Steven Van Cruchten Comparative Perinatal Development University of Antwerp Biography Publications Institution JoVE Articles Steven Van Cruchten has not added a biography. If you are Steven Van Cruchten and would like to personalize this page please email our Author Liaison for assistance. Publications Species Selection for Nonclinical Safety Assessment of Drug Candidates: Examples of Current Industry Practice Regulatory Toxicology and Pharmacology : RTP. Aug, 2021 | Pubmed ID: 34455009 Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling Frontiers in Pharmacology. 2021 | Pubmed ID: 33935788 Low Birth Weight Female Piglets Show Altered Intestinal Development, Gene Expression, and Epigenetic Changes at Key Developmental Loci FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 04, 2021 | Pubmed ID: 33734504 The Neonatal and Juvenile Pig in Pediatric Drug Discovery and Development Pharmaceutics. Dec, 2020 | Pubmed ID: 33396805 Refinement of the Zebrafish Embryo Developmental Toxicity Assay MethodsX. 2020 | Pubmed ID: 33134094 A Medium-Throughput System for In Vitro Oxidative Stress Assessment in IPEC-J2 Cells International Journal of Molecular Sciences. Oct, 2020 | Pubmed ID: 33019601 Short-chain Fructo-oligosaccharides Supplementation to Suckling Piglets: Assessment of Pre- and Post-weaning Performance and Gut Health PloS One. 2020 | Pubmed ID: 32502215 A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates Frontiers in Pharmacology. 2020 | Pubmed ID: 32477113 Birthweight Determines Intestinal Microvasculature Development and Alters Endothelial Nitric Oxide Synthase Density in Young Piglets Anatomia, Histologia, Embryologia. Sep, 2020 | Pubmed ID: 31995241 Use of Zebrafish in Drug Discovery Toxicology Chemical Research in Toxicology. 01, 2020 | Pubmed ID: 31625720 Glucose and Glycogen Levels in Piglets That Differ in Birth Weight and Vitality Heliyon. Sep, 2019 | Pubmed ID: 31687599 Does Intrauterine Crowding Affect the Force Generating Capacity and Muscle Composition of the Piglet Front Limb? PloS One. 2019 | Pubmed ID: 31600318 On the Characterisation of the Porcine Gland-specific Salivary Proteome Journal of Proteomics. 03, 2019 | Pubmed ID: 30707949 Advancing the Zebrafish Embryo Test for Endocrine Disruptor Screening Using Micro-injection: Ethinyl Estradiol As a Case Study Environmental Toxicology and Chemistry. 03, 2019 | Pubmed ID: 30569562 How Does Intrauterine Crowding Affect Locomotor Performance in Newborn Pigs? A Study of Force Generating Capacity and Muscle Composition of the Hind Limb PloS One. 2018 | Pubmed ID: 30550550 From MRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation During Zebrafish Embryonic and Larval Development International Journal of Molecular Sciences. Dec, 2018 | Pubmed ID: 30544719 The Porcine Tonsils and Peyer's Patches: A Stereological Morphometric Analysis in Conventionally and Artificially Reared Piglets Veterinary Immunology and Immunopathology. Dec, 2018 | Pubmed ID: 30502915 Editorial ETS 2018 Reproductive Toxicology (Elmsford, N.Y.). 09, 2018 | Pubmed ID: 30193665 Gene Transcription Ontogeny of Hypothalamic-pituitary-thyroid Axis Development in Early-life Stage Fathead Minnow and Zebrafish General and Comparative Endocrinology. 09, 2018 | Pubmed ID: 29733815 Does Intrauterine Crowding Affect Locomotor Development? A Comparative Study of Motor Performance, Neuromotor Maturation and Gait Variability Among Piglets That Differ in Birth Weight and Vitality PloS One. 2018 | Pubmed ID: 29689084 UPLC/MS MS Data of Testosterone Metabolites in Human and Zebrafish Liver Microsomes and Whole Zebrafish Larval Microsomes Data in Brief. Feb, 2018 | Pubmed ID: 29541660 Pre- and Postnatal Development of the Eye: A Species Comparison Birth Defects Research. Nov, 2017 | Pubmed ID: 28941218 How Innate is Locomotion in Precocial Animals? A Study on the Early Development of Spatio-temporal Gait Variables and Gait Symmetry in Piglets The Journal of Experimental Biology. 08, 2017 | Pubmed ID: 28768747 Antioxidants Reduce Reactive Oxygen Species but Not Embryotoxicity in the Metabolic Danio Rerio Test (mDarT) Reproductive Toxicology (Elmsford, N.Y.). 