Stella E. Tsirka Department of Pharmacological Sciences Stony Brook University Biography Publications Institution JoVE Articles Stella E. Tsirka has not added a biography. If you are Stella E. Tsirka and would like to personalize this page please email our Author Liaison for assistance. Publications Inflammatory Stress Response in A549 Cells As a Result of Exposure to Coal: Evidence for the Role of Pyrite in Coal Workers' Pneumoconiosis Pathogenesis Chemosphere. Jul, 2013 | Pubmed ID: 23895739 Members of the High Mobility Group B Protein Family Are Dynamically Expressed in Embryonic Neural Stem Cells Proteome Science. 2013 | Pubmed ID: 23621913 Microglia Actively Regulate the Number of Functional Synapses PloS One. 2013 | Pubmed ID: 23393609 The Annexin A2/S100A10 System in Health and Disease: Emerging Paradigms Journal of Biomedicine & Biotechnology. 2012 | Pubmed ID: 23193360 Inflammation Modulates Expression of Laminin in the Central Nervous System Following Ischemic Injury Journal of Neuroinflammation. 2012 | Pubmed ID: 22759265 P53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis Cell. Jun, 2012 | Pubmed ID: 22726440 Microglial Inhibitory Factor (MIF/TKP) Mitigates Secondary Damage Following Spinal Cord Injury Neurobiology of Disease. Sep, 2012 | Pubmed ID: 22613732 Tuftsin Promotes an Anti-inflammatory Switch and Attenuates Symptoms in Experimental Autoimmune Encephalomyelitis PloS One. 2012 | Pubmed ID: 22529957 Quantification of Particle-induced Inflammatory Stress Response: a Novel Approach for Toxicity Testing of Earth Materials Geochemical Transactions. 2012 | Pubmed ID: 22513118 The CCL2-CCR2 System Affects the Progression and Clearance of Intracerebral Hemorrhage Glia. May, 2012 | Pubmed ID: 22419223 Neuroimaging in Animal Seizure Models with (18)FDG-PET Epilepsy Research and Treatment. 2011 | Pubmed ID: 22937232 Animal Models of MS Reveal Multiple Roles of Microglia in Disease Pathogenesis Neurology Research International. 2011 | Pubmed ID: 22203900 Axonal Regrowth After Spinal Cord Injury Via Chondroitinase and the Tissue Plasminogen Activator (tPA)/plasmin System The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2011 | Pubmed ID: 22016526 Annexin A2 Promotes Glioma Cell Invasion and Tumor Progression The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2011 | Pubmed ID: 21976520 Mouse MCP1 C-terminus Inhibits Human MCP1-induced Chemotaxis and BBB Compromise Journal of Neurochemistry. Jul, 2011 | Pubmed ID: 21615737 Truncation of Monocyte Chemoattractant Protein 1 by Plasmin Promotes Blood-brain Barrier Disruption Journal of Cell Science. May, 2011 | Pubmed ID: 21486949 Microglia/macrophages Promote Glioma Progression Glia. Mar, 2011 | Pubmed ID: 21264953 Microglia Shape Adult Hippocampal Neurogenesis Through Apoptosis-coupled Phagocytosis Cell Stem Cell. Oct, 2010 | Pubmed ID: 20887954 The C Terminus of Mouse Monocyte Chemoattractant Protein 1 (MCP1) Mediates MCP1 Dimerization While Blocking Its Chemotactic Potency The Journal of Biological Chemistry. Oct, 2010 | Pubmed ID: 20682771 Tissue Plasminogen Activator Alters Intracellular Sequestration of Zinc Through Interaction with the Transporter ZIP4 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2010 | Pubmed ID: 20463217 Microglial Ablation and Lipopolysaccharide Preconditioning Affects Pilocarpine-induced Seizures in Mice Neurobiology of Disease. Jul, 2010 | Pubmed ID: 20382223 Decreased Serotonin Levels Associated with Behavioral Disinhibition in Tissue Plasminogen Activator Deficient (tPA-/-) Mice Brain Research. Apr, 2010 | Pubmed ID: 20156421 Endothelial NOS-deficient Mice Reveal Dual Roles for Nitric Oxide During Experimental Autoimmune Encephalomyelitis Glia. Aug, 2009 | Pubmed ID: 19170181 Tissue-type Plasminogen Activator As a Therapeutic Target in Stroke Expert Opinion on Therapeutic Targets. Feb, 2008 | Pubmed ID: 18208365 TPA-mediated Generation of Plasmin is Catalyzed by the Proteoglycan NG2 Glia. Jan, 2008 | Pubmed ID: 18000864 A Novel Approach for Imaging Brain-behavior Relationships in Mice Reveals Unexpected Metabolic Patterns During Seizures in the Absence of Tissue Plasminogen Activator NeuroImage. Oct, 2007 | Pubmed ID: 17707126 Modulation of Microglial/macrophage Activation by Macrophage Inhibitory Factor (TKP) or Tuftsin (TKPR) Attenuates the Disease Course of Experimental Autoimmune Encephalomyelitis BMC Immunology. 