Silvia Brunelli School of Medicine and Surgery University of Milano-Bicocca Biography Publications Institution JoVE Articles Silvia Brunelli has not added a biography. If you are Silvia Brunelli and would like to personalize this page please email our Author Liaison for assistance. Publications Nitric Oxide Donor Molsidomine Positively Modulates Myogenic Differentiation of Embryonic Endothelial Progenitors PloS One. 2016 | Pubmed ID: 27760216 Correction: High-throughput Screening for Modulators of ACVR1 Transcription: Discovery of Potential Therapeutics for Fibrodysplasia Ossificans Progressiva Disease Models & Mechanisms. Sep, 2016 | Pubmed ID: 27604694 Mesenchymal Transitions in Development and Disease Stem Cells International. 2016 | Pubmed ID: 27563313 High-throughput Screening for Modulators of ACVR1 Transcription: Discovery of Potential Therapeutics for Fibrodysplasia Ossificans Progressiva Disease Models & Mechanisms. Jun, 2016 | Pubmed ID: 27125279 Vascular Remodelling and Mesenchymal Transition in Systemic Sclerosis Stem Cells International. 2016 | Pubmed ID: 27069480 MeCP2 Affects Skeletal Muscle Growth and Morphology Through Non Cell-Autonomous Mechanisms PloS One. 2015 | Pubmed ID: 26098633 Intracellular Inactivation of Thyroid Hormone is a Survival Mechanism for Muscle Stem Cell Proliferation and Lineage Progression Cell Metabolism. Dec, 2014 | Pubmed ID: 25456740 Macrophage Plasticity in Skeletal Muscle Repair BioMed Research International. 2014 | Pubmed ID: 24860823 Hemogenic Endothelium Generates Mesoangioblasts That Contribute to Several Mesodermal Lineages in Vivo Development (Cambridge, England). May, 2014 | Pubmed ID: 24757004 Breast Screening Using 2D-mammography or Integrating Digital Breast Tomosynthesis (3D-mammography) for Single-reading or Double-reading--evidence to Guide Future Screening Strategies European Journal of Cancer (Oxford, England : 1990). Jul, 2014 | Pubmed ID: 24746887 ADAP2 in Heart Development: a Candidate Gene for the Occurrence of Cardiovascular Malformations in NF1 Microdeletion Syndrome Journal of Medical Genetics. Jul, 2014 | Pubmed ID: 24711647 Effect of Integrating 3D-mammography (digital Breast Tomosynthesis) with 2D-mammography on Radiologists' True-positive and False-positive Detection in a Population Breast Screening Trial European Journal of Cancer (Oxford, England : 1990). May, 2014 | Pubmed ID: 24582915 Interval Breast Cancers: Absolute and Proportional Incidence and Blinded Review in a Community Mammographic Screening Program European Journal of Radiology. Feb, 2014 | Pubmed ID: 24369953 Incremental Effect from Integrating 3D-mammography (tomosynthesis) with 2D-mammography: Increased Breast Cancer Detection Evident for Screening Centres in a Population-based Trial Breast (Edinburgh, Scotland). Feb, 2014 | Pubmed ID: 24316152 Nitric Oxide and Muscle Repair: Multiple Actions Converging on Therapeutic Efficacy European Journal of Pharmacology. May, 2014 | Pubmed ID: 24269596 Nitric Oxide Drives Embryonic Myogenesis in Chicken Through the Upregulation of Myogenic Differentiation Factors Experimental Cell Research. Jan, 2014 | Pubmed ID: 24240125 Gastric Cancer Does Not Affect the Expression of Atrophy-related Genes in Human Skeletal Muscle Muscle & Nerve. Apr, 2014 | Pubmed ID: 23835743 HuR and MiR-1192 Regulate Myogenesis by Modulating the Translation of HMGB1 MRNA Nature Communications. 2013 | Pubmed ID: 24005720 The Nitric Oxide-donor Molsidomine Modulates the Innate Inflammatory Response in a Mouse Model of Muscular Dystrophy European Journal of Pharmacology. Sep, 2013 | Pubmed ID: 23707352 Integration of 3D Digital Mammography with Tomosynthesis for Population Breast-cancer Screening (STORM): a Prospective Comparison Study The Lancet. Oncology. Jun, 2013 | Pubmed ID: 23623721 Requirement of Inducible Nitric Oxide Synthase for Skeletal Muscle Regeneration After Acute Damage Journal of Immunology (Baltimore, Md. : 1950). Feb, 2013 | Pubmed ID: 23335752 Cripto Regulates Skeletal Muscle Regeneration and Modulates