Shin'ichi Takeda Department of Molecular Therapy, National Institute of Neuroscience National Center of Neurology and Psychiatry Biography Publications Institution JoVE Articles Shin'ichi Takeda has not added a biography. If you are Shin'ichi Takeda and would like to personalize this page please email our Author Liaison for assistance. Publications Utility of Cystatin C for Estimating Glomerular Filtration Rate in Patients With Muscular Dystrophy International Heart Journal. May, 2016 | Pubmed ID: 27170475 Deletion of Exons 3-9 Encompassing a Mutational Hot Spot in the DMD Gene Presents an Asymptomatic Phenotype, Indicating a Target Region for Multiexon Skipping Therapy Journal of Human Genetics. Mar, 2016 | Pubmed ID: 27009627 Serum Osteopontin As a Novel Biomarker for Muscle Regeneration in Duchenne Muscular Dystrophy The American Journal of Pathology. May, 2016 | Pubmed ID: 26963343 Trends in Steroid Therapy for Duchenne Muscular Dystrophy in Japan Muscle & Nerve. Feb, 2016 | Pubmed ID: 26910583 Characterization of WWP1 Protein Expression in Skeletal Muscle of Muscular Dystrophy Chickens Journal of Biochemistry. Feb, 2016 | Pubmed ID: 26314333 A Disintegrin and Metalloprotease 10 (ADAM10) Is Indispensable for Maintenance of the Muscle Satellite Cell Pool The Journal of Biological Chemistry. Nov, 2015 | Pubmed ID: 26453297 Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche Cell Reports. Oct, 2015 | Pubmed ID: 26440893 Mesoangioblast Delivery of Miniagrin Ameliorates Murine Model of Merosin-deficient Congenital Muscular Dystrophy Type 1A Skeletal Muscle. 2015 | Pubmed ID: 26347253 Nonmechanical Roles of Dystrophin and Associated Proteins in Exercise, Neuromuscular Junctions, and Brains Brain Sciences. 2015 | Pubmed ID: 26230713 Differential Roles of MMP-9 in Early and Late Stages of Dystrophic Muscles in a Mouse Model of Duchenne Muscular Dystrophy Biochimica Et Biophysica Acta. Oct, 2015 | Pubmed ID: 26170062 Erratum: G-CSF Supports Long-term Muscle Regeneration in Mouse Models of Muscular Dystrophy Nature Communications. 2015 | Pubmed ID: 26084207 Muscle Satellite Cell Protein Teneurin-4 Regulates Differentiation During Muscle Regeneration Stem Cells (Dayton, Ohio). Oct, 2015 | Pubmed ID: 26013034 Prognostic Impact of Venous Thromboembolism in Patients with Duchenne Muscular Dystrophy: Prospective Multicenter 5-year Cohort Study International Journal of Cardiology. Jul, 2015 | Pubmed ID: 25965627 G-CSF Supports Long-term Muscle Regeneration in Mouse Models of Muscular Dystrophy Nature Communications. 2015 | Pubmed ID: 25865621 A Muscle-liver-fat Signalling Axis is Essential for Central Control of Adaptive Adipose Remodelling Nature Communications. 2015 | Pubmed ID: 25827749 Doublecortin Marks a New Population of Transiently Amplifying Muscle Progenitor Cells and is Required for Myofiber Maturation During Skeletal Muscle Regeneration Development (Cambridge, England). Feb, 2015 | Pubmed ID: 25670800 Fukutin is Prerequisite to Ameliorate Muscular Dystrophic Phenotype by Myofiber-selective LARGE Expression Scientific Reports. 