Thirumala-Devi Kanneganti Department of Immunology St. Jude Children's Research Hospital Biography Publications Institution JoVE Articles Thirumala-Devi Kanneganti has not added a biography. If you are Thirumala-Devi Kanneganti and would like to personalize this page please email our Author Liaison for assistance. Publications CD47 Halts -deficient Neutrophils from Provoking Lethal Inflammation Science Advances. Jan, 2023 | Pubmed ID: 36608128 AIM2 Sensors Mediate Immunity to Infection in Hepatocytes Proceedings of the National Academy of Sciences of the United States of America. Jan, 2023 | Pubmed ID: 36595704 Inflammasome Signaling in Colorectal Cancer Translational Research : the Journal of Laboratory and Clinical Medicine. Feb, 2023 | Pubmed ID: 36150688 Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines Pathogens (Basel, Switzerland). Nov, 2022 | Pubmed ID: 36558734 Determining Distinct Roles of IL-1α Through Generation of an IL-1α Knockout Mouse with No Defect in IL-1β Expression Frontiers in Immunology. 2022 | Pubmed ID: 36505497 Innate Immunity, Cytokine Storm, and Inflammatory Cell Death in COVID-19 Journal of Translational Medicine. Nov, 2022 | Pubmed ID: 36419185 Humans PIKK-up NLRP3 to Skip NEK7 Trends in Immunology. Dec, 2022 | Pubmed ID: 36404209 Pancancer Transcriptomic Profiling Identifies Key PANoptosis Markers As Therapeutic Targets for Oncology NAR Cancer. Dec, 2022 | Pubmed ID: 36329783 PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality Journal of Immunology (Baltimore, Md. : 1950). Nov, 2022 | Pubmed ID: 36253067 Molecular Mechanism of RIPK1 and Caspase-8 in Homeostatic Type I Interferon Production and Regulation Cell Reports. Oct, 2022 | Pubmed ID: 36198273 Single Cell Analysis of PANoptosome Cell Death Complexes Through an Expansion Microscopy Method Cellular and Molecular Life Sciences : CMLS. Sep, 2022 | Pubmed ID: 36169732 A BAF-fling Connection to RIPK1 Cell Research. Aug, 2022 | Pubmed ID: 35787662 Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease Cells. Jun, 2022 | Pubmed ID: 35741014 DEAD/H-Box Helicases in Immunity, Inflammation, Cell Differentiation, and Cell Death and Disease Cells. May, 2022 | Pubmed ID: 35626643 ZBP1-dependent Inflammatory Cell Death, PANoptosis, and Cytokine Storm Disrupt IFN Therapeutic Efficacy During Coronavirus Infection Science Immunology. Aug, 2022 | Pubmed ID: 35587515 It's All in the PAN: Crosstalk, Plasticity, Redundancies, Switches, and Interconnectedness Encompassed by PANoptosis Underlying the Totality of Cell Death-Associated Biological Effects Cells. Apr, 2022 | Pubmed ID: 35563804 NLRC4 Deficiency Leads to Enhanced Phosphorylation of MLKL and Necroptosis ImmunoHorizons. Mar, 2022 | Pubmed ID: 35301258 The Transcription Factor IRF9 Promotes Colorectal Cancer Via Modulating the IL-6/STAT3 Signaling Axis Cancers. Feb, 2022 | Pubmed ID: 35205671 Innate Immunity: the First Line of Defense Against SARS-CoV-2 Nature Immunology. Feb, 2022 | Pubmed ID: 35105981 Induces NLRP3 Inflammasome Activation and Caspase-8-mediated Apoptosis of Macrophages to Promote Lethal Anthrax Proceedings of the National Academy of Sciences of the United States of America. Jan, 2022 | Pubmed ID: 34996874 Fostering Experimental and Computational Synergy to Modulate Hyperinflammation Trends in Immunology. Jan, 2022 | Pubmed ID: 34844849 It's Just a Phase: NLRP6 Phase Separations Drive Signaling Cell Research. Feb, 2022 | Pubmed ID: 34837058 Integrated Stress Response Restricts Macrophage Necroptosis Life Science Alliance. Jan, 2022 | Pubmed ID: 34764207 The IFN-inducible GTPase IRGB10 Regulates Viral Replication and Inflammasome Activation During Influenza A Virus Infection in Mice European Journal of Immunology. Feb, 2022 | Pubmed ID: 34694641 Programming Inflammatory Cell Death for Therapy Pharmacology & Therapeutics. Apr, 2022 | Pubmed ID: 34619283 PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field Journal of Molecular Biology. Feb, 2022 | Pubmed ID: 34537233 Fungal Cell