Simon M. Hughes Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences King’s College London Biography Publications Institution JoVE Articles Simon M. Hughes has not added a biography. If you are Simon M. Hughes and would like to personalize this page please email our Author Liaison for assistance. Publications Cellular and Molecular Pathways Controlling Muscle Size in Response to Exercise The FEBS Journal. 03, 2022 | Pubmed ID: 33755332 Isolation of Myofibres and Culture of Muscle Stem Cells from Adult Zebrafish Bio-protocol. Sep, 2021 | Pubmed ID: 34604454 MRNP Granule Proteins Fmrp and Dcp1a Differentially Regulate MRNP Complexes to Contribute to Control of Muscle Stem Cell Quiescence and Activation Skeletal Muscle. 07, 2021 | Pubmed ID: 34238354 Knockout of Zebrafish Desmin Genes Does Not Cause Skeletal Muscle Degeneration but Alters Calcium Flux Scientific Reports. 04, 2021 | Pubmed ID: 33820917 Mef2c Factors Are Required for Early but Not Late Addition of Cardiomyocytes to the Ventricle Developmental Biology. 02, 2021 | Pubmed ID: 33245870 Circadian Regulation of Muscle Growth Independent of Locomotor Activity Proceedings of the National Academy of Sciences of the United States of America. 12, 2020 | Pubmed ID: 33229575 Myogenin is an Essential Regulator of Adult Myofibre Growth and Muscle Stem Cell Homeostasis ELife. 10, 2020 | Pubmed ID: 33001028 Fgf-driven Tbx Protein Activities Directly Induce and to Initiate Zebrafish Myogenesis Development (Cambridge, England). 04, 2020 | Pubmed ID: 32345657 Maternal Larp6 Controls Oocyte Development, Chorion Formation and Elevation Development (Cambridge, England). 02, 2020 | Pubmed ID: 32054660 EGF Receptor (EGFR) Inhibition Promotes a Slow-twitch Oxidative, over a Fast-twitch, Muscle Phenotype Scientific Reports. 06, 2019 | Pubmed ID: 31239465 Scleraxis Genes Are Required for Normal Musculoskeletal Development and for Rib Growth and Mineralization in Zebrafish FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 08, 2019 | Pubmed ID: 31100023 Myogenin Promotes Myocyte Fusion to Balance Fibre Number and Size Nature Communications. 10, 2018 | Pubmed ID: 30315160 Mef2 and the Skeletal Muscle Differentiation Program Seminars in Cell & Developmental Biology. 12, 2017 | Pubmed ID: 29154822 Myotome Adaptability Confers Developmental Robustness to Somitic Myogenesis in Response to Fibre Number Alteration Developmental Biology. 11, 2017 | Pubmed ID: 28887016 CRISPR/Cas9 Editing Reveals Novel Mechanisms of Clustered MicroRNA Regulation and Function Scientific Reports. 08, 2017 | Pubmed ID: 28819307 The Cannabinoid Receptor Interacting Proteins 1 of Zebrafish Are Not Required for Morphological Development, Viability or Fertility Scientific Reports. 07, 2017 | Pubmed ID: 28687732 Cellular Dynamics of Regeneration Reveals Role of Two Distinct Pax7 Stem Cell Populations in Larval Zebrafish Muscle Repair Disease Models & Mechanisms. 06, 2016 | Pubmed ID: 27149989 In Vivo Dynamics of Skeletal Muscle Dystrophin in Zebrafish Embryos Revealed by Improved FRAP Analysis ELife. Oct, 2015 | Pubmed ID: 26459831 Anaesthetic Tricaine Acts Preferentially on Neural Voltage-gated Sodium Channels and Fails to Block Directly Evoked Muscle Contraction PloS One. 2014 | Pubmed ID: 25090007 EIF4EBP3L Acts As a Gatekeeper of TORC1 in Activity-dependent Muscle Growth by Specifically Regulating Mef2ca Translational Initiation PLoS Biology. Oct, 2013 | Pubmed ID: 24143132 Notch Signalling is Required for the Formation of Structurally Stable Muscle Fibres in Zebrafish PloS One. 2013 | Pubmed ID: 23840804 Oesophageal and Sternohyal Muscle Fibres Are Novel Pax3-dependent Migratory Somite Derivatives Essential for Ingestion Development (Cambridge, England). Jul, 2013 | Pubmed ID: 23760954 Zebrafish Mef2ca and Mef2cb Are Essential for Both First and Second Heart Field Cardiomyocyte Differentiation Developmental Biology. Sep, 2012 | Pubmed ID: 22750409 Defective Cranial Skeletal Development, Larval Lethality and Haploinsufficiency in Myod Mutant Zebrafish Developmental Biology. Oct, 2011 | Pubmed ID: 21798255 Cdkn1c Drives Muscle Differentiation Through a Positive Feedback Loop with Myod Developmental Biology. Feb, 2011 | Pubmed ID: 21147088 Differential Requirements for Myogenic Regulatory Factors Distinguish Medial and Lateral Somitic, Cranial and Fin Muscle Fibre Populations Development (Cambridge, England). Feb, 2009 | Pubmed ID: 19141670 Other Model Organisms for Sarcomeric Muscle Diseases Advances in Experimental Medicine and Biology. 