2015 | Pubmed ID: 25661440 Low Intensity Training of Mdx Mice Reduces Carbonylation and Increases Expression Levels of Proteins Involved in Energy Metabolism and Muscle Contraction Free Radical Biology & Medicine. May, 2015 | Pubmed ID: 25660994 Intra-amniotic RAAV-mediated Microdystrophin Gene Transfer Improves Canine X-linked Muscular Dystrophy and May Induce Immune Tolerance Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2015 | Pubmed ID: 25586688 Doublecortin Marks a New Population of Transiently Amplifying Muscle Progenitor Cells and is Required for Myofiber Maturation During Skeletal Muscle Regeneration Development (Cambridge, England). Jan, 2015 | Pubmed ID: 25480916 [Exon Skipping Approach to Duchenne Muscular Dystorphy] Rinshō Shinkeigaku = Clinical Neurology. 2014 | Pubmed ID: 25672711 [Infrastructure for the Clinical Research of Muscular Dystrophies: Remudy and MDCTN] Rinshō Shinkeigaku = Clinical Neurology. 2014 | Pubmed ID: 25519964 Nationwide Patient Registry for GNE Myopathy in Japan Orphanet Journal of Rare Diseases. 2014 | Pubmed ID: 25303967 Neuromuscular Disease. DOK7 Gene Therapy Benefits Mouse Models of Diseases Characterized by Defects in the Neuromuscular Junction Science (New York, N.Y.). Sep, 2014 | Pubmed ID: 25237101 Discovery of Serum Protein Biomarkers in the Mdx Mouse Model and Cross-species Comparison to Duchenne Muscular Dystrophy Patients Human Molecular Genetics. Dec, 2014 | Pubmed ID: 25027324 Dystrophic Mdx Mice Develop Severe Cardiac and Respiratory Dysfunction Following Genetic Ablation of the Anti-inflammatory Cytokine IL-10 Human Molecular Genetics. Aug, 2014 | Pubmed ID: 24659498 Structural and Biochemical Characterization of O-mannose-linked Human Natural Killer-1 Glycan Expressed on Phosphacan in Developing Mouse Brains Glycobiology. Mar, 2014 | Pubmed ID: 24352591 α1-Syntrophin-deficient Mice Exhibit Impaired Muscle Force Recovery After Osmotic Shock Muscle & Nerve. May, 2014 | Pubmed ID: 24037898 Current Challenges and Future Directions in Recombinant AAV-Mediated Gene Therapy of Duchenne Muscular Dystrophy Pharmaceuticals (Basel, Switzerland). 2013 | Pubmed ID: 24276316 Inter-molecular Correlations in Liquid Se2Br2 Journal of Physics. Condensed Matter : an Institute of Physics Journal. Nov, 2013 | Pubmed ID: 24140925 Prednisolone Improves Walking in Japanese Duchenne Muscular Dystrophy Patients Journal of Neurology. Dec, 2013 | Pubmed ID: 24057148 Highly Efficient in Vivo Delivery of PMO into Regenerating Myotubes and Rescue in Laminin-α2 Chain-null Congenital Muscular Dystrophy Mice Human Molecular Genetics. Dec, 2013 | Pubmed ID: 23882132 Initial Pulmonary Respiration Causes Massive Diaphragm Damage and Hyper-CKemia in Duchenne Muscular Dystrophy Dog Scientific Reports. 2013 | Pubmed ID: 23851606 Manumycin A Corrects Aberrant Splicing of Clcn1 in Myotonic Dystrophy Type 1 (DM1) Mice Scientific Reports. 2013 | Pubmed ID: 23828222 Robust Long-term Transduction of Common Marmoset Neuromuscular Tissue With RAAV1 and RAAV9 Molecular Therapy. Nucleic Acids. 2013 | Pubmed ID: 23715217 Characteristics of Japanese Duchenne and Becker Muscular Dystrophy Patients in a Novel Japanese National Registry of Muscular Dystrophy (Remudy) Orphanet Journal of Rare Diseases. 2013 | Pubmed ID: 23601510 Capsaicin Mimics Mechanical Load-induced Intracellular Signaling Events: Involvement of TRPV1-mediated Calcium Signaling in Induction of Skeletal Muscle Hypertrophy Channels (Austin, Tex.). May-Jun, 2013 | Pubmed ID: 23584166 Impaired Viability of Muscle Precursor Cells in Muscular Dystrophy with Glycosylation Defects and Amelioration of Its Severe Phenotype by Limited Gene Expression Human Molecular Genetics. Aug, 2013 | Pubmed ID: 23562821 Translating the Genomics Revolution: the Need for an International Gene Therapy Consortium for Monogenic