Stephen R. Holdsworth Monash University Biography Publications Institution JoVE Articles Stephen R. Holdsworth has not added a biography. If you are Stephen R. Holdsworth and would like to personalize this page please email our Author Liaison for assistance. Publications Deoxyribonuclease 1 Reduces Pathogenic Effects of Cigarette Smoke Exposure in the Lung Scientific Reports. Sep, 2017 | Pubmed ID: 28935869 ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing Seminars in Nephrology. Sep, 2017 | Pubmed ID: 28863790 Dominant Protection from HLA-linked Autoimmunity by Antigen-specific Regulatory T Cells Nature. 05, 2017 | Pubmed ID: 28467828 T Cell Receptor Assessment in Autoimmune Disease Requires Access to the Most Adjacent Immunologically Active Organ Journal of Autoimmunity. Jul, 2017 | Pubmed ID: 28318808 Interleukin-17RA Promotes Humoral Responses and Glomerular Injury in Experimental Rapidly Progressive Glomerulonephritis Nephron. 2017 | Pubmed ID: 27941331 Induced Regulatory T Cells Are Phenotypically Unstable and Do Not Protect Mice from Rapidly Progressive Glomerulonephritis Immunology. Jan, 2017 | Pubmed ID: 27606831 Activated Renal Dendritic Cells Cross Present Intrarenal Antigens After Ischemia-Reperfusion Injury Transplantation. May, 2017 | Pubmed ID: 27495751 CD8+ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN Journal of the American Society of Nephrology : JASN. Jan, 2017 | Pubmed ID: 27288012 The NLRP3 Inflammasome in Kidney Disease and Autoimmunity Nephrology (Carlton, Vic.). Sep, 2016 | Pubmed ID: 27011059 Biologics for the Treatment of Autoimmune Renal Diseases Nature Reviews. Nephrology. Apr, 2016 | Pubmed ID: 26949177 Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase Journal of Immunology Research. 2016 | Pubmed ID: 26904693 Mast Cell Stabilization Ameliorates Autoimmune Anti-Myeloperoxidase Glomerulonephritis Journal of the American Society of Nephrology : JASN. May, 2016 | Pubmed ID: 26374606 Regulatory T Cells in Immune-mediated Renal Disease Nephrology (Carlton, Vic.). Feb, 2016 | Pubmed ID: 26206106 Endogenous Toll-Like Receptor 9 Regulates AKI by Promoting Regulatory T Cell Recruitment Journal of the American Society of Nephrology : JASN. Mar, 2016 | Pubmed ID: 26116356 Myeloperoxidase Peptide-Based Nasal Tolerance in Experimental ANCA-Associated GN Journal of the American Society of Nephrology : JASN. Feb, 2016 | Pubmed ID: 26047792 Targeting IL-17 and IL-23 in Immune Mediated Renal Disease Current Medicinal Chemistry. 2015 | Pubmed ID: 26521930 The Lung Immune Response to Bacteria in Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. Oct, 2015 | Pubmed ID: 26426789 Renal Participation of Myeloperoxidase in Antineutrophil Cytoplasmic Antibody (ANCA)-associated Glomerulonephritis Kidney International. Nov, 2015 | Pubmed ID: 26176828 Programmed Death 1 and Its Ligands Do Not Limit Experimental Foreign Antigen-induced Immune Complex Glomerulonephritis Nephrology (Carlton, Vic.). Dec, 2015 | Pubmed ID: 26043977 Cytokines: Names and Numbers You Should Care About Clinical Journal of the American Society of Nephrology : CJASN. Dec, 2015 | Pubmed ID: 25941193 FMS-like Tyrosine Kinase 3 Ligand Treatment Does Not Ameliorate Experimental Rapidly Progressive Glomerulonephritis PloS One. 2015 | Pubmed ID: 25849330 Nontypeable Haemophilus Influenzae Induces Sustained Lung Oxidative Stress and Protease Expression PloS One. 2015 | Pubmed ID: 25793977 Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase Arthritis & Rheumatology (Hoboken, N.J.). Jul, 2015 | Pubmed ID: 25777776 Mouse Models of Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis Current Pharmaceutical Design. 