Satellite Cell Determination by Antagonizing Myostatin Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012 | Pubmed ID: 23129614 Necdin Enhances Myoblasts Survival by Facilitating the Degradation of the Mediator of Apoptosis CCAR1/CARP1 PloS One. 2012 | Pubmed ID: 22905258 Transplanted Mesoangioblasts Require Macrophage IL-10 for Survival in a Mouse Model of Muscle Injury Journal of Immunology (Baltimore, Md. : 1950). Jun, 2012 | Pubmed ID: 22573810 Nitric Oxide Donor and Non Steroidal Anti Inflammatory Drugs As a Therapy for Muscular Dystrophies: Evidence from a Safety Study with Pilot Efficacy Measures in Adult Dystrophic Patients Pharmacological Research. Apr, 2012 | Pubmed ID: 22306844 Nitric Oxide Sustains Long-term Skeletal Muscle Regeneration by Regulating Fate of Satellite Cells Via Signaling Pathways Requiring Vangl2 and Cyclic GMP Stem Cells (Dayton, Ohio). Feb, 2012 | Pubmed ID: 22084027 Sphingosine 1-phosphate Induces Differentiation of Mesoangioblasts Towards Smooth Muscle. A Role for GATA6 PloS One. 2011 | Pubmed ID: 21629665 A Dual Acting Compound Releasing Nitric Oxide (NO) and Ibuprofen, NCX 320, Shows Significant Therapeutic Effects in a Mouse Model of Muscular Dystrophy Pharmacological Research. Sep, 2011 | Pubmed ID: 21609764 High-mobility Group Box 1 Release and Redox Regulation Accompany Regeneration and Remodeling of Skeletal Muscle Antioxidants & Redox Signaling. Oct, 2011 | Pubmed ID: 21294652 Diagnostic Accuracy in Coronary Stenosis: Comparison Between Visual Score and Quantitative Analysis (quantitative Computed Tomographic Angiography) in Coronary Angiography by Multidetector Computed Tomography-coronary Angiography and Quantitative Analysis (quantitative Coronary Angiography) in Conventional Coronary Angiography Journal of Computer Assisted Tomography. Sep-Oct, 2010 | Pubmed ID: 20861765 Skeletal Muscle of Gastric Cancer Patients Expresses Genes Involved in Muscle Regeneration Oncology Reports. Sep, 2010 | Pubmed ID: 20664982 Co-administration of Ibuprofen and Nitric Oxide is an Effective Experimental Therapy for Muscular Dystrophy, with Immediate Applicability to Humans British Journal of Pharmacology. Jul, 2010 | Pubmed ID: 20590643 Polarization Dictates Iron Handling by Inflammatory and Alternatively Activated Macrophages Haematologica. Nov, 2010 | Pubmed ID: 20511666 Biological Heterogeneity of Putative Bladder Cancer Stem-like Cell Populations from Human Bladder Transitional Cell Carcinoma Samples Cancer Science. Feb, 2010 | Pubmed ID: 19961489 Pax3:Foxc2 Reciprocal Repression in the Somite Modulates Muscular Versus Vascular Cell Fate Choice in Multipotent Progenitors Developmental Cell. Dec, 2009 | Pubmed ID: 20059958 Remodeling of the Chromatin Structure of the Facioscapulohumeral Muscular Dystrophy (FSHD) Locus and Upregulation of FSHD-related Gene 1 (FRG1) Expression During Human Myogenic Differentiation BMC Biology. Jul, 2009 | Pubmed ID: 19607661 The Low-affinity Receptor for Neurotrophins P75NTR Plays a Key Role for Satellite Cell Function in Muscle Repair Acting Via RhoA Molecular Biology of the Cell. Aug, 2009 | Pubmed ID: 19553472 Human Cardiac Mesoangioblasts Isolated from Hypertrophic Cardiomyopathies Are Greatly Reduced in Proliferation and Differentiation Potency Cardiovascular Research. Sep, 2009 | Pubmed ID: 19457891 Necdin is Expressed in Cachectic Skeletal Muscle to Protect Fibers from Tumor-induced Wasting Journal of Cell Science. Apr, 2009 | Pubmed ID: 19339547 Inflammatory and Alternatively Activated Human Macrophages Attract Vessel-associated Stem Cells, Relying on Separate HMGB1- and MMP-9-dependent Pathways Journal of Leukocyte Biology. May, 2009 | Pubmed ID: 19197071 TGFbeta Protects Mesoangioblasts from Apoptosis Via Sphingosine Kinase-1 Regulation Cellular Signalling. Feb, 2009 | Pubmed ID: 18983913 Skeletal Muscle Differentiation of Embryonic Mesoangioblasts Requires Pax3 Activity Stem Cells (Dayton, Ohio). Jan, 2009 | Pubmed ID: 18845762 The Immune System and the Repair of Skeletal Muscle Pharmacological Research. Aug, 2008 | Pubmed ID: 18639637 Binding of SFRP-3 to EGF in the Extra-cellular Space Affects Proliferation, Differentiation and Morphogenetic Events Regulated by the Two Molecules PloS One. Jun, 2008 | Pubmed ID: 18560570 Cell Death: Tipping the Balance of Autoimmunity and Tissue Repair Current Pharmaceutical Design. 