Diseases Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2013 | Pubmed ID: 23369965 Prognostic Impact of Left Ventricular Noncompaction in Patients with Duchenne/Becker Muscular Dystrophy--prospective Multicenter Cohort Study International Journal of Cardiology. Oct, 2013 | Pubmed ID: 23333368 Imatinib Attenuates Severe Mouse Dystrophy and Inhibits Proliferation and Fibrosis-marker Expression in Muscle Mesenchymal Progenitors Neuromuscular Disorders : NMD. Apr, 2013 | Pubmed ID: 23313020 Identification of Disease Specific Pathways Using in Vivo SILAC Proteomics in Dystrophin Deficient Mdx Mouse Molecular & Cellular Proteomics : MCP. May, 2013 | Pubmed ID: 23297347 Activation of Calcium Signaling Through Trpv1 by NNOS and Peroxynitrite As a Key Trigger of Skeletal Muscle Hypertrophy Nature Medicine. Jan, 2013 | Pubmed ID: 23202294 A Conserved Regulatory Element Located Far Downstream of the Gls Locus Modulates Gls Expression Through Chromatin Loop Formation During Myogenesis FEBS Letters. Sep, 2012 | Pubmed ID: 22979984 Extensive and Prolonged Restoration of Dystrophin Expression with Vivo-morpholino-mediated Multiple Exon Skipping in Dystrophic Dogs Nucleic Acid Therapeutics. Oct, 2012 | Pubmed ID: 22888777 Bodywide Skipping of Exons 45-55 in Dystrophic Mdx52 Mice by Systemic Antisense Delivery Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22869723 Laminin Regulates Postnatal Oligodendrocyte Production by Promoting Oligodendrocyte Progenitor Survival in the Subventricular Zone Glia. Oct, 2012 | Pubmed ID: 22706957 Calcitonin Receptor and Odz4 Are Differently Expressed in Pax7-positive Cells During Skeletal Muscle Regeneration Journal of Molecular Histology. Oct, 2012 | Pubmed ID: 22562803 Protein-anchoring Strategy for Delivering Acetylcholinesterase to the Neuromuscular Junction Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2012 | Pubmed ID: 22371845 Slow-dividing Satellite Cells Retain Long-term Self-renewal Ability in Adult Muscle Journal of Cell Science. Mar, 2012 | Pubmed ID: 22349695 [Induced Pluripotent Stem (iPS) Cell-based Cell Therapy for Muscular Dystrophy: Current Progress and Future Prospects] Brain and Nerve = Shinkei Kenkyū No Shinpo. Jan, 2012 | Pubmed ID: 22223500 Long-term Engraftment of Multipotent Mesenchymal Stromal Cells That Differentiate to Form Myogenic Cells in Dogs with Duchenne Muscular Dystrophy Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2012 | Pubmed ID: 21934652 [Exon-skipping Therapy for Duchenne Muscular Dystrophy] Rinshō Shinkeigaku = Clinical Neurology. Nov, 2011 | Pubmed ID: 22277414 Long-term Functional Adeno-associated Virus-microdystrophin Expression in the Dystrophic CXMDj Dog The Journal of Gene Medicine. Sep, 2011 | Pubmed ID: 22144143 Reprogramming Efficiency and Quality of Induced Pluripotent Stem Cells (iPSCs) Generated from Muscle-derived Fibroblasts of Mdx Mice at Different Ages PLoS Currents. 2011 | Pubmed ID: 22101343 Fibrosis and Adipogenesis Originate from a Common Mesenchymal Progenitor in Skeletal Muscle Journal of Cell Science. Nov, 2011 | Pubmed ID: 22045730 Hesr1 and Hesr3 Are Essential to Generate Undifferentiated Quiescent Satellite Cells and to Maintain Satellite Cell Numbers Development (Cambridge, England). Nov, 2011 | Pubmed ID: 21989910 Pathogenic Exon-trapping by SVA Retrotransposon and Rescue in Fukuyama Muscular Dystrophy Nature. Oct, 2011 | Pubmed ID: 21979053 Exon-skipping Therapy for Duchenne Muscular Dystrophy