Stuart H. Orkin Harvard Medical School Biography Publications Institution JoVE Articles Stuart H. Orkin has not added a biography. If you are Stuart H. Orkin and would like to personalize this page please email our Author Liaison for assistance. Publications Characterizing Heterogeneity in Leukemic Cells Using Single-cell Gene Expression Analysis Genome Biology. 2014 | Pubmed ID: 25517911 Complementary Genomic Approaches Highlight the PI3K/mTOR Pathway As a Common Vulnerability in Osteosarcoma Proceedings of the National Academy of Sciences of the United States of America. Dec, 2014 | Pubmed ID: 25512523 Mouse Regulatory DNA Landscapes Reveal Global Principles of Cis-regulatory Evolution Science (New York, N.Y.). Nov, 2014 | Pubmed ID: 25411453 A Comparative Encyclopedia of DNA Elements in the Mouse Genome Nature. Nov, 2014 | Pubmed ID: 25409824 Inflammatory Signaling Regulates Embryonic Hematopoietic Stem and Progenitor Cell Production Genes & Development. Dec, 2014 | Pubmed ID: 25395663 Myeloproliferative Neoplasms Can Be Initiated from a Single Hematopoietic Stem Cell Expressing JAK2-V617F The Journal of Experimental Medicine. Oct, 2014 | Pubmed ID: 25288396 TMEM14C is Required for Erythroid Mitochondrial Heme Metabolism The Journal of Clinical Investigation. Oct, 2014 | Pubmed ID: 25157825 Characterization of Genomic Deletion Efficiency Mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 Nuclease System in Mammalian Cells The Journal of Biological Chemistry. Aug, 2014 | Pubmed ID: 24907273 Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors Cell. Apr, 2014 | Pubmed ID: 24766805 Distinct, Strict Requirements for Gfi-1b in Adult Bone Marrow Red Cell and Platelet Generation The Journal of Experimental Medicine. May, 2014 | Pubmed ID: 24711581 Corepressor Rcor1 is Essential for Murine Erythropoiesis Blood. May, 2014 | Pubmed ID: 24652990 Analysis of Chromatin-state Plasticity Identifies Cell-type-specific Regulators of H3K27me3 Patterns Proceedings of the National Academy of Sciences of the United States of America. Jan, 2014 | Pubmed ID: 24395799 Distinct and Combinatorial Functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in Mouse Embryonic Stem Cell Identity Molecular Cell. Jan, 2014 | Pubmed ID: 24361252 Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-stage-specific Manner Cell Stem Cell. Jan, 2014 | Pubmed ID: 24239285 Calpain 2 Activation of P-TEFb Drives Megakaryocyte Morphogenesis and is Disrupted by Leukemogenic GATA1 Mutation Developmental Cell. Dec, 2013 | Pubmed ID: 24369834 An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level Science (New York, N.Y.). Oct, 2013 | Pubmed ID: 24115442 Mapping Cellular Hierarchy by Single-cell Analysis of the Cell Surface Repertoire Cell Stem Cell. Oct, 2013 | Pubmed ID: 24035353 Targeted Disruption of the EZH2-EED Complex Inhibits EZH2-dependent Cancer Nature Chemical Biology. Oct, 2013 | Pubmed ID: 23974116 Delineating the Mixed Lineage Leukemia Gene Expression Network in Hematopoietic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23824294 Histone Demethylase Lsd1 Represses Hematopoietic Stem and Progenitor Cell Signatures During Blood Cell Maturation ELife. 