2008 | Pubmed ID: 18220837 Impaired Generation of Mature Neurons by Neural Stem Cells from Hypomorphic Sox2 Mutants Development (Cambridge, England). Feb, 2008 | Pubmed ID: 18171687 Necdin Mediates Skeletal Muscle Regeneration by Promoting Myoblast Survival and Differentiation The Journal of Cell Biology. Oct, 2007 | Pubmed ID: 17954612 Sphingosine 1-phosphate Mediates Proliferation and Survival of Mesoangioblasts Stem Cells (Dayton, Ohio). Jul, 2007 | Pubmed ID: 17464089 Beta Catenin-independent Activation of MyoD in Presomitic Mesoderm Requires PKC and Depends on Pax3 Transcriptional Activity Developmental Biology. Apr, 2007 | Pubmed ID: 17275805 Nitric Oxide Release Combined with Nonsteroidal Antiinflammatory Activity Prevents Muscular Dystrophy Pathology and Enhances Stem Cell Therapy Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17182743 Nitric Oxide: Emerging Concepts About Its Use in Cell-based Therapies Expert Opinion on Investigational Drugs. Jan, 2007 | Pubmed ID: 17155852 Ex Vivo Treatment with Nitric Oxide Increases Mesoangioblast Therapeutic Efficacy in Muscular Dystrophy Journal of Cell Science. Dec, 2006 | Pubmed ID: 17158915 Complete Repair of Dystrophic Skeletal Muscle by Mesoangioblasts with Enhanced Migration Ability The Journal of Cell Biology. Jul, 2006 | Pubmed ID: 16831885 Follistatin Induction by Nitric Oxide Through Cyclic GMP: a Tightly Regulated Signaling Pathway That Controls Myoblast Fusion The Journal of Cell Biology. Jan, 2006 | Pubmed ID: 16401724 Accuracy of Ultrasound in the Detection of Liver Fibrosis in Chronic Viral Hepatitis La Radiologia Medica. Oct, 2005 | Pubmed ID: 16292241 A Role for MSX2 and Necdin in Smooth Muscle Differentiation of Mesoangioblasts and Other Mesoderm Progenitor Cells Trends in Cardiovascular Medicine. Apr, 2005 | Pubmed ID: 16039969 Mitochondrial Biogenesis by NO Yields Functionally Active Mitochondria in Mammals Proceedings of the National Academy of Sciences of the United States of America. Nov, 2004 | Pubmed ID: 15545607 TGFbeta/BMP Activate the Smooth Muscle/bone Differentiation Programs in Mesoangioblasts Journal of Cell Science. Sep, 2004 | Pubmed ID: 15331661 Msx2 and Necdin Combined Activities Are Required for Smooth Muscle Differentiation in Mesoangioblast Stem Cells Circulation Research. Jun, 2004 | Pubmed ID: 15155529 SOX3 is Required During the Formation of the Hypothalamo-pituitary Axis Nature Genetics. Mar, 2004 | Pubmed ID: 14981518 Bhlhb5 is Expressed in the CNS and Sensory Organs During Mouse Embryonic Development Gene Expression Patterns : GEP. Dec, 2003 | Pubmed ID: 14643684 Expression of Sox3 Throughout the Developing Central Nervous System is Dependent on the Combined Action of Discrete, Evolutionarily Conserved Regulatory Elements Genesis (New York, N.Y. : 2000). May, 2003 | Pubmed ID: 12748963 Die Induktion von Akute Skelettmuskelregeneration durch Cardio Injection Ombretta Guardiola1, Gennaro Andolfi1, Mario Tirone2,3, Francescopaolo Iavarone1, Silvia Brunelli2, Gabriella Minchiotti1 1Stem Cell Fate Laboratory, Institute of Genetics and Biophysics "A. Buzzati Traverso", CNR, 2School of Medicine and Surgery, University of Milano-Bicocca, 3Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute JoVE 54515 Developmental Biology
Die Induktion von Akute Skelettmuskelregeneration durch Cardio Injection Ombretta Guardiola1, Gennaro Andolfi1, Mario Tirone2,3, Francescopaolo Iavarone1, Silvia Brunelli2, Gabriella Minchiotti1 1Stem Cell Fate Laboratory, Institute of Genetics and Biophysics "A. Buzzati Traverso", CNR, 2School of Medicine and Surgery, University of Milano-Bicocca, 3Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute JoVE 54515 Developmental Biology