Wall Components Modulate Our Immune System Cell Surface (Amsterdam, Netherlands). Dec, 2021 | Pubmed ID: 34825116 Caspase-6 Promotes Activation of the Caspase-11-NLRP3 Inflammasome During Gram-negative Bacterial Infections The Journal of Biological Chemistry. Dec, 2021 | Pubmed ID: 34740613 ADAR1 Restricts ZBP1-mediated Immune Response and PANoptosis to Promote Tumorigenesis Cell Reports. Oct, 2021 | Pubmed ID: 34686350 NLRP3 Inflammasome Activation Triggers Gasdermin D-independent Inflammation Science Immunology. Oct, 2021 | Pubmed ID: 34678046 Cutting Edge: Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense During Influenza A Virus Infection Journal of Immunology (Baltimore, Md. : 1950). Nov, 2021 | Pubmed ID: 34663620 From Pyroptosis, Apoptosis and Necroptosis to PANoptosis: A Mechanistic Compendium of Programmed Cell Death Pathways Computational and Structural Biotechnology Journal. 2021 | Pubmed ID: 34504660 AIM2 Forms a Complex with Pyrin and ZBP1 to Drive PANoptosis and Host Defence Nature. Sep, 2021 | Pubmed ID: 34471287 Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth ImmunoHorizons. Jul, 2021 | Pubmed ID: 34290111 The 'cytokine Storm': Molecular Mechanisms and Therapeutic Prospects Trends in Immunology. Aug, 2021 | Pubmed ID: 34217595 Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia Thailandensis Pathogenesis MBio. Jun, 2021 | Pubmed ID: 34154417 TLR and IKK Complex-Mediated Innate Immune Signaling Inhibits Stress Granule Assembly Journal of Immunology (Baltimore, Md. : 1950). Jul, 2021 | Pubmed ID: 34145059 CovidExpress: an Interactive Portal for Intuitive Investigation on SARS-CoV-2 Related Transcriptomes BioRxiv : the Preprint Server for Biology. Aug, 2021 | Pubmed ID: 34075382 TLR2 Senses the SARS-CoV-2 Envelope Protein to Produce Inflammatory Cytokines Nature Immunology. Jul, 2021 | Pubmed ID: 33963333 Intestinal Tête-à-tête: Helminths Blunt Immunity Against Flaviviruses Cell Research. Jul, 2021 | Pubmed ID: 33846568 DDX3X Coordinates Host Defense Against Influenza Virus by Activating the NLRP3 Inflammasome and Type I Interferon Response The Journal of Biological Chemistry. 2021 | Pubmed ID: 33766561 Role of Inflammasomes/pyroptosis and PANoptosis During Fungal Infection PLoS Pathogens. Mar, 2021 | Pubmed ID: 33735255 NLRP3 Inflammasome in Cancer and Metabolic Diseases Nature Immunology. May, 2021 | Pubmed ID: 33707781 Sepsis Take-out: Inhibiting Bacterial Deliveries Immunity. Mar, 2021 | Pubmed ID: 33691128 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition) Autophagy. Feb, 2021 | Pubmed ID: 33634751 A MyD88/IL1R Axis Regulates PD-1 Expression on Tumor-Associated Macrophages and Sustains Their Immunosuppressive Function in Melanoma Cancer Research. May, 2021 | Pubmed ID: 33619117 Metabolic Regulation of Pyroptotic Cell Death Expands the Therapeutic Landscape for Treating Inflammatory Disease Signal Transduction and Targeted Therapy. Jan, 2021 | Pubmed ID: 33514689 Advances in Understanding Activation and Function of the NLRC4 Inflammasome International Journal of Molecular Sciences. Jan, 2021 | Pubmed ID: 33494299 Osteoclast Fusion and Bone Loss Are Restricted by Interferon Inducible Guanylate Binding Proteins Nature Communications. Jan, 2021 | Pubmed ID: 33479228 Publisher Correction: Galactosaminogalactan Activates the Inflammasome to Provide Host Protection Nature. Jan, 2021 | Pubmed ID: 33349706 Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes Cell. Jan, 2021 | Pubmed ID: 33278357 PANoptosis in Microbial Infection Current Opinion in Microbiology. Feb, 2021 | Pubmed ID: 32829024 Ets-2 Deletion in Myeloid Cells Attenuates IL-1α-mediated Inflammatory Disease Caused by a Ptpn6 Point Mutation Cellular & Molecular Immunology. Jul, 2021 | Pubmed ID: 32203187 Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense Journal of Cellular Immunology. 