2013 | Pubmed ID: 23795291 Corepressor-dependent Silencing of Fetal Hemoglobin Expression by BCL11A Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23576758 ETV1 Directs Androgen Metabolism and Confers Aggressive Prostate Cancer in Targeted Mice and Patients Genes & Development. Mar, 2013 | Pubmed ID: 23512661 Genome-wide Association Studies of Hematologic Phenotypes: a Window into Human Hematopoiesis Current Opinion in Genetics & Development. Jun, 2013 | Pubmed ID: 23477921 Sustained PU.1 Levels Balance Cell-cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells Molecular Cell. Mar, 2013 | Pubmed ID: 23395001 The Switch from Fetal to Adult Hemoglobin Cold Spring Harbor Perspectives in Medicine. Jan, 2013 | Pubmed ID: 23209159 TiF1-gamma Plays an Essential Role in Murine Hematopoiesis and Regulates Transcriptional Elongation of Erythroid Genes Developmental Biology. Jan, 2013 | Pubmed ID: 23159334 Altered Hematopoiesis in Trisomy 21 As Revealed Through in Vitro Differentiation of Isogenic Human Pluripotent Cells Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23045682 Combinatorial Assembly of Developmental Stage-specific Enhancers Controls Gene Expression Programs During Human Erythropoiesis Developmental Cell. Oct, 2012 | Pubmed ID: 23041383 Cyclin D3 Coordinates the Cell Cycle During Differentiation to Regulate Erythrocyte Size and Number Genes & Development. Sep, 2012 | Pubmed ID: 22929040 Reawakening Fetal Hemoglobin: Prospects for New Therapies for the β-globin Disorders Blood. Oct, 2012 | Pubmed ID: 22904296 Scl Represses Cardiomyogenesis in Prospective Hemogenic Endothelium and Endocardium Cell. Aug, 2012 | Pubmed ID: 22863011 The CACCC-binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and is Required for Proper Erythroid Maturation in Vivo Molecular and Cellular Biology. Aug, 2012 | Pubmed ID: 22711990 Exome Sequencing Identifies GATA1 Mutations Resulting in Diamond-Blackfan Anemia The Journal of Clinical Investigation. Jul, 2012 | Pubmed ID: 22706301 MAnorm: a Robust Model for Quantitative Comparison of ChIP-Seq Data Sets Genome Biology. 2012 | Pubmed ID: 22424423 Polycomb Repressive Complex 2 is Required for MLL-AF9 Leukemia Proceedings of the National Academy of Sciences of the United States of America. Mar, 2012 | Pubmed ID: 22396593 MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension: Results of a Network Bioinformatics Approach Circulation. Mar, 2012 | Pubmed ID: 22371328 Haploinsufficiency of Dnmt1 Impairs Leukemia Stem Cell Function Through Derepression of Bivalent Chromatin Domains Genes & Development. Feb, 2012 | Pubmed ID: 22345515 MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways Science Translational Medicine. Feb, 2012 | Pubmed ID: 22344686 A Human Stem Cell Model of Early Alzheimer's Disease Pathology in Down Syndrome Science Translational Medicine. Mar, 2012 | Pubmed ID: 22344463 PRC2 Directly Methylates GATA4 and Represses Its Transcriptional Activity Genes & Development. Jan, 2012 | Pubmed ID: 22215809 Dnmt3a Silences Hematopoietic Stem Cell Self-renewal Nature Genetics. Jan, 2012 | Pubmed ID: 22200773 2 Polycomb Complejo Represivo Regula El Desarrollo Normal Del Corazón Del Ratón Circulation Research. Feb, 2012 | Pubmed ID: 22158708 Embryonic Stem Cell-specific Signatures in Cancer: Insights into Genomic Regulatory Networks and Implications for Medicine Genome Medicine. 