Stephen M. Beverley Department of Molecular Microbiology Washington University School of Medicine Biography Publications Institution JoVE Articles Stephen M. Beverley has not added a biography. If you are Stephen M. Beverley and would like to personalize this page please email our Author Liaison for assistance. Publications Killed but Metabolically Active Leishmania As a Novel Whole-cell Vaccine for Visceral Leishmaniasis Clinical and Vaccine Immunology : CVI. Feb, 2012 | Pubmed ID: 22323556 [Mucocutaneous Leishmaniasis and an Undesired Passenger] Médecine Sciences : M/S. Nov, 2011 | Pubmed ID: 22130014 Folate Metabolic Pathways in Leishmania Essays in Biochemistry. 2011 | Pubmed ID: 22023442 Muco-cutaneous Leishmaniasis in the New World: the Ultimate Subversion Virulence. Nov-Dec, 2011 | Pubmed ID: 21971185 The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing PLoS Neglected Tropical Diseases. Aug, 2011 | Pubmed ID: 21886855 Leishmania RNA Virus Controls the Severity of Mucocutaneous Leishmaniasis Science (New York, N.Y.). Feb, 2011 | Pubmed ID: 21311023 Differential Microbicidal Effects of Human Histone Proteins H2A and H2B on Leishmania Promastigotes and Amastigotes Infection and Immunity. Mar, 2011 | Pubmed ID: 21189319 Phenylalanine Hydroxylase (PAH) from the Lower Eukaryote Leishmania Major Molecular and Biochemical Parasitology. Jan, 2011 | Pubmed ID: 20887755 Remodeling of Protein and MRNA Expression in Leishmania Mexicana Induced by Deletion of Glucose Transporter Genes Molecular and Biochemical Parasitology. Jan, 2011 | Pubmed ID: 20869991 Leishmania Major Survival in Selective Phlebotomus Papatasi Sand Fly Vector Requires a Specific SCG-encoded Lipophosphoglycan Galactosylation Pattern PLoS Pathogens. 2010 | Pubmed ID: 21085609 Retention and Loss of RNA Interference Pathways in Trypanosomatid Protozoans PLoS Pathogens. 2010 | Pubmed ID: 21060810 Sphingolipids in Parasitic Protozoa Advances in Experimental Medicine and Biology. 2010 | Pubmed ID: 20919659 Expansion of the Target of Rapamycin (TOR) Kinase Family and Function in Leishmania Shows That TOR3 is Required for Acidocalcisome Biogenesis and Animal Infectivity Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20551225 A Role for Tetrahydrofolates in the Metabolism of Iron-sulfur Clusters in All Domains of Life Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20489182 Phosphoproteome Dynamics Reveal Heat-shock Protein Complexes Specific to the Leishmania Donovani Infectious Stage Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20404152 Monitoring the Efficacy of Antimicrobial Photodynamic Therapy in a Murine Model of Cutaneous Leishmaniasis Using L. Major Expressing GFP Journal of Biophotonics. Jun, 2010 | Pubmed ID: 20376860 Deletion of UDP-glucose Pyrophosphorylase Reveals a UDP-glucose Independent UDP-galactose Salvage Pathway in Leishmania Major Glycobiology. Jul, 2010 | Pubmed ID: 20335578 Proteophosphoglycan Confers Resistance of Leishmania Major to Midgut Digestive Enzymes Induced by Blood Feeding in Vector Sand Flies Cellular Microbiology. Jul, 2010 | Pubmed ID: 20088949 Leishmania Major Glycosylation Mutants Require Phosphoglycans (lpg2-) but Not Lipophosphoglycan (lpg1-) for Survival in Permissive Sand Fly Vectors PLoS Neglected Tropical Diseases. 