2020 | Pubmed ID: 33426542 RIPK1 Distinctly Regulates -Induced Inflammatory Cell Death, PANoptosis ImmunoHorizons. Dec, 2020 | Pubmed ID: 33310881 Galactosaminogalactan Activates the Inflammasome to Provide Host Protection Nature. Dec, 2020 | Pubmed ID: 33268895 The Innate Immune System and Cell Death in Autoinflammatory and Autoimmune Disease Current Opinion in Immunology. Dec, 2020 | Pubmed ID: 33242752 Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines Trends in Immunology. Dec, 2020 | Pubmed ID: 33153908 Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes BioRxiv : the Preprint Server for Biology. Nov, 2020 | Pubmed ID: 33140051 ZBP1 Promotes Fungi-induced Inflammasome Activation and Pyroptosis, Apoptosis, and Necroptosis (PANoptosis) The Journal of Biological Chemistry. Dec, 2020 | Pubmed ID: 33109609 RIPK3 Promotes Expression and Pyrin Inflammasome Activation Via Modulation of MTOR Signaling Journal of Immunology (Baltimore, Md. : 1950). Nov, 2020 | Pubmed ID: 32989095 Acute IL-4 Governs Pathogenic T Cell Responses During Infection ImmunoHorizons. Sep, 2020 | Pubmed ID: 32948646 Advances in Inflammasome Research: Recent Breakthroughs and Future Hurdles Trends in Molecular Medicine. Nov, 2020 | Pubmed ID: 32948447 A Comprehensive Guide to Studying Inflammasome Activation and Cell Death Nature Protocols. Oct, 2020 | Pubmed ID: 32895525 Intracellular Innate Immune Receptors: Life Inside the Cell Immunological Reviews. Sep, 2020 | Pubmed ID: 32856334 NLRP12 in Innate Immunity and Inflammation Molecular Aspects of Medicine. Dec, 2020 | Pubmed ID: 32838963 Impaired NLRP3 Inflammasome Activation/pyroptosis Leads to Robust Inflammatory Cell Death Via Caspase-8/RIPK3 During Coronavirus Infection The Journal of Biological Chemistry. Oct, 2020 | Pubmed ID: 32763970 The Regulation of the ZBP1-NLRP3 Inflammasome and Its Implications in Pyroptosis, Apoptosis, and Necroptosis (PANoptosis) Immunological Reviews. Sep, 2020 | Pubmed ID: 32729116 ZBP1: A STARGᐰTE to Decode the Biology of Z-nucleic Acids in Disease The Journal of Experimental Medicine. Jul, 2020 | Pubmed ID: 32584411 The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis) Frontiers in Cellular and Infection Microbiology. 2020 | Pubmed ID: 32582562 PANoptosis Components, Regulation, and Implications Aging. Jun, 2020 | Pubmed ID: 32575071 Interferon Regulatory Factor 1 Regulates PANoptosis to Prevent Colorectal Cancer JCI Insight. Jun, 2020 | Pubmed ID: 32554929 DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma Developmental Cell. Aug, 2020 | Pubmed ID: 32553121 Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis) Frontiers in Cellular and Infection Microbiology. 2020 | Pubmed ID: 32547960 Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis Immunity. Jun, 2020 | Pubmed ID: 32428502 DDX3X Sits at the Crossroads of Liquid-Liquid and Prionoid Phase Transitions Arbitrating Life and Death Cell Fate Decisions in Stressed Cells DNA and Cell Biology. Jul, 2020 | Pubmed ID: 32397752 The Zα2 Domain of ZBP1 is a Molecular Switch Regulating Influenza-induced PANoptosis and Perinatal Lethality During Development The Journal of Biological Chemistry. Jun, 2020 | Pubmed ID: 32350114 Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense Cell. Apr, 2020 | Pubmed ID: 32298652 IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death Journal of Immunology (Baltimore, Md. : 1950). May, 2020 | Pubmed ID: 32205422 Toward Targeting Inflammasomes: Insights into Their Regulation and Activation Cell Research. Apr, 2020 | Pubmed ID: 32152420 Interferon Inducible GBPs Restrict Burkholderia Thailandensis motility Induced Cell-cell Fusion PLoS Pathogens. Mar, 2020 | Pubmed ID: 32150572 DNA Sensing in the Innate Immune Response Physiology (Bethesda, Md.). Mar, 2020 | Pubmed ID: 32027562 Caspases in Cell Death, Inflammation, and Pyroptosis Annual Review of Immunology. Apr, 2020 | Pubmed ID: 32017655 Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD Inflammation. Jun, 2020 | Pubmed ID: 32002713 Innate Immune Priming in the Absence of TAK1 Drives RIPK1 Kinase Activity-independent Pyroptosis, Apoptosis, Necroptosis, and Inflammatory