2015 | Pubmed ID: 25777754 T Cell Mediated Autoimmune Glomerular Disease in Mice Current Protocols in Immunology. Nov, 2014 | Pubmed ID: 25367126 Glomerulonephritis Induced by Heterologous Anti-GBM Globulin As a Planted Foreign Antigen Current Protocols in Immunology. Aug, 2014 | Pubmed ID: 25081909 FcγRIIB Regulates T-cell Autoreactivity, ANCA Production, and Neutrophil Activation to Suppress Anti-myeloperoxidase Glomerulonephritis Kidney International. Dec, 2014 | Pubmed ID: 24869670 Endogenous Myeloperoxidase is a Mediator of Joint Inflammation and Damage in Experimental Arthritis Arthritis & Rheumatology (Hoboken, N.J.). Apr, 2014 | Pubmed ID: 24757143 Innate IL-17A-producing Leukocytes Promote Acute Kidney Injury Via Inflammasome and Toll-like Receptor Activation The American Journal of Pathology. May, 2014 | Pubmed ID: 24631024 Histopathologic and Clinical Predictors of Kidney Outcomes in ANCA-associated Vasculitis American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. Feb, 2014 | Pubmed ID: 24183110 MicroRNA-155 a New Therapeutic Target in Crescentic GN Journal of the American Society of Nephrology : JASN. Dec, 2013 | Pubmed ID: 24158984 Myeloperoxidase (MPO)-specific CD4+ T Cells Contribute to MPO-anti-neutrophil Cytoplasmic Antibody (ANCA) Associated Glomerulonephritis Cellular Immunology. Mar, 2013 | Pubmed ID: 23665205 Neutrophil Myeloperoxidase Regulates T-cell-driven Tissue Inflammation in Mice by Inhibiting Dendritic Cell Function Blood. May, 2013 | Pubmed ID: 23509155 Reply: To PMID 23142009 The Journal of Allergy and Clinical Immunology. Apr, 2013 | Pubmed ID: 23453686 The HLA-DRB1*15:01-restricted Goodpasture's T Cell Epitope Induces GN Journal of the American Society of Nephrology : JASN. Feb, 2013 | Pubmed ID: 23411782 Thymic Deletion and Regulatory T Cells Prevent Antimyeloperoxidase GN Journal of the American Society of Nephrology : JASN. Mar, 2013 | Pubmed ID: 23393320 Chest Pain and Exacerbations of Bronchiectasis International Journal of General Medicine. 2012 | Pubmed ID: 23271921 Lung T-cell Responses to Nontypeable Haemophilus Influenzae in Patients with Chronic Obstructive Pulmonary Disease The Journal of Allergy and Clinical Immunology. Nov, 2012 | Pubmed ID: 23142009 Mast Cells Contribute to Peripheral Tolerance and Attenuate Autoimmune Vasculitis Journal of the American Society of Nephrology : JASN. Dec, 2012 | Pubmed ID: 23138486 The Immunodominant Myeloperoxidase T-cell Epitope Induces Local Cell-mediated Injury in Antimyeloperoxidase Glomerulonephritis Proceedings of the National Academy of Sciences of the United States of America. Sep, 2012 | Pubmed ID: 22955884 Mast Cell Activation and Degranulation Promotes Renal Fibrosis in Experimental Unilateral Ureteric Obstruction Kidney International. Sep, 2012 | Pubmed ID: 22673890 Endogenous Tim-1 (Kim-1) Promotes T-cell Responses and Cell-mediated Injury in Experimental Crescentic Glomerulonephritis Kidney International. May, 2012 | Pubmed ID: 22205357 Renal Dendritic Cells Adopt a Pro-inflammatory Phenotype in Obstructive Uropathy to Activate T Cells but Do Not Directly Contribute to