Lancet (London, England). Aug, 2011 | Pubmed ID: 21784507 Restoring Dystrophin Expression in Duchenne Muscular Dystrophy Muscle Progress in Exon Skipping and Stop Codon Read Through The American Journal of Pathology. Jul, 2011 | Pubmed ID: 21703390 Medium-range Correlation of Ag Ions in Superionic Melts of Ag2Se and AgI by Reverse Monte Carlo Structural Modelling-connectivity and Void Distribution Journal of Physics. Condensed Matter : an Institute of Physics Journal. Jun, 2011 | Pubmed ID: 21613697 Identification of Muscle-specific MicroRNAs in Serum of Muscular Dystrophy Animal Models: Promising Novel Blood-based Markers for Muscular Dystrophy PloS One. 2011 | Pubmed ID: 21479190 Current Status of Pharmaceutical and Genetic Therapeutic Approaches to Treat DMD Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2011 | Pubmed ID: 21468001 Reactive Gliosis of Astrocytes and Müller Glial Cells in Retina of POMGnT1-deficient Mice Molecular and Cellular Neurosciences. Jun, 2011 | Pubmed ID: 21447391 Synthesis of 2'-O-[2-(N-methylcarbamoyl)ethyl]ribonucleosides Using Oxa-Michael Reaction and Chemical and Biological Properties of Oligonucleotide Derivatives Incorporating These Modified Ribonucleosides The Journal of Organic Chemistry. May, 2011 | Pubmed ID: 21425877 Matrix Metalloproteinase-2 Ablation in Dystrophin-deficient Mdx Muscles Reduces Angiogenesis Resulting in Impaired Growth of Regenerated Muscle Fibers Human Molecular Genetics. May, 2011 | Pubmed ID: 21320869 Mammalian Models of Duchenne Muscular Dystrophy: Pathological Characteristics and Therapeutic Applications Journal of Biomedicine & Biotechnology. 2011 | Pubmed ID: 21274260 SynArfGEF is a Guanine Nucleotide Exchange Factor for Arf6 and Localizes Preferentially at Post-synaptic Specializations of Inhibitory Synapses Journal of Neurochemistry. Mar, 2011 | Pubmed ID: 21198641 Antisense Oligo-mediated Multiple Exon Skipping in a Dog Model of Duchenne Muscular Dystrophy Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21194037 The Status of Exon Skipping As a Therapeutic Approach to Duchenne Muscular Dystrophy Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2011 | Pubmed ID: 20978473 [Derivation of Engraftable Myogenic Precursors from Murine ES/iPS Cells and Generation of Disease-specific IPS Cells from Patients with Duchenne Muscular Dystrophy (DMD) and Other Diseases] Rinshō Shinkeigaku = Clinical Neurology. Nov, 2010 | Pubmed ID: 21921492 [Molecular Therapy for Muscular Dystrophy] Nihon Rinsho. Japanese Journal of Clinical Medicine. Aug, 2010 | Pubmed ID: 20976941 In-frame Dystrophin Following Exon 51-skipping Improves Muscle Pathology and Function in the Exon 52-deficient Mdx Mouse Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2010 | Pubmed ID: 20823833 Antisense PMO Found in Dystrophic Dog Model Was Effective in Cells from Exon 7-deleted DMD Patient PloS One. 2010 | Pubmed ID: 20805873 Six Family Genes Control the Proliferation and Differentiation of Muscle Satellite Cells Experimental Cell Research. Oct, 2010 | Pubmed ID: 20696153 Progress in Muscular Dystrophy Research with Special Emphasis on Gene Therapy Proceedings of the Japan Academy. Series B, Physical and Biological Sciences. 