Stephen Kron Department of Molecular Genetics and Cell Biology University of Chicago Biography Publications Institution JoVE Articles Stephen Kron has not added a biography. If you are Stephen Kron and would like to personalize this page please email our Author Liaison for assistance. Publications Loss of MEN1 Function Impairs DNA Repair Capability of Pancreatic Neuroendocrine Tumors Endocrine-related Cancer. 03, 2022 | Pubmed ID: 35171113 TdT-dUTP DSB End Labeling (TUDEL), for Specific, Direct In Situ Labeling of DNA Double Strand Breaks Methods in Molecular Biology (Clifton, N.J.). 2022 | Pubmed ID: 35094335 Genomic Studies Controvert the Existence of the CUX1 P75 Isoform Scientific Reports. 01, 2022 | Pubmed ID: 34997000 Polyphosphate Degradation by Nudt3-Zn Mediates Oxidative Stress Response Cell Reports. 11, 2021 | Pubmed ID: 34788624 Pseudomonas Syringae Effector HopZ3 Suppresses the Bacterial AvrPto1-tomato PTO Immune Complex Via Acetylation PLoS Pathogens. 11, 2021 | Pubmed ID: 34724007 Loss of a 7q Gene, CUX1, Disrupts Epigenetically Driven DNA Repair and Drives Therapy-related Myeloid Neoplasms Blood. 09, 2021 | Pubmed ID: 34473231 UltraPlex Hapten-Based Multiplexed Fluorescent Immunohistochemistry Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 34331291 Multiplexed Tissue Tomography Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 34331280 Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells Cell Biochemistry and Biophysics. Sep, 2021 | Pubmed ID: 34085165 Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy Journal of the National Cancer Institute. 10, 2021 | Pubmed ID: 33792717 Lipid-derived Electrophiles Mediate the Effects of Chemotherapeutic Topoisomerase I Poisons Cell Chemical Biology. 06, 2021 | Pubmed ID: 33352117 Subcellular Localization of the J-protein Sis1 Regulates the Heat Shock Response The Journal of Cell Biology. 01, 2021 | Pubmed ID: 33326013 Small-molecule Drug Repurposing to Target DNA Damage Repair and Response Pathways Seminars in Cancer Biology. 01, 2021 | Pubmed ID: 32113999 Targeted Covalent Inhibition of Telomerase ACS Chemical Biology. 03, 2020 | Pubmed ID: 32017522 Genetic Analysis of Hsp70 Phosphorylation Sites Reveals a Role in Candida Albicans Cell and Colony Morphogenesis Biochimica Et Biophysica Acta. Proteins and Proteomics. 03, 2020 | Pubmed ID: 31964485 The Nuclear Structural Protein NuMA is a Negative Regulator of 53BP1 in DNA Double-strand Break Repair Nucleic Acids Research. 11, 2019 | Pubmed ID: 31511892 Immune Profiles in Primary Squamous Cell Carcinoma of the Head and Neck Oral Oncology. 09, 2019 | Pubmed ID: 31422218 Mevalonate Pathway Activity As a Determinant of Radiation Sensitivity in Head and Neck Cancer Molecular Oncology. 09, 2019 | Pubmed ID: 31225926 Repair-independent Functions of DNA-PKcs Protect Irradiated Cells from Mitotic Slippage and Accelerated Senescence Journal of Cell Science. 07, 2019 | Pubmed ID: 31189537 Phosphoregulation of the Oncogenic Protein Regulator of Cytokinesis 1 (PRC1) by the Atypical CDK16/CCNY Complex Experimental & Molecular Medicine. 04, 2019 | Pubmed ID: 30992425 A Cmap-enabled Gene Expression Signature-matching Approach Identifies Small-molecule Inducers of Accelerated Cell Senescence BMC Genomics. Apr, 2019 | Pubmed ID: 30987592 Targeted Antibody and Cytokine Cancer Immunotherapies Through Collagen Affinity Science Translational Medicine. 