Fibrosis The American Journal of Pathology. Jan, 2012 | Pubmed ID: 22079432 Mast Cells Mediate Acute Kidney Injury Through the Production of TNF Journal of the American Society of Nephrology : JASN. Dec, 2011 | Pubmed ID: 22021718 Tim-1 Promotes Cisplatin Nephrotoxicity American Journal of Physiology. Renal Physiology. Nov, 2011 | Pubmed ID: 21835770 Interleukin-17A Promotes Early but Attenuates Established Disease in Crescentic Glomerulonephritis in Mice The American Journal of Pathology. Sep, 2011 | Pubmed ID: 21741931 The Emergence of TH17 Cells As Effectors of Renal Injury Journal of the American Society of Nephrology : JASN. Feb, 2011 | Pubmed ID: 21289213 The IL-27 Receptor Has Biphasic Effects in Crescentic Glomerulonephritis Mediated Through Th1 Responses The American Journal of Pathology. Feb, 2011 | Pubmed ID: 21281790 Endogenous Foxp3(+) T-regulatory Cells Suppress Anti-glomerular Basement Membrane Nephritis Kidney International. May, 2011 | Pubmed ID: 21248715 Toll-like Receptor 2 Induces Th17 Myeloperoxidase Autoimmunity While Toll-like Receptor 9 Drives Th1 Autoimmunity in Murine Vasculitis Arthritis and Rheumatism. Apr, 2011 | Pubmed ID: 21190299 The Th17-defining Transcription Factor RORγt Promotes Glomerulonephritis Journal of the American Society of Nephrology : JASN. Mar, 2011 | Pubmed ID: 21183590 Lung Diffusing Capacity in Adult Bronchiectasis: a Longitudinal Study Respiratory Care. Dec, 2010 | Pubmed ID: 21122177 Toll-like Receptor 9 Enhances Nephritogenic Immunity and Glomerular Leukocyte Recruitment, Exacerbating Experimental Crescentic Glomerulonephritis The American Journal of Pathology. Nov, 2010 | Pubmed ID: 20847283 Intrinsic Renal Cell and Leukocyte-derived TLR4 Aggravate Experimental Anti-MPO Glomerulonephritis Kidney International. Dec, 2010 | Pubmed ID: 20844472 Review: T Helper 17 Cells: Their Role in Glomerulonephritis Nephrology (Carlton, Vic.). Aug, 2010 | Pubmed ID: 20649870 Th17 Cells Promote Autoimmune Anti-myeloperoxidase Glomerulonephritis Journal of the American Society of Nephrology : JASN. Jun, 2010 | Pubmed ID: 20299361 Th1 and Th17 Cells Induce Proliferative Glomerulonephritis Journal of the American Society of Nephrology : JASN. Dec, 2009 | Pubmed ID: 19820122 Atorvastatin Enhances Humoral Immune Responses but Does Not Alter Renal Injury in Experimental Crescentic Glomerulonephritis Nephrology (Carlton, Vic.). Oct, 2009 | Pubmed ID: 19796023 Endogenous CD100 Promotes Glomerular Injury and Macrophage Recruitment in Experimental Crescentic Glomerulonephritis Immunology. Sep, 2009 | Pubmed ID: 19689741 IL-1RI Deficiency Ameliorates Early Experimental Renal Interstitial Fibrosis Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Oct, 2009 | Pubmed ID: 19465557 Phenotypes of Adult Bronchiectasis: Onset of Productive Cough in Childhood and Adulthood COPD. Apr, 2009 | Pubmed ID: 19378226 IL-23, Not IL-12, Directs Autoimmunity to the Goodpasture Antigen Journal of the American Society of Nephrology : JASN. May, 2009 | Pubmed ID: 19357249 Role of Mast Cells in Progressive Renal Diseases Journal of the American Society of Nephrology : JASN. Dec, 2008 | Pubmed ID: 18776124 Advances in the Pathogenesis of Goodpasture's Disease: from Epitopes to Autoantibodies to Effector T Cells Journal of Autoimmunity. Nov, 2008 | Pubmed ID: 18502098 T-bet Deficiency Attenuates Renal Injury in