2010 | Pubmed ID: 20689232 Post-translational Maturation of Dystroglycan is Necessary for Pikachurin Binding and Ribbon Synaptic Localization The Journal of Biological Chemistry. Oct, 2010 | Pubmed ID: 20682766 Gene Therapy for Muscle Disease Experimental Cell Research. Nov, 2010 | Pubmed ID: 20580709 Neuronal NOS is Dislocated During Muscle Atrophy in Amyotrophic Lateral Sclerosis Journal of the Neurological Sciences. Jul, 2010 | Pubmed ID: 20435320 Genetic Background Affects Properties of Satellite Cells and Mdx Phenotypes The American Journal of Pathology. May, 2010 | Pubmed ID: 20304955 Efficient Gene Transfer into Neurons in Monkey Brain by Adeno-associated Virus 8 Neuroreport. Apr, 2010 | Pubmed ID: 20224455 Mesenchymal Progenitors Distinct from Satellite Cells Contribute to Ectopic Fat Cell Formation in Skeletal Muscle Nature Cell Biology. Feb, 2010 | Pubmed ID: 20081842 The Structure of Molten CuCl, CuI and Their Mixtures As Investigated by Using Neutron Diffraction Journal of Physics. Condensed Matter : an Institute of Physics Journal. Feb, 2009 | Pubmed ID: 21817319 [Exon Skipping Therapy for Duchenne Muscular Dystrophy by Using Antisense Morpholino] Rinshō Shinkeigaku = Clinical Neurology. Nov, 2009 | Pubmed ID: 20030230 Age-dependent Expression of Hephaestin in the Brain of Ceruloplasmin-deficient Mice Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS). 2009 | Pubmed ID: 19747625 Evaluation of Dystrophic Dog Pathology by Fat-suppressed T2-weighted Imaging Muscle & Nerve. Nov, 2009 | Pubmed ID: 19670324 CCN3 and Bone Marrow Cells Journal of Cell Communication and Signaling. Jun, 2009 | Pubmed ID: 19626464 Ubiquitin Ligase Cbl-b is a Negative Regulator for Insulin-like Growth Factor 1 Signaling During Muscle Atrophy Caused by Unloading Molecular and Cellular Biology. Sep, 2009 | Pubmed ID: 19546233 Scalable Purification of Adeno-associated Virus Serotype 1 (AAV1) and AAV8 Vectors, Using Dual Ion-exchange Adsorptive Membranes Human Gene Therapy. Sep, 2009 | Pubmed ID: 19534598 Exon-skipping Therapy for Duchenne Muscular Dystrophy Neuropathology : Official Journal of the Japanese Society of Neuropathology. Aug, 2009 | Pubmed ID: 19486303 Generation of Transplantable, Functional Satellite-like Cells from Mouse Embryonic Stem Cells FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2009 | Pubmed ID: 19168704 Characterization of Deletion Breakpoints in Patients with Dystrophinopathy Carrying a Deletion of Exons 45-55 of the Duchenne Muscular Dystrophy (DMD) Gene Journal of Human Genetics. Feb, 2009 | Pubmed ID: 19158820 A Renaissance for Antisense Oligonucleotide Drugs in Neurology: Exon Skipping Breaks New Ground Archives of Neurology. Jan, 2009 | Pubmed ID: 19139297 Reduced Proliferative Activity of Primary POMGnT1-null Myoblasts in Vitro Mechanisms of Development. Mar-Apr, 2009 | Pubmed ID: 19114101 Residual Laminin-binding Activity and Enhanced Dystroglycan Glycosylation by LARGE in Novel Model Mice to Dystroglycanopathy Human Molecular Genetics. Feb, 2009 | Pubmed ID: 19017726 Hepcidin, an Antimicrobial Peptide is Downregulated in Ceruloplasmin-deficient Mice Peptides. Feb, 2009 | Pubmed ID: 18948155 Transduction Efficiency and Immune Response Associated with the Administration of AAV8 Vector into Dog Skeletal Muscle Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2009 | Pubmed ID: 18941441 A Deficit of Brain Dystrophin Impairs Specific Amygdala GABAergic Transmission and Enhances Defensive Behaviour in Mice Brain : a Journal of Neurology. Jan, 2009 | Pubmed ID: 18927146 MicroRNA-206 is Highly Expressed in Newly Formed Muscle Fibers: Implications Regarding Potential for Muscle Regeneration and Maturation in Muscular Dystrophy Cell Structure and Function. 