2008 | Pubmed ID: 19181102 Wnt Signaling Promotes AChR Aggregation at the Neuromuscular Synapse in Collaboration with Agrin Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19020093 Nerve-dependent Changes in Skeletal Muscle Myosin Heavy Chain After Experimental Denervation and Cross-reinnervation and in a Demyelinating Mouse Model of Charcot-Marie-Tooth Disease Type 1A Muscle & Nerve. Dec, 2008 | Pubmed ID: 19016545 Sequential Actions of Pax3 and Pax7 Drive Xanthophore Development in Zebrafish Neural Crest Developmental Biology. May, 2008 | Pubmed ID: 18417109 Development of Mandibular, Hyoid and Hypobranchial Muscles in the Zebrafish: Homologies and Evolution of These Muscles Within Bony Fishes and Tetrapods BMC Developmental Biology. Feb, 2008 | Pubmed ID: 18307809 MyoD- and Nerve-dependent Maintenance of MyoD Expression in Mature Muscle Fibres Acts Through the DRR/PRR Element BMC Developmental Biology. Jan, 2008 | Pubmed ID: 18215268 Dystrobrevin and Dystrophin Family Gene Expression in Zebrafish Gene Expression Patterns : GEP. Jan, 2008 | Pubmed ID: 18042440 Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) Expression in Zebrafish Skeletal Muscle, Brain and Notochord Gene Expression Patterns : GEP. Oct, 2007 | Pubmed ID: 17916448 Mrf4 (myf6) is Dynamically Expressed in Differentiated Zebrafish Skeletal Muscle Gene Expression Patterns : GEP. Aug, 2007 | Pubmed ID: 17638597 Mef2s Are Required for Thick Filament Formation in Nascent Muscle Fibres Development (Cambridge, England). Jul, 2007 | Pubmed ID: 17537787 The Dystrotelin, Dystrophin and Dystrobrevin Superfamily: New Paralogues and Old Isoforms BMC Genomics. Jan, 2007 | Pubmed ID: 17233888 Signals and Myogenic Regulatory Factors Restrict Pax3 and Pax7 Expression to Dermomyotome-like Tissue in Zebrafish Developmental Biology. Feb, 2007 | Pubmed ID: 17094960 Comparison of Neurolin (ALCAM) and Neurolin-like Cell Adhesion Molecule (NLCAM) Expression in Zebrafish Gene Expression Patterns : GEP. Oct, 2006 | Pubmed ID: 16750657 Evidence That Satellite Cell Decrement Contributes to Preferential Decline in Nuclear Number from Large Fibres During Murine Age-related Muscle Atrophy Journal of Cell Science. Oct, 2005 | Pubmed ID: 16219688 Fgf8 Drives Myogenic Progression of a Novel Lateral Fast Muscle Fibre Population in Zebrafish Development (Cambridge, England). Oct, 2005 | Pubmed ID: 16120642 The Kinase Domain of Titin Controls Muscle Gene Expression and Protein Turnover Science (New York, N.Y.). Jun, 2005 | Pubmed ID: 15802564 Hedgehog Can Drive Terminal Differentiation of Amniote Slow Skeletal Muscle BMC Developmental Biology. Jul, 2004 | Pubmed ID: 15238161 Hedgehog Regulation of Superficial Slow Muscle Fibres in Xenopus and the Evolution of Tetrapod Trunk Myogenesis Development (Cambridge, England). Jul, 2004 | Pubmed ID: 15201218 Muscle Differentiation: a Gene for Slow Muscle? Current Biology : CB. Feb, 2004 | Pubmed ID: 15027468 Intermediate Filament-co-localized Molecules with Myosin Heavy Chain Epitopes Define Distinct Cellular Domains in Hair Follicles and Epidermis BMC Cell Biology. Aug, 2003 | Pubmed ID: 12899730 Acridine Mutagenesis of Zebrafish (Danio Rerio) Mutation Research. Apr, 2003 | Pubmed ID: 12650900 Aging-related Satellite Cell Differentiation Defect Occurs Prematurely After Ski-induced Muscle Hypertrophy American Journal of Physiology. Cell Physiology. Oct, 2002 | Pubmed ID: 12225986 Muscular Expressions: Profiling Genes in Complex Tissues Genome Biology. 2001 | Pubmed ID: 11790260 Myogenin Induces a Shift of Enzyme Activity from Glycolytic to Oxidative Metabolism in Muscles of Transgenic Mice The Journal of Cell Biology. May, 1999 | Pubmed ID: 10225962 The Role of Hedgehog Proteins in Vertebrate Slow and Fast Skeletal Muscle Patterning Acta Physiologica Scandinavica. Jul, 1998 | Pubmed ID: 9715744 Notochord Induction of Zebrafish Slow Muscle Mediated by Sonic Hedgehog Genes & Development. Sep, 1997 | Pubmed ID: 9303533 MyoD Protein is Differentially Accumulated in Fast and Slow Skeletal Muscle Fibres and Required for Normal Fibre Type Balance in Rodents Mechanisms of Development. Jan, 1997 | Pubmed ID: 9076685 Real Time and Repeated Measurement of Skeletal Muscle Growth in Individual Live Zebrafish Subjected to Altered Electrical Activity Michael Attwaters*1, Jeffrey J. Kelu*1, Tapan G. Pipalia1, Simon M. Hughes1 1Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King’s College London JoVE 64063 Developmental Biology
Real Time and Repeated Measurement of Skeletal Muscle Growth in Individual Live Zebrafish Subjected to Altered Electrical Activity Michael Attwaters*1, Jeffrey J. Kelu*1, Tapan G. Pipalia1, Simon M. Hughes1 1Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King’s College London JoVE 64063 Developmental Biology