Experimental Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Mar, 2008 | Pubmed ID: 18235099 Distinct in Vivo Roles of CD80 and CD86 in the Effector T-cell Responses Inducing Antigen-induced Arthritis Immunology. Aug, 2008 | Pubmed ID: 18217945 Intrarenal Antigens Activate CD4+ Cells Via Co-stimulatory Signals from Dendritic Cells Journal of the American Society of Nephrology : JASN. Mar, 2008 | Pubmed ID: 18184859 Leukocytes in Glomerular Injury Seminars in Immunopathology. Nov, 2007 | Pubmed ID: 17938927 Cytokines in Glomerulonephritis Seminars in Nephrology. May, 2007 | Pubmed ID: 17533006 Microbiologic Follow-up Study in Adult Bronchiectasis Respiratory Medicine. Aug, 2007 | Pubmed ID: 17467966 Endogenous Myeloperoxidase Promotes Neutrophil-mediated Renal Injury, but Attenuates T Cell Immunity Inducing Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Mar, 2007 | Pubmed ID: 17267745 CD100 Enhances Dendritic Cell and CD4+ Cell Activation Leading to Pathogenetic Humoral Responses and Immune Complex Glomerulonephritis Journal of Immunology (Baltimore, Md. : 1950). Sep, 2006 | Pubmed ID: 16920982 Anti-neutrophil Cytoplasmic Antibodies and Effector CD4+ Cells Play Nonredundant Roles in Anti-myeloperoxidase Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Jul, 2006 | Pubmed ID: 16769746 Characterisation of the Onset and Presenting Clinical Features of Adult Bronchiectasis Respiratory Medicine. Dec, 2006 | Pubmed ID: 16650970 T Cells in Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. May, 2006 | Pubmed ID: 16624930 Inducible Co-stimulatory Molecule Ligand is Protective During the Induction and Effector Phases of Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Apr, 2006 | Pubmed ID: 16540559 The Isolation and Purification of Biologically Active Recombinant and Native Autoantigens for the Study of Autoimmune Disease Journal of Immunological Methods. Jan, 2006 | Pubmed ID: 16388818 A Pathogenetic Role for Mast Cells in Experimental Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Jan, 2006 | Pubmed ID: 16319187 Outcome in Adult Bronchiectasis COPD. Mar, 2005 | Pubmed ID: 17136958 Granulocyte Macrophage Colony-stimulating Factor Expression by Both Renal Parenchymal and Immune Cells Mediates Murine Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Sep, 2005 | Pubmed ID: 16033860 Leukocyte Phenotype and Function Predicts Infection Risk in Renal Transplant Recipients Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Oct, 2005 | Pubmed ID: 16030032 CD80 and CD86 Costimulatory Molecules Regulate Crescentic Glomerulonephritis by Different Mechanisms Kidney International. Aug, 2005 | Pubmed ID: 16014035 Glomerular Expression of CD80 and CD86 is Required for Leukocyte Accumulation and Injury in Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Jul, 2005 | Pubmed ID: 15944341 IL-12p40 and IL-18 in Crescentic Glomerulonephritis: IL-12p40 is the Key Th1-defining Cytokine Chain, Whereas IL-18 Promotes Local Inflammation and Leukocyte Recruitment Journal of the American Society of Nephrology : JASN. Jul, 2005 | Pubmed ID: 15888563 Experimental Autoimmune Goodpasture's Disease: a Pathogenetic Role for Both Effector Cells and Antibody in Injury Kidney International. Feb, 2005 | Pubmed ID: 15673304 Endogenous IL-13 Limits Humoral Responses and Injury in Experimental Glomerulonephritis but Does Not Regulate Th1 Cell-mediated Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Sep, 