Shikhar Mehta Department Name Institution Name Biography Publications Institution JoVE Articles Shikhar Mehta Shikhar Mehta is a PhD Candidate in the Department of Bioengineering at Northeastern University in Boston, MA. He received his bachelor’s degree in Chemical Engineering from Northeastern University in 2016.His great interest in sports and its associated traumatic joint injuries led him to pursue graduate research in the development of strategies to prevent the onset of post-traumatic osteoarthritis. During his time as a research assistant in Dr. Ambika Bajpayee’s lab, he developed an in vitro co-culture model that better represents the in vivo joint environment following injury. The model showed the protective effects that synovium tissue exerts on cartilage and emphasized the importance of targeting multiple joint tissues for therapy. He has also developed in vitro systems to simultaneously evaluate the biological and mechanical responses to advanced glycation endproduct formation and their inhibitors in an aging model of osteoarthritis. Currently, he is working on designing a positively charged drug conjugate which can enhance intra-cartilage targeting to provide long-term therapeutic effect with a single administration.Shikhar Mehta has received the Northeastern University College of Engineering Student Leadership Award in 2017 and presented posters and talks at conferences. His career interests lie in the biotech industry with a focus on drug delivery, musculoskeletal diseases and orthopedics. Publications Multi-arm Avidin Nano-construct for Intra-cartilage Delivery of Small Molecule Drugs Journal of Controlled Release : Official Journal of the Controlled Release Society. 02, 2020 | Pubmed ID: 31843642 Interleukin-1 Receptor Antagonist (IL-1Ra) is More Effective in Suppressing Cytokine-induced Catabolism in Cartilage-synovium Co-culture Than in Cartilage Monoculture Arthritis Research & Therapy. 11, 2019 | Pubmed ID: 31722745 Cartilage Penetrating Cationic Peptide Carriers for Applications in Drug Delivery to Avascular Negatively Charged Tissues Acta Biomaterialia. 07, 2019 | Pubmed ID: 30529083 Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers Armin Vedadghavami1, Shikhar Mehta1, Ambika G. Bajpayee1,2 1Department of Bioengineering, Northeastern University, 2Department of Mechanical & Industrial Engineering, Northeastern University JoVE 61340 Bioengineering
Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers Armin Vedadghavami1, Shikhar Mehta1, Ambika G. Bajpayee1,2 1Department of Bioengineering, Northeastern University, 2Department of Mechanical & Industrial Engineering, Northeastern University JoVE 61340 Bioengineering