2011 | Pubmed ID: 22126538 Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing Science (New York, N.Y.). Nov, 2011 | Pubmed ID: 21998251 Zfp281 Functions As a Transcriptional Repressor for Pluripotency of Mouse Embryonic Stem Cells Stem Cells (Dayton, Ohio). Nov, 2011 | Pubmed ID: 21915945 A Functional Element Necessary for Fetal Hemoglobin Silencing The New England Journal of Medicine. Sep, 2011 | Pubmed ID: 21879898 MicroRNA-21 Limits in Vivo Immune Response-mediated Activation of the IL-12/IFN-gamma Pathway, Th1 Polarization, and the Severity of Delayed-type Hypersensitivity Journal of Immunology (Baltimore, Md. : 1950). Sep, 2011 | Pubmed ID: 21849676 La Pérdida De La Desmetilasa Retinoblastoma Proteína De Unión 2 (RBP2) Histona Suprime La Tumorigénesis En Ratones Que Carecen Rb1 O Hombres1 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011 | Pubmed ID: 21788502 Chromatin Connections to Pluripotency and Cellular Reprogramming Cell. Jun, 2011 | Pubmed ID: 21663790 Genome Medicine: Stem Cells, Genomics and Translational Research Genome Medicine. 2011 | Pubmed ID: 21658298 The Erythroid/myeloid Lineage Fate Paradigm Takes a New Player The EMBO Journal. Mar, 2011 | Pubmed ID: 21407249 Context-dependent Function of "GATA Switch" Sites in Vivo Blood. May, 2011 | Pubmed ID: 21398579 Tet1 Y TET2 Regular 5-hidroximetilcitosina La Producción Y La Especificación De Linaje Celular En Las Células Madre Embrionarias De Ratón Cell Stem Cell. Feb, 2011 | Pubmed ID: 21295276 MicroARN-15a Y De La Ley -16-1 Via MYB Para Elevar La Expresión De Hemoglobina Fetal En Humanos Trisomía 13 Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21205891 Update on Fetal Hemoglobin Gene Regulation in Hemoglobinopathies Current Opinion in Pediatrics. Feb, 2011 | Pubmed ID: 21157349 Therapeutic Levels of Fetal Hemoglobin in Erythroid Progeny of β-thalassemic CD34+ Cells After Lentiviral Vector-mediated Gene Transfer Blood. Mar, 2011 | Pubmed ID: 21156846 Networking Erythropoiesis The Journal of Experimental Medicine. Nov, 2010 | Pubmed ID: 21098097 Fine-mapping at Three Loci Known to Affect Fetal Hemoglobin Levels Explains Additional Genetic Variation Nature Genetics. Dec, 2010 | Pubmed ID: 21057501 Modifier Genes in Mendelian Disorders: the Example of Hemoglobin Disorders Annals of the New York Academy of Sciences. Dec, 2010 | Pubmed ID: 21039591 Epigenetic Antagonism Between Polycomb and SWI/SNF Complexes During Oncogenic Transformation Cancer Cell. Oct, 2010 | Pubmed ID: 20951942 A Myc Network Accounts for Similarities Between Embryonic Stem and Cancer Cell Transcription Programs Cell. Oct, 2010 | Pubmed ID: 20946988 A Single Cis Element Maintains Repression of the Key Developmental Regulator Gata2 PLoS Genetics. Sep, 2010 | Pubmed ID: 20838598 Differential Roles of Sall4 Isoforms in Embryonic Stem Cell Pluripotency Molecular and Cellular Biology. Nov, 2010 | Pubmed ID: 20837710 Training Program in Cancer and Blood Diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute American Journal of Hematology. Oct, 2010 | Pubmed ID: 20730793 Transcriptional Silencing of Fetal Hemoglobin by BCL11A Annals of the New York Academy of Sciences. Aug, 2010 | Pubmed ID: 20712774 Developmental Stage-specific Interplay of GATA1 and IGF Signaling in Fetal Megakaryopoiesis and Leukemogenesis Genes & Development. Aug, 2010 | Pubmed ID: 20679399 Medicine. Sickle Cell Disease at 100 Years Science (New York, N.Y.). Jul, 2010 | Pubmed ID: 20647458 Controla El Destino TIF1gamma Eritroide Celular, Regulando La Transcripción De Elongación Cell. Jul, 2010 | Pubmed ID: 20603019 Sumoylation Regulates Interaction of FOG1 with C-terminal-binding Protein (CTBP) The Journal of Biological Chemistry. Sep, 2010 | Pubmed ID: 20587419 Transcriptional Silencing of {gamma}-globin by BCL11A Involves Long-range Interactions and Cooperation with SOX6 Genes & Development. Apr, 2010 | Pubmed ID: 20395365 DNA Methylation in Adult Stem Cells: New Insights into Self-renewal Epigenetics : Official Journal of the DNA Methylation Society. Apr, 2010 | Pubmed ID: 20364115 Advances in the Understanding of Haemoglobin Switching British Journal of Haematology. Apr, 2010 | Pubmed ID: 20201948 MiR-125b-2 is a Potential OncomiR on Human Chromosome 21 in Megakaryoblastic Leukemia Genes & Development. Mar, 2010 | Pubmed ID: 20194440 Musings on Genome Medicine: Hepatitis C Genome Medicine. 