04, 2019 | Pubmed ID: 30971453 Repurposing Drugs for Cancer Radiotherapy: Early Successes and Emerging Opportunities Cancer Journal (Sudbury, Mass.). Mar/Apr, 2019 | Pubmed ID: 30896532 O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors Molecular Cancer Research : MCR. 06, 2019 | Pubmed ID: 30885991 The Nuclear Structural Protein NuMA is a Negative Regulator of 53BP1 in DNA Double-strand Break Repair Nucleic Acids Research. 04, 2019 | Pubmed ID: 30812030 STING Promotes Homeostasis Via Regulation of Cell Proliferation and Chromosomal Stability Cancer Research. 04, 2019 | Pubmed ID: 30482772 Nondestructive, Multiplex Three-dimensional Mapping of Immune Infiltrates in Core Needle Biopsy Laboratory Investigation; a Journal of Technical Methods and Pathology. 09, 2019 | Pubmed ID: 30401959 Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment Molecular Cancer Therapeutics. 01, 2019 | Pubmed ID: 30322947 Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors Via Interactions with Endothelial Selectins Small (Weinheim an Der Bergstrasse, Germany). 12, 2018 | Pubmed ID: 30411856 Phospho-dependent Recruitment of the Yeast NuA4 Acetyltransferase Complex by MRX at DNA Breaks Regulates RPA Dynamics During Resection Proceedings of the National Academy of Sciences of the United States of America. 10, 2018 | Pubmed ID: 30224481 The Atypical Cyclin CNTD2 Promotes Colon Cancer Cell Proliferation and Migration Scientific Reports. 08, 2018 | Pubmed ID: 30087414 Three-Dimensional Analysis of the Human Pancreas Endocrinology. 03, 2018 | Pubmed ID: 29390052 Radiation-enhanced Delivery of Plasmid DNA to Tumors Utilizing a Novel PEI Polyplex Cancer Gene Therapy. 08, 2018 | Pubmed ID: 29255216 Simple Strategies to Enhance Discovery of Acetylation Post-translational Modifications by Quadrupole-orbitrap LC-MS/MS Biochimica Et Biophysica Acta. Proteins and Proteomics. Feb, 2018 | Pubmed ID: 29050961 HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation Molecular Cancer Therapeutics. 02, 2018 | Pubmed ID: 29030460 Multiplex Three-dimensional Optical Mapping of Tumor Immune Microenvironment Scientific Reports. 12, 2017 | Pubmed ID: 29208908 A Signature of Enhanced Lipid Metabolism, Lipid Peroxidation and Aldehyde Stress in Therapy-induced Senescence Cell Death Discovery. 2017 | Pubmed ID: 29090099 Radiation-enhanced Delivery of Systemically Administered Amphiphilic-CpG Oligodeoxynucleotide Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2017 | Pubmed ID: 28987882 Chemical Inhibitors of Candida Albicans Hyphal Morphogenesis Target Endocytosis Scientific Reports. 07, 2017 | Pubmed ID: 28720834 Lipid-derived Reactive Aldehydes Link Oxidative Stress to Cell Senescence Cell Death & Disease. 09, 2016 | Pubmed ID: 27607581 Image-Guided Radiotherapy Targets Macromolecules Through Altering the Tumor Microenvironment Molecular Pharmaceutics. Oct, 2016 | Pubmed ID: 27560921 Repurposing Cephalosporin Antibiotics As Pro-senescent Radiosensitizers Oncotarget. Jun, 2016 | Pubmed ID: 27129153 Nanoparticle Formulations of Cisplatin for Cancer Therapy Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. 