Disease The Journal of Experimental Medicine. Mar, 2020 | Pubmed ID: 31869420 Inflammasomes and the Fine Line Between Defense and Disease Current Opinion in Immunology. Feb, 2020 | Pubmed ID: 31837596 The Nonreceptor Tyrosine Kinase SYK Drives Caspase-8/NLRP3 Inflammasome-mediated Autoinflammatory Osteomyelitis The Journal of Biological Chemistry. Mar, 2020 | Pubmed ID: 31719149 Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells Journal of Virology. Jan, 2020 | Pubmed ID: 31694942 Inflammasomes in the Pathophysiology of Autoinflammatory Syndromes Journal of Leukocyte Biology. Mar, 2020 | Pubmed ID: 31608507 Pyroptosis in Antiviral Immunity Current Topics in Microbiology and Immunology. Dec, 2019 | Pubmed ID: 31875268 ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis) Frontiers in Cellular and Infection Microbiology. 2019 | Pubmed ID: 31850239 Targeting Apoptosis Inhibition to Activate Antitumor Immunity Trends in Immunology. Dec, 2019 | Pubmed ID: 31735511 Hidden Aspects of Valency in Immune System Regulation Trends in Immunology. Dec, 2019 | Pubmed ID: 31734148 DDX3X Acts As a Live-or-die Checkpoint in Stressed Cells by Regulating NLRP3 Inflammasome Nature. Sep, 2019 | Pubmed ID: 31511697 Role of AIM2 Inflammasome in Inflammatory Diseases, Cancer and Infection European Journal of Immunology. Nov, 2019 | Pubmed ID: 31372985 Cell Death-mediated Cytokine Release and Its Therapeutic Implications The Journal of Experimental Medicine. Jul, 2019 | Pubmed ID: 31186281 On the Road to Discovering the Elusive Executioner of Pyroptosis Journal of Immunology (Baltimore, Md. : 1950). Apr, 2019 | Pubmed ID: 30885986 Diverging Inflammasome Signals in Tumorigenesis and Potential Targeting Nature Reviews. Cancer. Apr, 2019 | Pubmed ID: 30842595 Enhanced IL-1β Production is Mediated by a TLR2-MYD88-NLRP3 Signaling Axis During Coinfection with Influenza A Virus and Streptococcus Pneumoniae PloS One. 2019 | Pubmed ID: 30794604 Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging Cell Reports. Jan, 2019 | Pubmed ID: 30673616 Fueling Ketone Metabolism Quenches Salt-Induced Hypertension Trends in Endocrinology and Metabolism: TEM. Mar, 2019 | Pubmed ID: 30670332 Differential Role of the NLRP3 Inflammasome in Infection and Tumorigenesis Immunology. Apr, 2019 | Pubmed ID: 30666624 Sterile Particle-induced Inflammation is Mediated by Macrophages Releasing IL-33 Through a Bruton's Tyrosine Kinase-dependent Pathway Nature Materials. Mar, 2019 | Pubmed ID: 30664693 The Signposts and Winding Roads to Immunity and Inflammation Nature Reviews. Immunology. Feb, 2019 | Pubmed ID: 30602731 Fungal Ligands Released by Innate Immune Effectors Promote Inflammasome Activation During Aspergillus Fumigatus Infection Nature Microbiology. Feb, 2019 | Pubmed ID: 30510167 TNF/TNFR Axis Promotes Pyrin Inflammasome Activation and Distinctly Modulates Pyrin Inflammasomopathy The Journal of Clinical Investigation. Jan, 2019 | Pubmed ID: 30457980 Innate Immune Adaptor MyD88 Deficiency Prevents Skin Inflammation in SHARPIN-deficient Mice Cell Death and Differentiation. Mar, 2019 | Pubmed ID: 30038386 The NLRC4 Inflammasome Requires IRF8-dependent Production of NAIPs Cell Stress. May, 2018 | Pubmed ID: 31225480 Is Inflammasome a Potential Target of Prophylaxis in Rheumatic Heart Disease? Circulation. Dec, 2018 | Pubmed ID: 30571276 Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection Against Journal of Immunology (Baltimore, Md. : 1950). Dec, 2018 | Pubmed ID: 30404813 Gasdermin D Mediates the Pathogenesis of Neonatal-onset Multisystem Inflammatory Disease in Mice PLoS Biology. Nov, 2018 | Pubmed ID: 30388107 SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer Immunity. Sep, 2018 | Pubmed ID: 30231985 Lung γδ T Cells Mediate Protective Responses During Neonatal Influenza Infection That Are Associated with Type 2 Immunity Immunity. Sep, 2018 | Pubmed ID: 30170813 Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses Journal of Immunology (Baltimore, Md. : 1950). Sep, 2018 | Pubmed ID: 30082320 Guanylate Binding Proteins Facilitate Caspase-11-dependent Pyroptosis in Response to Type 3 Secretion System-negative Cell Death Discovery. 