2010 | Pubmed ID: 20193049 Perturbed Hematopoiesis in the Tc1 Mouse Model of Down Syndrome Blood. Apr, 2010 | Pubmed ID: 20154221 Systematic Tracking of Cell Fate Changes Nature Biotechnology. Feb, 2010 | Pubmed ID: 20139953 Jumonji Modulates Polycomb Activity and Self-renewal Versus Differentiation of Stem Cells Cell. Dec, 2009 | Pubmed ID: 20064376 Musings on Genome Medicine: Enzyme-replacement Therapy of the Lysosomal Storage Diseases Genome Medicine. 2009 | Pubmed ID: 20017892 Insights into GATA-1-mediated Gene Activation Versus Repression Via Genome-wide Chromatin Occupancy Analysis Molecular Cell. Nov, 2009 | Pubmed ID: 19941827 Musings on Genome Medicine: Crohn's Disease Genome Medicine. 2009 | Pubmed ID: 19891793 Musings on Genome Medicine: the Slow but Inexorable Process of Medical Care Reform in the United States Genome Medicine. 2009 | Pubmed ID: 19822025 DNA Methyltransferase 1 is Essential for and Uniquely Regulates Hematopoietic Stem and Progenitor Cells Cell Stem Cell. Oct, 2009 | Pubmed ID: 19796624 Musings on Genome Medicine: the Obama Effect Redux Genome Medicine. 2009 | Pubmed ID: 19769781 Developmental and Species-divergent Globin Switching Are Driven by BCL11A Nature. Aug, 2009 | Pubmed ID: 19657335 Translational Isoforms of FOG1 Regulate GATA1-interacting Complexes The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19654328 GATA-2 Reinforces Megakaryocyte Development in the Absence of GATA-1 Molecular and Cellular Biology. Sep, 2009 | Pubmed ID: 19620289 TEL-AML1 Corrupts Hematopoietic Stem Cells to Persist in the Bone Marrow and Initiate Leukemia Cell Stem Cell. Jul, 2009 | Pubmed ID: 19570513 Musings on Genome Medicine: Cholesterol and Coronary Artery Disease Genome Medicine. 2009 | Pubmed ID: 19519958 Musings on Genome Medicine: Cancer Genetics and the Promise of Effective Treatment Genome Medicine. 2009 | Pubmed ID: 19439059 Musings on Genome Medicine: Gene Therapy Genome Medicine. 2009 | Pubmed ID: 19435468 Musings on Genome Medicine: Genome Wide Association Studies Genome Medicine. 2009 | Pubmed ID: 19348690 Musings on Genome Medicine: the Obama Effect Genome Medicine. 2009 | Pubmed ID: 19341501 Musings on Genome Medicine: Abuse of Genetic Tests Genome Medicine. 2009 | Pubmed ID: 19341489 A Genome-wide RNAi Screen Identifies a New Transcriptional Module Required for Self-renewal Genes & Development. Apr, 2009 | Pubmed ID: 19339689 Use of in Vivo Biotinylation to Study Protein-protein and Protein-DNA Interactions in Mouse Embryonic Stem Cells Nature Protocols. 2009 | Pubmed ID: 19325547 Tandem Affinity Purification of Protein Complexes in Mouse Embryonic Stem Cells Using in Vivo Biotinylation Current Protocols in Stem Cell Biology. Mar, 2009 | Pubmed ID: 19306258 MEF2C Es Un Objetivo Linaje Restringido De Scl/Tal1 Y Regula Megacariopoyesis Y La Homeostasis De Células B Blood. Apr, 2009 | Pubmed ID: 19211936 Glimpses of the Epigenetic Landscape Cell Stem Cell. Jan, 2009 | Pubmed ID: 19128786 ADAR1 is Essential for the Maintenance of Hematopoiesis and Suppression of Interferon Signaling Nature Immunology. Jan, 2009 | Pubmed ID: 19060901 Expresión Humana Hemoglobina Fetal Está Regulado Por El Desarrollo BCL11A Etapa Específica De Represor Science (New York, N.Y.). Dec, 2008 | Pubmed ID: 19056937 EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency Molecular Cell. Nov, 2008 | Pubmed ID: 19026780 Polycomb Group Proteins Ezh2 and Rnf2 Direct Genomic Contraction and Imprinted Repression in Early Mouse Embryos Developmental Cell. Nov, 2008 | Pubmed ID: 18848501 Rb and Hematopoiesis: Stem Cells to Anemia Cell Division. 