2008 | Pubmed ID: 18827405 Suppression of Macrophage Functions Impairs Skeletal Muscle Regeneration with Severe Fibrosis Experimental Cell Research. Oct, 2008 | Pubmed ID: 18775697 Predominant Localization of EFA6A, a Guanine Nucleotide Exchange Factor for ARF6, at the Perisynaptic Photoreceptor Processes Brain Research. Oct, 2008 | Pubmed ID: 18708035 Muscle CD31(-) CD45(-) Side Population Cells Promote Muscle Regeneration by Stimulating Proliferation and Migration of Myoblasts The American Journal of Pathology. Sep, 2008 | Pubmed ID: 18669618 Recombinant Adeno-associated Virus Type 8-mediated Extensive Therapeutic Gene Delivery into Skeletal Muscle of Alpha-sarcoglycan-deficient Mice Human Gene Therapy. Jul, 2008 | Pubmed ID: 18578595 The Ubiquitin Ligase Gene (WWP1) is Responsible for the Chicken Muscular Dystrophy FEBS Letters. Jun, 2008 | Pubmed ID: 18501710 Selective Vacuolar Degeneration in Dystrophin-deficient Canine Purkinje Fibers Despite Preservation of Dystrophin-associated Proteins with Overexpression of Dp71 Circulation. May, 2008 | Pubmed ID: 18458171 Downstream Utrophin Enhancer is Required for Expression of Utrophin in Skeletal Muscle The Journal of Gene Medicine. Jun, 2008 | Pubmed ID: 18338831 Follow-up of Three Patients with a Large In-frame Deletion of Exons 45-55 in the Duchenne Muscular Dystrophy (DMD) Gene Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. Jul, 2008 | Pubmed ID: 18261911 CD90-positive Cells, an Additional Cell Population, Produce Laminin Alpha2 Upon Transplantation to Dy(3k)/dy(3k) Mice Experimental Cell Research. Jan, 2008 | Pubmed ID: 17963748 Transgenic Expression of a Myostatin Inhibitor Derived from Follistatin Increases Skeletal Muscle Mass and Ameliorates Dystrophic Pathology in Mdx Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2008 | Pubmed ID: 17893249 Comparison of Partial Structures of Melts of Superionic AgI and CuI and Non-superionic AgCl Journal of Physics. Condensed Matter : an Institute of Physics Journal. Aug, 2007 | Pubmed ID: 21694124 NO Production Results in Suspension-induced Muscle Atrophy Through Dislocation of Neuronal NOS The Journal of Clinical Investigation. Sep, 2007 | Pubmed ID: 17786240 Autologous Transplantation of SM/C-2.6(+) Satellite Cells Transduced with Micro-dystrophin CS1 CDNA by Lentiviral Vector into Mdx Mice Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2007 | Pubmed ID: 17726457 Deficiency of Cbl-b Gene Enhances Infiltration and Activation of Macrophages in Adipose Tissue and Causes Peripheral Insulin Resistance in Mice Diabetes. Oct, 2007 | Pubmed ID: 17601987 Molecular Signature of Quiescent Satellite Cells in Adult Skeletal Muscle Stem Cells (Dayton, Ohio). Oct, 2007 | Pubmed ID: 17600112 Activation and Localization of Matrix Metalloproteinase-2 and -9 in the Skeletal Muscle of the Muscular Dystrophy Dog (CXMDJ) BMC Musculoskeletal Disorders. 2007 | Pubmed ID: 17598883 [Therapeutic Strategy for Muscular Dystrophies] Brain and Nerve = Shinkei Kenkyū No Shinpo. Apr, 2007 | Pubmed ID: 17447528 Cardiac Side Population Cells Have a Potential to Migrate and Differentiate into Cardiomyocytes in Vitro and in Vivo The Journal of Cell Biology. Jan, 2007 | Pubmed ID: 17261849 [Stem Cell Based Cell Therapy for Muscular Dystrophy] Rinshō Shinkeigaku = Clinical Neurology. Nov, 2006 | Pubmed ID: 17432228 Cardiac Involvement in Beagle-based Canine X-linked Muscular Dystrophy in Japan (CXMDJ): Electrocardiographic, Echocardiographic, and Morphologic Studies BMC Cardiovascular Disorders. 