09, 2016 | Pubmed ID: 26848041 Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors Cell Reports. Feb, 2016 | Pubmed ID: 26804907 Linking Cancer Metabolism to DNA Repair and Accelerated Senescence Molecular Cancer Research : MCR. Feb, 2016 | Pubmed ID: 26538285 A Toolkit for Bioimaging Using Near-infrared AgInS/ZnS Quantum Dots Journal of Materials Chemistry. B. Nov, 2015 | Pubmed ID: 32262876 The Dynamic Interactome of Human Aha1 Upon Y223 Phosphorylation Data in Brief. Dec, 2015 | Pubmed ID: 26693507 Acetylation of an NB-LRR Plant Immune-Effector Complex Suppresses Immunity Cell Reports. Nov, 2015 | Pubmed ID: 26586425 C-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells Cell Reports. Aug, 2015 | Pubmed ID: 26235616 The Quantitative Changes in the Yeast Hsp70 and Hsp90 Interactomes Upon DNA Damage Data in Brief. Mar, 2015 | Pubmed ID: 26217697 Disruption of the Lamin A and Matrin-3 Interaction by Myopathic LMNA Mutations Human Molecular Genetics. Aug, 2015 | Pubmed ID: 25948554 Quantitative Proteomics of the Yeast Hsp70/Hsp90 Interactomes During DNA Damage Reveal Chaperone-dependent Regulation of Ribonucleotide Reductase Journal of Proteomics. Jan, 2015 | Pubmed ID: 25452130 DNA-directed Assembly of Antibody-fluorophore Conjugates for Quantitative Multiparametric Flow Cytometry Chembiochem : a European Journal of Chemical Biology. Jan, 2014 | Pubmed ID: 24375983 DNA Resection Proteins Sgs1 and Exo1 Are Required for G1 Checkpoint Activation in Budding Yeast DNA Repair. Sep, 2013 | Pubmed ID: 23835406 The Yin and Yang of Cyclin Control by Nutrients Cell Cycle (Georgetown, Tex.). Mar, 2013 | Pubmed ID: 23470456 Activity Assay of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Triple-negative Breast Cancer Cells Using Peptide-conjugated Magnetic Beads Assay and Drug Development Technologies. Feb, 2013 | Pubmed ID: 22994968 CDK-dependent Hsp70 Phosphorylation Controls G1 Cyclin Abundance and Cell-cycle Progression Cell. Dec, 2012 | Pubmed ID: 23217712 Photocleavable Peptide-oligonucleotide Conjugates for Protein Kinase Assays by MALDI-TOF MS Molecular BioSystems. Sep, 2012 | Pubmed ID: 22772337 Properties of Resistant Cells Generated from Lung Cancer Cell Lines Treated with EGFR Inhibitors BMC Cancer. Mar, 2012 | Pubmed ID: 22433462 Radiation-inducible Immunotherapy for Cancer: Senescent Tumor Cells As a Cancer Vaccine Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2012 | Pubmed ID: 22334019 Annotator: Postprocessing Software for Generating Function-based Signatures from Quantitative Mass Spectrometry Journal of Proteome Research. Mar, 2012 | Pubmed ID: 22224429 Ionizing Radiation-induced Foci Persistence Screen to Discover Enhancers of Accelerated Senescence International Journal of High Throughput Screening. Mar, 2011 | Pubmed ID: 26097382 Response of Human Prostate Cancer Cells and Tumors to Combining PARP Inhibition with Ionizing Radiation Molecular Cancer Therapeutics. Jul, 2011 | Pubmed ID: 21571912 A Pairwise Chemical Genetic Screen Identifies New Inhibitors of Glucose Transport Chemistry & Biology. Feb, 2011 | Pubmed ID: 21338919 A Magnetic Bead-based Protein Kinase Assay with Dual Detection Techniques Analytical Biochemistry. Jan, 2011 | Pubmed ID: 20807497 Photocleavable Peptide-conjugated Magnetic Beads for Protein Kinase Assays by MALDI-TOF MS Bioconjugate Chemistry. Oct, 2010 | Pubmed