2008 | Pubmed ID: 18775080 GATA4 Mediates Gene Repression in the Mature Mouse Small Intestine Through Interactions with Friend of GATA (FOG) Cofactors Developmental Biology. Oct, 2008 | Pubmed ID: 18692040 DNA Polymorphisms at the BCL11A, HBS1L-MYB, and Beta-globin Loci Associate with Fetal Hemoglobin Levels and Pain Crises in Sickle Cell Disease Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008 | Pubmed ID: 18667698 Conditional Mouse Osteosarcoma, Dependent on P53 Loss and Potentiated by Loss of Rb, Mimics the Human Disease Genes & Development. Jun, 2008 | Pubmed ID: 18559481 Requirement of Nanog Dimerization for Stem Cell Self-renewal and Pluripotency Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18436640 Targeted Disruption of the Basic Krüppel-like Factor Gene (Klf3) Reveals a Role in Adipogenesis Molecular and Cellular Biology. Jun, 2008 | Pubmed ID: 18391014 La Aparición De Células Madre Hematopoyéticas Se Inicia En El Sistema Vascular De La Placenta En La Ausencia De Circulación Cell Stem Cell. Mar, 2008 | Pubmed ID: 18371450 An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells Cell. Mar, 2008 | Pubmed ID: 18358816 PRC1 and Suv39h Specify Parental Asymmetry at Constitutive Heterochromatin in Early Mouse Embryos Nature Genetics. Apr, 2008 | Pubmed ID: 18311137 Antagonism of FOG-1 and GATA Factors in Fate Choice for the Mast Cell Lineage The Journal of Experimental Medicine. Mar, 2008 | Pubmed ID: 18299398 SnapShot: Hematopoyesis Cell. Feb, 2008 | Pubmed ID: 18295585 Hematopoyesis: Un Paradigma En Evolución Para La Biología De Células Madre Cell. Feb, 2008 | Pubmed ID: 18295580 Oct4 Dependence of Chromatin Structure Within the Extended Nanog Locus in ES Cells Genes & Development. Mar, 2008 | Pubmed ID: 18283123 Rb Intrinsically Promotes Erythropoiesis by Coupling Cell Cycle Exit with Mitochondrial Biogenesis Genes & Development. Feb, 2008 | Pubmed ID: 18258751 Genome-wide Association Study Shows BCL11A Associated with Persistent Fetal Hemoglobin and Amelioration of the Phenotype of Beta-thalassemia Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18245381 A Protein Roadmap to Pluripotency and Faithful Reprogramming Cells, Tissues, Organs. 2008 | Pubmed ID: 18196921 Stem Cells Down Under-ISSCR 2007 Cell Stem Cell. Sep, 2007 | Pubmed ID: 18399027 Site-directed, Virus-free, and Inducible RNAi in Embryonic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18093939 ETV6-NTRK3 Fusion Oncogene Initiates Breast Cancer from Committed Mammary Progenitors Via Activation of AP1 Complex Cancer Cell. Dec, 2007 | Pubmed ID: 18068631 Immunology: Changed Destiny Nature. Sep, 2007 | Pubmed ID: 17898754 Epigenetic Regulation of Hematopoietic Differentiation by Gfi-1 and Gfi-1b is Mediated by the Cofactors CoREST and LSD1 Molecular Cell. Aug, 2007 | Pubmed ID: 17707228 La Prostaglandina E2 Regula La Homeostasis De Vertebrados De Células Madre Hematopoyéticas Nature. Jun, 2007 | Pubmed ID: 17581586 Rb Regulates Interactions Between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment Cell. Jun, 2007 | Pubmed ID: 17574022 Gata4 is Necessary for Normal Pulmonary