2004 | Pubmed ID: 15339986 Fibrin Independent Proinflammatory Effects of Tissue Factor in Experimental Crescentic Glomerulonephritis Kidney International. Aug, 2004 | Pubmed ID: 15253718 Experimental Autoimmune Anti-glomerular Basement Membrane Glomerulonephritis: a Protective Role for IFN-gamma Journal of the American Society of Nephrology : JASN. Jul, 2004 | Pubmed ID: 15213264 An IL-12-independent Role for CD40-CD154 in Mediating Effector Responses: Studies in Cell-mediated Glomerulonephritis and Dermal Delayed-type Hypersensitivity Journal of Immunology (Baltimore, Md. : 1950). Jul, 2004 | Pubmed ID: 15210767 Ex Vivo Lymphocyte Proliferative Function is Severely Inhibited in Renal Transplant Patients on Mycophenolate Mofetil Treatment Transplant Immunology. Jun-Jul, 2004 | Pubmed ID: 15203129 Leukocyte-derived Interleukin-1beta Interacts with Renal Interleukin-1 Receptor I to Promote Renal Tumor Necrosis Factor and Glomerular Injury in Murine Crescentic Glomerulonephritis The American Journal of Pathology. Jun, 2004 | Pubmed ID: 15161633 Contributions of IL-1beta and IL-1alpha to Crescentic Glomerulonephritis in Mice Journal of the American Society of Nephrology : JASN. Apr, 2004 | Pubmed ID: 15034093 The Role of Flow Cytometric ANCA Detection in Screening for Acute Pauci-immune Crescentic Glomerulonephritis Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Feb, 2004 | Pubmed ID: 14736960 Intrinsic Renal Cell Expression of CD40 Directs Th1 Effectors Inducing Experimental Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Nov, 2003 | Pubmed ID: 14569091 Intrinsic Renal Cells Are the Major Source of Tumor Necrosis Factor Contributing to Renal Injury in Murine Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Jul, 2003 | Pubmed ID: 12819238 T Cells in Glomerulonephritis Springer Seminars in Immunopathology. May, 2003 | Pubmed ID: 12778334 Plasminogen Activator Inhibitor-1 is a Significant Determinant of Renal Injury in Experimental Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Jun, 2003 | Pubmed ID: 12761249 Laboratory Assessment of Immune Function in Renal Transplant Patients Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. May, 2003 | Pubmed ID: 12686675 Adaptive Immunity to Nontypeable Haemophilus Influenzae American Journal of Respiratory and Critical Care Medicine. Feb, 2003 | Pubmed ID: 12433671 IFN-gamma Production by Intrinsic Renal Cells and Bone Marrow-derived Cells is Required for Full Expression of Crescentic Glomerulonephritis in Mice Journal of Immunology (Baltimore, Md. : 1950). Apr, 2002 | Pubmed ID: 11937574 The Requirement for Granulocyte-macrophage Colony-stimulating Factor and Granulocyte Colony-stimulating Factor in Leukocyte-mediated Immune Glomerular Injury Journal of the American Society of Nephrology : JASN. Feb, 2002 | Pubmed ID: 11805162 Visualisere makrofag ekstracellulære fælder ved hjælp af konfokalmikroskopi Roleen Sharma1,2, Kim M. O'Sullivan2, Stephen R. Holdsworth2, Philip G. Bardin1,2, Paul T. King1,2 1Monash Lung and Sleep, Monash Medical Centre, 2Monash University JoVE 56459 Immunology and Infection
Visualisere makrofag ekstracellulære fælder ved hjælp af konfokalmikroskopi Roleen Sharma1,2, Kim M. O'Sullivan2, Stephen R. Holdsworth2, Philip G. Bardin1,2, Paul T. King1,2 1Monash Lung and Sleep, Monash Medical Centre, 2Monash University JoVE 56459 Immunology and Infection