2018 | Pubmed ID: 30062052 Genetic Deficiency of NOD2 Confers Resistance to Invasive Aspergillosis Nature Communications. Jul, 2018 | Pubmed ID: 29980664 The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation Immunity. Jul, 2018 | Pubmed ID: 29958799 The Inflammasome Starts Rolling Nature Reviews. Immunology. Aug, 2018 | Pubmed ID: 29858587 ASK1/2 Signaling Promotes Inflammation in a Mouse Model of Neutrophilic Dermatosis The Journal of Clinical Investigation. May, 2018 | Pubmed ID: 29629899 IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation Cell. May, 2018 | Pubmed ID: 29576451 Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses During Francisella Novicida Infection Cell Reports. Mar, 2018 | Pubmed ID: 29562174 Food for Training-Western Diet and Inflammatory Memory Cell Metabolism. Mar, 2018 | Pubmed ID: 29514058 TAK1 Restricts Spontaneous NLRP3 Activation and Cell Death to Control Myeloid Proliferation The Journal of Experimental Medicine. Apr, 2018 | Pubmed ID: 29500178 ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming The American Journal of Pathology. Apr, 2018 | Pubmed ID: 29353059 Stressed-out ROS Take a Silent Death Route Nature Immunology. Feb, 2018 | Pubmed ID: 29348507 Gasdermin D Flashes an Exit Signal for IL-1 Immunity. Jan, 2018 | Pubmed ID: 29343431 IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death During Influenza Virus Infection Journal of Immunology (Baltimore, Md. : 1950). Feb, 2018 | Pubmed ID: 29321274 Function and Regulation of IL-1α in Inflammatory Diseases and Cancer Immunological Reviews. Jan, 2018 | Pubmed ID: 29247991 Mechanisms and Consequences of Inflammasome Activation Journal of Molecular Biology. Jan, 2018 | Pubmed ID: 29247654 ZBP1: Innate Sensor Regulating Cell Death and Inflammation Trends in Immunology. Feb, 2018 | Pubmed ID: 29236673 Triggers a CGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation Journal of Immunology (Baltimore, Md. : 1950). Jan, 2018 | Pubmed ID: 29203515 Pyrin Inflammasome Regulates Tight Junction Integrity To Restrict Colitis and Tumorigenesis Gastroenterology. Mar, 2018 | Pubmed ID: 29203393 Recent Advances in Inflammasome Biology Current Opinion in Immunology. Feb, 2018 | Pubmed ID: 29128729 The Absence of NOD1 Enhances Killing of Through Modulation of Dectin-1 Expression Frontiers in Immunology. 2017 | Pubmed ID: 29326692 Caspase-1 Engagement and TLR-Induced C-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4 Cell Reports. Dec, 2017 | Pubmed ID: 29262324 Inflammasome Activation and Assembly at a Glance Journal of Cell Science. Dec, 2017 | Pubmed ID: 29196474 CGAMP: A Tale of Two Signals The Journal of Experimental Medicine. Dec, 2017 | Pubmed ID: 29150429 Inflammatory Cell Death in Intestinal Pathologies Immunological Reviews. Nov, 2017 | Pubmed ID: 29027223 Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins MBio. Oct, 2017 | Pubmed ID: 28974614 Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC Via the CGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor Journal of Immunology (Baltimore, Md. : 1950). Nov, 2017 | Pubmed ID: 28947539 Toll-like Receptor 2 Induced Cytotoxic T-lymphocyte-associated Protein 4 Regulates Aspergillus-induced Regulatory T-cells with Pro-inflammatory Characteristics Scientific Reports. Sep, 2017 | Pubmed ID: 28904353 Inflammatory Bowel Disease and the NLRP3 Inflammasome The New England Journal of Medicine. Aug, 2017 | Pubmed ID: 28813221 Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components Infection and Immunity. Oct, 2017 | Pubmed ID: 28784930 War on Viruses: LC3 Recruits GTPases Cell Host & Microbe. Jul, 2017 | Pubmed ID: 28704655 ZBP1/DAI Ubiquitination and Sensing of Influenza VRNPs Activate Programmed Cell Death The Journal of Experimental Medicine. Aug, 2017 | Pubmed ID: 28634194 Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8 T Cell Function and Impaired Viral Clearance Journal of Virology. Sep, 2017 | Pubmed ID: 28615208 NLRC3 Regulates Cellular Proliferation and Apoptosis to Attenuate the Development of Colorectal Cancer Cell Cycle (Georgetown, Tex.). Jul, 2017 | Pubmed ID: 28598238 Mechanisms Governing Inflammasome Activation, Assembly and Pyroptosis Induction International Immunology. May, 2017 | Pubmed ID: 28531279 Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β Journal of Immunology (Baltimore, Md. : 1950). Jun, 2017 | Pubmed ID: 28468974 Molecular Mechanisms and Functions of Pyroptosis, Inflammatory Caspases and Inflammasomes in Infectious Diseases Immunological Reviews. May, 2017 | Pubmed ID: 28462526 Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease Immunity. Apr, 2017 | Pubmed ID: 28410990 Inflammasome Activation by Nucleic Acids and Nucleosomes in Sterile Inflammation… or is It Sterile? The FEBS Journal. Aug, 2017 | Pubmed ID: 28374568 Differential Roles of Caspase-1 and Caspase-11 in Infection and Inflammation Scientific Reports. Mar, 2017 | Pubmed ID: 28345580 Regulation and Functions of NLRP3 Inflammasome During Influenza Virus Infection Molecular Immunology. Jun, 2017 | Pubmed ID: 28169000 Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9 Journal of Immunology (Baltimore, Md. : 1950). Mar, 2017 | Pubmed ID: 28130494 Inflammasomes and Cancer Cancer Immunology Research. Feb, 2017 | Pubmed ID: 28093447 IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever The American Journal of Pathology. Feb, 2017 | Pubmed ID: 27998728 Interferon-inducible Guanylate-binding Proteins at the Interface of Cell-autonomous Immunity and Inflammasome Activation Journal of Leukocyte Biology. Jan, 2017 | Pubmed ID: 27418355 Critical Role of Caspase-8-mediated IL-1 Signaling in Promoting Th2 Responses During Asthma Pathogenesis Mucosal Immunology. 01, 2017 | Pubmed ID: 27007676 NLRC3 is an Inhibitory Sensor of PI3K-mTOR Pathways in Cancer Nature. Dec, 2016 | Pubmed ID: 27951586 ZBP1/DAI is an Innate Sensor of Influenza Virus Triggering the NLRP3 Inflammasome and Programmed Cell Death Pathways Science Immunology. Aug, 2016 | Pubmed ID: 27917412 Distinct Role of IL-1β in Instigating Disease in Sharpin Mice Scientific Reports. Nov, 2016 | Pubmed ID: 27892465 Regulation of Lysosomal Dynamics and Autophagy by CTSB/cathepsin B Autophagy. Dec, 2016 | Pubmed ID: 27786577 IL-33 Regulates the IgA-microbiota Axis to Restrain IL-1α-dependent Colitis and Tumorigenesis The Journal of Clinical Investigation. Dec, 2016 | Pubmed ID: 27775548 IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes Cell. Oct, 2016 | Pubmed ID: 27693356 Rewiring Cellular Metabolism Via the AKT/mTOR Pathway Contributes to Host Defence Against Mycobacterium Tuberculosis in Human and Murine Cells European Journal of Immunology. Nov, 2016 | Pubmed ID: 27624090 Cathepsin B Modulates Lysosomal Biogenesis and Host Defense Against Francisella Novicida Infection The Journal of Experimental Medicine. Sep, 2016 | Pubmed ID: 27551156 The Cell Biology of Inflammasomes: Mechanisms of Inflammasome Activation and Regulation The Journal of Cell Biology. Jun, 2016 | Pubmed ID: 27325789 DOCK2 Confers Immunity and Intestinal Colonization Resistance to Citrobacter Rodentium Infection Scientific Reports. Jun, 2016 | Pubmed ID: 27291827 Autoinflammatory Skin Disorders: The Inflammasomme in Focus Trends in Molecular Medicine. Jul, 2016 | Pubmed ID: 27267764 Microbiota and Caspase-1/caspase-8 Regulate IL-1β-mediated Bone Disease Gut Microbes. Jul, 2016 | Pubmed ID: 27148834 Autophagy Suppresses Host Adaptive Immune Responses Toward Borrelia Burgdorferi Journal of Leukocyte Biology. Sep, 2016 | Pubmed ID: 27101991 NLRP3 Inflammasome Plays a Redundant Role with Caspase 8 to Promote IL-1β-mediated Osteomyelitis Proceedings of the National Academy of Sciences of the United States of America. Apr, 2016 | Pubmed ID: 27071119 DNA-sensing Inflammasomes: Regulation of Bacterial Host