2010 | Pubmed ID: 20084096 Phospholipid and Sphingolipid Metabolism in Leishmania Molecular and Biochemical Parasitology. Apr, 2010 | Pubmed ID: 20026359 Identification of Transport-critical Residues in a Folate Transporter from the Folate-biopterin Transporter (FBT) Family The Journal of Biological Chemistry. Jan, 2010 | Pubmed ID: 19923217 A Transposon Toolkit for Gene Transfer and Mutagenesis in Protozoan Parasites Genetica. Mar, 2010 | Pubmed ID: 19763844 Degradation of Host Sphingomyelin is Essential for Leishmania Virulence PLoS Pathogens. Dec, 2009 | Pubmed ID: 20011126 Inoculation of Killed Leishmania Major into Immune Mice Rapidly Disrupts Immunity to a Secondary Challenge Via IL-10-mediated Process Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19666482 Leishmania Major Phosphoglycans Influence the Host Early Immune Response by Modulating Dendritic Cell Functions Infection and Immunity. Aug, 2009 | Pubmed ID: 19487470 The Enzymes of the 10-formyl-tetrahydrofolate Synthetic Pathway Are Found Exclusively in the Cytosol of the Trypanosomatid Parasite Leishmania Major Molecular and Biochemical Parasitology. Aug, 2009 | Pubmed ID: 19450731 PTR1-dependent Synthesis of Tetrahydrobiopterin Contributes to Oxidant Susceptibility in the Trypanosomatid Protozoan Parasite Leishmania Major Current Genetics. Jun, 2009 | Pubmed ID: 19396443 Leishmania Major Lacking Arginase (ARG) Are Auxotrophic for Polyamines but Retain Infectivity to Susceptible BALB/c Mice Molecular and Biochemical Parasitology. May, 2009 | Pubmed ID: 19393161 Regulated Expression of the Leishmania Major Surface Virulence Factor Lipophosphoglycan Using Conditionally Destabilized Fusion Proteins Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19383793 A Novel Role for Stat1 in Phagosome Acidification and Natural Host Resistance to Intracellular Infection by Leishmania Major PLoS Pathogens. Apr, 2009 | Pubmed ID: 19381261 Demonstration of Genetic Exchange During Cyclical Development of Leishmania in the Sand Fly Vector Science (New York, N.Y.). Apr, 2009 | Pubmed ID: 19359589 Leishmania Donovani Lacking the Golgi GDP-Man Transporter LPG2 Exhibit Attenuated Virulence in Mammalian Hosts Experimental Parasitology. Jul, 2009 | Pubmed ID: 19328787 Methylene Tetrahydrofolate Dehydrogenase/cyclohydrolase and the Synthesis of 10-CHO-THF Are Essential in Leishmania Major Molecular Microbiology. Mar, 2009 | Pubmed ID: 19183277 Amplification of an Alternate Transporter Gene Suppresses the Avirulent Phenotype of Glucose Transporter Null Mutants in Leishmania Mexicana Molecular Microbiology. Jan, 2009 | Pubmed ID: 19017272 Migratory Dermal Dendritic Cells Act As Rapid Sensors of Protozoan Parasites PLoS Pathogens. Nov, 2008 | Pubmed ID: 19043558 Developmentally Regulated Sphingolipid Synthesis in African Trypanosomes Molecular Microbiology. Oct, 2008 | Pubmed ID: 18699867 Leishmania Major Intracellular Survival is Not Altered in SHP-1 Deficient Mev or CD45-/- Mice Experimental Parasitology. Nov, 2008 | Pubmed ID: 18682252 Phylogenomic and Functional Analysis of Pterin-4a-carbinolamine Dehydratase Family (COG2154) Proteins in Plants and Microorganisms Plant Physiology. Apr, 2008 | Pubmed ID: 18245455 The Role of the Mitochondrial Glycine Cleavage Complex in the Metabolism and Virulence of the Protozoan Parasite Leishmania Major The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 17981801 Characterization of Inositol Phosphorylceramides from Leishmania Major by Tandem Mass Spectrometry with Electrospray Ionization Journal of the American Society for Mass Spectrometry. Sep, 2007 | Pubmed ID: 17627842 Comparisons of Mutants Lacking the Golgi UDP-galactose or GDP-mannose Transporters Establish That Phosphoglycans Are Important for Promastigote but Not Amastigote Virulence in Leishmania Major Infection and Immunity. Sep, 2007 | Pubmed ID: 17606605 Two Functionally Divergent UDP-Gal Nucleotide Sugar Transporters Participate in Phosphoglycan Synthesis in Leishmania Major The Journal of Biological Chemistry. May, 2007 | Pubmed ID: 17347153 A Lipophosphoglycan-independent Development of Leishmania in Permissive Sand Flies Microbes and Infection / Institut Pasteur. Mar, 2007 | Pubmed ID: 17307009 Redirection of Sphingolipid Metabolism Toward De Novo Synthesis of Ethanolamine in Leishmania The EMBO Journal. Feb, 2007 | Pubmed