2006 | Pubmed ID: 17140458 Identification and Characterization of a Novel Human Dysferlin Transcript: Dysferlin_v1 Human Genetics. Oct, 2006 | Pubmed ID: 16896923 Expansion of Revertant Fibers in Dystrophic Mdx Muscles Reflects Activity of Muscle Precursor Cells and Serves As an Index of Muscle Regeneration Journal of Cell Science. Jul, 2006 | Pubmed ID: 16757519 Ubiquitin Ligase Cbl-b Downregulates Bone Formation Through Suppression of IGF-I Signaling in Osteoblasts During Denervation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. May, 2006 | Pubmed ID: 16734387 Zeta-sarcoglycan is a Functional Homologue of Gamma-sarcoglycan in the Formation of the Sarcoglycan Complex Experimental Cell Research. Jul, 2006 | Pubmed ID: 16635485 Functional Heterogeneity of Side Population Cells in Skeletal Muscle Biochemical and Biophysical Research Communications. Mar, 2006 | Pubmed ID: 16455057 Major Clinical and Histopathological Characteristics of Canine X-linked Muscular Dystrophy in Japan, CXMDJ Acta Myologica : Myopathies and Cardiomyopathies : Official Journal of the Mediterranean Society of Myology / Edited by the Gaetano Conte Academy for the Study of Striated Muscle Diseases. Oct, 2005 | Pubmed ID: 16550932 Intracellular Localization of Dysferlin and Its Association with the Dihydropyridine Receptor Acta Myologica : Myopathies and Cardiomyopathies : Official Journal of the Mediterranean Society of Myology / Edited by the Gaetano Conte Academy for the Study of Striated Muscle Diseases. Oct, 2005 | Pubmed ID: 16550931 Up-regulation of Mitogen Activated Protein Kinases in Mdx Skeletal Muscle Following Chronic Treadmill Exercise Biochimica Et Biophysica Acta. Jun, 2005 | Pubmed ID: 15949699 Participation of Bone Marrow-derived Cells in Fibrotic Changes in Denervated Skeletal Muscle The American Journal of Pathology. Jun, 2005 | Pubmed ID: 15920157 Coordinate Control of Axon Defasciculation and Myelination by Laminin-2 and -8 The Journal of Cell Biology. Feb, 2005 | Pubmed ID: 15699217 Epsilon-sarcoglycan Compensates for Lack of Alpha-sarcoglycan in a Mouse Model of Limb-girdle Muscular Dystrophy Human Molecular Genetics. Mar, 2005 | Pubmed ID: 15689353 The Utrophin Promoter A Drives High Expression of the Transgenic LacZ Gene in Liver, Testis, Colon, Submandibular Gland, and Small Intestine The Journal of Gene Medicine. Feb, 2005 | Pubmed ID: 15538725 [Current Status and Perspective of Gene Therapy on Dystrophic Animal Model] Rinshō Shinkeigaku = Clinical Neurology. Nov, 2004 | Pubmed ID: 15651329 AAV Vector-mediated Microdystrophin Expression in a Relatively Small Percentage of Mdx Myofibers Improved the Mdx Phenotype Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2004 | Pubmed ID: 15509500 Development of a Safe Oral Abeta Vaccine Using Recombinant Adeno-associated Virus Vector for Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Oct, 2004 | Pubmed ID: 15505369 Mac-1(low) Early Myeloid Cells in the Bone Marrow-derived SP Fraction Migrate into Injured Skeletal Muscle and Participate in Muscle Regeneration Biochemical and Biophysical Research Communications. Sep, 2004 | Pubmed ID: 15358135 Laminin Alpha1 Chain Reduces Muscular Dystrophy in Laminin Alpha2 Chain Deficient Mice Human Molecular Genetics. Aug, 2004 | Pubmed ID: 15213105 Identification and Characterization of Epsilon-sarcoglycans in the