Shimin Le Mechanobiology Institute National University of Singapore Biography Publications Institution JoVE Articles Shimin Le has not added a biography. If you are Shimin Le and would like to personalize this page please email our Author Liaison for assistance. Publications Elasticity of the Transition State Leading to an Unexpected Mechanical Stabilization of Titin Immunoglobulin Domains Angewandte Chemie (International Ed. in English). May, 2017 | Pubmed ID: 28394039 Uncovering Mechanosensing Mechanisms at the Single Protein Level Using Magnetic Tweezers Methods (San Diego, Calif.). Feb, 2016 | Pubmed ID: 26318089 Disturbance-free Rapid Solution Exchange for Magnetic Tweezers Single-molecule Studies Nucleic Acids Research. Sep, 2015 | Pubmed ID: 26007651 Mechanochemical Regulations of RPA's Binding to SsDNA Scientific Reports. Mar, 2015 | Pubmed ID: 25787788 Mechanical Force Antagonizes the Inhibitory Effects of RecX on RecA Filament Formation in Mycobacterium Tuberculosis Nucleic Acids Research. Oct, 2014 | Pubmed ID: 25294832 Mechanosensing of DNA Bending in a Single Specific Protein-DNA Complex Scientific Reports. Dec, 2013 | Pubmed ID: 24336435 Dynamics and Regulation of RecA Polymerization and De-Polymerization on Double-Stranded DNA PloS One. 2013 | Pubmed ID: 23825559 Revealing the Competition Between Peeled SsDNA, Melting Bubbles, and S-DNA During DNA Overstretching by Single-molecule Calorimetry Proceedings of the National Academy of Sciences of the United States of America. Mar, 2013 | Pubmed ID: 23431154 Force and ATP Hydrolysis Dependent Regulation of RecA Nucleoprotein Filament by Single-stranded DNA Binding Protein Nucleic Acids Research. Jan, 2013 | Pubmed ID: 23221642 Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers Huijuan You*1, Shimin Le*2,3, Hu Chen2,4, Linyan Qin1, Jie Yan2,4,5 1School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 2Mechanobiology Institute, National University of Singapore, 3Department of Physics, National University of Singapore, 4Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Lab for Soft Functional Materials Research, Department of Physics, Xiamen University, 5Center for Bioimaging Sciences, National University of Singapore JoVE 56328 Biochemistry
Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers Huijuan You*1, Shimin Le*2,3, Hu Chen2,4, Linyan Qin1, Jie Yan2,4,5 1School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 2Mechanobiology Institute, National University of Singapore, 3Department of Physics, National University of Singapore, 4Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Lab for Soft Functional Materials Research, Department of Physics, Xiamen University, 5Center for Bioimaging Sciences, National University of Singapore JoVE 56328 Biochemistry