2007 | Pubmed ID: 17634104 Brain Edema After Intracerebral Hemorrhage: Mechanisms, Treatment Options, Management Strategies, and Operative Indications Neurosurgical Focus. 2007 | Pubmed ID: 17613237 Nitric Oxide Synthase Isoforms Undertake Unique Roles During Excitotoxicity Stroke; a Journal of Cerebral Circulation. Jun, 2007 | Pubmed ID: 17446423 Proteolytic Activation of Monocyte Chemoattractant Protein-1 by Plasmin Underlies Excitotoxic Neurodegeneration in Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2007 | Pubmed ID: 17301181 Nitric Oxide Mediates Neurodegeneration and Breakdown of the Blood-brain Barrier in TPA-dependent Excitotoxic Injury in Mice Journal of Cell Science. Jan, 2006 | Pubmed ID: 16410551 PET Imaging of Glucose Metabolism in a Mouse Model of Temporal Lobe Epilepsy Synapse (New York, N.Y.). Feb, 2006 | Pubmed ID: 16320304 Contribution of Extracellular Proteolysis and Microglia to Intracerebral Hemorrhage Neurocritical Care. 2005 | Pubmed ID: 16159103 Fibrin-modifying Serine Proteases Thrombin, TPA, and Plasmin in Ischemic Stroke: a Review Glia. Jun, 2005 | Pubmed ID: 15846799 Neuroprotection by Inhibition of Matrix Metalloproteinases in a Mouse Model of Intracerebral Haemorrhage Brain : a Journal of Neurology. Jul, 2005 | Pubmed ID: 15800021 Phospholipase D1-promoted Release of Tissue Plasminogen Activator Facilitates Neurite Outgrowth The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2005 | Pubmed ID: 15716416 Tuftsin Fragment 1-3 is Beneficial when Delivered After the Induction of Intracerebral Hemorrhage Stroke; a Journal of Cerebral Circulation. Mar, 2005 | Pubmed ID: 15692122 Tissue Plasminogen Activator and Glial Function Glia. Jan, 2005 | Pubmed ID: 15494978 Increased Expression of Two Phospholipase D Isoforms During Experimentally Induced Hippocampal Mossy Fiber Outgrowth Glia. Apr, 2004 | Pubmed ID: 14999815 Modulation of Zinc Toxicity by Tissue Plasminogen Activator Molecular and Cellular Neurosciences. Jan, 2004 | Pubmed ID: 14962749 Protective Role of Tuftsin Fragment 1-3 in an Animal Model of Intracerebral Hemorrhage Annals of Neurology. Nov, 2003 | Pubmed ID: 14595655 Cell Type-specific Roles for Tissue Plasminogen Activator Released by Neurons or Microglia After Excitotoxic Injury The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2003 | Pubmed ID: 12716930 Involvement of Tissue Plasminogen Activator in Onset and Effector Phases of Experimental Allergic Encephalomyelitis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2002 | Pubmed ID: 12486171 Microglial Activation and Recruitment, but Not Proliferation, Suffice to Mediate Neurodegeneration Cell Death and Differentiation. Aug, 2002 | Pubmed ID: 12107823 Tissue Plasminogen Activator As a Modulator of Neuronal Survival and Function Biochemical Society Transactions. Apr, 2002 | Pubmed ID: 12023855 Extracellular Proteases and Neuronal Cell Death Cellular and Molecular Biology (Noisy-le-Grand, France). Mar, 2002 | Pubmed ID: 11990450 Tissue Plasminogen Activator Mediates Microglial Activation Via Its Finger Domain Through Annexin II The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2002 | Pubmed ID: 11978811 Partial Rescue of Neural Apoptosis in the Lurcher Mutant Mouse Through Elimination of Tissue Plasminogen Activator Development (Cambridge, England). Apr, 2002 | Pubmed ID: 11934869 Culturing Microglia from the Neonatal and Adult Central Nervous System Robert Bronstein*1,2, Luisa Torres*2,3, Jillian C. Nissen*2,3, Stella E. Tsirka2 1Program in Neuroscience, Stony Brook University, 2Department of Pharmacological Sciences, Stony Brook University, 3Program in Molecular and Cellular Pharmacology, Stony Brook University JoVE 50647 Immunology and Infection
Culturing Microglia from the Neonatal and Adult Central Nervous System Robert Bronstein*1,2, Luisa Torres*2,3, Jillian C. Nissen*2,3, Stella E. Tsirka2 1Program in Neuroscience, Stony Brook University, 2Department of Pharmacological Sciences, Stony Brook University, 3Program in Molecular and Cellular Pharmacology, Stony Brook University JoVE 50647 Immunology and Infection