Lobar Development American Journal of Respiratory Cell and Molecular Biology. Apr, 2007 | Pubmed ID: 17142311 The Hypomorphic Gata1low Mutation Alters the Proliferation/differentiation Potential of the Common Megakaryocytic-erythroid Progenitor Blood. Feb, 2007 | Pubmed ID: 17038527 Developmental Origin of a Bipotential Myocardial and Smooth Muscle Cell Precursor in the Mammalian Heart Cell. Dec, 2006 | Pubmed ID: 17123591 A Protein Interaction Network for Pluripotency of Embryonic Stem Cells Nature. Nov, 2006 | Pubmed ID: 17093407 El Viaje De Desarrollo De Las Células Madre Hematopoyéticas Development (Cambridge, England). Oct, 2006 | Pubmed ID: 16968814 Unraveling the Transcriptional Network Controlling ES Cell Pluripotency Genome Biology. 2006 | Pubmed ID: 16942632 Rb is Dispensable for Self-renewal and Multilineage Differentiation of Adult Hematopoietic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Jun, 2006 | Pubmed ID: 16754850 Notch Signaling Requires GATA-2 to Inhibit Myelopoiesis from Embryonic Stem Cells and Primary Hemopoietic Progenitors Journal of Immunology (Baltimore, Md. : 1950). May, 2006 | Pubmed ID: 16621992 Characterization of a Megakaryocyte-specific Enhancer of the Key Hemopoietic Transcription Factor GATA1 The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16551635 Identification of Distinct Molecular Phenotypes in Acute Megakaryoblastic Leukemia by Gene Expression Profiling Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16492768 Reactions to the Hwang Scandal Science (New York, N.Y.). Feb, 2006 | Pubmed ID: 16459360 Phosphorylation of Gata1 at Serine Residues 72, 142, and 310 is Not Essential for Hematopoiesis in Vivo Blood. May, 2006 | Pubmed ID: 16391009 Zinc-finger Transcription Factor Gfi-1: Versatile Regulator of Lymphocytes, Neutrophils and Hematopoietic Stem Cells Current Opinion in Hematology. Jan, 2006 | Pubmed ID: 16319680 Specification of Astrocytes by BHLH Protein SCL in a Restricted Region of the Neural Tube Nature. Nov, 2005 | Pubmed ID: 16292311 Chipping Away at the Embryonic Stem Cell Network Cell. Sep, 2005 | Pubmed ID: 16179251 La Placenta Como Un Sitio Para El Desarrollo De Células Madre Hematopoyéticas Experimental Hematology. Sep, 2005 | Pubmed ID: 16140153 Phosphatidylinositol 3-kinase/Akt Induced by Erythropoietin Renders the Erythroid Differentiation Factor GATA-1 Competent for TIMP-1 Gene Transactivation Molecular and Cellular Biology. Sep, 2005 | Pubmed ID: 16107690 The Transcription Factor GATA2 Regulates Differentiation of Brown Adipocytes EMBO Reports. Sep, 2005 | Pubmed ID: 16082385 Stem Cells: the Road Not Taken Nature. Jun, 2005 | Pubmed ID: 15931202 Developmental Stage-selective Effect of Somatically Mutated Leukemogenic Transcription Factor GATA1 Nature Genetics. Jun, 2005 | Pubmed ID: 15895080 Asimetría Temprana De La Transcripción Del Gen En La Corteza Cerebral Humana Embrionaria Del Izquierdo Y Derecha Science (New York, N.Y.). Jun, 2005 | Pubmed ID: 15894532 La Haploinsuficiencia De GATA-2 Adultos Perturba De Células Madre Hematopoyéticas Homeostasis Blood. Jul, 2005 | Pubmed ID: 15811962 La Placenta Es Un Nicho De Células Madre Hematopoyéticas Developmental Cell. Mar, 2005 | Pubmed ID: 15737932 Tie2Cre Mediada Por La Ablación De Genes Define El Gen De Células Madre De La Leucemia (SCL/tal1) Dependiente De La Ventana Durante La De Células Madre Hematopoyéticas Para El Desarrollo Blood. May, 2005 | Pubmed ID: 15677556 Coregulation of GATA Factors by the Friend of GATA (FOG) Family of Multitype Zinc Finger Proteins Seminars in Cell & Developmental Biology. Feb, 2005 | Pubmed ID: 15659346 Enforced Expression of PU.1 Rescues Osteoclastogenesis from Embryonic Stem Cells Lacking Tal-1 Stem Cells (Dayton, Ohio). 