Defense and the Gut Microbiota Pathogens and Disease. Jun, 2016 | Pubmed ID: 27056948 Immune Responses Against Protozoan Parasites: a Focus on the Emerging Role of Nod-like Receptors Cellular and Molecular Life Sciences : CMLS. Aug, 2016 | Pubmed ID: 27032699 Type I Interferon Keeps IL-1β in Check Cell Host & Microbe. Mar, 2016 | Pubmed ID: 26962937 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition) Autophagy. Jan, 2016 | Pubmed ID: 26799652 Converging Roles of Caspases in Inflammasome Activation, Cell Death and Innate Immunity Nature Reviews. Immunology. Jan, 2016 | Pubmed ID: 26655628 AIM2 Inflammasome in Infection, Cancer, and Autoimmunity: Role in DNA Sensing, Inflammation, and Innate Immunity European Journal of Immunology. Feb, 2016 | Pubmed ID: 26626159 Gasdermin D: the Long-awaited Executioner of Pyroptosis Cell Research. Nov, 2015 | Pubmed ID: 26482951 Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation Through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation Scientific Reports. Sep, 2015 | Pubmed ID: 26412089 NLRP12 in Autoimmune Diseases Oncotarget. Aug, 2015 | Pubmed ID: 26343520 Innate Immunity Against Leishmania Infections Cellular Microbiology. Sep, 2015 | Pubmed ID: 26249747 Molecular Characterization of LC3-associated Phagocytosis Reveals Distinct Roles for Rubicon, NOX2 and Autophagy Proteins Nature Cell Biology. Jul, 2015 | Pubmed ID: 26098576 Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer Cell. Jul, 2015 | Pubmed ID: 26095253 Innate Immune Recognition of MtDNA--an Undercover Signal? Cell Metabolism. Jun, 2015 | Pubmed ID: 26039443 A20 is a Regulator of Necroptosis Nature Immunology. Jun, 2015 | Pubmed ID: 25988900 NALP3 Inflammasome Upregulation and CASP1 Cleavage of the Glucocorticoid Receptor Cause Glucocorticoid Resistance in Leukemia Cells Nature Genetics. Jun, 2015 | Pubmed ID: 25938942 The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells Immunity. Apr, 2015 | Pubmed ID: 25888258 Regulation of Inflammasome Activation Immunological Reviews. May, 2015 | Pubmed ID: 25879280 The Inflammasome: Firing Up Innate Immunity Immunological Reviews. May, 2015 | Pubmed ID: 25879279 The Transcription Factor IRF1 and Guanylate-binding Proteins Target Activation of the AIM2 Inflammasome by Francisella Infection Nature Immunology. May, 2015 | Pubmed ID: 25774715 Inflammasome Control of Viral Infection Current Opinion in Virology. Jun, 2015 | Pubmed ID: 25771504 Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection Against Aspergillus Infection Cell Host & Microbe. Mar, 2015 | Pubmed ID: 25704009 An NLRP3 Inflammasome-triggered Th2-biased Adaptive Immune Response Promotes Leishmaniasis The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25689249 Cutting Edge: SHARPIN is Required for Optimal NLRP3 Inflammasome Activation Journal of Immunology (Baltimore, Md. : 1950). Mar, 2015 | Pubmed ID: 25637014 IL-10 Engages Macrophages to Shift Th17 Cytokine Dependency and Pathogenicity During T-cell-mediated Colitis Nature Communications. Jan, 2015 | Pubmed ID: 25607885 MHCII-independent CD4+ T Cells Protect Injured CNS Neurons Via IL-4 The Journal of Clinical Investigation. Feb, 2015 | Pubmed ID: 25607842 Flagellin-induced NLRC4 Phosphorylation Primes the Inflammasome for Activation by NAIP5 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2015 | Pubmed ID: 25605939 Drak2 is Not Required for Tumor Surveillance and Suppression International Immunology. Mar, 2015 | Pubmed ID: 25568303 Mitochondria: Diversity in the Regulation of the NLRP3 Inflammasome Trends in Molecular Medicine. Mar, 2015 | Pubmed ID: 25500014 Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation The American Journal of Pathology. Jan, 2015 | Pubmed ID: 25451151 Cutting Edge: STING Mediates Protection Against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation Journal of Immunology (Baltimore, Md. : 1950). Nov, 2014 | Pubmed ID: 25320273 Dietary Modulation of the Microbiome Affects Autoinflammatory Disease