ID: 17290222 Biochemical and Genetic Analysis of Methylenetetrahydrofolate Reductase in Leishmania Metabolism and Virulence The Journal of Biological Chemistry. Dec, 2006 | Pubmed ID: 17032644 Genomic Organization and Expression of the Expanded SCG/L/R Gene Family of Leishmania Major: Internal Clusters and Telomeric Localization of SCGs Mediating Species-specific LPG Modifications Molecular and Biochemical Parasitology. Apr, 2006 | Pubmed ID: 16464509 Immunization with Persistent Attenuated Delta Lpg2 Leishmania Major Parasites Requires Adjuvant to Provide Protective Immunity in C57BL/6 Mice Infection and Immunity. Jan, 2006 | Pubmed ID: 16369039 Demonstration by Heterologous Expression That the Leishmania SCA1 Gene Encodes an Arabinopyranosyltransferase Glycobiology. Mar, 2006 | Pubmed ID: 16272216 Structures of Leishmania Major Pteridine Reductase Complexes Reveal the Active Site Features Important for Ligand Binding and to Guide Inhibitor Design Journal of Molecular Biology. Sep, 2005 | Pubmed ID: 16055151 The Genome of the Kinetoplastid Parasite, Leishmania Major Science (New York, N.Y.). Jul, 2005 | Pubmed ID: 16020728 Identification of a DNA Fragment That Increases Mitotic Stability of Episomal Linear DNAs in Leishmania Major International Journal for Parasitology. Aug, 2005 | Pubmed ID: 15996670 Eukaryotic UDP-galactopyranose Mutase (GLF Gene) in Microbial and Metazoal Pathogens Eukaryotic Cell. Jun, 2005 | Pubmed ID: 15947206 Leishmania Salvage and Remodelling of Host Sphingolipids in Amastigote Survival and Acidocalcisome Biogenesis Molecular Microbiology. Mar, 2005 | Pubmed ID: 15720561 Reconstitution of GDP-mannose Transport Activity with Purified Leishmania LPG2 Protein in Liposomes The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15542612 Infection and Immunity. Dec, 2004 | Pubmed ID: 15557638 Flypaper for Parasites Cell. Oct, 2004 | Pubmed ID: 15507202 Central Memory T Cells Mediate Long-term Immunity to Leishmania Major in the Absence of Persistent Parasites Nature Medicine. Oct, 2004 | Pubmed ID: 15448686 The Application of Gene Expression Microarray Technology to Kinetoplastid Research Current Molecular Medicine. Sep, 2004 | Pubmed ID: 15357212 Identification of a Compensatory Mutant (lpg2-REV) of Leishmania Major Able to Survive As Amastigotes Within Macrophages Without LPG2-dependent Glycoconjugates and Its Significance to Virulence and Immunization Strategies Infection and Immunity. Jun, 2004 | Pubmed ID: 15155672 In Vitro Shuttle Mutagenesis Using Engineered Mariner Transposons Methods in Molecular Biology (Clifton, N.J.). 2004 | Pubmed ID: 15153636 Expression Profiling Using Random Genomic DNA Microarrays Identifies Differentially Expressed Genes Associated with Three Major Developmental Stages of the Protozoan Parasite Leishmania Major Molecular and Biochemical Parasitology. Jul, 2004 | Pubmed ID: 15138069 The LPG1 Gene Family of Leishmania Major Molecular and Biochemical Parasitology. Jul, 2004 | Pubmed ID: 15138063 Vaccination with Phosphoglycan-deficient Leishmania Major Protects Highly Susceptible Mice from Virulent Challenge Without Inducing a Strong Th1 Response Journal of Immunology (Baltimore, Md. : 1950). Mar, 2004 | Pubmed ID: 15004184 Sphingolipids Are Essential for Differentiation but Not Growth in Leishmania The EMBO Journal. Nov, 2003 | Pubmed ID: 14609948 An in Vitro System for Developmental and Genetic Studies of Leishmania Donovani Phosphoglycans Molecular and Biochemical Parasitology. Aug, 2003 | Pubmed ID: 14550894 The H Region HTBF Gene Mediates Terbinafine Resistance in Leishmania Major Molecular and Biochemical Parasitology. Sep, 2003 | Pubmed ID: 12967714 Persistence Without Pathology in Phosphoglycan-deficient Leishmania Major Science (New York, N.Y.). Aug, 2003 | Pubmed ID: 12947201 Functional Genetic