09, 2017 | Pubmed ID: 28663077 In Vitro CYP-mediated Drug Metabolism in the Zebrafish (embryo) Using Human Reference Compounds Toxicology in Vitro : an International Journal Published in Association with BIBRA. Aug, 2017 | Pubmed ID: 28506817 Artificial Rearing Influences the Morphology, Permeability and Redox State of the Gastrointestinal Tract of Low and Normal Birth Weight Piglets Journal of Animal Science and Biotechnology. 2017 | Pubmed ID: 28405313 Evaluating Complex Mixtures in the Zebrafish Embryo by Reconstituting Field Water Samples: A Metal Pollution Case Study International Journal of Molecular Sciences. Mar, 2017 | Pubmed ID: 28257097 Effect of Artificial Rearing of Piglets on the Volume Densities of M Cells in the Tonsils of the Soft Palate and Ileal Peyer's Patches Veterinary Immunology and Immunopathology. Feb, 2017 | Pubmed ID: 28166927 In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition During Early Zebrafish Development International Journal of Molecular Sciences. Jan, 2017 | Pubmed ID: 28117738 In Vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Göttingen Minipigs Pharmaceutical Research. 04, 2017 | Pubmed ID: 28097507 In Vitro Investigation of Six Antioxidants for Pig Diets Antioxidants (Basel, Switzerland). Nov, 2016 | Pubmed ID: 27845706 In Vitro CYP1A Activity in the Zebrafish: Temporal but Low Metabolite Levels During Organogenesis and Lack of Gender Differences in the Adult Stage Reproductive Toxicology (Elmsford, N.Y.). 09, 2016 | Pubmed ID: 27046732 Xenobiotic Metabolism in the Zebrafish: a Review of the Spatiotemporal Distribution, Modulation and Activity of Cytochrome P450 Families 1 to 3 The Journal of Toxicological Sciences. Feb, 2016 | Pubmed ID: 26763387 Organ Data from the Developing Göttingen Minipig: First Steps Towards a Juvenile PBPK Model Journal of Pharmacokinetics and Pharmacodynamics. Apr, 2016 | Pubmed ID: 26687458 Incubation at 32.5°C and Above Causes Malformations in the Zebrafish Embryo Reproductive Toxicology (Elmsford, N.Y.). Aug, 2015 | Pubmed ID: 26005098 Age-related Differences in CYP3A Abundance and Activity in the Liver of the Göttingen Minipig Basic & Clinical Pharmacology & Toxicology. Nov, 2015 | Pubmed ID: 25892190 Ontogeny of CYP3A and P-glycoprotein in the Liver and the Small Intestine of the Göttingen Minipig: an Immunohistochemical Evaluation Basic & Clinical Pharmacology & Toxicology. May, 2014 | Pubmed ID: 24224644 M Cell Specific Markers in Man and Domestic Animals: Valuable Tools in Vaccine Development Comparative Immunology, Microbiology and Infectious Diseases. Jul, 2013 | Pubmed ID: 23618793 Alternative Models to Study the Intestinal Barrier Function of Piglets Alternatives to Laboratory Animals : ATLA. Dec, 2012 | Pubmed ID: 23398344 Osteopontin Alters the Functional Profile of Porcine Microglia in Vitro Cell Biology International. 2012 | Pubmed ID: 22974008 Interferon-γ Modulates the Functional Profile of In-vitro-cultured Porcine Microglia Neuroreport. Jun, 2012 | Pubmed ID: 22581042 Aachener Minipigs의 멸균 심낭염 심방 근 병증 및 심방 세동을위한 모델로서 Michiel R. L. Tubeeckx1, Steven Laga2, Christel Jacobs3, Marina Stroe4, Steven Van Cruchten4, Bo Goovaerts1, Jens Van fraeyenhove1, Hielko Miljoen5, Guido R. Y. De Meyer1, Gilles W. De Keulenaer1,6, Hein Heidbuchel5,7, Vincent F. M. Segers1,5 1Laboratory of Physiopharmacology, University of Antwerp, 2Department of Cardiac Surgery, University Hospital Antwerp, 3Department of Animal Welfare, University of Antwerp, 4Comparative Perinatal Development, University of Antwerp, 5Department of Cardiology, University Hospital Antwerp, 6Department of Cardiology, ZNA Middelheim Hospital, 7Research Group Cardiovascular Diseases, GENCOR, University of Antwerp JoVE 63094 Medicine
Aachener Minipigs의 멸균 심낭염 심방 근 병증 및 심방 세동을위한 모델로서 Michiel R. L. Tubeeckx1, Steven Laga2, Christel Jacobs3, Marina Stroe4, Steven Van Cruchten4, Bo Goovaerts1, Jens Van fraeyenhove1, Hielko Miljoen5, Guido R. Y. De Meyer1, Gilles W. De Keulenaer1,6, Hein Heidbuchel5,7, Vincent F. M. Segers1,5 1Laboratory of Physiopharmacology, University of Antwerp, 2Department of Cardiac Surgery, University Hospital Antwerp, 3Department of Animal Welfare, University of Antwerp, 4Comparative Perinatal Development, University of Antwerp, 5Department of Cardiology, University Hospital Antwerp, 6Department of Cardiology, ZNA Middelheim Hospital, 7Research Group Cardiovascular Diseases, GENCOR, University of Antwerp JoVE 63094 Medicine