Central Nervous System Brain Research. Molecular Brain Research. Jun, 2004 | Pubmed ID: 15193417 Purification and Cell-surface Marker Characterization of Quiescent Satellite Cells from Murine Skeletal Muscle by a Novel Monoclonal Antibody Experimental Cell Research. Jun, 2004 | Pubmed ID: 15149854 [Gene Therapy for Muscular Dystrophy] No to Hattatsu. Brain and Development. Mar, 2004 | Pubmed ID: 15031985 Alpha1-syntrophin Modulates Turnover of ABCA1 The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14722086 Skeletal Muscle Gene Expression in Space-flown Rats FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2004 | Pubmed ID: 14715702 Negamycin Restores Dystrophin Expression in Skeletal and Cardiac Muscles of Mdx Mice Journal of Biochemistry. Nov, 2003 | Pubmed ID: 14688241 Expression Profiling of Cytokines and Related Genes in Regenerating Skeletal Muscle After Cardiotoxin Injection: a Role for Osteopontin The American Journal of Pathology. Jul, 2003 | Pubmed ID: 12819025 Canine X-linked Muscular Dystrophy in Japan (CXMDJ) Experimental Animals / Japanese Association for Laboratory Animal Science. Apr, 2003 | Pubmed ID: 12806883 Quantitative Evaluation of Expression of Iron-metabolism Genes in Ceruloplasmin-deficient Mice Biochimica Et Biophysica Acta. Dec, 2002 | Pubmed ID: 12393173 Alpha1-syntrophin-deficient Skeletal Muscle Exhibits Hypertrophy and Aberrant Formation of Neuromuscular Junctions During Regeneration The Journal of Cell Biology. Sep, 2002 | Pubmed ID: 12221071 Stable Micro-dystrophin Gene Transfer Using an Integrating Adeno-retroviral Hybrid Vector Ameliorates the Dystrophic Pathology in Mdx Mouse Muscle Human Molecular Genetics. Jul, 2002 | Pubmed ID: 12095914 Micro-dystrophin CDNA Ameliorates Dystrophic Phenotypes when Introduced into Mdx Mice As a Transgene Biochemical and Biophysical Research Communications. May, 2002 | Pubmed ID: 12054513 Progression of Dystrophic Features and Activation of Mitogen-activated Protein Kinases and Calcineurin by Physical Exercise, in Hearts of Mdx Mice FEBS Letters. Jun, 2002 | Pubmed ID: 12044863 Effects of Microgravity on Myogenic Factor Expressions During Postnatal Development of Rat Skeletal Muscle Journal of Applied Physiology (Bethesda, Md. : 1985). May, 2002 | Pubmed ID: 11960943 Muscle Regeneration by Reconstitution with Bone Marrow or Fetal Liver Cells from Green Fluorescent Protein-gene Transgenic Mice Journal of Cell Science. Mar, 2002 | Pubmed ID: 11884527 Interleukin 6 Induces Overexpression of the Sarcolemmal Utrophin in Neonatal Mdx Skeletal Muscle Human Gene Therapy. Mar, 2002 | Pubmed ID: 11874629 Intracellular Cell-autonomous Association of Notch and Its Ligands: a Novel Mechanism of Notch Signal Modification Developmental Biology. Jan, 2002 | Pubmed ID: 11784114 Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy Bailey Miskew Nichols*1, Yoshitsugu Aoki*2, Mutsuki Kuraoka2, Joshua J.A. Lee1, Shin'ichi Takeda2, Toshifumi Yokota1 1Department of Medical Genetics, University of Alberta Faculty of Medicine and Dentistry, 2Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry JoVE 53776 Medicine
Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy Bailey Miskew Nichols*1, Yoshitsugu Aoki*2, Mutsuki Kuraoka2, Joshua J.A. Lee1, Shin'ichi Takeda2, Toshifumi Yokota1 1Department of Medical Genetics, University of Alberta Faculty of Medicine and Dentistry, 2Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry JoVE 53776 Medicine