Identification of PRP1, an ABC Transporter Superfamily Member Conferring Pentamidine Resistance in Leishmania Major Molecular and Biochemical Parasitology. Aug, 2003 | Pubmed ID: 12946844 Ether Phospholipids and Glycosylinositolphospholipids Are Not Required for Amastigote Virulence or for Inhibition of Macrophage Activation by Leishmania Major The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12944391 The Role(s) of Lipophosphoglycan (LPG) in the Establishment of Leishmania Major Infections in Mammalian Hosts Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12869694 Identification of Genes Encoding Arabinosyltransferases (SCA) Mediating Developmental Modifications of Lipophosphoglycan Required for Sand Fly Transmission of Leishmania Major The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12750366 Improvements in Transfection Efficiency and Tests of RNA Interference (RNAi) Approaches in the Protozoan Parasite Leishmania Molecular and Biochemical Parasitology. May, 2003 | Pubmed ID: 12742588 Functional Identification of Galactosyltransferases (SCGs) Required for Species-specific Modifications of the Lipophosphoglycan Adhesin Controlling Leishmania Major-sand Fly Interactions The Journal of Biological Chemistry. May, 2003 | Pubmed ID: 12604613 Transposon Mutagenesis of Mycobacterium Marinum Identifies a Locus Linking Pigmentation and Intracellular Survival Infection and Immunity. Feb, 2003 | Pubmed ID: 12540574 Protozomics: Trypanosomatid Parasite Genetics Comes of Age Nature Reviews. Genetics. Jan, 2003 | Pubmed ID: 12509749 Leishmania LPG3 Encodes a GRP94 Homolog Required for Phosphoglycan Synthesis Implicated in Parasite Virulence but Not Viability The EMBO Journal. Sep, 2002 | Pubmed ID: 12198148 Characterization of Quinonoid-dihydropteridine Reductase (QDPR) from the Lower Eukaryote Leishmania Major The Journal of Biological Chemistry. Oct, 2002 | Pubmed ID: 12151409 Non-pathogenic Trypanosomatid Protozoa As a Platform for Protein Research and Production Protein Expression and Purification. Jul, 2002 | Pubmed ID: 12135552 Putting the Leishmania Genome to Work: Functional Genomics by Transposon Trapping and Expression Profiling Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jan, 2002 | Pubmed ID: 11839181 В естественных изображений трансгенных Паразиты Leishmania в реальный хост Colin J. Thalhofer1, Joel W. Graff2, Laurie Love-Homan3, Suzanne M. Hickerson4, Noah Craft5, Stephen M. Beverley4, Mary E. Wilson6,7 1Interdisciplinary Immunology Program, University of Iowa, and the VA Medical Center, 2Department of Biochemistry, University of Iowa, and the VA Medical Center, 3Department of Internal Medicine, University of Iowa, 4Department of Molecular Microbiology, Washington University School of Medicine, 5Division of Dermatology, Harbor-UCLA Medical Center, Hanley-Hardison Research Center, 6Interdisciplinary Immunology Program, Iowa City VA Medical Center, 7Departments of Internal Medicine, Microbiology and Epidemiology, University of Iowa JoVE 1980 Immunology and Infection
В естественных изображений трансгенных Паразиты Leishmania в реальный хост Colin J. Thalhofer1, Joel W. Graff2, Laurie Love-Homan3, Suzanne M. Hickerson4, Noah Craft5, Stephen M. Beverley4, Mary E. Wilson6,7 1Interdisciplinary Immunology Program, University of Iowa, and the VA Medical Center, 2Department of Biochemistry, University of Iowa, and the VA Medical Center, 3Department of Internal Medicine, University of Iowa, 4Department of Molecular Microbiology, Washington University School of Medicine, 5Division of Dermatology, Harbor-UCLA Medical Center, Hanley-Hardison Research Center, 6Interdisciplinary Immunology Program, Iowa City VA Medical Center, 7Departments of Internal Medicine, Microbiology and Epidemiology, University of Iowa JoVE 1980 Immunology and Infection