2005 | Pubmed ID: 15625130 Genes De La Orientación Y Las Estrategias De Transgénicos Para El Análisis De Desarrollo Hematopoyético En El Ratón Methods in Molecular Medicine. 2005 | Pubmed ID: 15492385 Toward Improving Caenorhabditis Elegans Phenome Mapping with an ORFeome-based RNAi Library Genome Research. Oct, 2004 | Pubmed ID: 15489339 GATA-2 Juega Dos Papeles Funcionalmente Distintos Durante La Ontogenia De Las Células Madre Hematopoyéticas The Journal of Experimental Medicine. Oct, 2004 | Pubmed ID: 15466621 Gfi-1 Restricts Proliferation and Preserves Functional Integrity of Haematopoietic Stem Cells Nature. Oct, 2004 | Pubmed ID: 15457180 A Critical Role for Eosinophils in Allergic Airways Remodeling Science (New York, N.Y.). Sep, 2004 | Pubmed ID: 15375268 Tel/Etv6 is an Essential and Selective Regulator of Adult Hematopoietic Stem Cell Survival Genes & Development. Oct, 2004 | Pubmed ID: 15371326 El Gen De Pez Cebra Moonshine Codifica La Transcripción Del Factor Intermediario 1gamma, Un Regulador Esencial De La Hematopoyesis PLoS Biology. Aug, 2004 | Pubmed ID: 15314655 Decoding Hematopoietic Specificity in the Helix-loop-helix Domain of the Transcription Factor SCL/Tal-1 Molecular and Cellular Biology. Sep, 2004 | Pubmed ID: 15314159 Endogenous Oncogenic K-ras(G12D) Stimulates Proliferation and Widespread Neoplastic and Developmental Defects Cancer Cell. Apr, 2004 | Pubmed ID: 15093544 Transforming Acidic Coiled-coil Protein 3 (TACC3) Controls Friend of GATA-1 (FOG-1) Subcellular Localization and Regulates the Association Between GATA-1 and FOG-1 During Hematopoiesis The Journal of Biological Chemistry. May, 2004 | Pubmed ID: 15037632 Defective Neural Tube Closure and Anteroposterior Patterning in Mice Lacking the LIM Protein LMO4 or Its Interacting Partner Deaf-1 Molecular and Cellular Biology. Mar, 2004 | Pubmed ID: 14966286 The SWI/SNF Complex--chromatin and Cancer Nature Reviews. Cancer. Feb, 2004 | Pubmed ID: 14964309 More Than Blood, a Novel Gene Required for Mammalian Postimplantation Development Molecular and Cellular Biology. Feb, 2004 | Pubmed ID: 14729962 Coregulator-dependent Facilitation of Chromatin Occupancy by GATA-1 Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14715908 Functional Overlap of GATA-1 and GATA-2 in Primitive Hematopoietic Development Blood. Jan, 2004 | Pubmed ID: 14504093 Priming the Hematopoietic Pump Immunity. Nov, 2003 | Pubmed ID: 14614848 Endothelial Lineage-mediated Loss of the GATA Cofactor Friend of GATA 1 Impairs Cardiac Development Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003 | Pubmed ID: 14614148 Combinatorial Interactions of Serpent, Lozenge, and U-shaped Regulate Crystal Cell Lineage Commitment During Drosophila Hematopoiesis Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003 | Pubmed ID: 14504400 Papel Esencial Para La Prdx1 Peroxirredoxina En Defensa Antioxidante Eritrocitos Y Supresión Tumoral Nature. Jul, 2003 | Pubmed ID: 12891360 GATA-1 As a Regulator of Mast Cell Differentiation Revealed by the Phenotype of the GATA-1low Mouse Mutant The Journal of Experimental Medicine. Feb, 2003 | Pubmed ID: 12566412 Conservar Las Células Madre Hematopoyéticas Actividad a Largo Plazo Repoblamiento Y Multipotencia En La Ausencia Del Gen De Células Madre SCL/tal-1 Leucemia Nature. Jan, 2003 | Pubmed ID: 12540851 