ID: 20860375 Epigenetic Modifications in Double-strand Break DNA Damage Signaling and Repair Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2010 | Pubmed ID: 20823147 Quantifying the Sensitivities of EGF Receptor (EGFR) Tyrosine Kinase Inhibitors in Drug Resistant Non-small Cell Lung Cancer (NSCLC) Cells Using Hydrogel-based Peptide Array Biosensors & Bioelectronics. Oct, 2010 | Pubmed ID: 20729058 Poly(ADP-ribose) Polymerase Inhibitor Induces Accelerated Senescence in Irradiated Breast Cancer Cells and Tumors Cancer Research. Aug, 2010 | Pubmed ID: 20610628 Peptide Reporters of Kinase Activity in Whole Cell Lysates Biopolymers. 2010 | Pubmed ID: 20593469 A Bead-based Activity Screen for Small-molecule Inhibitors of Signal Transduction in Chronic Myelogenous Leukemia Cells Molecular Cancer Therapeutics. May, 2010 | Pubmed ID: 20423990 Cell Treatment and Lysis in 96-well Filter-bottom Plates for Screening Bcr-Abl Activity and Inhibition in Whole-cell Extracts Journal of Biomolecular Screening. Apr, 2010 | Pubmed ID: 20237206 Dissection of Rad9 BRCT Domain Function in the Mitotic Checkpoint Response to Telomere Uncapping DNA Repair. Dec, 2009 | Pubmed ID: 19880356 A Phosphorylation-independent Role for the Yeast Cyclin-dependent Kinase Activating Kinase Cak1 Gene. Nov, 2009 | Pubmed ID: 19647054 Morphogenesis Signaling Components Influence Cell Cycle Regulation by Cyclin Dependent Kinase Cell Division. Jul, 2009 | Pubmed ID: 19566963 Rapid Validation of Mascot Search Results Via Stable Isotope Labeling, Pair Picking, and Deconvolution of Fragmentation Patterns Molecular & Cellular Proteomics : MCP. Aug, 2009 | Pubmed ID: 19435713 Kinase Activation in Circulating Cells: Opportunities for Biomarkers for Diagnosis and Therapeutic Monitoring Expert Opinion on Medical Diagnostics. Jan, 2008 | Pubmed ID: 23485115 Synthesis Enables Identification of the Cellular Target of Leucascandrolide A and Neopeltolide Nature Chemical Biology. Jul, 2008 | Pubmed ID: 18516048 Phosphoprotein Profiling by PA-GeLC-MS/MS Journal of Proteome Research. Jul, 2008 | Pubmed ID: 18510356 A Solid-phase Bcr-Abl Kinase Assay in 96-well Hydrogel Plates Analytical Biochemistry. Apr, 2008 | Pubmed ID: 18194660 Investigating Quantitation of Phosphorylation Using MALDI-TOF Mass Spectrometry Journal of Mass Spectrometry : JMS. Apr, 2008 | Pubmed ID: 18064576 Non-catalytic Function for ATR in the Checkpoint Response Cell Cycle (Georgetown, Tex.). Aug, 2007 | Pubmed ID: 17721080 Photocleavable Peptide Hydrogel Arrays for MALDI-TOF Analysis of Kinase Activity The Analyst. Oct, 2006 | Pubmed ID: 17003856 Yeast G1 DNA Damage Checkpoint Regulation by H2A Phosphorylation is Independent of Chromatin Remodeling Proceedings of the National Academy of Sciences of the United States of America. Sep, 2006 | Pubmed ID: 16940359 Control of the Yeast Cell Cycle with a Photocleavable Alpha-factor Analogue Angewandte Chemie (International Ed. in English). Sep, 2006 | Pubmed ID: 16937420 Assaying Bcr-Abl Kinase Activity and Inhibition in Whole Cell Extracts by Phosphorylation of Substrates Immobilized on Agarose Beads Analytical Biochemistry. Dec, 2005 | Pubmed ID: 16236241 Optimizing Thiophosphorylation in the Presence of Competing Phosphorylation with MALDI-TOF-MS Detection Journal of Proteome