Nature. Dec, 2014 | Pubmed ID: 25274309 Reactive Oxygen Species Regulate Caspase-11 Expression and Activation of the Non-canonical NLRP3 Inflammasome During Enteric Pathogen Infection PLoS Pathogens. Sep, 2014 | Pubmed ID: 25254654 Negative Regulation of the NLRP3 Inflammasome by A20 Protects Against Arthritis Nature. Aug, 2014 | Pubmed ID: 25043000 Nucleotide Oligomerization and Binding Domain 2-dependent Dendritic Cell Activation is Necessary for Innate Immunity and Optimal CD8+ T Cell Responses to Influenza A Virus Infection Journal of Virology. Aug, 2014 | Pubmed ID: 24872587 Caspase-11 is Expressed in the Colonic Mucosa and Protects Against Dextran Sodium Sulfate-induced Colitis Mucosal Immunology. Nov, 2014 | Pubmed ID: 24850431 Beyond Canonical Inflammasomes: Emerging Pathways in IL-1-mediated Autoinflammatory Disease Seminars in Immunopathology. Sep, 2014 | Pubmed ID: 24838628 RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3 Cell. May, 2014 | Pubmed ID: 24813850 Fungal Chitin Dampens Inflammation Through IL-10 Induction Mediated by NOD2 and TLR9 Activation PLoS Pathogens. Apr, 2014 | Pubmed ID: 24722226 Activation of the NLRP1b Inflammasome Independently of ASC-mediated Caspase-1 Autoproteolysis and Speck Formation Nature Communications. 2014 | Pubmed ID: 24492532 FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes Journal of Immunology (Baltimore, Md. : 1950). Feb, 2014 | Pubmed ID: 24453255 Critical Role for Inflammasome-independent IL-1β Production in Osteomyelitis Proceedings of the National Academy of Sciences of the United States of America. Jan, 2014 | Pubmed ID: 24395792 Salmonella Exploits NLRP12-dependent Innate Immune Signaling to Suppress Host Defenses During Infection Proceedings of the National Academy of Sciences of the United States of America. Jan, 2014 | Pubmed ID: 24347638 Role of Type I Interferons in Inflammasome Activation, Cell Death, and Disease During Microbial Infection Frontiers in Cellular and Infection Microbiology. 2013 | Pubmed ID: 24273750 Unsolved Mysteries in NLR Biology Frontiers in Immunology. Sep, 2013 | Pubmed ID: 24062750 The Expanding Role of NLRs in Antiviral Immunity Immunological Reviews. Sep, 2013 | Pubmed ID: 23947344 NLRP6 in Infection and Inflammation Microbes and Infection. 2013 | Pubmed ID: 23811097 RIP1-driven Autoinflammation Targets IL-1α Independently of Inflammasomes and RIP3 Nature. Jun, 2013 | Pubmed ID: 23708968 Receptor Interacting Protein Kinase 2-mediated Mitophagy Regulates Inflammasome Activation During Virus Infection Nature Immunology. May, 2013 | Pubmed ID: 23525089 Autophagy Modulates Borrelia Burgdorferi-induced Production of Interleukin-1β (IL-1β) The Journal of Biological Chemistry. Mar, 2013 | Pubmed ID: 23386602 Innate Immune Pathways in Host Defense Mediators of Inflammation. 2012 | Pubmed ID: 23326019 Murine Borrelia Arthritis is Highly Dependent on ASC and Caspase-1, but Independent of NLRP3 Arthritis Research & Therapy. Nov, 2012 | Pubmed ID: 23148704 IL-1 Family Cytokines Trigger Sterile Inflammatory Disease Frontiers in Immunology. 2012 | Pubmed ID: 23087690 Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense Against Enteropathogens The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22898816 Membrane Damage During Listeria Monocytogenes Infection Triggers a Caspase-7 Dependent Cytoprotective Response PLoS Pathogens. 2012 | Pubmed ID: 22807671 NLRP6 Negatively Regulates Innate Immunity and Host Defence Against Bacterial Pathogens Nature. Aug, 2012 | Pubmed ID: 22763455 The Role of Inflammasome Modulation in Virulence Virulence. May, 2012 | Pubmed ID: 22546900 선천면역세포사멸을 평가하기 위한 카스파아제 활성화 평가 Joo-Hui Han1, Rebecca E. Tweedell1, Thirumala-Devi Kanneganti1 1Department of Immunology, St. Jude Children's Research Hospital JoVE 64308 Immunology and Infection
선천면역세포사멸을 평가하기 위한 카스파아제 활성화 평가 Joo-Hui Han1, Rebecca E. Tweedell1, Thirumala-Devi Kanneganti1 1Department of Immunology, St. Jude Children's Research Hospital JoVE 64308 Immunology and Infection