Intrinsic Requirement for Zinc Finger Transcription Factor Gfi-1 in Neutrophil Differentiation Immunity. Jan, 2003 | Pubmed ID: 12530980 The Zinc Finger Transcription Factor Gfi1, Implicated in Lymphomagenesis, is Required for Inner Ear Hair Cell Differentiation and Survival Development (Cambridge, England). Jan, 2003 | Pubmed ID: 12441305 La Expresión De CD41 Marca El Inicio De La Hematopoyesis Definitiva En El Embrión De Ratón Blood. Jan, 2003 | Pubmed ID: 12393529 Highly Penetrant, Rapid Tumorigenesis Through Conditional Inversion of the Tumor Suppressor Gene Snf5 Cancer Cell. Nov, 2002 | Pubmed ID: 12450796 The SCL Complex Regulates C-kit Expression in Hematopoietic Cells Through Functional Interaction with Sp1 Blood. Oct, 2002 | Pubmed ID: 12239153 Gonadal Differentiation, Sex Determination and Normal Sry Expression in Mice Require Direct Interaction Between Transcription Partners GATA4 and FOG2 Development (Cambridge, England). Oct, 2002 | Pubmed ID: 12223418 Dysregulation of Protein Modification by ISG15 Results in Brain Cell Injury Genes & Development. Sep, 2002 | Pubmed ID: 12208842 X-linked Thrombocytopenia with Thalassemia from a Mutation in the Amino Finger of GATA-1 Affecting DNA Binding Rather Than FOG-1 Interaction Blood. Sep, 2002 | Pubmed ID: 12200364 Stem-cell Competition Nature. Jul, 2002 | Pubmed ID: 12097889 GATA-factor Dependence of the Multitype Zinc-finger Protein FOG-1 for Its Essential Role in Megakaryopoiesis Proceedings of the National Academy of Sciences of the United States of America. Jul, 2002 | Pubmed ID: 12077323 The Use of Altered Specificity Mutants to Probe Specific Protein-protein Interactions Involved in the Activation of GATA-1 Target Genes Methods (San Diego, Calif.). Jan, 2002 | Pubmed ID: 12054907 Targeted Deletion of a High-affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage in Vivo The Journal of Experimental Medicine. Jun, 2002 | Pubmed ID: 12045237 Transcriptional Regulation of Erythropoiesis: an Affair Involving Multiple Partners Oncogene. May, 2002 | Pubmed ID: 12032775 Distinct Domains of the GATA-1 Cofactor FOG-1 Differentially Influence Erythroid Versus Megakaryocytic Maturation Molecular and Cellular Biology. Jun, 2002 | Pubmed ID: 12024038 Interaction Between FOG-1 and the Corepressor C-terminal Binding Protein is Dispensable for Normal Erythropoiesis in Vivo Molecular and Cellular Biology. May, 2002 | Pubmed ID: 11940669 La Hematopoyesis Y Células Madre: Plasticidad Versus Heterogeneidad Del Desarrollo Nature Immunology. Apr, 2002 | Pubmed ID: 11919568 La Búsqueda De La Hemangioblasto Journal of Hematotherapy & Stem Cell Research. Feb, 2002 | Pubmed ID: 11847000 The Zinc-finger Proto-oncogene Gfi-1b is Essential for Development of the Erythroid and Megakaryocytic Lineages Genes & Development. Feb, 2002 | Pubmed ID: 11825872 Generación de deleciones genómicas en líneas celulares de mamíferos a través de CRISPR / Cas9 Daniel E. Bauer*1,2,3, Matthew C. Canver*1, Stuart H. Orkin1,2,3,4 1Harvard Medical School, 2Division of Hematology/Oncology, Boston Children's Hospital, 3Department of Pediatric Oncology, Dana-Farber Cancer Institute, 4Howard Hughes Medical Institute Biology
Generación de deleciones genómicas en líneas celulares de mamíferos a través de CRISPR / Cas9 Daniel E. Bauer*1,2,3, Matthew C. Canver*1, Stuart H. Orkin1,2,3,4 1Harvard Medical School, 2Division of Hematology/Oncology, Boston Children's Hospital, 3Department of Pediatric Oncology, Dana-Farber Cancer Institute, 4Howard Hughes Medical Institute Biology