Research. Sep-Oct, 2005 | Pubmed ID: 16212443 Role of Dot1-dependent Histone H3 Methylation in G1 and S Phase DNA Damage Checkpoint Functions of Rad9 Molecular and Cellular Biology. Oct, 2005 | Pubmed ID: 16166626 Yeast Cell Death During DNA Damage Arrest is Independent of Caspase or Reactive Oxygen Species The Journal of Cell Biology. Aug, 2004 | Pubmed ID: 15289493 Relevance and Irrelevance of DNA Damage Response to Radiotherapy DNA Repair. Aug-Sep, 2004 | Pubmed ID: 15279813 Monitoring Changes in the Subcellular Location of Proteins in S. Cerevisiae Methods in Molecular Biology (Clifton, N.J.). 2004 | Pubmed ID: 14970663 Histone H2AX Phosphorylation As a Predictor of Radiosensitivity and Target for Radiotherapy The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14561744 Asynchronous Cell Cycle and Asymmetric Vacuolar Inheritance in True Hyphae of Candida Albicans Eukaryotic Cell. Jun, 2003 | Pubmed ID: 12796285 Design and Implementation of Algorithms for Focus Automation in Digital Imaging Time-lapse Microscopy Cytometry. Dec, 2002 | Pubmed ID: 12454979 NuA4 Subunit Yng2 Function in Intra-S-phase DNA Damage Response Molecular and Cellular Biology. Dec, 2002 | Pubmed ID: 12417725 An Essential Function of Yeast Cyclin-dependent Kinase Cdc28 Maintains Chromosome Stability The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12359726 Bcl-x(L) Complements Saccharomyces Cerevisiae Genes That Facilitate the Switch from Glycolytic to Oxidative Metabolism The Journal of Biological Chemistry. Nov, 2002 | Pubmed ID: 12244097 Digital Time-lapse Microscopy of Yeast Cell Growth Methods in Enzymology. 2002 | Pubmed ID: 12073352 Robust G1 Checkpoint Arrest in Budding Yeast: Dependence on DNA Damage Signaling and Repair Journal of Cell Science. Apr, 2002 | Pubmed ID: 11950891 Sensing, Signalling and Integrating Physical Processes During Saccharomyces Cerevisiae Invasive and Filamentous Growth Microbiology (Reading, England). Apr, 2002 | Pubmed ID: 11932437 Peptide Chips for the Quantitative Evaluation of Protein Kinase Activity Nature Biotechnology. Mar, 2002 | Pubmed ID: 11875428 Marker-fusion PCR for One-step Mutagenesis of Essential Genes in Yeast Yeast (Chichester, England). Jan, 2002 | Pubmed ID: 11788969 Enhanced Cell Polarity in Mutants of the Budding Yeast Cyclin-dependent Kinase Cdc28p Molecular Biology of the Cell. Nov, 2001 | Pubmed ID: 11694591 Role of Oxidative Phosphorylation in Bax Toxicity Molecular and Cellular Biology. May, 2000 | Pubmed ID: 10779348 Regulation of G2/M Progression by the STE Mitogen-activated Protein Kinase Pathway in Budding Yeast Filamentous Growth Molecular Biology of the Cell. Oct, 1999 | Pubmed ID: 10512868 Akış Sitometrisi ile Yaşlanan Tümör Hücrelerinin Tanımlanması ve Zenginleştirilmesi için Uzak Kırmızı Floresan Yaşlanma İlişkili β-Galaktosidaz Probu Amy Flor1, Joanna Pagacz1, DeShawn Thompson1, Stephen Kron1 1Department of Molecular Genetics and Cell Biology, University of Chicago JoVE 64176 Cancer Research
Akış Sitometrisi ile Yaşlanan Tümör Hücrelerinin Tanımlanması ve Zenginleştirilmesi için Uzak Kırmızı Floresan Yaşlanma İlişkili β-Galaktosidaz Probu Amy Flor1, Joanna Pagacz1, DeShawn Thompson1, Stephen Kron1 1Department of Molecular Genetics and Cell Biology, University of Chicago JoVE 64176 Cancer Research