ID: 21687706 Fatal Mycotic Aneurysms Due to Scedosporium and Pseudallescheria Infection Journal of Clinical Microbiology. May, 2011 | Pubmed ID: 21430108 Development and Validation of a Multiplex PCR for Detection of Scedosporium Spp. in Respiratory Tract Specimens from Patients with Cystic Fibrosis Journal of Clinical Microbiology. Apr, 2011 | Pubmed ID: 21325557 Echinocandin Antifungal Drugs in Fungal Infections: a Comparison Drugs. Jan, 2011 | Pubmed ID: 21175238 Recent Advances in Management of Cryptococcal Meningitis: Commentary F1000 Medicine Reports. 2010 | Pubmed ID: 21170376 Abundance of Pseudallescheria/Scedosporium Species in the Australian Urban Environment Suggests a Possible Source for Scedosporiosis Including the Colonization of Airways in Cystic Fibrosis Medical Mycology. Nov, 2010 | Pubmed ID: 21067333 Scedosporium Aurantiacum is As Virulent As S. Prolificans, and Shows Strain-specific Virulence Differences, in a Mouse Model Medical Mycology. Nov, 2010 | Pubmed ID: 21067330 Clinical Associations and Prevalence of Scedosporium Spp. in Australian Cystic Fibrosis Patients: Identification of Novel Risk Factors? Medical Mycology. Nov, 2010 | Pubmed ID: 21067328 New Molecular and Surrogate Biomarker-based Tests in the Diagnosis of Bacterial and Fungal Infection in Febrile Neutropenic Patients Current Opinion in Infectious Diseases. Dec, 2010 | Pubmed ID: 20827189 SecA1 Gene Sequence Polymorphisms for Species Identification of Nocardia Species and Recognition of Intraspecies Genetic Diversity Journal of Clinical Microbiology. Nov, 2010 | Pubmed ID: 20810768 Antifungal Therapy in Invasive Fungal Infections Current Opinion in Pharmacology. Oct, 2010 | Pubmed ID: 20598943 In Vitro Antifungal Activities of Bis(alkylpyridinium)alkane Compounds Against Pathogenic Yeasts and Molds Antimicrobial Agents and Chemotherapy. Aug, 2010 | Pubmed ID: 20530227 Protein-losing Enteropathy and Hypogammaglobulinaemia As First Manifestations of Disseminated Histoplasmosis Coincident with Nocardia Infection Journal of Medical Microbiology. May, 2010 | Pubmed ID: 20133412 Comparison of Whole Blood, Serum, and Plasma for Early Detection of Candidemia by Multiplex-tandem PCR Journal of Clinical Microbiology. Mar, 2010 | Pubmed ID: 20042634 Identification of Pathogenic Nocardia Species by Reverse Line Blot Hybridization Targeting the 16S RRNA and 16S-23S RRNA Gene Spacer Regions Journal of Clinical Microbiology. Feb, 2010 | Pubmed ID: 19955277 Fungal-derived Immune Modulating Molecules Advances in Experimental Medicine and Biology. 2009 | Pubmed ID: 20054979 Assignment of Reference 5'-end 16S RDNA Sequences and Species-Specific Sequence Polymorphisms Improves Species Identification of Nocardia The Open Microbiology Journal. 2009 | Pubmed ID: 19639036 Not Just Little Adults: Candidemia Epidemiology, Molecular Characterization, and Antifungal Susceptibility in Neonatal and Pediatric Patients Pediatrics. May, 2009 | Pubmed ID: 19403503 Genotyping of Scedosporium Species: a Review of Molecular Approaches Medical Mycology. Jun, 2009 | Pubmed ID: 19085455 Practical Method for Detection and Identification of Candida, Aspergillus, and Scedosporium Spp. by Use of Rolling-circle Amplification Journal of Clinical Microbiology. Jul, 2008 | Pubmed ID: 18495860 Molecular Typing of Australian Scedosporium Isolates Showing Genetic Variability and Numerous S. Aurantiacum Emerging Infectious Diseases. Feb, 2008 | Pubmed ID: 18258122 Treatment of Scedosporiosis with Voriconazole: Clinical Experience with 107 Patients Antimicrobial Agents and Chemotherapy. May, 2008 | Pubmed ID: 18212110 Antifungal Agents The Medical Journal of Australia. Oct, 2007 | Pubmed ID: 17908006 In Vitro Activities of Miltefosine and Two Novel Antifungal Biscationic Salts Against a Panel of 77 Dermatophytes Antimicrobial Agents and Chemotherapy. Jun, 2007 | Pubmed ID: 17371821 Cryptococcal Phospholipase B Antigen is Not Detected in Serum of Patients Infected with Cryptococcus Neoformans Using a Sandwich Enzyme-linked Immunosorbent Assay FEMS Yeast Research. May, 2007 | Pubmed ID: 17266733 Cryptococcal Phospholipases: a Novel Lysophospholipase Discovered in the Pathogenic Fungus Cryptococcus Gattii The Biochemical Journal. Dec, 2004 | Pubmed ID: 15320865 A Review of Nucleic Acid-based Diagnostic Tests for Systemic Mycoses with an Emphasis on Polymerase Chain Reaction-based Assays Medical Mycology. Aug, 2002 | Pubmed ID: 12230214 Strain-dependent Effects of Environmental Signals on the Production of Extracellular Phospholipase by Cryptococcus Neoformans FEMS Microbiology Letters. Apr, 2002 | Pubmed ID: 12007802 Cryptococcosis in Australasia and the Treatment of Cryptococcal and Other Fungal Infections with Liposomal Amphotericin B The Journal of Antimicrobial Chemotherapy. Feb, 2002 | Pubmed ID: 11801583 Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance Chayanika Biswas*1, Sharon C-A. Chen*1,2,3, Catriona Halliday1,2, Elena Martinez1, Rebecca J. Rockett1, Qinning Wang1, Verlaine J. Timms1, Rajat Dhakal1, Rosemarie Sadsad1, Karina J. Kennedy4, Geoffrey Playford4,5, Deborah J. Marriott6, Monica A. Slavin7, Tania C. Sorrell1,3, Vitali Sintchenko1,2,3 1Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, 2Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, 3Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, 4Department of Microbiology and Infectious Diseases, Canberra Hospital and Health Services, Australian National University Medical School, 5Infection Management Services, Australian National University Medical School, 6Department of Microbiology and Infectious Diseases, St. Vincent's Hospital, 7Department of Infectious Diseases, Peter MacCallum Cancer Centre JoVE 56714 Medicine
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance Chayanika Biswas*1, Sharon C-A. Chen*1,2,3, Catriona Halliday1,2, Elena Martinez1, Rebecca J. Rockett1, Qinning Wang1, Verlaine J. Timms1, Rajat Dhakal1, Rosemarie Sadsad1, Karina J. Kennedy4, Geoffrey Playford4,5, Deborah J. Marriott6, Monica A. Slavin7, Tania C. Sorrell1,3, Vitali Sintchenko1,2,3 1Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, 2Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, 3Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, 4Department of Microbiology and Infectious Diseases, Canberra Hospital and Health Services, Australian National University Medical School, 5Infection Management Services, Australian National University Medical School, 6Department of Microbiology and Infectious Diseases, St. Vincent's Hospital, 7Department of Infectious Diseases, Peter MacCallum Cancer Centre JoVE 56714 Medicine